Article
Peripheral Vascular Disease
Douglas D. DeCarolis, Amy Gravely, Christine M. Olney, Areef Ishani
Summary: This analysis suggests that long-term exposure to thiazide-type diuretics and renin-angiotensin system blockers is associated with reduced adverse cardiovascular events, while long-term exposure to beta-blockers may increase the risk of cardiovascular events.
Review
Peripheral Vascular Disease
Jun Kyoung, Rohit R. Atluri, Tao Yang
Summary: The gut microbiota plays a crucial role in drug metabolism, including antihypertensive drugs, and understanding this interaction may lead to better therapeutic outcomes. Resistant hypertension, a subset of patients with poor response to antihypertensive medications, is linked to the gut microbiota.
Article
Neurosciences
Jing Zhou, Rod L. Walker, Shelly L. Gray, Zachary A. Marcum, Douglas Barthold, James D. Bowen, Wayne McCormick, Susan M. McCurry, Eric B. Larson, Paul K. Crane
Summary: The study found that higher glucose levels are associated with dementia risk, and that hypertension and antihypertensive treatments do not appear to affect this association. Further research is needed to explore the impact of midlife and specific antihypertensive treatments on this relationship.
JOURNAL OF ALZHEIMERS DISEASE
(2021)
Article
Peripheral Vascular Disease
Catherine G. Derington, Adam P. Bress, Andrew E. Moran, William S. Weintraub, Jennifer S. Herrick, William C. Cushman, Ian M. Kronish, Barry Stults, Daichi Shimbo, Paul Muntner, Tom Greene, Jeffrey T. Bates, Tara I. Chang, Lois Anne Katz, Shakaib U. Rehman, Christianne L. Roumie, Leonardo Tamariz, Jordan B. King
Summary: In the SPRINT study, the use of ACE inhibitors or ARBs, thiazide diuretics, and calcium channel blockers in combination is favored to target systolic blood pressure (SBP) < 120 mm Hg, instead of using ACE/ARB monotherapy to target SBP < 140 mm Hg.
Article
Peripheral Vascular Disease
Giuseppe Mancia, Rita Facchetti, Fosca Quarti-Trevano, Guido Grassi
Summary: This study analyzed the effects of antihypertensive treatment on office and ambulatory blood pressure in patients with white-coat hypertension (WCH). The results showed that antihypertensive treatment effectively reduced office blood pressure in WCH patients, but had no effect on ambulatory blood pressure. These findings were consistent regardless of the type of treatment used.
JOURNAL OF HYPERTENSION
(2022)
Article
Peripheral Vascular Disease
Tao Yang, Xue Mei, Ethel Tackie-Yarboi, Millicent Tambari Akere, Jun Kyoung, Blair Mell, Ji-Youn Yeo, Xi Cheng, Jasenka Zubcevic, Elaine M. Richards, Carl J. Pepine, Mohan K. Raizada, Isaac T. Schiefer, Bina Joe
Summary: This study reveals that gut microbiota can catabolize antihypertensive medications and compromise their blood pressure-lowering effects. Specifically, C. comes, a species in the bacterial genus Coprococcus, catabolizes ester ACE inhibitors through esterase activity, leading to reduced antihypertensive effects. This finding provides a new mechanistic explanation for the low efficacy of antihypertensive medications in hypertensive individuals.
Article
Cardiac & Cardiovascular Systems
Fanghua Li, Anbang Sun, Feng Wu, Dongshan Zhang, Zhanzheng Zhao
Summary: Blood pressure control rates have not improved among US adult patients taking antihypertensive medications over the last decade. Many CKD adults require combination therapy to reach the recommended blood pressure target. However, the proportion of adult CKD patients on monotherapy or combination therapy has not been quantified.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2023)
Article
Peripheral Vascular Disease
Jaejin An, Tiffany Luong, Lei Qian, Rong Wei, Ran Liu, Paul Muntner, Jeffrey Brettler, Marc G. Jaffe, Andrew E. Moran, Kristi Reynolds
Summary: The study found that patients who initiated ACEI-thiazide diuretic combination therapy were more likely to achieve BP goals compared with those who initiated monotherapy.
Article
Medicine, General & Internal
Felix Mahfoud, David E. Kandzari, Kazuomi Kario, Raymond R. Townsend, Michael A. Weber, Roland E. Schmieder, Konstantinos Tsioufis, Stuart Pocock, Kyriakos Dimitriadis, James W. Choi, Cara East, Richard D'Souza, Andrew S. P. Sharp, Sebastian Ewen, Antony Walton, Ingrid Hopper, Sandeep Brar, Pamela McKenna, Martin Fahy, Michael Boehm
Summary: In this study, the long-term safety and efficacy of renal denervation were evaluated. The results showed that renal denervation produced a clinically meaningful and lasting blood pressure reduction up to 36 months, independent of concomitant antihypertensive medications and without major safety events.
Editorial Material
Medicine, General & Internal
Anuj A. Patel, David S. Goldfarb
Summary: This article compares first-line diuretics with other classes of antihypertensive drugs in the treatment of hypertension.
ANNALS OF INTERNAL MEDICINE
(2023)
Review
Nutrition & Dietetics
Nestor Ibarz-Blanch, Diego Morales, Enrique Calvo, Laura Ros-Medina, Begona Muguerza, Francisca Isabel Bravo, Manuel Suarez
Summary: This study reviews the mechanisms of blood pressure regulation by natural antihypertensive compounds and their efficacy depending on consumption time. While many studies have investigated the impact of food-derived compounds such as phenolic compounds or peptides on blood pressure, only a few have addressed the relevance of time consumption. Therefore, further research is needed to fully understand the interactions along the time-nutrition-hypertension axis.
Article
Medicine, General & Internal
James P. K. Sheppard, Constantinos Koshiaris, Richard Stevens, Sarah A. Lay-Flurrie, Amitava Banerjee, Brandon K. A. Bellows, Andrew J. Clegg, F. D. Richard Hobbs, Rupert A. Payne, Subhashisa Swain, Juliet A. Usher-Smith, Richard J. McManus
Summary: This study found that blood pressure-lowering treatment is associated with an increased risk of serious adverse events, particularly in older and frail patients. The analysis suggests that prescribing new treatment in these populations may be just as likely to cause a serious fall as it would prevent a stroke or heart attack.
Review
Chemistry, Applied
Arshdeep Kaur, Bababode Adesegun Kehinde, Poorva Sharma, Deepansh Sharma, Sawinder Kaur
Summary: Bioactive peptides from food sources have shown potential as therapeutic agents for hypertension by inhibiting ACE and reducing blood pressure. Research has focused on the isolation, hydrolysis, and biofunctionality testing of these peptides, providing valuable literature for hypertension treatment.
Review
Peripheral Vascular Disease
Satoshi Kidoguchi, Naoki Sugano, Takashi Yokoo, Hidehiro Kaneko, Hiroshi Akazawa, Mikio Mukai, Koichi Node, Yuichiro Yano, Akira Nishiyama
Summary: This article reviews the studies on antihypertensive drugs and cancer, with a focus on clinical trial results. However, the results of these studies are inconsistent and the evidence remains limited. The heterogeneity in study designs makes it difficult to clarify the causal relationship between antihypertensive drugs and cancer.
AMERICAN JOURNAL OF HYPERTENSION
(2022)
Article
Nutrition & Dietetics
Jose C. E. Serrano, Eva Castro-Boque, Alicia Garcia-Carrasco, Maria Ines Moran-Valero, Daniel Gonzalez-Hedstrom, Marcelino Bermudez-Lopez, Jose Manuel Valdivielso, Alberto E. Espinel, Manuel Portero-Otin
Summary: This study validates the antihypertensive effects of an optimized extract of aged black garlic with low doses of S-allyl-cysteine (SAC) in a Grade I hypertensive population. The results show a reduction in blood pressure, an increase in nitric oxide and antioxidant capacity, and a decrease in uric acid levels and ACE activity. No changes in endothelial function and inflammatory cytokines were observed.
Article
Nutrition & Dietetics
Yunyang Deng, Junjie Huang, Martin Chi Sang Wong
Summary: This study investigated the causal associations of alcohol and coffee with colorectal cancer (CRC) risk in an East Asian population using Mendelian randomization (MR). The results showed that genetically predicted alcohol use and consumption were positively associated with CRC risk, while genetically predicted coffee consumption was inversely related to CRC risk.
EUROPEAN JOURNAL OF NUTRITION
(2023)
Article
Nursing
Arthur Tang, Kin-Kit Li, SeungHee Han, Kin On Kwok, Neo Tung, Wilson Tam
Summary: This study examines and verifies the effects of various strategies, such as the use of Twitter, international collaboration, the use of ResearchGate, and open access publishing, on amplifying the citation count of research articles in nursing. The findings demonstrate that these strategies can effectively increase the citation count of nursing articles.
JOURNAL OF NURSING SCHOLARSHIP
(2023)
Article
Oncology
Junjie Huang, Sze Chai Chan, Veeleah Lok, Lin Zhang, Xu Lin, Don Eliseo Lucero-Prisno, Wanghong Xu, Zhi-Jie Zheng, Edmar Elcarte, Mellissa Withers, Martin C. S. Wong
Summary: This study evaluated the global incidence, mortality, associated risk factors, and temporal trends of central nervous system (CNS) cancer. The results showed that the overall incidence and mortality rates of CNS cancer were relatively stable globally, but there was an increasing trend in younger male population. Some higher Human Development Index (HDI) countries also showed an increasing mortality rate, indicating a need for further research and exploration of the reasons behind these trends.
Article
Computer Science, Hardware & Architecture
Binwu Zhu, Xinyun Zhang, Yibo Lin, Bei Yu, Martin Wong
Summary: This study proposes the first DRC script generation framework that utilizes deep learning and multi-task learning techniques to automatically identify key parameters and generate executable scripts, thus reducing the time for design rule checking.
ACM TRANSACTIONS ON DESIGN AUTOMATION OF ELECTRONIC SYSTEMS
(2023)
Review
Nursing
Chiew Jiat Rosalind Siah, Yong Shian Goh, Jungup Lee, Sum Ngok Poon, Jenna Qing Yun Ow Yong, Wai-San Wilson Tam
Summary: Globally, many people living in fast-paced urban settings struggle with stress and responding positively to crises, resulting in prolonged distress and negative impacts on mental and physical health. Forest bathing has been suggested as a way to provide psychological and physiological benefits. This systematic review evaluated the effects of forest bathing on psychological and physiological outcomes, finding that it can significantly reduce symptoms of depression and anxiety. However, the benefits in physiological outcomes were not as prominent. This review emphasizes the potential therapeutic role of forests and provides evidence-based support for forest conservation.
INTERNATIONAL JOURNAL OF MENTAL HEALTH NURSING
(2023)
Article
Immunology
Junjie Huang, Calvin K. M. Cheung, Vera M. W. Keung, Amelia S. C. Lo, Sze Chai Chan, Wing Sze Pang, Queenie H. Y. Li, Lancelot W. H. Mui, Albert Lee, Martin C. S. Wong
Summary: This study aimed to investigate the recent childhood immunization rate and identify factors affecting vaccination uptake in young children in Hong Kong. It was found that children were more likely to be fully vaccinated at a younger age, with higher household income, and if they were the first child in the family.
Article
Endocrinology & Metabolism
Martin C. S. Wong, Junjie Huang, Harry H. X. Wang, Sarah T. Y. Yau, Jeremy Y. C. Teoh, Peter K. F. Chiu, Chi-Fai Ng, Eman Yee-Man Leung
Summary: By analyzing a large database of people with diabetes who received cystoscopy in China, a clinical scoring system was developed and validated to predict the risk of bladder cancer and guide urgent cystoscopy evaluation. The scoring system, based on independent risk factors, classified individuals into average risk and high risk groups. This scoring system can effectively stratify high-risk individuals who should consider earlier cystoscopy.
Article
Nursing
Ying Jiang, Ci Zhang, Jingfang Hong, Wilson Wai San Tam, Hadassah Joann Ramachandran, Wenru Wang
Summary: This study examined the relationships of person-related, problem-related, and environment-related factors to self-care behaviors in heart failure management. The results showed that better social support was directly associated with higher levels of self-care confidence, and higher levels of self-care confidence were associated with better self-care maintenance and self-care management. There was also an indirect relationship between social support and self-care behaviors through the mediator of self-care confidence.
INTERNATIONAL JOURNAL OF NURSING STUDIES
(2023)
Article
Nursing
Brigitte Fong Yeong Woo, Wilson Wai San Tam, Kevin Hartman, Wentao Zhou
Summary: The aim of this study was to explore factors associated with academic performance in the Master of Nursing programme. The findings showed that age was significantly associated with overall cumulative academic performance, with younger students outperforming older students on average. Unmarried students were also associated with better cumulative academic performance in the Clinical Practicum 2 module. The study suggests that the requirement of five years of clinical experience as an admission criterion for the Master of Nursing programme in Singapore should be reassessed.
INTERNATIONAL NURSING REVIEW
(2023)
Article
Nursing
Arthur Tang, Kin-Kit Li, Kin On Kwok, Liujiao Cao, Stanley Luong, Wilson Tam
Summary: This study explores the transparency of generative AI use in nursing academic research journals, emphasizing the importance of declaring the usage of generative AI in manuscripts. The findings show that only 37.6% of nursing journals require explicit statements about generative AI use. Declaring generative AI tools is crucial for maintaining transparency and credibility in academic writing.
JOURNAL OF NURSING SCHOLARSHIP
(2023)
Article
Immunology
Xue Liang, Jiming Li, Yuan Fang, Qingpeng Zhang, Martin C. S. Wong, Fuk-yuen Yu, Danhua Ye, Paul Shing-fong Chan, Joseph Kawuki, Siyu Chen, Phoenix K. H. Mo, Zixin Wang
Summary: This study investigated the associations of COVID-19 vaccination, perceptions related to COVID-19 and seasonal influenza vaccination (SIV), with the behavioural intention to receive SIV among older adults in Hong Kong, China. It found that concerns about the negative impact of SIV and COVID-19 vaccination on each other and the perceived risk of co-infection with COVID-19 and seasonal influenza were associated with the intention to receive SIV.
Editorial Material
Oncology
Martin C. S. Wong, Junjie Huang, Peter S. Liang
CLINICAL AND TRANSLATIONAL MEDICINE
(2023)
Article
Medicine, General & Internal
Zixin Wang, Paul Shing-fong Chan, Yuan Fang, Fuk-yuen Yu, Danhua Ye, Qingpeng Zhang, Martin C. S. Wong, Phoenix K. H. Mo
Summary: Receiving seasonal influenza vaccination (SIV) is important during the COVID-19 pandemic. This study aimed to evaluate the efficacy of a stages of change (SOC)-tailored online intervention in increasing SIV uptake among Hong Kong residents 65 years or older compared to a standard, non-SOC-tailored online intervention.
Article
Psychology, Developmental
Junjie Huang, Vera M. W. Keung, Calvin K. M. Cheung, Amelia S. C. Lo, Sze Chai Chan, Wing Sze Pang, Lancelot W. H. Mui, Albert Lee, Martin C. S. Wong
Summary: This study explored the association between negative mental health conditions and demographic characteristics, socioeconomic background and health-related parameters in primary and secondary school students in Hong Kong. The results indicated that both very high and low parent expectations were risk factors for suicidality and psychological distress in primary school students, as well as psychological distress in secondary school students. Being bullied was a significant risk factor for all conditions in primary school students. Having one's own bedroom was associated with suicidality in primary school students, while having three or more close friends and higher life satisfaction were significantly linked to a lower risk of negative mental health conditions in secondary school students.
CHILD CARE HEALTH AND DEVELOPMENT
(2023)
Proceedings Paper
Computer Science, Artificial Intelligence
Su Zheng, Lancheng Zou, Siting Liu, Yibo Lin, Bei Yu, Martin Wong
Summary: In this paper, a method is proposed to mitigate the distribution shift problem in congestion prediction through optical flow prediction and invariant feature space learning technique, leading to improved congestion prediction performance and placement results.
2023 60TH ACM/IEEE DESIGN AUTOMATION CONFERENCE, DAC
(2023)
