SOCE and cancer: Recent progress and new perspectives

Inside-out Ca2+ signalling prompted by STIM1 conformational switch

(2015) Guolin Ma et al.   Nature Communications

Enhanced Orai1 and STIM1 expression as well as store operated Ca2+ entry in therapy resistant ovary carcinoma cells

(2015) Sebastian Schmidt et al.   Oncotarget

Orai1 and STIM1 are critical for cell migration and proliferation of clear cell renal cell carcinoma

(2014) Ji-Hee Kim et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Orai1 and STIM1 mediate SOCE and contribute to apoptotic resistance of pancreatic adenocarcinoma

(2014) Kateryna Kondratska et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

CD4+ and CD8+ T cell–dependent antiviral immunity requires STIM1 and STIM2

(2014) Patrick J. Shaw et al.   JOURNAL OF CLINICAL INVESTIGATION

STIM1, a direct target of microRNA-185, promotes tumor metastasis and is associated with poor prognosis in colorectal cancer

(2014) Z Zhang et al.   ONCOGENE

STIM1 overexpression promotes colorectal cancer progression, cell motility and COX-2 expression

(2014) J-Y Wang et al.   ONCOGENE

Store-Operated Ca2+ Entry (SOCE) Regulates Melanoma Proliferation and Cell Migration

(2014) Masanari Umemura et al.   PLoS One

Inhibition of store-operated Ca2+ entry suppresses EGF-induced migration and eliminates extravasation from vasculature in nasopharyngeal carcinoma cell

(2013) Jinyan Zhang et al.   CANCER LETTERS

Molecular pharmacology of store-operated CRAC channels

(2013) Amit Jairaman et al.   Channels

STIM1 and STIM2-mediated Ca2+influx regulates antitumour immunity by CD8+T cells

(2013) Carl Weidinger et al.   EMBO Molecular Medicine

The apoptosis of non-small cell lung cancer induced by cisplatin through modulation of STIM1

(2013) Wenjun Li et al.   EXPERIMENTAL AND TOXICOLOGIC PATHOLOGY

The ER Ca2+ sensor STIM1 regulates actomyosin contractility of migratory cells

(2013) Y.-T. Chen et al.   JOURNAL OF CELL SCIENCE

Suppression of STIM1 inhibits human glioblastoma cell proliferation and induces G0/G1 phase arrest

(2013) Guilin Li et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Calcium Signaling via Orai1 Is Essential for Induction of the Nuclear Orphan Receptor Pathway To Drive Th17 Differentiation

(2013) K.-D. Kim et al.   JOURNAL OF IMMUNOLOGY

Characterization of a novel CRAC inhibitor that potently blocks human T cell activation and effector functions

(2013) Gang Chen et al.   MOLECULAR IMMUNOLOGY

Initial activation of STIM1, the regulator of store-operated calcium entry

(2013) Yubin Zhou et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Orai3 Constitutes a Native Store-Operated Calcium Entry That Regulates Non Small Cell Lung Adenocarcinoma Cell Proliferation

(2013) Anne-Sophie Ay et al.   PLoS One

Antibody-Mediated Targeting of the Orai1 Calcium Channel Inhibits T Cell Function

(2013) Jennifer H. Cox et al.   PLoS One

Regulation of STIM1/Orai1-dependent Ca2+ signalling in platelets

(2013) Patrick Münzer et al.   THROMBOSIS AND HAEMOSTASIS

STIM1/Orai1 coiled-coil interplay in the regulation of store-operated calcium entry

(2013) Peter B. Stathopulos et al.   Nature Communications

Knockdown of stromal interaction molecule 1 (STIM1) suppresses store-operated calcium entry, cell proliferation and tumorigenicity in human epidermoid carcinoma A431 cells

(2012) Junko Yoshida et al.   BIOCHEMICAL PHARMACOLOGY

ORAI3 silencing alters cell proliferation and cell cycle progression via c-myc pathway in breast cancer cells

(2012) Malika Faouzi et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Blockade of store-operated Ca2+ entry inhibits hepatocarcinoma cell migration and invasion by regulating focal adhesion turnover

(2012) Ning Yang et al.   CANCER LETTERS

The action of selective CRAC channel blockers is affected by the Orai pore geometry

(2012) Isabella Derler et al.   CELL CALCIUM

Orai3 is an estrogen receptor α-regulated Ca2+ channel that promotes tumorigenesis

(2012) Rajender K. Motiani et al.   FASEB JOURNAL

NF-κB and the link between inflammation and cancer

(2012) Joseph A. DiDonato et al.   IMMUNOLOGICAL REVIEWS

Calcium Channels and Pumps in Cancer: Changes and Consequences

(2012) Gregory R. Monteith et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Regulation of lymphocyte function by ORAI and STIM proteins in infection and autoimmunity

(2012) Patrick J. Shaw et al.   JOURNAL OF PHYSIOLOGY-LONDON

STIM proteins: dynamic calcium signal transducers

(2012) Jonathan Soboloff et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Store-Operated Ca2+ Entry Is Remodelled and Controls In Vitro Angiogenesis in Endothelial Progenitor Cells Isolated from Tumoral Patients

(2012) Francesco Lodola et al.   PLoS One

Crystal Structure of the Calcium Release-Activated Calcium Channel Orai

(2012) X. Hou et al.   SCIENCE

The relationship between tissue factor and cancer progression: insights from bench and bedside

(2011) Y. W. van den Berg et al.   BLOOD

Global cancer statistics

(2011) Ahmedin Jemal et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Orai1 and CRAC Channel Dependence of VEGF-Activated Ca 2+ Entry and Endothelial Tube Formation

(2011) Jing Li et al.   CIRCULATION RESEARCH

Structural requirements for the inhibition of calcium mobilization and mast cell activation by the pyrazole derivative BTP2

(2011) Mankit Law et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Antiviral and Regulatory T Cell Immunity in a Patient with Stromal Interaction Molecule 1 Deficiency

(2011) S. Fuchs et al.   JOURNAL OF IMMUNOLOGY

ORAI1-Mediated Calcium Influx in Lactation and in Breast Cancer

(2011) D. McAndrew et al.   MOLECULAR CANCER THERAPEUTICS

ORAI1-mediated calcium influx is required for human cytotoxic lymphocyte degranulation and target cell lysis

(2011) A. Maul-Pavicic et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Calcium store sensor stromal-interaction molecule 1-dependent signaling plays an important role in cervical cancer growth, migration, and angiogenesis

(2011) Y.-F. Chen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Vascular Endothelial Growth Factor Stimulates Endothelial Colony Forming Cells Proliferation and Tubulogenesis by Inducing Oscillations in Intracellular Ca2+ Concentration

(2011) Silvia Dragoni et al.   STEM CELLS

Store-Operated Calcium Channels: New Perspectives on Mechanism and Function

(2011) R. S. Lewis   Cold Spring Harbor Perspectives in Biology

Molecular Basis of Calcium Signaling in Lymphocytes: STIM and ORAI

(2010) Patrick G. Hogan et al.   Annual Review of Immunology

Silencing stromal interaction molecule 1 by RNA interference inhibits the proliferation and migration of endothelial progenitor cells

(2010) Chun-yan Kuang et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Immunity, Inflammation, and Cancer

(2010) Sergei I. Grivennikov et al.   CELL

TRPC channels as STIM1-regulated SOCs

(2010) Joseph P. Yuan et al.   Channels

T-cell-specific deletion of STIM1 and STIM2 protects mice from EAE by impairing the effector functions of Th1 and Th17 cells

(2010) Jian Ma et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Whole-exome sequencing-based discovery of STIM1 deficiency in a child with fatal classic Kaposi sarcoma

(2010) Minji Byun et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Store-Operated Ca2+ Entry through ORAI1 Is Critical for T Cell-Mediated Autoimmunity and Allograft Rejection

(2010) C.-A. McCarl et al.   JOURNAL OF IMMUNOLOGY

Essential Role for the CRAC Activation Domain in Store-dependent Oligomerization of STIM1

(2010) Elizabeth D. Covington et al.   MOLECULAR BIOLOGY OF THE CELL

Store-operated CRAC channels: function in health and disease

(2010) Anant B. Parekh   NATURE REVIEWS DRUG DISCOVERY

Pore architecture of the ORAI1 store-operated calcium channel

(2010) Y. Zhou et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Store-Operated Ca2+ Entry Is Expressed in Human Endothelial Progenitor Cells

(2010) Yuly Sánchez-Hernández et al.   STEM CELLS AND DEVELOPMENT

Orai1 contributes to the establishment of an apoptosis-resistant phenotype in prostate cancer cells

(2010) M Flourakis et al.   Cell Death & Disease

Orai1 and STIM1 Are Critical for Breast Tumor Cell Migration and Metastasis

(2009) Shengyu Yang et al.   CANCER CELL

Receptor Channel TRPC6 Is a Key Mediator of Notch-Driven Glioblastoma Growth and Invasiveness

(2009) S. Chigurupati et al.   CANCER RESEARCH

STIM1 Clusters and Activates CRAC Channels via Direct Binding of a Cytosolic Domain to Orai1

(2009) Chan Young Park et al.   CELL

STIM1 Is a Calcium Sensor Specialized for Digital Signaling

(2009) Gary S. Bird et al.   CURRENT BIOLOGY

T Helper 17 Cells Promote Cytotoxic T Cell Activation in Tumor Immunity

(2009) Natalia Martin-Orozco et al.   IMMUNITY

Chemico-genetic identification of drebrin as a regulator of calcium responses

(2009) Jason C. Mercer et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Blockade of TRPC6 channels induced G2/M phase arrest and suppressed growth in human gastric cancer cells

(2009) Rong Cai et al.   INTERNATIONAL JOURNAL OF CANCER

STIM and Orai: Dynamic Intermembrane Coupling to Control Cellular Calcium Signals

(2009) Xiaoxiang Deng et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Stromal Interaction Molecules 1 and 2 Are Key Regulators of Autoreactive T Cell Activation in Murine Autoimmune Central Nervous System Inflammation

(2009) M. K. Schuhmann et al.   JOURNAL OF IMMUNOLOGY

TRPC channels function independently of STIM1 and Orai1

(2009) Wayne I. DeHaven et al.   JOURNAL OF PHYSIOLOGY-LONDON

SOAR and the polybasic STIM1 domains gate and regulate Orai channels

(2009) Joseph P. Yuan et al.   NATURE CELL BIOLOGY

STIM1 gates the store-operated calcium channel ORAI1 in vitro

(2009) Yubin Zhou et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Transient receptor potential channel C3 contributes to the progression of human ovarian cancer

(2009) S L Yang et al.   ONCOGENE

STIM1 and calmodulin interact with Orai1 to induce Ca2+-dependent inactivation of CRAC channels

(2009) F. M. Mullins et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structural determinants of ion permeation in CRAC channels

(2009) Beth A. McNally et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Systemic Endocrine Instigation of Indolent Tumor Growth Requires Osteopontin

(2008) Sandra S. McAllister et al.   CELL

Stim1 and Orai1 Mediate CRAC Currents and Store-Operated Calcium Entry Important for Endothelial Cell Proliferation

(2008) Iskandar F. Abdullaev et al.   CIRCULATION RESEARCH

Characterization of YM-58483/BTP2, a novel store-operated Ca2+ entry blocker, on T cell-mediated immune responses in vivo

(2008) Keiko Ohga et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Endothelial progenitor cells and cardiovascular homeostasis: Clinical implications

(2008) Giulio Pompilio et al.   INTERNATIONAL JOURNAL OF CARDIOLOGY

Dynamic Coupling of the Putative Coiled-coil Domain of ORAI1 with STIM1 Mediates ORAI1 Channel Activation

(2008) Martin Muik et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Complex Actions of 2-Aminoethyldiphenyl Borate on Store-operated Calcium Entry

(2008) Wayne I. DeHaven et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

TRPC3 Controls Agonist-stimulated Intracellular Ca2+Release by Mediating the Interaction between Inositol 1,4,5-Trisphosphate Receptor and RACK1

(2008) Bidhan C. Bandyopadhyay et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

2-Aminoethoxydiphenyl borate directly facilitates and indirectly inhibits STIM1-dependent gating of CRAC channels

(2008) Christine Peinelt et al.   JOURNAL OF PHYSIOLOGY-LONDON

Hair Loss and Defective T- and B-Cell Function in Mice Lacking ORAI1

(2008) Y. Gwack et al.   MOLECULAR AND CELLULAR BIOLOGY

Inflammation: Gearing the journey to cancer

(2008) J KUNDU et al.   MUTATION RESEARCH-REVIEWS IN MUTATION RESEARCH

The CRAC channel consists of a tetramer formed by Stim-induced dimerization of Orai dimers

(2008) Aubin Penna et al.   NATURE

Functional interactions among Orai1, TRPCs, and STIM1 suggest a STIM-regulated heteromeric Orai/TRPC model for SOCE/Icrac channels

(2008) Y. Liao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Endothelial Progenitor Cells Control the Angiogenic Switch in Mouse Lung Metastasis

(2008) D. Gao et al.   SCIENCE

Functional relevance of the de novo coupling between hTRPC1 and type II IP3 receptor in store-operated Ca2+ entry in human platelets

(2007) Isaac Jardín et al.   CELLULAR SIGNALLING