Article
Medicine, General & Internal
Annalisa Astolfi, Francesca Cipriani, Daria Messelodi, Matilde De Luca, Valentina Indio, Costanza Di Chiara, Arianna Giannetti, Lorenza Ricci, Iria Neri, Annalisa Patrizi, Giampaolo Ricci, Andrea Pession
Summary: This study revealed that children with atopic dermatitis carrying FLG mutations are at higher risk of developing severe food allergies, such as anaphylaxis. Peanut and hazelnut were identified as high-risk foods for patients with FLG mutations.
JOURNAL OF CLINICAL MEDICINE
(2021)
Review
Biochemistry & Molecular Biology
Verena Moosbrugger-Martinz, Corinne Leprince, Marie-Claire Mechin, Michel Simon, Stefan Blunder, Robert Gruber, Sandrine Dubrac
Summary: The discovery of loss-of-function mutations in the filaggrin gene has shed new light on the understanding of skin conditions such as ichthyosis vulgaris and atopic dermatitis. However, there is still much to learn about how filaggrin deficiency contributes to atopic dermatitis and the factors that lead to reduced filaggrin levels. This review re-evaluates the roles of filaggrin in the epidermis and atopic dermatitis, providing insights into its importance for keratinocyte alignment, maintenance of epidermal texture, and cellular abnormalities.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Chunying Xiao, Zhongbin Sun, Jixin Gao, Yaxing Bai, Chen Zhang, Bingyu Pang, Hongjiang Qiao, Meng Fu, Erle Dang, Gang Wang
Summary: This study demonstrated the critical role of skin barrier protein FLG in the pathogenesis of atopic dermatitis, with CPT-induced dermatitis being more severe in Flg(-/-) mice compared to wild-type mice. Additionally, emollients MPS and ceramide partially restored epidermal function and alleviated skin inflammation in the Flg(-/-) mouse model of AD induced by CPT.
Review
Biochemistry & Molecular Biology
Petra Pavel, Stefan Blunder, Verena Moosbrugger-Martinz, Peter M. Elias, Sandrine Dubrac
Summary: Atopic dermatitis is a chronic inflammatory skin disease influenced by both genetic and environmental factors. Alterations of the epidermal barrier and lipid abnormalities play crucial roles in the development and inflammation of the disease.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Dermatology
Alexander Salava, Ville Salo, Anita Remitz
Summary: Keratosis pilaris (KP) is associated with atopic dermatitis (AD) but its role in disease severity and concomitant atopic diseases varies between populations. A study on Finnish AD patients found that KP was not linked to disease severity, asthma, or atopic sensitization. However, it was significantly associated with palmar hyperlinearity and a specific filaggrin loss-of-function mutation. The prevalence of KP in the cohort was low, which may be due to the rarity of the tested gene mutations in the Finnish population.
JOURNAL OF DERMATOLOGY
(2022)
Article
Allergy
Haengdueng Jeong, Nakyum Lee, Chanyang Uhm, Kyungrae Cho, Heeju Oh, Yeseul Oh, KeLun Zhang, Hye Li Kim, James R. Goldenring, Kyung-Min Lim, Chang Ook Park, Ki Taek Nam
Summary: Rab-25 plays an important role in maintaining skin barrier function and keratinization in atopic dermatitis (AD).
Article
Dermatology
Zhen Zhang, Jiawen Chen, Yijun Yang, Ruoqu Wei, Peiyi Sun, Wenqing Zhang, Wange Zhou, Yifeng Guo, Zhirong Yao
Summary: Intravenous immunoglobulin (IVIG) therapy has shown efficacy and safety in children with severe atopic dermatitis (AD). Treatment response was seen in 60% of patients, with significant improvement in Scoring Atopic Dermatitis index. Furthermore, baseline total serum IgE levels and eosinophil counts decreased significantly after treatment.
DERMATOLOGIC THERAPY
(2022)
Article
Allergy
Anna Maria Andersson, Julie Solberg, Anders Koch, Lone Skov, Ivone Jakasa, Sanja Kezic, Jacob Pontoppidan Thyssen
Summary: This study analyzed biomarkers in children with atopic dermatitis using tape strips and skin biopsies, finding that cytokine profiles in lesional skin were associated with disease severity, food allergy, and filaggrin gene mutations. Levels of TARC, CTACK, IL-8, and IL-18 in tape strips correlated significantly with AD severity, while skin biopsy data did not show significant correlations. Sampling the stratum corneum with non-invasive tape strips may be useful for identifying biomarkers associated with disease severity, food allergy, and filaggrin mutations.
Article
Dermatology
Hila Emmert, Hansjoerg Baurecht, Frederieke Thielking, Dora Stoelzl, Elke Rodriguez, Inken Harder, Ehrhardt Proksch, Stephan Weidinger
Summary: This study revealed significant differences in lipid composition between body sites and between AD patients and healthy individuals, as well as correlations between skin microbiome and skin lipid alterations in AD.
EXPERIMENTAL DERMATOLOGY
(2021)
Review
Allergy
Jessica W. Hui-Beckman, Elena Goleva, Evgeny Berdyshev, Donald Y. M. Leung
Summary: Atopic dermatitis (AD) and food allergy (FA) are closely related and one-third of AD children develop concomitant FA. Epithelial barrier dysfunction is important in both diseases. Genetic factors such as filaggrin mutations and IL-4 receptor alpha chain polymorphisms are associated with increased risk. In addition, several environmental exposures lead to reduced filaggrin and contribute to skin barrier dysfunction. Staphylococcus aureus colonization appears to contribute to AD and FA as well as activating the type 2 immune response. Comprehensive multiomic studies have identified distinct atopic endotypes with unique characteristics, providing an opportunity for improved diagnosis and prevention of atopy.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2023)
Article
Allergy
Tammy Gonzalez, Mariana L. Stevens, Asel Baatyrbek Kyzy, Rosario Alarcon, Hua He, John W. Kroner, Daniel Spagna, Brittany Grashel, Elaine Sidler, Lisa J. Martin, Jocelyn M. Biagini Myers, Gurjit K. Khurana Hershey, Andrew B. Herr
Summary: In the first US early-life cohort of children with atopic dermatitis, the presence of staphylococcal biofilms on skin lesions was found to be associated with increased disease severity, suggesting a pathogenic role forS aureus biofilms in atopic dermatitis development. Additionally, the balance between S epidermidis and S aureus, as well as their biofilm propensity, may have important implications for atopic dermatitis.
Article
Chemistry, Multidisciplinary
Bum Soo Lee, Ye-Ryeong Cho, Minju Jeong, Yoon Seo Jang, Jin-Chul Kim, Sanguine Byun, Ki Hyun Kim
Summary: This study investigated the inhibitory effects of Cornus walteri on atopic dermatitis (AD). The results showed that Cornus walteri reduced the secretion of AD-related chemokines and upregulated filaggrin. Phytochemical analysis led to the identification of six potential bioactive constituents in Cornus walteri, and three of them significantly inhibited the expression of eotaxin-3. These findings suggest that Cornus walteri and its active compounds have potential as therapeutic agents for treating AD.
APPLIED SCIENCES-BASEL
(2022)
Article
Biochemistry & Molecular Biology
Nahoko Zeze, Makiko Kido-Nakahara, Gaku Tsuji, Eriko Maehara, Yuki Sato, Sawako Sakai, Kei Fujishima, Akiko Hashimoto-Hachiya, Masutaka Furue, Takeshi Nakahara
Summary: Atopic dermatitis is a skin disorder characterized by inflammation, barrier disruption, and intense itch. This study investigates the involvement of the extracellular signal-regulated kinase (ERK) pathway in the pathogenesis of atopic dermatitis. The results suggest that the ERK pathway plays a role in the development of atopic dermatitis and may be a potential therapeutic target.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Dermatology
Masataka Ota, Takashi Sasaki, Tamotsu Ebihara, Emiko Yokosawa, Yumi Murakami, Hiroshi Matsunaka, Yuko Chinuki, Masayuki Amagai, Eishin Morita
Summary: The study found that loss-of-function mutations of the filaggrin (FLG) gene do not affect the severity of atopic dermatitis (AD) or skin barrier function, and have little impact on the amount of FLG protein and total amino acids in the stratum corneum of lesional skin. The results suggest that the production of FLG in skin lesions is influenced by the activation of Th2-dominant inflammatory cells along with FLG abnormalities.
JOURNAL OF DERMATOLOGY
(2021)
Article
Veterinary Sciences
Rosanna Marsella, Kim Ahrens, Rachel Wilkes
Summary: Skin barrier dysfunction is important in atopic dermatitis and may be related to differences in cell growth behavior rather than tight junction protein differences. Atopic keratinocytes have lower TEER than normal keratinocytes, indicating higher epithelial permeability.
VETERINARY SCIENCES
(2022)
Letter
Immunology
Asena Pinar Sefer, Louis Marie Charbonnier, Nurhan Kasap, Bengu Akcam, Yasemin Kendir Demirkol, Sevgi Bilgic Eltan, Ahmet Ozen, Elif Karakoc-Aydiner, Safa Baris
JOURNAL OF CLINICAL IMMUNOLOGY
(2021)
Correction
Immunology
Hani Harb, Emmanuel Stephen-Victor, Elena Crestani, Mehdi Benamar, Amir Massoud, Ye Cui, Louis-Marie Charbonnier, Sena Arbag, Safa Baris, Amparito Cunnigham, Juan Manuel Leyva-Castillo, Raif S. Geha, Amirhosein J. Mousavi, Boris Guennewig, Klaus Schmitz-Abe, Constantinos Sioutas, Wanda Phipatanakul, Talal A. Chatila
Summary: The paper has been amended and the updated version can be accessed via a link at the top of the paper.
Article
Immunology
Nurhan Kasap, Velat Celik, Sakine Isik, Pakize Cennetoglu, Ayca Kiykim, Sevgi Bilgic Eltan, Ercan Nain, Ismail Ogulur, Dilek Baser, Emre Akkelle, Mehmet Halil Celiksoy, Burcu Kocamis, Funda Erol Cipe, Ayse Deniz Yucelten, Elif Karakoc-Aydiner, Ahmet Ozen, Safa Baris
Summary: Hyper-IgE syndrome (HIES) patients may share similar features with severe atopic dermatitis (SAD) patients, but analyzing clinical and laboratory markers can help differentiate the two disorders. Different types of HIES have distinct characteristics, with STAT3-HIES patients exhibiting specific facial appearance and skin issues, while DOCK8 deficiency patients are prone to mucocutaneous candidiasis and Herpes infection.
CLINICAL IMMUNOLOGY
(2021)
Letter
Immunology
Sevgi Bilgic Eltan, Asena Pinar Sefer, Ibrahim Serhat Karakus, Ahmet Ozen, Elif Karakoc-Aydiner, Safa Baris
JOURNAL OF CLINICAL IMMUNOLOGY
(2021)
Article
Multidisciplinary Sciences
Zinan Z. Zhang, Yu Zhang, Tingyan He, Colin L. Sweeney, Safa Baris, Elif Karakoc-Aydiner, Yikun Yao, Deniz Ertem, Helen F. Matthews, Claudia Gonzaga-Jauregui, Harry L. Malech, Helen C. Su, Ahmet Ozen, Kenneth G. C. Smith, Michael J. Lenardo
Summary: IL-37 mutation in a 4-month-old male from a consanguineous family led to infantile inflammatory bowel disease (I-IBD) with persistent diarrhea. The patient's cells showed increased intracellular IL-37 expression and proinflammatory cytokine production. Insights from this patient suggest a potential role of the IL-18 and IL-37 axis in colonic homeostasis.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Immunology
Kaela Drzewiecki, Jungmin Choi, Joseph Brancale, Michael A. Leney-Greene, Sinan Sari, Buket Dalgic, Aysel Unlusoy Aksu, Gulseren Lvigen Sahin, Ahmet Ozen, Safa Baris, Elif Karakoc-Aydiner, Dhanpat Jain, David Kleiner, Michael Schmalz, Kadakkal Radhakrishnan, Junhui Zhang, Kasper Hoebe, Helen C. Su, Joao P. Pereira, Michael J. Lenardo, Richard P. Lifton, Silvia Vilarinho
Summary: Portal hypertension is a major contributor to decompensation and death from liver disease. Research shows that homozygous damaging mutations in GIMAP5 can lead to capillarization of liver endothelial cells and ultimately result in portal hypertension. Understanding the pathogenesis of advanced liver disease is crucial for developing new therapies to reduce adverse outcomes.
JOURNAL OF EXPERIMENTAL MEDICINE
(2021)
Article
Hematology
Sevgi Kostel Bal, Sarah Giuliani, Jana Block, Peter Repiscak, Christoph Hafemeister, Tala Shahin, Nurhan Kasap, Bernhard Ransmayr, Yirun Miao, Cheryl van de Wetering, Alexandra Frohne, Raul Jimenez Heredia, Michael Schuster, Samaneh Zoghi, Vanessa Hertlein, Marini Thian, Aleksandr Bykov, Royala Babayeva, Sevgi Bilgic Eltan, Elif Karakoc-Aydiner, Lisa E. Shaw, Iftekhar Chowdhury, Markku Varjosalo, Rafael J. Arguello, Matthias Farlik, Ahmet Ozen, Edgar Serfling, Loic Dupre, Christoph Bock, Florian Halbritter, J. Thomas Hannich, Irinka Castanon, Michael J. Kraakman, Safa Baris, Kaan Boztug
Summary: In this study, the researchers investigated the role of NFATC1 mutations in human immunity and found evidence of metabolic plasticity in patient T cells. The study also demonstrated that metformin and rosiglitazone can improve the effector functions of patient T cells.
Meeting Abstract
Immunology
Asena Pinar Sefer, Salim Can, Alper Bulutoglu, Dilek Baser, Ali Islek, Derya Ufuk Altintas, Safa Baris, Elif Karakoc Aydiner, Bernice Lo, Ahmet Ozen
CLINICAL IMMUNOLOGY
(2023)
Correction
Immunology
Nalan Yakici, Alexandra Y. Kreins, Mehmet Cihangir Catak, Royala Babayeva, Baran Erman, Heather Kenney, Hatice Eke-Gungor, Pablo A. Cea, Tomoki Kawai, Marita Bosticardo, Ottavia Maria Delmonte, Stuart Adams, Yu-Tong Fan, Francesca Pala, Ayberk Turkyilmaz, Evey Howley, Austen Worth, Hakan Kot, Asena Pinar Sefer, Altan Kara, Alper Bulutoglu, Sevgi Bilgic-Eltan, Melek Yorgun Altunbas, Feyza Bayram Catak, Ibrahim Serhat Karakus, Emrah Karatay, Sidem Didar Tekeoglu, Metin Eser, Davut Albayrak, Senol Citli, Ayca Kiykim, Elif Karakoc-Aydiner, Ahmet Ozen, Sujal Ghosh, Holger Gohlke, Fazil Orhan, Luigi D. Notarangelo, E. Graham Davies, Safa Baris
CLINICAL IMMUNOLOGY
(2023)
Meeting Abstract
Immunology
Ahmet Ozen, Voranush Chongsrisawat, Asena Pinar Sefer, Burcu Kolukisa, Jessica J. Jalbert, Jutta L. Miller, Karoline A. Meagher, Taylor Brackin, Hagit Baris Feldman, Orly Eshach Adiv, Safa Baris, Elif Karakoc-Aydiner, Sevgi Bilgic Eltan, Melek Yorgun Altunbas, Rabia Ergelen, Ivan J. Fuss, Heather Moorman, Mary Magliocco, Helen Matthews, Beatriz E. Marciano, Narissara Suratannon, Pantipa Chatchatee, Kanya Suphapeetiporn, Caryn F. Trbovic, Michael E. Burczynski, Umesh Chaudhari, Lorah Perlee, Olivier A. Harari, Michael J. Lenardo
Article
Gastroenterology & Hepatology
Holm H. Uhlig, Claire Booth, Judy Cho, Marla Dubinsky, Anne M. Griffiths, Bodo Grimbacher, Sophie Hambleton, Ying Huang, Kelsey Jones, Jochen Kammermeier, Hirokazu Kanegane, Sibylle Koletzko, Daniel Kotlarz, Christoph Klein, Michael J. Lenardo, Bernice Lo, Dermot P. B. Mcgovern, Ahmet Ozen, Lissy de Ridder, Frank Ruemmele, Dror S. Shouval, Scott B. Snapper, Simon P. Travis, Dan Turner, David C. Wilson, Aleixo M. Muise
Summary: This Expert Recommendation reviews the therapeutic landscape for monogenic inflammatory bowel disease (mIBD) and proposes recommendations for standardized reporting of clinical outcomes. The field of mIBD lacks randomized controlled trials and relies on retrospective observational data. More than 25 off-label therapeutics and cellular therapies have been reported, but heterogeneous reporting of outcomes hinders the generation of robust therapeutic evidence.
NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY
(2023)
Article
Respiratory System
Esra Karabiber, Ozge Atik, Fatma Merve Tepetam, Bilgehan Ergan, Arzu Ilki, Elif Karakoc Aydiner, Ahmet Ozen, Fatma Ozyer, Safa Baris
Summary: Vaccines against SARS-CoV-2 are effective in patients with inborn errors of immunity, with full immunization associated with lower hospitalization rates and shorter symptomatic duration.
TUBERKULOZ VE TORAKS-TUBERCULOSIS AND THORAX
(2023)
Article
Pediatrics
Perran Boran, Selin Yildirim, Elif Karakoc-Aydiner, Ismail Ogulur, Ahmet Ozen, Goncagul Haklar, Ahmet Koc, Tunc Akkoc, Isil Barlan
Summary: Vitamin B12 deficiency is a commonly underestimated issue in developing countries. The study found that infants with vitamin B12 deficiency had lower levels of regulatory T cells compared to the control group. While the percentage of Tregs increased after treatment, the change was not significant. Additionally, proinflammatory cytokines were reduced after vitamin supplementation, suggesting potential anti-inflammatory effects. Further research is needed to explore the clinical implications of these findings in relation to emerging allergies, autoimmune disorders, and inflammation.
MINERVA PEDIATRICS
(2021)
Meeting Abstract
Immunology
Burcu Kocamis Kolukisa, Nurhan Kasap, Sevgi Bilgic Eltan, Dilek Baser, Gamze Akgun, Asena Pinar Sefer, Yasemin Kendir Demirkol, Elif Karakoc Aydiner, Ekrem Unal, Ahmet Ozen, Safa Baris
JOURNAL OF CLINICAL IMMUNOLOGY
(2021)