Review article: linaclotide for the management of irritable bowel syndrome with constipation

Linaclotide Inhibits Colonic Nociceptors and Relieves Abdominal Pain via Guanylate Cyclase-C and Extracellular Cyclic Guanosine 3′,5′-Monophosphate

(2013) Joel Castro et al.   GASTROENTEROLOGY

Gastrointestinal pain: Unraveling a novel endogenous pathway through uroguanylin/guanylate cyclase-C/cGMP activation

(2013) Inmaculada Silos-Santiago et al.   PAIN

Emerging receptor target in the pharmacotherapy of irritable bowel syndrome with constipation

(2013) L Ashley Blackshaw et al.   Expert Review of Gastroenterology & Hepatology

Factors affecting satisfaction with treatment in European women with chronic constipation: An internet survey

(2013) Anton Emmanuel et al.   United European Gastroenterology Journal

Levels of satisfaction with current chronic constipation treatment options in Europe - an internet survey

(2012) S. Müller-Lissner et al.   ALIMENTARY PHARMACOLOGY & THERAPEUTICS

Randomised clinical trials: linaclotide phase 3 studies in IBS-C - a prespecified further analysis based on European Medicines Agency-specified endpoints

(2012) E. M. M. Quigley et al.   ALIMENTARY PHARMACOLOGY & THERAPEUTICS

Linaclotide for Irritable Bowel Syndrome With Constipation: A 26-Week, Randomized, Double-blind, Placebo-Controlled Trial to Evaluate Efficacy and Safety

(2012) William D Chey et al.   AMERICAN JOURNAL OF GASTROENTEROLOGY

Effect of Gender on Prevalence of Irritable Bowel Syndrome in the Community: Systematic Review and Meta-Analysis

(2012) Rebecca M Lovell et al.   AMERICAN JOURNAL OF GASTROENTEROLOGY

A 12-Week, Randomized, Controlled Trial With a 4-Week Randomized Withdrawal Period to Evaluate the Efficacy and Safety of Linaclotide in Irritable Bowel Syndrome With Constipation

(2012) Satish Rao et al.   AMERICAN JOURNAL OF GASTROENTEROLOGY

Global Prevalence of and Risk Factors for Irritable Bowel Syndrome: A Meta-analysis

(2012) Rebecca M. Lovell et al.   Clinical Gastroenterology and Hepatology

Irritable bowel syndrome with constipation: a European-focused systematic literature review of disease burden

(2012) J. Fortea et al.   JOURNAL OF MEDICAL ECONOMICS

Health-related quality of life, work productivity and health care resource use associated with constipation predominant irritable bowel syndrome

(2011) Marco DiBonaventura et al.   CURRENT MEDICAL RESEARCH AND OPINION

The pharmacokinetics, pharmacodynamics, clinical efficacy, safety and tolerability of linaclotide

(2011) Noel Lee et al.   Expert Opinion on Drug Metabolism & Toxicology

S3-Leitlinie Reizdarmsyndrom: Definition, Pathophysiologie, Diagnostik und Therapie. Gemeinsame Leitlinie der Deutschen Gesellschaft für Verdauungs- und Stoffwechselkrankheiten (DGVS) und der Deutschen Gesellschaft für Neurogastroenterologie und Motilität (DGNM)

(2011) P. Layer et al.   ZEITSCHRIFT FUR GASTROENTEROLOGIE

Clinical trial: phase 2 study of lubiprostone for irritable bowel syndrome with constipation

(2010) J. F. JOHANSON et al.   ALIMENTARY PHARMACOLOGY & THERAPEUTICS

Corruption of homeostatic mechanisms in the guanylyl cyclase c signaling pathway underlying colorectal tumorigenesis

(2010) Li Peng et al.   CANCER BIOLOGY & THERAPY

Linaclotide, through activation of guanylate cyclase C, acts locally in the gastrointestinal tract to elicit enhanced intestinal secretion and transit

(2010) Robert W. Busby et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Taking a Lesson From Microbial Diarrheagenesis in the Management of Chronic Constipation

(2010) Adil E. Bharucha et al.   GASTROENTEROLOGY

Linaclotide Improves Abdominal Pain and Bowel Habits in a Phase IIb Study of Patients With Irritable Bowel Syndrome With Constipation

(2010) Jeffrey M. Johnston et al.   GASTROENTEROLOGY

Linaclotide is a potent and selective guanylate cyclase C agonist that elicits pharmacological effects locally in the gastrointestinal tract

(2010) Alexander P. Bryant et al.   LIFE SCIENCES

A systematic review of efficacy and tolerability of mebeverine in irritable bowel syndrome

(2010) Mahnaz Darvish-Damavandi   WORLD JOURNAL OF GASTROENTEROLOGY

Bacterial Heat-Stable Enterotoxins: Translation of Pathogenic Peptides into Novel Targeted Diagnostics and Therapeutics

(2010) Jieru E. Lin et al.   Toxins

The Effect of Tegaserod on Symptoms and Quality of Life in Korean Women with Irritable Bowel Syndrome with Constipation

(2010) Yong Sung Kim et al.   Journal of Neurogastroenterology and Motility

International Survey of Patients With IBS

(2009) Douglas A. Drossman et al.   JOURNAL OF CLINICAL GASTROENTEROLOGY

Guanylate cyclase C-mediated antinociceptive effects of linaclotide in rodent models of visceral pain

(2009) h. eutamene et al.   NEUROGASTROENTEROLOGY AND MOTILITY

Clinical trial: lubiprostone in patients with constipation-associated irritable bowel syndrome - results of two randomized, placebo-controlled studies

(2008) D. A. DROSSMAN et al.   ALIMENTARY PHARMACOLOGY & THERAPEUTICS

Pilot Study on the Effect of Linaclotide in Patients With Chronic Constipation

(2008) Jeffrey M Johnston et al.   AMERICAN JOURNAL OF GASTROENTEROLOGY

Chronic migraine in the population: Burden, diagnosis, and satisfaction with treatment

(2008) M. E. Bigal et al.   NEUROLOGY

Persistent Depression and Anxiety in the United States: Prevalence and Quality of Care

(2008) A. S. Young et al.   PSYCHIATRIC SERVICES