Randomised clinical trials: linaclotide phase 3 studies in IBS-C - a prespecified further analysis based on European Medicines Agency-specified endpoints
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Title
Randomised clinical trials: linaclotide phase 3 studies in IBS-C - a prespecified further analysis based on European Medicines Agency-specified endpoints
Authors
Keywords
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Journal
ALIMENTARY PHARMACOLOGY & THERAPEUTICS
Volume 37, Issue 1, Pages 49-61
Publisher
Wiley
Online
2012-11-01
DOI
10.1111/apt.12123
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Note: Only part of the references are listed.- Linaclotide for Irritable Bowel Syndrome With Constipation: A 26-Week, Randomized, Double-blind, Placebo-Controlled Trial to Evaluate Efficacy and Safety
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- A 12-Week, Randomized, Controlled Trial With a 4-Week Randomized Withdrawal Period to Evaluate the Efficacy and Safety of Linaclotide in Irritable Bowel Syndrome With Constipation
- (2012) Satish Rao et al. AMERICAN JOURNAL OF GASTROENTEROLOGY
- Global Prevalence of and Risk Factors for Irritable Bowel Syndrome: A Meta-analysis
- (2012) Rebecca M. Lovell et al. Clinical Gastroenterology and Hepatology
- Characteristics of Acute Pain Attacks in Patients With Irritable Bowel Syndrome Meeting Rome III Criteria
- (2011) Per M Hellström et al. AMERICAN JOURNAL OF GASTROENTEROLOGY
- Health-related quality of life, work productivity and health care resource use associated with constipation predominant irritable bowel syndrome
- (2011) Marco DiBonaventura et al. CURRENT MEDICAL RESEARCH AND OPINION
- Two Randomized Trials of Linaclotide for Chronic Constipation
- (2011) Anthony J. Lembo et al. NEW ENGLAND JOURNAL OF MEDICINE
- Meta-analysis: factors affecting placebo response rate in the irritable bowel syndrome
- (2010) A. C. Ford et al. ALIMENTARY PHARMACOLOGY & THERAPEUTICS
- Measuring symptoms in the irritable bowel syndrome: development of a framework for clinical trials
- (2010) B. M. R. Spiegel et al. ALIMENTARY PHARMACOLOGY & THERAPEUTICS
- Linaclotide, through activation of guanylate cyclase C, acts locally in the gastrointestinal tract to elicit enhanced intestinal secretion and transit
- (2010) Robert W. Busby et al. EUROPEAN JOURNAL OF PHARMACOLOGY
- Linaclotide Improves Abdominal Pain and Bowel Habits in a Phase IIb Study of Patients With Irritable Bowel Syndrome With Constipation
- (2010) Jeffrey M. Johnston et al. GASTROENTEROLOGY
- Current Medical Treatments of Dyspepsia and Irritable Bowel Syndrome
- (2010) Michael Camilleri et al. GASTROENTEROLOGY CLINICS OF NORTH AMERICA
- Linaclotide is a potent and selective guanylate cyclase C agonist that elicits pharmacological effects locally in the gastrointestinal tract
- (2010) Alexander P. Bryant et al. LIFE SCIENCES
- Societal costs for irritable bowel syndrome – a population based study
- (2010) Markku T. Hillilä et al. SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY
- Efficacy of 5-HT3 Antagonists and 5-HT4 Agonists in Irritable Bowel Syndrome: Systematic Review and Meta-Analysis
- (2009) Alexander C Ford et al. AMERICAN JOURNAL OF GASTROENTEROLOGY
- Guanylate cyclase C-mediated antinociceptive effects of linaclotide in rodent models of visceral pain
- (2009) h. eutamene et al. NEUROGASTROENTEROLOGY AND MOTILITY
- Predictors of Patient-Assessed Illness Severity in Irritable Bowel Syndrome
- (2008) Brennan Spiegel et al. AMERICAN JOURNAL OF GASTROENTEROLOGY
- Challenges to the Therapeutic Pipeline for Irritable Bowel Syndrome: End Points and Regulatory Hurdles
- (2008) Michael Camilleri et al. GASTROENTEROLOGY
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