Structural Models of Ligand-Gated Ion Channels: Sites of Action for Anesthetics and Ethanol
Published 2013 View Full Article
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Title
Structural Models of Ligand-Gated Ion Channels: Sites of Action for Anesthetics and Ethanol
Authors
Keywords
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Journal
ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH
Volume 38, Issue 3, Pages 595-603
Publisher
Wiley
Online
2013-10-25
DOI
10.1111/acer.12283
References
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Related references
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- Mapping General Anesthetic Binding Site(s) in Human α1β3 γ-Aminobutyric Acid Type A Receptors with [3H]TDBzl-Etomidate, a Photoreactive Etomidate Analogue
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- Methyl Effects on Protein–Ligand Binding
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- Microsecond Simulations Indicate that Ethanol Binds between Subunits and Could Stabilize an Open-State Model of a Glycine Receptor
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- Anesthetic sites and allosteric mechanisms of action on Cys-loop ligand-gated ion channels
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- X-ray structures of general anaesthetics bound to a pentameric ligand-gated ion channel
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- Principles of activation and permeation in an anion-selective Cys-loop receptor
- (2011) Ryan E. Hibbs et al. NATURE
- Structural basis for alcohol modulation of a pentameric ligand-gated ion channel
- (2011) R. J. Howard et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- GABAA receptors as molecular targets of general anesthetics: identification of binding sites provides clues to allosteric modulation
- (2010) Richard W. Olsen et al. Canadian Journal of Anesthesia-Journal canadien d anesthesie
- Numerous Classes of General Anesthetics Inhibit Etomidate Binding to γ-Aminobutyric Acid Type A (GABAA) Receptors
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- A Medicinal Chemist’s Guide to Molecular Interactions
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- Alcohol- and Alcohol Antagonist-Sensitive Human GABAA Receptors: Tracking Subunit Incorporation into Functional Receptors
- (2010) P. Meera et al. MOLECULAR PHARMACOLOGY
- Molecular targets and mechanisms for ethanol action in glycine receptors
- (2010) Daya I. Perkins et al. PHARMACOLOGY & THERAPEUTICS
- High-level expression and purification of Cys-loop ligand-gated ion channels in a tetracycline-inducible stable mammalian cell line: GABAAand serotonin receptors
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- γ-Amino Butyric Acid Type A Receptor Mutations at β2N265 Alter Etomidate Efficacy While Preserving Basal and Agonist-dependent Activity
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- A prokaryotic perspective on pentameric ligand-gated ion channel structure
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- Neurosteroids Allosterically Modulate Binding of the Anesthetic Etomidate to γ-Aminobutyric Acid Type A Receptors
- (2009) Guo-Dong Li et al. JOURNAL OF BIOLOGICAL CHEMISTRY
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- (2009) Daya I. Perkins et al. JOURNAL OF BIOLOGICAL CHEMISTRY
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