Biosynthesis of Ursolic Acid and Oleanolic Acid in Saccharomyces cerevisiae

β-Amyrin synthase (EsBAS) and β-amyrin 28-oxidase (CYP716A244) in oleanane-type triterpene saponin biosynthesis in Eleutherococcus senticosus

(2017) Hye-Jeong Jo et al.   PHYTOCHEMISTRY

Ursolic acid-loaded chitosan nanoparticles induce potent anti-angiogenesis in tumor

(2016) Hua Jin et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Pharmacokinetics in Vitro and in Vivo of Two Novel Prodrugs of Oleanolic Acid in Rats and Its Hepatoprotective Effects against Liver Injury Induced by CCl4

(2016) Zongjiang Yu et al.   MOLECULAR PHARMACEUTICS

Identification and expression profiling of a new β-amyrin synthase gene (GmBAS3) from soybean

(2016) M. M. Ali et al.   RUSSIAN JOURNAL OF PLANT PHYSIOLOGY

Refactoring β-amyrin synthesis inSaccharomyces cerevisiae

(2015) Genlin Zhang et al.   AICHE JOURNAL

Functional analysis of β-amyrin synthase gene in ginsenoside biosynthesis by RNA interference

(2015) Che Zhao et al.   PLANT CELL REPORTS

A pentacyclic triterpene natural product, ursolic acid and its prodrug US597 inhibit targets within cell adhesion pathway and prevent cancer metastasis

(2015) Liping Xiang et al.   Oncotarget

The Synergistic Biologic Activity of Oleanolic and Ursolic Acids in Complex with Hydroxypropyl-γ-Cyclodextrin

(2014) Codruţa Soica et al.   MOLECULES

Isolation and characterization of an oxidosqualene cyclase gene encoding a β-amyrin synthase involved in Polygala tenuifolia Willd. saponin biosynthesis

(2014) Mei Lan Jin et al.   PLANT CELL REPORTS

Producing aglycons of ginsenosides in bakers' yeast

(2014) Zhubo Dai et al.   Scientific Reports

Synthesis and biological evaluation of ursolic acid-triazolyl derivatives as potential anti-cancer agents

(2013) Showkat Rashid et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Purification, kinetics, inhibitors and CD for recombinant β-amyrin synthase fromEuphorbia tirucalli L and functional analysis of the DCTA motif, which is highly conserved among oxidosqualene cyclases

(2013) Ryousuke Ito et al.   FEBS Journal

High-level semi-synthetic production of the potent antimalarial artemisinin

(2013) C. J. Paddon et al.   NATURE

Cloning and characterization of the gene encoding β-amyrin synthase in the glycyrrhizic acid biosynthetic pathway in Glycyrrhiza uralensis

(2013) Honghao Chen et al.   Acta Pharmaceutica Sinica B

Production of miltiradiene by metabolically engineeredSaccharomyces cerevisiae

(2012) Zhubo Dai et al.   BIOTECHNOLOGY AND BIOENGINEERING

Dynamic control of gene expression in Saccharomyces cerevisiae engineered for the production of plant sesquitepene α-santalene in a fed-batch mode

(2012) Gionata Scalcinati et al.   METABOLIC ENGINEERING

Molecular characterization of the pentacyclic triterpenoid biosynthetic pathway in Catharanthus roseus

(2012) Lili Huang et al.   PLANTA

Production of amorphadiene in yeast, and its conversion to dihydroartemisinic acid, precursor to the antimalarial agent artemisinin

(2012) P. J. Westfall et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Ursolic acid protects diabetic mice against monocyte dysfunction and accelerated atherosclerosis

(2011) Sarah L. Ullevig et al.   ATHEROSCLEROSIS

An unusual plant triterpene synthase with predominant α-amyrin-producing activity identified by characterizing oxidosqualene cyclases from Malus × domestica

(2011) Cyril Brendolise et al.   FEBS Journal

New Synthetic Triterpenoids: Potent Agents for Prevention and Treatment of Tissue Injury Caused by Inflammatory and Oxidative Stress

(2011) Michael B. Sporn et al.   JOURNAL OF NATURAL PRODUCTS

Phytochemical investigation and biological studies ofBombax malabaricumflowers

(2011) Ali M. El-Hagrassi et al.   NATURAL PRODUCT RESEARCH

CYP716A Subfamily Members are Multifunctional Oxidases in Triterpenoid Biosynthesis

(2011) Ery O. Fukushima et al.   PLANT AND CELL PHYSIOLOGY

Medicago truncatulaCYP716A12 Is a Multifunctional Oxidase Involved in the Biosynthesis of Hemolytic Saponins

(2011) Maria Carelli et al.   PLANT CELL

Real-time PCR-based determination of gene copy numbers inPichia pastoris

(2010) Sandra Abad et al.   Biotechnology Journal

Xanthine Oxidase Inhibitory Triterpenoid and Phloroglucinol from Guttiferaceous Plants Inhibit Growth and Induced Apoptosis in Human NTUB1 Cells through a ROS-Dependent Mechanism

(2010) Kai-Wei Lin et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Two Oxidosqualene Cyclases Responsible for Biosynthesis of Tomato Fruit Cuticular Triterpenoids

(2010) Z. Wang et al.   PLANT PHYSIOLOGY

Evaluation of ursolic acid isolated from Ilex paraguariensis and derivatives on aromatase inhibition

(2008) Simone C.B. Gnoatto et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Engineering triterpene production in Saccharomyces cerevisiae-β-amyrin synthase from Artemisia annua

(2008) James Kirby et al.   FEBS Journal

Anti-mycobacterial activity of five plant species used as traditional medicines in the Western Cape Province (South Africa)

(2008) Kapinga Bamuamba et al.   JOURNAL OF ETHNOPHARMACOLOGY

DNA assembler, an in vivo genetic method for rapid construction of biochemical pathways

(2008) Zengyi Shao et al.   NUCLEIC ACIDS RESEARCH

Licorice  -amyrin 11-oxidase, a cytochrome P450 with a key role in the biosynthesis of the triterpene sweetener glycyrrhizin

(2008) H. Seki et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Preliminary study of the anti-inflammatory activity of hexane extract and fractions from Bursera simaruba (Linneo) Sarg. (Burseraceae) leaves

(2007) M.E. Carretero et al.   JOURNAL OF ETHNOPHARMACOLOGY