Article
Nanoscience & Nanotechnology
Jianping Liu, Luyao Sun, Li Li, Run Zhang, Zhi Ping Xu
Summary: A novel trifunctional LDH nanosystem was developed for combined photochemotherapy of skin cancer by releasing drugs in an acid-triggered manner and generating heating and reactive oxygen species upon laser irradiation, which nearly eradicated tumor tissues with minimal side effects.
ACS APPLIED MATERIALS & INTERFACES
(2021)
Article
Chemistry, Physical
George Kitis, Vasilis Pagonis
Summary: This paper investigates the effect of very low dose rates and also low doses on thermoluminescence (TL) signals using a basic one-trap one-recombination center model (OTOR). The simulations show that at very low dose rates, the assumptions of quasi-equilibrium conditions (QE) are violated, resulting in a significant distortion of the shapes of TL glow curves and an increase in the estimated half-life of the electron traps. These findings have important implications for the analysis of TL signals and highlight the need for researchers to consider these effects in dosimetric applications.
RADIATION PHYSICS AND CHEMISTRY
(2023)
Article
Biochemistry & Molecular Biology
R. Mahalakshmi, J. Priyanga, Dipita Bhakta-Guha, Gunjan Guha
Summary: This study demonstrates that low doses of rapamycin can alleviate aging-associated mitochondrial dyshomeostasis in WRL-68 cells, such as oxidative damage to mitochondrial nucleic acids and proteins, as well as imbalance in mitochondrial density, membrane potential, biogenesis, mitophagy, and overall metabolism.
MOLECULAR BIOLOGY REPORTS
(2022)
Review
Endocrinology & Metabolism
Mariangela Rondanelli, Clara Gasparri, Gabriella Peroni, Milena Anna Faliva, Maurizio Naso, Simone Perna, Philip Bazire, Ignacio Sajuox, Roberto Maugeri, Chiara Rigon
Summary: Studies have shown that very low calorie diets and very low carbohydrate diets can affect the gut microbiota composition of obese patients, while very low calorie ketogenic diets alter the composition of fecal microbial populations and impact the plasma metabolome and fecal bile acid composition.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Pharmacology & Pharmacy
Yinan Shi, Chenxin Gu, Tongtong Zhao, Yangfan Jia, Changlei Bao, Ang Luo, Qiang Guo, Ying Han, Jian Wang, Stephen M. Black, Ankit A. Desai, Haiyang Tang
Summary: Prolonged rapamycin treatment activates PDGFR signaling partially via mTORC2 inhibition. Combination therapy with rapamycin and imatinib may be a more effective strategy for the treatment of PAH, reducing proliferation and migration of hPASMCs and attenuating pulmonary hypertension in pre-clinical studies.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Engineering, Biomedical
Rajasekharreddy Pala, Ayan K. Barui, Ashraf M. Mohieldin, Jing Zhou, Surya M. Nauli
Summary: A novel polycystic kidney-specific-targeting nanoparticles (NPs) have been developed to enhance the efficacy and tolerability of rapamycin, resulting in improved kidney function in polycystic kidney disease (PKD) mice. This polycystic kidney-targeting nanotechnology demonstrates a new era of nanomedicine in the treatment of chronic kidney diseases.
Article
Plant Sciences
Fernando Ferrari Putti, Bianca Bueno Nogueira, Angela Vacaro de Souza, Eduardo Festozo Vicente, Willian Aparecido Leoti Zanetti, Diogo de Lucca Sartori, Jessica Pigatto de Queiroz Barcelos
Summary: It is known that poorly performed fertigation directly impacts on tomato production and biometric components. In addition, consumers are also affected by interrelated characteristics that interfere with the acceptability of the fruit, such as the physicochemical parameters and nutrients in the fruit. Eco-friendly technologies, such as irrigation with ultra-low frequency electromagnetic treated-water, can attenuate the inadequate management of fertigation and improve marketable fruit yields. This study investigated the impact of treated water with very low-frequency electromagnetic resonance fields on physical, chemical, and nutritional parameters of tomato fruits at different nutrient solution strengths. The results showed that the electromagnetically treated water improved the physicochemical quality parameters and reduced the number of fruits with blossom-end rot. Overall, this study demonstrated that green technology could enhance tomato fruit production and quality.
Article
Neurosciences
Eduardo J. Fusse, Franciele F. Scarante, Maria A. Vicente, Mariana M. Marrubia, Flavia Turcato, Davi S. Scomparin, Melissa A. Ribeiro, Maria J. Figueiredo, Tamires A. V. Brigante, Francisco S. Guimaraes, Alline C. Campos
Summary: Repeated exposure to psychosocial stress alters the endocannabinoid system and affects brain regions associated with emotional distress. Enhancing the effects of endocannabinoids through pharmacological inhibition induces an anti-stress behavioral effect, possibly mediated by the mTOR signaling pathway.
NEUROSCIENCE LETTERS
(2024)
Article
Engineering, Electrical & Electronic
Zongyu Li, Kenneth Lange, Jeffrey A. Fessler
Summary: This paper proposes novel phase retrieval algorithms for maximum likelihood estimation in low-count scenarios with independent Poisson-distributed measurements. The algorithms utilize a modified Wirtinger flow with step sizes based on observed Fisher information and a novel curvature for majorize-minimize algorithms. Simulation experiments demonstrate that the proposed algorithms outperform existing optimization methods in terms of reconstruction quality and convergence speed.
IEEE TRANSACTIONS ON COMPUTATIONAL IMAGING
(2022)
Article
Food Science & Technology
Aristidis Tsatsakis, Nadezhda Tyshko, Marina Goumenou, Svetlana Shestakova, El'vira O. Sadykova, Valentin M. Zhminchenko, Ovidiu Zlatian, Daniela Calina, Valentina A. Pashorina, Nikolaj S. Nikitin, Marina D. Trebukh, Maria S. Loginova, Eleanora N. Trushina, Oksana K. Mustafina, Ludmila Avrenyeva, Galina Guseva, Nikita Trusov, Lidiya Kravchenko, Antonio F. Hernandez, Anca Oana Docea
Summary: This study found that exposure to a mixture of pesticides and chronic vitamin deficiency can lead to abnormal blood and urine biochemistry, increased oxidative stress and detoxification enzyme levels, as well as changes in organ pathology.
FOOD AND CHEMICAL TOXICOLOGY
(2021)
Article
Nutrition & Dietetics
Teppei Matsumura, Yuki Takamura, Kazushi Fukuzawa, Kazuya Nakagawa, Shunya Nonoyama, Keigo Tomoo, Hayato Tsukamoto, Yasushi Shinohara, Motoyuki Iemitsu, Akinori Nagano, Tadao Isaka, Takeshi Hashimoto
Summary: The effectiveness of low doses of caffeine in enhancing jump performance has been debated, but this study found that even at a dose as low as 1 mg/kg, caffeine improved vertical jump performance in a dose-independent manner.
INTERNATIONAL JOURNAL OF SPORT NUTRITION AND EXERCISE METABOLISM
(2023)
Article
Biochemistry & Molecular Biology
Natalia Rukoyatkina, Valentina Shpakova, Julia Sudnitsyna, Michael Panteleev, Stephanie Makhoul, Stepan Gambaryan, Kerstin Jurk
Summary: Our study demonstrated that curcumin exerts inhibitory effects on platelets through promoting procoagulant platelet formation instead of platelet apoptosis. Additionally, curcumin induced autophagy in platelets and inhibited platelet P-glycoprotein activity, contributing to its inhibitory effect on platelets through complex processes.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Computer Science, Artificial Intelligence
Maneet Singh, Shruti Nagpal, Richa Singh, Mayank Vatsa
Summary: This research proposes a novel DeriveNet model for VLR/LR classification, which focuses on learning effective class boundaries by utilizing the class-specific domain knowledge. The DeriveNet model achieves state-of-the-art performance across different VLR/LR classification tasks, demonstrating its utility.
IEEE TRANSACTIONS ON PATTERN ANALYSIS AND MACHINE INTELLIGENCE
(2022)
Article
Geochemistry & Geophysics
Zhaoliang Pi, Licheng Jiao, Fang Liu, Xu Liu, Lingling Li, Biao Hou, Shuyuan Yang
Summary: This article proposes a practical neural network framework for detecting tiny moving vehicles in satellite videos with low imaging quality. The article addresses the challenges of distinguishing true objects from noise and other distractors caused by instability factors such as illumination changes, motion blurs, and low contrast. The proposed model integrates motion information from adjacent frames to extract semantic features and uses a transformer to refine the features for key point estimation and scale prediction.
IEEE TRANSACTIONS ON GEOSCIENCE AND REMOTE SENSING
(2022)
Article
Environmental Sciences
Yunyun Wang, Pierre-Andre Lafon, Lucie Salvador-Prince, Aroa Relano Gines, Francoise Trousse, Joan Torrent, Corinne Prevostel, Carole Crozet, Jianfeng Liu, Veronique Perrier
Summary: The study found that gestational exposure to fungicide residues can significantly promote the growth of neural precursor cells, possibly leading to neurogenesis corruption through the interaction of the PI3K/Akt and Wnt/β-catenin signaling pathways. In addition, this exposure also alters protein expression in neonates and affects the proliferation and differentiation of neural stem cells.
ENVIRONMENTAL RESEARCH
(2021)
Article
Multidisciplinary Sciences
Astha Malik, Roman V. Kondratov, Roudabeh J. Jamasbi, Michael E. Geusz
Article
Endocrinology & Metabolism
William E. Samsa, Amit Vasanji, Ronald J. Midura, Roman V. Kondratov
Article
Biochemistry & Molecular Biology
Sonal A. Patel, Amol Chaudhari, Richa Gupta, Nikkhil Velingkaar, Roman V. Kondratov
Article
Biochemistry & Molecular Biology
Tanmay Majumdar, Jayeeta Dhar, Sonal Patel, Roman Kondratov, Sailen Barik
Article
Multidisciplinary Sciences
Sonal A. Patel, Nikkhil Velingkaar, Kuldeep Makwana, Amol Chaudhari, Roman Kondratov
SCIENTIFIC REPORTS
(2016)
Article
Cell Biology
Amol Chaudhari, Richa Gupta, Sonal Patel, Nikkhil Velingkaar, Roman Kondratov
MOLECULAR BIOLOGY OF THE CELL
(2017)
Article
Multidisciplinary Sciences
Artem A. Astafev, Sonal A. Patel, Roman V. Kondratov
SCIENTIFIC REPORTS
(2017)
Article
Cell Biology
Richa Tulsian, Nikkhil Velingkaar, Roman Kondratov
Article
Multidisciplinary Sciences
Astha Malik, Roudabeh J. Jamasbi, Roman V. Kondratov, Michael E. Geusz
Article
Biochemistry & Molecular Biology
Kuldeep Makwana, Neha Gosai, Allan Poe, Roman V. Kondratov
Article
Cell Biology
Nikkhil Velingkaar, Volha Mezhnina, Allan Poe, Kuldeep Makwana, Richa Tulsian, Roman V. Kondratov
Review
Biology
Sonal A. Patel, Roman V. Kondratov
Summary: The earth's rotation creates a 24-hour day and night cycle, with many biological functions controlled by an internal circadian clock. This clock coordinates periodic changes in physiological and behavioral activities, playing a crucial role in helping organisms adapt to their environment. Understanding the interaction between circadian rhythms and physiology is important in preventing and managing diseases like cancer.
Article
Biochemistry & Molecular Biology
Volha Mezhnina, Oghogho P. Ebeigbe, Allan Poe, Roman V. Kondratov
Summary: This article discusses the role of the circadian clock and mitochondrial rhythms in maintaining ROS homeostasis. The circadian clock regulates mitochondrial functions, including nutrient flux, oxidation, antioxidant defense, and mitochondrial dynamics. Understanding the molecular mechanisms of circadian control of mitochondrial functions is essential in preventing metabolic diseases and delaying aging.
ANTIOXIDANTS & REDOX SIGNALING
(2022)
Article
Cell Biology
Volha Mezhnina, Ryan Pearce, Allan Poe, Nikkhil Velingkaar, Artem Astafev, Oghogho P. Ebeigbe, Kuldeep Makwana, Yana Sandlers, Roman V. Kondratov
Article
Cell Biology
Kuldeep Makwana, Sonal Arvind Patel, Nikkhil Velingkaar, Jey Sabith Ebron, Girish C. Shukla, Roman V. Kondratov
