Hutchinson-Gilford progeria syndrome through the lens of transcription

Chromatin modifications: The driving force of senescence and aging?

(2016) Teresa DiMauro et al.   Aging-US

Genomic instability and DNA damage responses in progeria arising from defective maturation of prelamin A

(2016) Phillip R. Musich et al.   Aging-US

Impact papers on aging in 2009

(2016) Mikhail V. Blagosklonny et al.   Aging-US

Identification of differential protein interactors of lamin A and progerin

(2014) Nard Kubben et al.   Nucleus

DNA Sequence-Dependent Compartmentalization and Silencing of Chromatin at the Nuclear Lamina

(2012) Joseph M. Zullo et al.   CELL

Step-Wise Methylation of Histone H3K9 Positions Heterochromatin at the Nuclear Periphery

(2012) Benjamin D. Towbin et al.   CELL

Lamin B1 loss is a senescence-associated biomarker

(2012) Adam Freund et al.   MOLECULAR BIOLOGY OF THE CELL

Lamin A tail modification by SUMO1 is disrupted by familial partial lipodystrophy–causing mutations

(2012) Dan N. Simon et al.   MOLECULAR BIOLOGY OF THE CELL

Axis of ageing: telomeres, p53 and mitochondria

(2012) Ergün Sahin et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Regulation of prelamin A but not lamin C by miR-9, a brain-specific microRNA

(2012) H.-J. Jung et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Exome Sequencing and Functional Analysis Identifies BANF1 Mutation as the Cause of a Hereditary Progeroid Syndrome

(2011) Xose S. Puente et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Nuclear Mechanics in Disease

(2011) Monika Zwerger et al.   Annual Review of Biomedical Engineering

DNA-damage accumulation and replicative arrest in Hutchinson–Gilford progeria syndrome

(2011) Phillip R. Musich et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

The nuclear lamina and heterochromatin: a complex relationship: Table 1

(2011) Erin M. Bank et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Regulating the levels of key factors in cell cycle and DNA repair: New pathways revealed by lamins

(2011) Abena B. Redwood et al.   CELL CYCLE

An EDMD Mutation in C. elegans Lamin Blocks Muscle-Specific Gene Relocation and Compromises Muscle Integrity

(2011) Anna Mattout et al.   CURRENT BIOLOGY

Notch signaling: simplicity in design, versatility in function

(2011) E. R. Andersson et al.   DEVELOPMENT

A new pathway that regulates 53BP1 stability implicates Cathepsin L and vitamin D in DNA repair

(2011) Ignacio Gonzalez-Suarez et al.   EMBO JOURNAL

Chromatin: constructing the big picture

(2011) Bas van Steensel   EMBO JOURNAL

Subcellular localization of SREBP1 depends on its interaction with the C-terminal region of wild-type and disease related A-type lamins

(2011) Isabelle Duband-Goulet et al.   EXPERIMENTAL CELL RESEARCH

The role of nuclear lamin B1 in cell proliferation and senescence

(2011) T. Shimi et al.   GENES & DEVELOPMENT

The accumulation of un-repairable DNA damage in laminopathy progeria fibroblasts is caused by ROS generation and is prevented by treatment with N-acetyl cysteine

(2011) Shane A. Richards et al.   HUMAN MOLECULAR GENETICS

Progerin and telomere dysfunction collaborate to trigger cellular senescence in normal human fibroblasts

(2011) Kan Cao et al.   JOURNAL OF CLINICAL INVESTIGATION

The Defective Nuclear Lamina in Hutchinson-Gilford Progeria Syndrome Disrupts the Nucleocytoplasmic Ran Gradient and Inhibits Nuclear Localization of Ubc9

(2011) J. B. Kelley et al.   MOLECULAR AND CELLULAR BIOLOGY

Telomere dysfunction induces metabolic and mitochondrial compromise

(2011) Ergün Sahin et al.   NATURE

The nucleoskeleton as a genome-associated dynamic 'network of networks'

(2011) Dan N. Simon et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Discordant Gene Expression Signatures and Related Phenotypic Differences in Lamin A- and A/C-Related Hutchinson-Gilford Progeria Syndrome (HGPS)

(2011) Martina Plasilova et al.   PLoS One

Diverse Roles and Interactions of the SWI/SNF Chromatin Remodeling Complex Revealed Using Global Approaches

(2011) Ghia M. Euskirchen et al.   PLoS Genetics

Farnesyltransferase inhibitor treatment restores chromosome territory positions and active chromosome dynamics in Hutchinson-Gilford progeria syndrome cells

(2011) Ishita S Mehta et al.   GENOME BIOLOGY

Direct actin binding to A- and B-type lamin tails and actin filament bundling by the lamin A tail

(2011) Dan N. Simon et al.   Nucleus

Nurturing the genome: A-type lamins preserve genomic stability

(2011) Ignacio Gonzalez-Suarez et al.   Nucleus

Gene expression, chromosome position and lamin A/C mutations

(2011) Megan J. Puckelwartz et al.   Nucleus

Cardiovascular Pathology in Hutchinson-Gilford Progeria: Correlation With the Vascular Pathology of Aging

(2010) Michelle Olive et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Lamins: ‘structure goes cycling’: Figure 1

(2010) Mirta Boban et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Relationships at the nuclear envelope: lamins and nuclear pore complexes in animals and plants: Figure 1

(2010) Jindriska Fiserova et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Lamin A precursor induces barrier-to-autointegration factor nuclear localization

(2010) Cristina Capanni et al.   CELL CYCLE

The nuclear envelope can control gene expression and cell cycle progression via miRNA regulation

(2010) Ashraf Malhas et al.   CELL CYCLE

A Human iPSC Model of Hutchinson Gilford Progeria Reveals Vascular Smooth Muscle and Mesenchymal Stem Cell Defects

(2010) Jinqiu Zhang et al.   Cell Stem Cell

Functional Coupling between the Extracellular Matrix and Nuclear Lamina by Wnt Signaling in Progeria

(2010) Lidia Hernandez et al.   DEVELOPMENTAL CELL

Accumulation of distinct prelamin A variants in human diploid fibroblasts differentially affects cell homeostasis

(2010) Jose Candelario et al.   EXPERIMENTAL CELL RESEARCH

PPARγ in adipocyte differentiation and metabolism - Novel insights from genome-wide studies

(2010) Rasmus Siersbaek et al.   FEBS LETTERS

The spatial dynamics of tissue-specific promoters during C. elegans development

(2010) P. Meister et al.   GENES & DEVELOPMENT

Role of progerin-induced telomere dysfunction in HGPS premature cellular senescence

(2010) E. K. Benson et al.   JOURNAL OF CELL SCIENCE

A Novel Proteomics Approach to Identify SUMOylated Proteins and Their Modification Sites in Human Cells

(2010) Frederic Galisson et al.   MOLECULAR & CELLULAR PROTEOMICS

Linking functional decline of telomeres, mitochondria and stem cells during ageing

(2010) Ergün Sahin et al.   NATURE

Progeria syndromes and ageing: what is the connection?

(2010) Christopher R. Burtner et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Defective Lamin A-Rb Signaling in Hutchinson-Gilford Progeria Syndrome and Reversal by Farnesyltransferase Inhibition

(2010) Jackleen Marji et al.   PLoS One

Altered Chromosomal Positioning, Compaction, and Gene Expression with a Lamin A/C Gene Mutation

(2010) Stephanie K. Mewborn et al.   PLoS One

Transforming Growth Factor-β and Notch Signaling Mediate Stem Cell Differentiation into Smooth Muscle Cells

(2010) Kyle Kurpinski et al.   STEM CELLS

Nuclear Lamins

(2010) T. Dechat et al.   Cold Spring Harbor Perspectives in Biology

Nuclear Functions of Actin

(2010) N. Visa et al.   Cold Spring Harbor Perspectives in Biology

Lamin-binding Proteins

(2010) K. L. Wilson et al.   Cold Spring Harbor Perspectives in Biology

Peroxisome Proliferator-Activated Receptor γ and Cardiovascular Diseases

(2009) Hiroyuki Takano et al.   CIRCULATION JOURNAL

miR-23 regulation of lamin B1 is crucial for oligodendrocyte development and myelination

(2009) S.-T. Lin et al.   Disease Models & Mechanisms

Novel roles for A-type lamins in telomere biology and the DNA damage response pathway

(2009) Ignacio Gonzalez-Suarez et al.   EMBO JOURNAL

Role of A-type lamins in signaling, transcription, and chromatin organization

(2009) Vicente Andrés et al.   JOURNAL OF CELL BIOLOGY

A-type lamins and signaling: The PI 3-kinase/Akt pathway moves forward

(2009) Sandra Marmiroli et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Effect of progerin on the accumulation of oxidized proteins in fibroblasts from Hutchinson Gilford progeria patients

(2009) Gabriela Viteri et al.   MECHANISMS OF AGEING AND DEVELOPMENT

NURD keeps chromatin young

(2009) Eran Meshorer et al.   NATURE CELL BIOLOGY

Ageing-related chromatin defects through loss of the NURD complex

(2009) Gianluca Pegoraro et al.   NATURE CELL BIOLOGY

Telomere Diseases

(2009) Rodrigo T. Calado et al.   NEW ENGLAND JOURNAL OF MEDICINE

Barrier-to-Autointegration Factor Proteome Reveals Chromatin-Regulatory Partners

(2009) Rocío Montes de Oca et al.   PLoS One

A progeria mutation reveals functions for lamin A in nuclear assembly, architecture, and chromosome organization

(2009) P. Taimen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Increased mechanosensitivity and nuclear stiffness in Hutchinson–Gilford progeria cells: effects of farnesyltransferase inhibitors

(2008) Valerie L. R. M. Verstraeten et al.   AGING CELL

Inhibition of Lamin A/C Attenuates Osteoblast Differentiation and Enhances RANKL-Dependent Osteoclastogenesis

(2008) Martina Rauner et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Effect of Lamin A/C Knockdown on Osteoblast Differentiation and Function

(2008) Rahima Akter et al.   JOURNAL OF BONE AND MINERAL RESEARCH

The highly conserved nuclear lamin Ig-fold binds to PCNA: its role in DNA replication

(2008) Dale K. Shumaker et al.   JOURNAL OF CELL BIOLOGY

Sumoylation regulates lamin A function and is lost in lamin A mutants associated with familial cardiomyopathies

(2008) Yu-Qian Zhang et al.   JOURNAL OF CELL BIOLOGY

The nuclear lamina promotes telomere aggregation and centromere peripheral localization during senescence of human mesenchymal stem cells

(2008) V. Raz et al.   JOURNAL OF CELL SCIENCE

Inhibition of  -catenin signaling causes defects in postnatal cartilage development

(2008) M. Chen et al.   JOURNAL OF CELL SCIENCE

Lamin A-dependent misregulation of adult stem cells associated with accelerated ageing

(2008) Paola Scaffidi et al.   NATURE CELL BIOLOGY

Tethering by lamin A stabilizes and targets the ING1 tumour suppressor

(2008) Xijing Han et al.   NATURE CELL BIOLOGY

Combined treatment with statins and aminobisphosphonates extends longevity in a mouse model of human premature aging

(2008) Ignacio Varela et al.   NATURE MEDICINE

Phenotype and Course of Hutchinson–Gilford Progeria Syndrome

(2008) Melissa A. Merideth et al.   NEW ENGLAND JOURNAL OF MEDICINE

Notch Signaling in Osteoblasts

(2008) E. Canalis   Science Signaling

Involvement of xeroderma pigmentosum group A (XPA) in progeria arising from defective maturation of prelamin A

(2007) Yiyong Liu et al.   FASEB JOURNAL