Regulatory B cells in human inflammatory and autoimmune diseases: from mouse models to clinical research

CD24hiCD27+ and plasmablast-like regulatory B cells in human chronic graft-versus-host disease

(2015) A. de Masson et al.   BLOOD

Alteration of circulating type 2 follicular helper T cells and regulatory B cells underlies the comorbid association of allergic rhinitis with bronchial asthma

(2015) Ryuta Kamekura et al.   CLINICAL IMMUNOLOGY

IL-10–overexpressing B cells regulate innate and adaptive immune responses

(2015) Barbara Stanic et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Impaired function of CD19+CD24hiCD38hiregulatory B cells in patients with pemphigus

(2014) H.-Q. Zhu et al.   BRITISH JOURNAL OF DERMATOLOGY

Multi-parametric flow cytometric and genetic investigation of the peripheral B cell compartment in human type 1 diabetes

(2014) W. S. Thompson et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Interleukin-10+Regulatory B Cells Arise Within Antigen-Experienced CD40+B Cells to Maintain Tolerance to Islet Autoantigens

(2014) Sonja Kleffel et al.   DIABETES

Role of Regulatory B Cells in Chronic Intestinal Inflammation

(2014) Akihiko Oka et al.   INFLAMMATORY BOWEL DISEASES

IL-10-producing regulatory B cells induced by IL-33 (BregIL-33) effectively attenuate mucosal inflammatory responses in the gut

(2014) Susanne Sattler et al.   JOURNAL OF AUTOIMMUNITY

B Lymphocyte Depletion by CD20 Monoclonal Antibody Prevents Diabetes in Nonobese Diabetic Mice despite Isotype-Specific Differences in Fc R Effector Functions

(2014) Y. Xiu et al.   JOURNAL OF IMMUNOLOGY

TLR-Activated B Cells Suppress T Cell-Mediated Autoimmunity

(2014) V. Lampropoulou et al.   JOURNAL OF IMMUNOLOGY

Interleukin 10 (IL-10)–Producing CD1dhi Regulatory B Cells From Schistosoma Haematobium–Infected Individuals Induce IL-10–Positive T Cells and Suppress Effector T-Cell Cytokines

(2014) Luciën E. P. M. van der Vlugt et al.   JOURNAL OF INFECTIOUS DISEASES

T Follicular Helper Cells and Regulatory B Cells Dynamics in Systemic Lupus Erythematosus

(2014) Xue Yang et al.   PLoS One

Involvement of Suppressive B-Lymphocytes in the Mechanism of Tolerogenic Dendritic Cell Reversal of Type 1 Diabetes in NOD Mice

(2014) Valentina Di Caro et al.   PLoS One

Regulatory B Cells Are Inversely Associated with Disease Activity in Rheumatoid Arthritis

(2014) Jinhyun Kim et al.   YONSEI MEDICAL JOURNAL

Regulatory B10 Cells Are Decreased in Patients With Rheumatoid Arthritis and Are Inversely Correlated With Disease Activity

(2014) Claire I. Daien et al.   Arthritis & Rheumatology

Impaired Suppressive Capacity of Activation-Induced Regulatory B Cells in Systemic Lupus Erythematosus

(2014) Nele Gao et al.   Arthritis & Rheumatology

CD24hiCD27+B cells from patients with allergic asthma have impaired regulatory activity in response to lipopolysaccharide

(2013) L. E. P. M. van der Vlugt et al.   CLINICAL AND EXPERIMENTAL ALLERGY

Reduced numbers of regulatory B cells are negatively correlated with disease activity in patients with new-onset rheumatoid arthritis

(2013) Liang Ma et al.   CLINICAL RHEUMATOLOGY

B-cell linker protein expression contributes to controlling allergic and autoimmune diseases by mediating IL-10 production in regulatory B cells

(2013) Guihua Jin et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

IgG4 production is confined to human IL-10–producing regulatory B cells that suppress antigen-specific immune responses

(2013) Willem van de Veen et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Peritoneal Cavity Regulatory B Cells (B10 Cells) Modulate IFN- +CD4+ T Cell Numbers during Colitis Development in Mice

(2013) D. Maseda et al.   JOURNAL OF IMMUNOLOGY

CD19+CD24hiCD38hi B Cells Maintain Regulatory T Cells While Limiting TH1 and TH17 Differentiation

(2013) F. Flores-Borja et al.   Science Translational Medicine

Long-Term Remissions of Severe Pemphigus After Rituximab Therapy Are Associated with Prolonged Failure of Desmoglein B Cell Response

(2013) N. Colliou et al.   Science Translational Medicine

Mechanisms of peripheral tolerance to allergens

(2012) O. U. Soyer et al.   ALLERGY

IL-10–Producing Regulatory B10 Cells Ameliorate Collagen-Induced Arthritis via Suppressing Th17 Cell Generation

(2012) Min Yang et al.   AMERICAN JOURNAL OF PATHOLOGY

Immune Regulatory Function of B Cells

(2012) Claudia Mauri et al.   Annual Review of Immunology

Tolerogenic effects of interferon-gamma with induction of allergen-specific interleukin-10-producing regulatory B cell (Br1) changes in non-IgE-mediated food allergy

(2012) Joonyong Noh et al.   CELLULAR IMMUNOLOGY

Rituximab-associated Colitis

(2012) Mahesh Bhalme et al.   INFLAMMATORY BOWEL DISEASES

Regulatory B cells control T-cell autoimmunity through IL-21-dependent cognate interactions

(2012) Ayumi Yoshizaki et al.   NATURE

Schistosomes Induce Regulatory Features in Human and Mouse CD1dhi B Cells: Inhibition of Allergic Inflammation by IL-10 and Regulatory T Cells

(2012) Luciën E. P. M. van der Vlugt et al.   PLoS One

Interleukin-10 produced by B cells is crucial for the suppression of Th17/Th1 responses, induction of T regulatory type 1 cells and reduction of collagen-induced arthritis

(2012) Natalie A Carter et al.   ARTHRITIS RESEARCH & THERAPY

An Evidence-Based Systematic Review on Medical Therapies for Inflammatory Bowel Disease

(2011) Nicholas J Talley et al.   AMERICAN JOURNAL OF GASTROENTEROLOGY

IL-10–Producing Regulatory B10 Cells Inhibit Intestinal Injury in a Mouse Model

(2011) Koichi Yanaba et al.   AMERICAN JOURNAL OF PATHOLOGY

Human CD19+CD25high B regulatory cells suppress proliferation of CD4+ T cells and enhance Foxp3 and CTLA-4 expression in T-regulatory cells

(2011) Aharon Kessel et al.   AUTOIMMUNITY REVIEWS

Increasing Incidence and Prevalence of the Inflammatory Bowel Diseases With Time, Based on Systematic Review

(2011) Natalie A. Molodecky et al.   GASTROENTEROLOGY

Randomised placebo-controlled trial of rituximab (anti-CD20) in active ulcerative colitis

(2011) K. Leiper et al.   GUT

The Calcium Sensors STIM1 and STIM2 Control B Cell Regulatory Function through Interleukin-10 Production

(2011) Masanori Matsumoto et al.   IMMUNITY

Novel regulatory functions for Toll-like receptor-activated B cells during intracellular bacterial infection

(2011) Simon Fillatreau   IMMUNOLOGICAL REVIEWS

B Cells Exposed to Enterobacterial Components Suppress Development of Experimental Colitis

(2011) Esben Gjerlff Wedebye Schmidt et al.   INFLAMMATORY BOWEL DISEASES

B Cell-Derived IL-10 Does Not Regulate Spontaneous Systemic Autoimmunity in MRL.Faslpr Mice

(2011) L. L. Teichmann et al.   JOURNAL OF IMMUNOLOGY

Reduction in IL-10 producing B cells (Breg) in multiple sclerosis is accompanied by a reduced naïve/memory Breg ratio during a relapse but not in remission

(2011) Stephanie Knippenberg et al.   JOURNAL OF NEUROIMMUNOLOGY

B10 cells and regulatory B cells balance immune responses during inflammation, autoimmunity, and cancer

(2010) David J. DiLillo et al.   Annals of the New York Academy of Sciences

Inflammatory Bowel Disease

(2010) Arthur Kaser et al.   Annual Review of Immunology

Characterization of a rare IL-10-competent B-cell subset in humans that parallels mouse regulatory B10 cells

(2010) Y. Iwata et al.   BLOOD

Characterisation of allergen-specific responses of IL-10-producing regulatory B cells (Br1) in Cow Milk Allergy

(2010) Joonyong Noh et al.   CELLULAR IMMUNOLOGY

Regulation of immunity and autoimmunity by B cells

(2010) Claudia Mauri   CURRENT OPINION IN IMMUNOLOGY

CD19+CD24hiCD38hi B Cells Exhibit Regulatory Capacity in Healthy Individuals but Are Functionally Impaired in Systemic Lupus Erythematosus Patients

(2010) Paul A. Blair et al.   IMMUNITY

Decreased production of interleukin-10 and transforming growth factor-β in Toll-like receptor-activated intestinal B cells in SAMP1/Yit mice

(2010) Yoshiyuki Mishima et al.   IMMUNOLOGY

Regulatory B cells prevent and reverse allergic airway inflammation via FoxP3-positive T regulatory cells in a murine model

(2010) Sylvie Amu et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Protective and Pathogenic Roles for B Cells during Systemic Autoimmunity in NZB/W F1 Mice

(2010) K. M. Haas et al.   JOURNAL OF IMMUNOLOGY

Regulatory B Cells (B10 Cells) and Regulatory T Cells Have Independent Roles in Controlling Experimental Autoimmune Encephalomyelitis Initiation and Late-Phase Immunopathogenesis

(2010) T. Matsushita et al.   JOURNAL OF IMMUNOLOGY

Regulatory B Cells (B10 Cells) Have a Suppressive Role in Murine Lupus: CD19 and B10 Cell Deficiency Exacerbates Systemic Autoimmunity

(2010) R. Watanabe et al.   JOURNAL OF IMMUNOLOGY

Decreased IL-10 production mediated by Toll-like receptor 9 in B cells in multiple sclerosis

(2010) Makoto Hirotani et al.   JOURNAL OF NEUROIMMUNOLOGY

Severe Ulcerative Colitis After Rituximab Therapy

(2010) D. S. Ardelean et al.   PEDIATRICS

Allergen-specific B cell subset responses in cow’s milk allergy of late eczematous reactions in atopic dermatitis

(2009) Jae Ho Lee et al.   CELLULAR IMMUNOLOGY

Helminth Antigens Modulate Immune Responses in Cells from Multiple Sclerosis Patients through TLR2-Dependent Mechanisms

(2009) J. Correale et al.   JOURNAL OF IMMUNOLOGY

Selective Targeting of B Cells with Agonistic Anti-CD40 Is an Efficacious Strategy for the Generation of Induced Regulatory T2-Like B Cells and for the Suppression of Lupus in MRL/lpr Mice

(2009) P. A. Blair et al.   JOURNAL OF IMMUNOLOGY

Helminth infections associated with multiple sclerosis induce regulatory B cells

(2008) Jorge Correale et al.   ANNALS OF NEUROLOGY

B lymphocytes: how they develop and function

(2008) T. W. LeBien et al.   BLOOD

Cytokine-producing B lymphocytes—key regulators of immunity

(2008) Frances E Lund   CURRENT OPINION IN IMMUNOLOGY

A Regulatory B Cell Subset with a Unique CD1dhiCD5+ Phenotype Controls T Cell-Dependent Inflammatory Responses

(2008) Koichi Yanaba et al.   IMMUNITY

B-lymphocyte contributions to human autoimmune disease

(2008) Koichi Yanaba et al.   IMMUNOLOGICAL REVIEWS

Regulatory B cells as inhibitors of immune responses and inflammation

(2008) Jean-David Bouaziz et al.   IMMUNOLOGICAL REVIEWS

B cells limit epitope spreading and reduce severity of EAE induced with PLP peptide in BALB/c mice

(2008) Jeri-Anne Lyons et al.   JOURNAL OF AUTOIMMUNITY

Regulatory B cells inhibit EAE initiation in mice while other B cells promote disease progression

(2008) Takashi Matsushita et al.   JOURNAL OF CLINICAL INVESTIGATION

The ‘short’ history of regulatory B cells

(2007) Claudia Mauri et al.   TRENDS IN IMMUNOLOGY