Enantioselective Synthesis of Tropanes via [3+3] Annulation of Cyclic Azomethine Ylides with Substituted 2-Vinylindoles and 2-Vinylpyrroles

Synthesis of (−)-Pyrido[3,4-b]homotropane (PHT) and (±)-PHT via an Intramolecular Cross [3+2] Cycloaddition Strategy

(2018) Bingxia Sun et al.   ADVANCED SYNTHESIS & CATALYSIS

Chiral Silver Complex-Catalyzed Diastereoselective and Enantioselective Michael Addition of 1-Pyrroline-5-carboxylates to α-Enones

(2017) Akihiro Koizumi et al.   JOURNAL OF ORGANIC CHEMISTRY

Stereoselective Synthesis of Pyrrolidines Containing a 3-Fluoro Quaternary Stereocenter via Copper(I)-Catalyzed Asymmetric 1,3-Dipolar Cycloaddition

(2017) Yang-Zi Liu et al.   JOURNAL OF ORGANIC CHEMISTRY

Diastereo- and enantioselective construction of spirooxindole scaffolds through a catalytic asymmetric [3 + 3] cycloaddition

(2017) Can Li et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

[3 + 3] Cycloaddition of in Situ Formed Azaoxyallyl Cations with 2-Alkenylindoles: An Approach to Tetrahydro-β-carbolinones

(2017) Kaifan Zhang et al.   ORGANIC LETTERS

Current Trends towards the Synthesis of Bioactive Heterocycles and Natural Products Using 1,3-Dipolar Cycloadditions (1,3-DC) with Azomethine Ylides

(2017) H. Döndas et al.   SYNTHESIS-STUTTGART

Chiral phosphoric acid catalyzed aza-Friedel-Crafts alkylation of indoles with cyclic aryl α-ketimino esters

(2017) Yunlong Zhao et al.   TETRAHEDRON LETTERS

Recent advances in the enantioselective 1,3-dipolar cycloaddition of azomethine ylides and dipolarophiles

(2017) Bilel Bdiri et al.   TETRAHEDRON-ASYMMETRY

Enantioselective Aza-Friedel–Crafts Reaction of Indoles with Ketimines Catalyzed by Chiral Potassium Binaphthyldisulfonates

(2017) Manabu Hatano et al.   ACS Catalysis

Direct coupling of sp3 carbon of alkanes with α,β-unsaturated carbonyl compounds using a copper/hydroperoxide system

(2017) Yun Lan et al.   Organic Chemistry Frontiers

ChiralN,N′-Dioxide-Zinc(II) Complex-Catalyzed Asymmetric Aza-Friedel-Crafts Reaction of Isatin-Derived Ketimines with Indoles

(2016) Xiying Zhang et al.   ADVANCED SYNTHESIS & CATALYSIS

Construction of Tropane Derivatives by the Organocatalytic Asymmetric Dearomatization of Isoquinolines

(2016) Jin-Hui Xu et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Catalytic Enantioselective and Regioselective [3+3] Cycloadditions Using 2-Indolylmethanols as 3 C Building Blocks

(2016) Xiao-Xue Sun et al.   CHEMISTRY-A EUROPEAN JOURNAL

Progress in 1,3-dipolar cycloadditions in the recent decade: an update to strategic development towards the arsenal of organic synthesis

(2016) Maya Shankar Singh et al.   TETRAHEDRON

Cu(I)-Catalyzed Chemoselective and Stereoselective [3 + 3] Cycloaddition of Azomethine Ylides with 2-Indolylnitroethylenes: Facile Access to Highly Substituted Tetrahydro-γ-Carbolines

(2016) Wu-Lin Yang et al.   ACS Catalysis

Enantioselective Construction of Cyclic Indolyl α-Amino Estersviaa Friedel-Crafts Alkylation Reaction

(2015) Liang Wu et al.   ADVANCED SYNTHESIS & CATALYSIS

Catalytic chemoselective [3+3] cycloadditions of azomethine ylides with quinone monoimides leading to the construction of a dihydrobenzoxazine scaffold

(2015) Cong-Shuai Wang et al.   CHEMICAL COMMUNICATIONS

The copper-catalyzed asymmetric construction of a dispiropyrrolidine skeleton via 1,3-dipolar cycloaddition of azomethine ylides to α-alkylidene succinimides

(2015) Wu-Lin Yang et al.   CHEMICAL COMMUNICATIONS

Recent Advances of Catalytic Asymmetric 1,3-Dipolar Cycloadditions

(2015) Takuya Hashimoto et al.   CHEMICAL REVIEWS

Diastereodivergent Asymmetric Michael Addition of Cyclic Azomethine Ylides to Nitroalkenes: Direct Approach for the Synthesis of 1,7-Diazaspiro[4.4]nonane Diastereoisomers

(2015) Chun-Yan Li et al.   CHEMISTRY-A EUROPEAN JOURNAL

Chiral N,O-Ligand/[Cu(OAc)2]-Catalyzed Asymmetric Construction of 4-Aminopyrrolidine Derivatives by 1,3-Dipolar Cycloaddition of Azomethine Ylides with α-Phthalimidoacrylates

(2015) Zheng Wang et al.   CHEMISTRY-A EUROPEAN JOURNAL

Copper- and Silver-Catalyzed Diastereo- and Enantioselective Conjugate Addition Reaction of 1-Pyrroline Esters to Nitroalkenes: Diastereoselectivity Switch by Chiral Metal Complexes

(2015) Akihiro Koizumi et al.   JOURNAL OF ORGANIC CHEMISTRY

Cu(i)/TF-BiphamPhos-catalyzed asymmetric Michael addition of cyclic ketimino esters to alkylidene malonates

(2015) Zhi-Yong Xue et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Asymmetric Construction of Spirocyclic Pyrrolidine-thia(oxa)zolidinediones via N,O-Ligand/Cu(I) Catalyzed 1,3-Dipolar Cycloaddition of Azomethine Ylides with 5-Alkylidene Thia(oxa)zolidine-2,4-diones

(2015) Wu-Lin Yang et al.   ORGANIC LETTERS

Brønsted Acid or Lewis Acid Catalyzed [3+3] Cycloaddition of Azomethine Imines with N-Benzyl Azomethine Ylide: A Facile Access to Bicyclic N-Heterocycles

(2015) Jia Liu et al.   SYNLETT

Brønsted acid-promoted [3 + 3] cycloaddition of azomethine ylides with quinone monoimine: a practical method towards dihydrobenzoxazine derivatives

(2015) Yang Wu et al.   RSC Advances

Catalytic Enantioselective 1,3-Dipolar Cycloadditions of Azomethine Ylides for Biology-Oriented Synthesis

(2014) Rishikesh Narayan et al.   ACCOUNTS OF CHEMICAL RESEARCH

Recent advances in the catalytic asymmetric 1,3-dipolar cycloaddition of azomethine ylides

(2014) Javier Adrio et al.   CHEMICAL COMMUNICATIONS

Catalytic Asymmetric Formal [3+3] Cycloaddition of an Azomethine Ylide with 3-Indolylmethanol: Enantioselective Construction of a Six-Membered Piperidine Framework

(2014) Feng Shi et al.   CHEMISTRY-A EUROPEAN JOURNAL

Diastereo- and Enantioselective Construction of a Bispirooxindole Scaffold Containing a Tetrahydro-β-carboline Moiety through an Organocatalytic Asymmetric Cascade Reaction

(2014) Wei Dai et al.   CHEMISTRY-A EUROPEAN JOURNAL

Cu(I)-Catalyzed Highly Enantioselective [3 + 3] Cycloaddition between Two Different 1,3-Dipoles, Phthalazinium Dicyanomethanides and Iminoester-Derived Azomethine Ylides

(2014) Chunhao Yuan et al.   ORGANIC LETTERS

Diastereoselective Synthesis of Functionalized Tetrahydrocarbazoles via a Domino-Ring Opening–Cyclization of Donor–Acceptor Cyclopropanes with Substituted 2-Vinylindoles

(2014) Ranadeep Talukdar et al.   ORGANIC LETTERS

Catalytic Asymmetric Construction of Azabicyclo[2.2.1]heptanes Bearing Two Quaternary Stereogenic Centers via Silver(I)-Catalyzed 1,3-Dipolar Cyclo­addition of Cyclic Azomethine Ylides

(2014) Chun-Jiang Wang et al.   SYNLETT

Synthesis of 7-azabicyclo[2.2.1]heptane-1-carboxylate via silver/ThioClickFerrophos-catalyzed asymmetric 1,3-dipolar cycloaddition of dihydropyrrole ester with N-substituted maleimide

(2014) Atsuo Tada et al.   TETRAHEDRON LETTERS

Chiral Brønsted Acid Catalyzed Stereoselective [3+3] Cycloaddition Reaction of Azomethine Ylide to Vinylimine Intermediates: Constructing Fully Functionalized Chiral Tetrahydro-β-Carboline

(2013) Jianzhou Huang et al.   ACTA CHIMICA SINICA

Chiral Phosphoric Acid-Catalyzed Asymmetric Aza-Friedel-Crafts Reaction of Indoles with CyclicN-Acylketimines: Enantioselective Synthesis of Trifluoromethyldihydroquinazolines

(2013) Ke-Feng Zhang et al.   ADVANCED SYNTHESIS & CATALYSIS

Asymmetric Synthesis of Pyrroloindolones by N-Heterocyclic Carbene Catalyzed [2+3] Annulation of α-Chloroaldehydes with Nitrovinylindoles

(2013) Qijian Ni et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Enantioselective Copper-Catalyzed [3+3] Cycloaddition of Azomethine Ylides with Azomethine Imines

(2013) Hongchao Guo et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Catalytic Enantioselective Synthesis of Functionalized Tropanes Reveals Novel Inhibitors of Hedgehog Signaling

(2013) Rishikesh Narayan et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Catalytic Asymmetric 1,3-Dipolar Cycloaddition of Two Different Ylides: Facile Access to Chiral 1,2,4-Triazinane Frameworks

(2013) Min-Chao Tong et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

1,3-Dipolar Cycloaddition-based Synthesis of Diverse Heterocyclic Scaffolds

(2013) Wei Zhang   CHEMISTRY LETTERS

Alstoniaphyllines A–C, Unusual Nitrogenous Derivatives from the Bark of Alstonia macrophylla

(2013) Sarot Cheenpracha et al.   JOURNAL OF NATURAL PRODUCTS

Chiral Brønsted acid-catalyzed enantioselective addition of indoles to ketimines

(2013) Taichi Kano et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Silver/ThioClickFerrophos Complex as an Effective Catalyst for Asymmetric Conjugate Addition of Glycine Imino Ester to Unsaturated Malonates and α-Enones

(2013) Takashi Konno et al.   ORGANIC LETTERS

A Novel Method for Synthesizing N-Alkoxycarbonyl Aryl α-Imino Esters and Their Applications in Enantioselective Transformations

(2012) Yu Qian et al.   ADVANCED SYNTHESIS & CATALYSIS

Epiminocyclohepta[b]indole analogs as 5-HT6 antagonists

(2012) Alan J. Henderson et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

The highly enantioselective addition of indoles and pyrroles to isatins-derived N-Boc ketimines catalyzed by chiral phosphoric acids

(2012) Jingchao Feng et al.   CHEMICAL COMMUNICATIONS

Brønsted Acid Catalyzed Enantioselective α-Amidoalkylation in the Synthesis of Isoindoloisoquinolines

(2012) Eider Aranzamendi et al.   JOURNAL OF ORGANIC CHEMISTRY

Asymmetric Brønsted Acid-Catalyzed Friedel-Crafts Reactions of Indoles with Cyclic Imines - Efficient Generation of Nitrogen-Substituted Quaternary Carbon Centers

(2011) Magnus Rueping et al.   ADVANCED SYNTHESIS & CATALYSIS

An exo- and Enantioselective 1,3-Dipolar Cycloaddition of Azomethine Ylides with Alkylidene Malonates Catalyzed by a N,O-Ligand/Cu(OAc)2-Derived Chiral Complex

(2011) Ming Wang et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Novel dipolarophiles and dipoles in the metal-catalyzed enantioselective 1,3-dipolar cycloaddition of azomethine ylides

(2011) Javier Adrio et al.   CHEMICAL COMMUNICATIONS

Organocatalyzed Enantioselective Synthesis of Quaternary Carbon-Containing Isoindolin-1-ones

(2011) Xiaolei Yu et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

Enantioselective Organocatalytic Synthesis of Quaternary α-Amino Acids Bearing a CF3Moiety

(2011) Ralph Husmann et al.   ORGANIC LETTERS

Phosphonium ion tagged chiral phosphoric acids and their application in Friedel–Crafts reactions of indoles

(2011) Julia Hermeke et al.   TETRAHEDRON

Efficient Construction of Oxa- and Aza-[n.2.1] Skeletons: Lewis Acid Catalyzed Intramolecular [3+2] Cycloaddition of Cyclopropane 1,1-Diesters with Carbonyls and Imines

(2010) Siyang Xing et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

New Route to the Synthesis of the Isocryptolepine Alkaloid and Its Related Skeletons Using a Modified Pictet-Spengler Reaction

(2008) Piyush K. Agarwal et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

Process Research and Scale-up of a Commercialisable Route to Maraviroc (UK-427,857), a CCR-5 Receptor Antagonist

(2008) Jens Åhman et al.   ORGANIC PROCESS RESEARCH & DEVELOPMENT

Development of a Bulk Enabling Route to Maraviroc (UK-427,857), a CCR-5 Receptor Antagonist

(2008) Sarah J. Haycock-Lewandowski et al.   ORGANIC PROCESS RESEARCH & DEVELOPMENT