Pros and cons of using biomarkers versus clinical decisions in start and stop decisions for antibiotics in the critical care setting

Preventive and therapeutic strategies in critically ill patients with highly resistant bacteria

(2015) Matteo Bassetti et al.   INTENSIVE CARE MEDICINE

Adjunct prednisone therapy for patients with community-acquired pneumonia: a multicentre, double-blind, randomised, placebo-controlled trial

(2015) Claudine Angela Blum et al.   LANCET

Trial of Short-Course Antimicrobial Therapy for Intraabdominal Infection

(2015) Robert G. Sawyer et al.   NEW ENGLAND JOURNAL OF MEDICINE

Systemic Inflammatory Response Syndrome Criteria in Defining Severe Sepsis

(2015) Kirsi-Maija Kaukonen et al.   NEW ENGLAND JOURNAL OF MEDICINE

Procalcitonin Algorithm in Critically Ill Adults with Undifferentiated Infection or Suspected Sepsis. A Randomized Controlled Trial

(2014) Yahya Shehabi et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Use of Procalcitonin in Patients With Various Degrees of Chronic Kidney Disease Including Renal Replacement Therapy

(2014) E. Grace et al.   CLINICAL INFECTIOUS DISEASES

Impact of de-escalation on ICU patients’ prognosis

(2014) Jan J. De Waele et al.   INTENSIVE CARE MEDICINE

De-escalation as a potential way of reducing antibiotic use and antimicrobial resistance in ICU

(2014) Jean-Francois Timsit et al.   INTENSIVE CARE MEDICINE

De-escalation versus continuation of empirical antimicrobial treatment in severe sepsis: a multicenter non-blinded randomized noninferiority trial

(2014) Marc Leone et al.   INTENSIVE CARE MEDICINE

Pre-analytic factors and initial biomarker levels in community-acquired pneumonia patients

(2014) Alexander Kutz et al.   BMC Anesthesiology

β-Lactam Monotherapy vs β-Lactam–Macrolide Combination Treatment in Moderately Severe Community-Acquired Pneumonia

(2014) Nicolas Garin et al.   JAMA Internal Medicine

Impact of Rapid Organism Identification via Matrix-Assisted Laser Desorption/Ionization Time-of-Flight Combined With Antimicrobial Stewardship Team Intervention in Adult Patients With Bacteremia and Candidemia

(2013) Angela M. Huang et al.   CLINICAL INFECTIOUS DISEASES

Procalcitonin Versus C-Reactive Protein for Guiding Antibiotic Therapy in Sepsis

(2013) Carolina F. Oliveira et al.   CRITICAL CARE MEDICINE

What can be expected from antimicrobial de-escalation in the critically ill?

(2013) Marin H. Kollef   INTENSIVE CARE MEDICINE

Surviving Sepsis Campaign: International Guidelines for Management of Severe Sepsis and Septic Shock, 2012

(2013) R. P. Dellinger et al.   INTENSIVE CARE MEDICINE

De-escalation of antimicrobial treatment in neutropenic patients with severe sepsis: results from an observational study

(2013) Djamel Mokart et al.   INTENSIVE CARE MEDICINE

De-escalation of empirical therapy is associated with lower mortality in patients with severe sepsis and septic shock

(2013) J. Garnacho-Montero et al.   INTENSIVE CARE MEDICINE

Procalcitonin as diagnostic biomarker of sepsis

(2013) Arash Afshari et al.   LANCET INFECTIOUS DISEASES

Procalcitonin as a diagnostic marker for sepsis: a systematic review and meta-analysis

(2013) Christina Wacker et al.   LANCET INFECTIOUS DISEASES

Effectiveness and Safety of Procalcitonin-Guided Antibiotic Therapy in Lower Respiratory Tract Infections in “Real Life”

(2012) Frank Dusemund   ARCHIVES OF INTERNAL MEDICINE

Procalcitonin to Guide Initiation and Duration of Antibiotic Treatment in Acute Respiratory Infections: An Individual Patient Data Meta-Analysis

(2012) Philipp Schuetz et al.   CLINICAL INFECTIOUS DISEASES

New Approaches to Sepsis: Molecular Diagnostics and Biomarkers

(2012) K. Reinhart et al.   CLINICAL MICROBIOLOGY REVIEWS

Procalcitonin usefulness for the initiation of antibiotic treatment in intensive care unit patients*

(2012) Nathalie Layios et al.   CRITICAL CARE MEDICINE

Linking antimicrobial prescribing to antimicrobial resistance in the ICU: Before and after an antimicrobial stewardship program

(2012) Amy Hurford et al.   Epidemics

Biomarker-guided antibiotic therapy in adult critically ill patients: a critical review

(2012) Pedro Póvoa et al.   Annals of Intensive Care

Procalcitonin to Guide Duration of Antimicrobial Therapy in Intensive Care Units: A Systematic Review

(2011) R. Agarwal et al.   CLINICAL INFECTIOUS DISEASES

International Clinical Practice Guidelines for the Treatment of Acute Uncomplicated Cystitis and Pyelonephritis in Women: A 2010 Update by the Infectious Diseases Society of America and the European Society for Microbiology and Infectious Diseases

(2011) Kalpana Gupta et al.   CLINICAL INFECTIOUS DISEASES

Strategies for Reduction in Duration of Antibiotic Use in Hospitalized Patients

(2011) Y. Hayashi et al.   CLINICAL INFECTIOUS DISEASES

Guidelines for the management of adult lower respiratory tract infections - Full version

(2011) M. Woodhead et al.   CLINICAL MICROBIOLOGY AND INFECTION

Procalcitonin-guided interventions against infections to increase early appropriate antibiotics and improve survival in the intensive care unit: A randomized trial*

(2011) Jens U. Jensen et al.   CRITICAL CARE MEDICINE

Can procalcitonin help identify associated bacterial infection in patients with severe influenza pneumonia? A multicentre study

(2011) E. Cuquemelle et al.   INTENSIVE CARE MEDICINE

Impact of antimicrobial stewardship in critical care: a systematic review

(2011) R. Kaki et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Elevated procalcitonin predicts Gram-negative sepsis in haematological patients with febrile neutropenia

(2011) Irma Koivula et al.   SCANDINAVIAN JOURNAL OF INFECTIOUS DISEASES

Procalcitonin-guided algorithms of antibiotic therapy in the intensive care unit: A systematic review and meta-analysis of randomized controlled trials

(2010) Petros Kopterides et al.   CRITICAL CARE MEDICINE

Impact of time to antibiotics on survival in patients with severe sepsis or septic shock in whom early goal-directed therapy was initiated in the emergency department*

(2010) David F. Gaieski et al.   CRITICAL CARE MEDICINE

Procalcitonin and C-reactive protein in severe 2009 H1N1 influenza infection

(2010) Paul Robert Ingram et al.   INTENSIVE CARE MEDICINE

Use of procalcitonin to reduce patients' exposure to antibiotics in intensive care units (PRORATA trial): a multicentre randomised controlled trial

(2010) Lila Bouadma et al.   LANCET

Procalcitonin in sepsis and systemic inflammation: a harmful biomarker and a therapeutic target

(2009) Kenneth L. Becker et al.   BRITISH JOURNAL OF PHARMACOLOGY

Procalcitonin for reduced antibiotic exposure in ventilator-associated pneumonia: a randomised study

(2009) D. Stolz et al.   EUROPEAN RESPIRATORY JOURNAL

International Study of the Prevalence and Outcomes of Infection in Intensive Care Units

(2009) Jean-Louis Vincent   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Usefulness of procalcitonin for the diagnosis of ventilator-associated pneumonia

(2008) Charles-Edouard Luyt et al.   INTENSIVE CARE MEDICINE

Procalcitonin (PCT)-guided algorithm reduces length of antibiotic treatment in surgical intensive care patients with severe sepsis: results of a prospective randomized study

(2008) S. Schroeder et al.   LANGENBECKS ARCHIVES OF SURGERY

Use of Procalcitonin to Shorten Antibiotic Treatment Duration in Septic Patients

(2007) Vandack Nobre et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE