New Approaches to Sepsis: Molecular Diagnostics and Biomarkers

Combination Biomarkers to Diagnose Sepsis in the Critically Ill Patient

(2012) Sébastien Gibot et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

suPAR as a prognostic biomarker in sepsis

(2012) Katia Donadello et al.   BMC Medicine

Genetics and genomics in pediatric septic shock

(2012) Hector R. Wong   CRITICAL CARE MEDICINE

Diagnostic utility of LightCycler SeptiFast and procalcitonin assays in the diagnosis of bloodstream infection in immunocompromised patients

(2012) M.V. Mauro et al.   DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE

The sensitivity of neutrophil CD64 expression as a biomarker of bacterial infection is low in critically ill patients

(2012) Antoine Gros et al.   INTENSIVE CARE MEDICINE

Multiplex PCR for Rapid and Improved Diagnosis of Bloodstream Infections in Liver Transplant Recipients

(2012) Peter-Michael Rath et al.   JOURNAL OF CLINICAL MICROBIOLOGY

Diagnostic Performance of a Multiple Real-Time PCR Assay in Patients with Suspected Sepsis Hospitalized in an Internal Medicine Ward

(2012) L. Pasqualini et al.   JOURNAL OF CLINICAL MICROBIOLOGY

Failure to reduce C-reactive protein levels more than 25% in the last 24 hours before intensive care unit discharge predicts higher in-hospital mortality: A cohort study

(2012) Otavio T. Ranzani et al.   JOURNAL OF CRITICAL CARE

Targeted metabolomics for discrimination of systemic inflammatory disorders in critically ill patients

(2012) Diana Schmerler et al.   JOURNAL OF LIPID RESEARCH

Rapid detection of bloodstream pathogens by real-time PCR in patients with sepsis

(2012) Katharina Grif et al.   WIENER KLINISCHE WOCHENSCHRIFT

The Emerging Field of Quantitative Blood Metabolomics for Biomarker Discovery in Critical Illnesses

(2011) Natalie J. Serkova et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Serum C-Reactive Protein as a Predictor of Morbidity and Mortality in Intensive Care Unit Patients After Esophagectomy

(2011) Michel E. van Genderen et al.   ANNALS OF THORACIC SURGERY

Meta-Analysis and Systematic Review of Procalcitonin-Guided Therapy in Respiratory Tract Infections

(2011) Hui Li et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Procalcitonin Algorithms for Antibiotic Therapy Decisions

(2011) Philipp Schuetz   ARCHIVES OF INTERNAL MEDICINE

Procalcitonin for diagnosis of infection and guide to antibiotic decisions: past, present and future

(2011) Philipp Schuetz et al.   BMC Medicine

Biomarkers in the Critically Ill Patient: Procalcitonin

(2011) Konrad Reinhart et al.   CRITICAL CARE CLINICS

Procalcitonin-guided interventions against infections to increase early appropriate antibiotics and improve survival in the intensive care unit: A randomized trial*

(2011) Jens U. Jensen et al.   CRITICAL CARE MEDICINE

A combined score of pro- and anti-inflammatory interleukins improves mortality prediction in severe sepsis

(2011) David Andaluz-Ojeda et al.   CYTOKINE

Evaluation of a commercial multiplex PCR test (SeptiFast) in the etiological diagnosis of community-onset bloodstream infections

(2011) P. Josefson et al.   EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES

Immunomodulatory therapy for sepsis: an update

(2011) Eirini Christaki et al.   Expert Review of Anti-Infective Therapy

High pentraxin 3 level predicts septic shock and bacteremia at the onset of febrile neutropenia after intensive chemotherapy of hematologic patients

(2011) M. Vanska et al.   HAEMATOLOGICA

Evaluation of potential biomarkers for the discrimination of bacterial and viral infections

(2011) P. Chalupa et al.   INFECTION

Role of procalcitonin and C-reactive protein in differentiation of mixed bacterial infection from 2009 H1N1 viral pneumonia

(2011) Shin Ahn et al.   Influenza and Other Respiratory Viruses

Can procalcitonin help identify associated bacterial infection in patients with severe influenza pneumonia? A multicentre study

(2011) E. Cuquemelle et al.   INTENSIVE CARE MEDICINE

Will polymerase chain reaction (PCR)-based diagnostics improve outcome in septic patients? A clinical view

(2011) Mathias W. Pletz et al.   INTENSIVE CARE MEDICINE

Serum procalcitonin as a diagnostic marker for neonatal sepsis: a systematic review and meta-analysis

(2011) Evridiki K. Vouloumanou et al.   INTENSIVE CARE MEDICINE

Immunosuppression in Patients Who Die of Sepsis and Multiple Organ Failure

(2011) Jonathan S. Boomer et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Multiplex PCR Allows Rapid and Accurate Diagnosis of Bloodstream Infections in Newborns and Children with Suspected Sepsis

(2011) Barbara Lucignano et al.   JOURNAL OF CLINICAL MICROBIOLOGY

Discriminative Value of Inflammatory Biomarkers for Suspected Sepsis

(2011) Ephraim L. Tsalik et al.   JOURNAL OF EMERGENCY MEDICINE

A genomic storm in critically injured humans

(2011) Wenzhong Xiao et al.   JOURNAL OF EXPERIMENTAL MEDICINE

suPAR - a future risk marker

(2011) Jesper Eugen-Olsen   JOURNAL OF INTERNAL MEDICINE

PCR-based rapid sepsis diagnosis effectively guides clinical treatment in patients with new onset of SIRS

(2011) Uwe Lodes et al.   LANGENBECKS ARCHIVES OF SURGERY

High Plasma Level of Long Pentraxin 3 (PTX3) Is Associated with Fatal Disease in Bacteremic Patients: A Prospective Cohort Study

(2011) Reetta Huttunen et al.   PLoS One

Lipopolysaccharide-Binding Protein for Monitoring of Postoperative Sepsis: Complemental to C-Reactive Protein or Redundant?

(2011) Klaus Tschaikowsky et al.   PLoS One

Cytokine Profiles in Sepsis Have Limited Relevance for Stratifying Patients in the Emergency Department: A Prospective Observational Study

(2011) Virginie Lvovschi et al.   PLoS One

A proteomic view of the host-pathogen interaction: The host perspective

(2011) Anetta Hartlova et al.   PROTEOMICS

C-Reactive Protein Alone or Combined With Cardiac Troponin T for Risk Stratification of Respiratory Intensive Care Unit Patients

(2011) S. Ozsu et al.   Respiratory Care

Procalcitonin guidance for reduction of antibiotic use in low-risk outpatients with community-acquired pneumonia

(2011) WEI LONG et al.   RESPIROLOGY

Multiplex polymerase chain reaction pathogen detection in patients with suspected septicemia after trauma, emergency, and burn surgery

(2011) Nam K. Tran et al.   SURGERY

Temporal Trends in the Epidemiology of Severe Postoperative Sepsis after Elective Surgery

(2010) Brian T. Bateman et al.   ANESTHESIOLOGY

C-reactive protein as a predictor of outcome after discharge from the intensive care: a prospective observational study

(2010) N Al-Subaie et al.   BRITISH JOURNAL OF ANAESTHESIA

Procalcitonin Levels Predict Bacteremia in Patients With Community-Acquired Pneumonia

(2010) Fabian Müller et al.   CHEST

Diagnostic accuracy of sTREM-1 to identify infection in critically ill patients with systemic inflammatory response syndrome

(2010) Jaime Latour-Pérez et al.   CLINICAL BIOCHEMISTRY

Bundled care for septic shock: An analysis of clinical trials*

(2010) Amisha V. Barochia et al.   CRITICAL CARE MEDICINE

Procalcitonin-guided algorithms of antibiotic therapy in the intensive care unit: A systematic review and meta-analysis of randomized controlled trials

(2010) Petros Kopterides et al.   CRITICAL CARE MEDICINE

The Surviving Sepsis Campaign: Results of an international guideline-based performance improvement program targeting severe sepsis*

(2010) Mitchell M. Levy et al.   CRITICAL CARE MEDICINE

Plasma interleukin-8 is not an effective risk stratification tool for adults with vasopressor-dependent septic shock*

(2010) Carolyn S. Calfee et al.   CRITICAL CARE MEDICINE

Serum procalcitonin, C-reactive protein and white blood cell levels following hypothermia after cardiac arrest: a retrospective cohort study

(2010) Philipp Schuetz et al.   EUROPEAN JOURNAL OF CLINICAL INVESTIGATION

Procalcitonin guidance and reduction of antibiotic use in acute respiratory tract infection

(2010) O. Burkhardt et al.   EUROPEAN RESPIRATORY JOURNAL

Role of calcium in lipopolysaccharide-induced calcitonin gene expression in human adipocytes

(2010) Tanja M Radimerski et al.   Innate Immunity

Persisting high levels of plasma pentraxin 3 over the first days after severe sepsis and septic shock onset are associated with mortality

(2010) Tommaso Mauri et al.   INTENSIVE CARE MEDICINE

The Lingering Consequences of Sepsis

(2010) Derek C. Angus   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Long-term Cognitive Impairment and Functional Disability Among Survivors of Severe Sepsis

(2010) Theodore J. Iwashyna et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Host-response biomarkers for diagnosis of late-onset septicemia and necrotizing enterocolitis in preterm infants

(2010) Pak Cheung Ng et al.   JOURNAL OF CLINICAL INVESTIGATION

Multiplex Blood PCR in Combination with Blood Cultures for Improvement of Microbiological Documentation of Infection in Febrile Neutropenia

(2010) F. Lamoth et al.   JOURNAL OF CLINICAL MICROBIOLOGY

Predictive value of procalcitonin, interleukin-6, and C-reactive protein for survival in postoperative patients with severe sepsis

(2010) Klaus Tschaikowsky et al.   JOURNAL OF CRITICAL CARE

The diagnostic role of Procalcitonin and other biomarkers in discriminating infectious from non-infectious fever

(2010) M. Limper et al.   JOURNAL OF INFECTION

The role of a real-time PCR technology for rapid detection and identification of bacterial and fungal pathogens in whole-blood samples

(2010) Hideaki Obara et al.   JOURNAL OF INFECTION AND CHEMOTHERAPY

Procalcitonin in intensive care units: the PRORATA trial

(2010) William Tarnow-Mordi et al.   LANCET

Procalcitonin in intensive care units: the PRORATA trial – Authors' reply

(2010) Lila Bouadma et al.   LANCET

Use of procalcitonin to reduce patients' exposure to antibiotics in intensive care units (PRORATA trial): a multicentre randomised controlled trial

(2010) Lila Bouadma et al.   LANCET

Circulating mitochondrial DAMPs cause inflammatory responses to injury

(2010) Qin Zhang et al.   NATURE

Programmed death-1–induced interleukin-10 production by monocytes impairs CD4+ T cell activation during HIV infection

(2010) Elias A Said et al.   NATURE MEDICINE

Immunotherapy for Sepsis — A New Approach against an Ancient Foe

(2010) Richard S. Hotchkiss et al.   NEW ENGLAND JOURNAL OF MEDICINE

Acute Pulmonary Embolism

(2010) Giancarlo Agnelli et al.   NEW ENGLAND JOURNAL OF MEDICINE

Automated Extraction Improves Multiplex Molecular Detection of Infection in Septic Patients

(2010) Benito J. Regueiro et al.   PLoS One

MOLECULAR IDENTIFICATION OF BLOODSTREAM PATHOGENS IN PATIENTS PRESENTING TO THE EMERGENCY DEPARTMENT WITH SUSPECTED SEPSIS

(2010) Manuela Avolio et al.   SHOCK

Should C-reactive protein concentration at ICU discharge be used as a prognostic marker?

(2010) Joana Silvestre et al.   BMC Anesthesiology

Granulocyte–Macrophage Colony-stimulating Factor to Reverse Sepsis-associated Immunosuppression

(2009) Christian Meisel et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Clinical impact of a commercially available multiplex PCR system for rapid detection of pathogens in patients with presumed sepsis

(2009) Christine Dierkes et al.   BMC INFECTIOUS DISEASES

Midregional Proadrenomedullin as a Prognostic Tool in Community-Acquired Pneumonia

(2009) David T. Huang et al.   CHEST

Hospital and Societal Costs of Antimicrobial‐Resistant Infections in a Chicago Teaching Hospital: Implications for Antibiotic Stewardship

(2009) Rebecca R. Roberts et al.   CLINICAL INFECTIOUS DISEASES

Antibiotic treatment interruption of suspected lower respiratory tract infections based on a single procalcitonin measurement at hospital admission—a randomized trial

(2009) K.B. Kristoffersen et al.   CLINICAL MICROBIOLOGY AND INFECTION

Multiplex real-time PCR and blood culture for identification of bloodstream pathogens in patients with suspected sepsis

(2009) H. Westh et al.   CLINICAL MICROBIOLOGY AND INFECTION

Preliminary clinical study using a multiplex real-time PCR test for the detection of bacterial and fungal DNA directly in blood

(2009) F. Wallet et al.   CLINICAL MICROBIOLOGY AND INFECTION

Lipopolysaccharide binding protein in a surgical intensive care unit: A marker of sepsis?*

(2009) Yasser Sakr et al.   CRITICAL CARE MEDICINE

Guidelines for evaluation of new fever in critically ill adult patients: 2008 update from the American College of Critical Care Medicine and the Infectious Diseases Society of America

(2009) Naomi P. O’Grady et al.   CRITICAL CARE MEDICINE

Surviving Sepsis Campaign: International guidelines for management of severe sepsis and septic shock: 2008

(2009) R Phillip Dellinger et al.   CRITICAL CARE MEDICINE

Genomic expression profiling across the pediatric systemic inflammatory response syndrome, sepsis, and septic shock spectrum*

(2009) Hector R. Wong et al.   CRITICAL CARE MEDICINE

Potential clinical utility of polymerase chain reaction in microbiological testing for sepsis

(2009) Lutz Eric Lehmann et al.   CRITICAL CARE MEDICINE

Biomarkers of sepsis

(2009) John C. Marshall et al.   CRITICAL CARE MEDICINE

Gene-expression profiling of peripheral blood mononuclear cells in sepsis*

(2009) Benjamin M. P. Tang et al.   CRITICAL CARE MEDICINE

Procalcitonin for reduced antibiotic exposure in ventilator-associated pneumonia: a randomised study

(2009) D. Stolz et al.   EUROPEAN RESPIRATORY JOURNAL

A multicenter trial to compare blood culture with polymerase chain reaction in severe human sepsis

(2009) Frank Bloos et al.   INTENSIVE CARE MEDICINE

Improved detection of blood stream pathogens by real-time PCR in severe sepsis

(2009) Lutz Eric Lehmann et al.   INTENSIVE CARE MEDICINE

Effect of Procalcitonin-Based Guidelines vs Standard Guidelines on Antibiotic Use in Lower Respiratory Tract Infections

(2009) Philipp Schuetz et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

CD64 Index Provides Simple and Predictive Testing for Detection and Monitoring of Sepsis and Bacterial Infection in Hospital Patients

(2009) M. Icardi et al.   JOURNAL OF CLINICAL MICROBIOLOGY

Truncated Human Cytidylate-Phosphate-Deoxyguanylate-Binding Protein for Improved Nucleic Acid Amplification Technique-Based Detection of Bacterial Species in Human Samples

(2009) S. Sachse et al.   JOURNAL OF CLINICAL MICROBIOLOGY

Utility of a Commercially Available Multiplex Real-Time PCR Assay To Detect Bacterial and Fungal Pathogens in Febrile Neutropenia

(2009) M. von Lilienfeld-Toal et al.   JOURNAL OF CLINICAL MICROBIOLOGY

Multiplex PCR To Diagnose Bloodstream Infections in Patients Admitted from the Emergency Department with Sepsis

(2009) Ephraim L. Tsalik et al.   JOURNAL OF CLINICAL MICROBIOLOGY

Soluble triggering receptor expressed on myeloid cells 1 and the diagnosis of sepsis

(2009) Mitra Barati et al.   JOURNAL OF CRITICAL CARE

Diagnosis of bloodstream infections in immunocompromised patients by real-time PCR

(2009) Stefania Varani et al.   JOURNAL OF INFECTION

PTX3 predicts severe disease in febrile patients at the emergency department

(2009) Martijn D. de Kruif et al.   JOURNAL OF INFECTION

Laboratory diagnosis of late-onset sepsis in newborns by multiplex real-time PCR

(2009) M. Paolucci et al.   JOURNAL OF MEDICAL MICROBIOLOGY

Accurate and rapid identification of bacterial species from positive blood cultures with a DNA-based microarray platform: an observational study

(2009) Päivi Tissari et al.   LANCET

The sepsis seesaw: tilting toward immunosuppression

(2009) Richard S Hotchkiss et al.   NATURE MEDICINE

The value of procalcitonin at predicting the severity of acute pancreatitis and development of infected pancreatic necrosis: Systematic review

(2009) Reza Mofidi et al.   SURGERY

High mortality risk among individuals assumed to be TB-negative can be predicted using a simple test

(2009) Paulo Rabna et al.   TROPICAL MEDICINE & INTERNATIONAL HEALTH

Mikrobiologisches Sepsis-Screening chirurgischer Intensivpatienten mit dem „Lightcycler“ Septifast®-Test – eine Pilotstudie

(2009) U. Lodes et al.   ZENTRALBLATT FUR CHIRURGIE

Utility of Interleukin-12 and Interleukin-10 in Comparison with Other Cytokines and Acute-Phase Reactants in the Diagnosis of Neonatal Sepsis

(2008) Catherine Sherwin et al.   AMERICAN JOURNAL OF PERINATOLOGY

Interleukin-8 as a Stratification Tool for Interventional Trials Involving Pediatric Septic Shock

(2008) Hector R. Wong et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Procalcitonin-Guided Antibiotic Use vs a Standard Approach for Acute Respiratory Tract Infections in Primary Care

(2008) Matthias Briel et al.   ARCHIVES OF INTERNAL MEDICINE

A prospective randomized controlled trial comparing PCR-based and empirical treatment with liposomal amphotericin B in patients after allo-SCT

(2008) H Hebart et al.   BONE MARROW TRANSPLANTATION

Predictors of 30-Day Mortality and Hospital Costs in Patients With Ventilator-Associated Pneumonia Attributed to Potentially Antibiotic-Resistant Gram-Negative Bacteria

(2008) Katherine E. Kollef et al.   CHEST

Procalcitonin has bioactivity at calcitonin receptor family complexes: Potential mediator implications in sepsis*

(2008) Patrick M. Sexton et al.   CRITICAL CARE MEDICINE

Multiplex polymerase chain reaction detection enhancement of bacteremia and fungemia*

(2008) Richard F. Louie et al.   CRITICAL CARE MEDICINE

Combination of biphasic transmittance waveform with blood procalcitonin levels for diagnosis of sepsis in acutely ill patients

(2008) Ahmed N. Zakariah et al.   CRITICAL CARE MEDICINE

A prospective, multicenter derivation of a biomarker panel to assess risk of organ dysfunction, shock, and death in emergency department patients with suspected sepsis

(2008) Nathan I. Shapiro et al.   CRITICAL CARE MEDICINE

An international survey: Public awareness and perception of sepsis*

(2008) Francesca M. Rubulotta et al.   CRITICAL CARE MEDICINE

The long pentraxin PTX3 as a prototypic humoral pattern recognition receptor: interplay with cellular innate immunity

(2008) Barbara Bottazzi et al.   IMMUNOLOGICAL REVIEWS

The Role of Procalcitonin in Febrile Neutropenic Patients: Review of the Literature

(2008) Y. Sakr et al.   INFECTION

HMGB1 as a predictor of organ dysfunction and outcome in patients with severe sepsis

(2008) Sari Karlsson et al.   INTENSIVE CARE MEDICINE

Diagnostic value of the soluble triggering receptor expressed on myeloid cells-1 in bacterial infection: a meta-analysis

(2008) Jing Jiyong et al.   INTENSIVE CARE MEDICINE

Reactivation of Cytomegalovirus Infection in Critically Ill Immunocompetent Patients—Reply

(2008) Ajit P. Limaye   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Improvement in Process of Care and Outcome After a Multicenter Severe Sepsis Educational Program in Spain

(2008) Ricard Ferrer   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

LightCycler SeptiFast assay as a tool for the rapid diagnosis of sepsis in patients during antimicrobial therapy

(2008) A. Vince et al.   JOURNAL OF MEDICAL MICROBIOLOGY

Molecular diagnosis of sepsis in neutropenic patients with haematological malignancies

(2008) N. Mancini et al.   JOURNAL OF MEDICAL MICROBIOLOGY

Procalcitonin (PCT)-guided algorithm reduces length of antibiotic treatment in surgical intensive care patients with severe sepsis: results of a prospective randomized study

(2008) S. Schroeder et al.   LANGENBECKS ARCHIVES OF SURGERY

Unknown

(2008) Guillaume Monneret et al.   MOLECULAR MEDICINE

Origin and physiological roles of inflammation

(2008) Ruslan Medzhitov   NATURE

Hydrocortisone Therapy for Patients with Septic Shock

(2008) Charles L. Sprung et al.   NEW ENGLAND JOURNAL OF MEDICINE

Plasticity of the Systemic Inflammatory Response to Acute Infection during Critical Illness: Development of the Riboleukogram

(2008) Jonathan E. McDunn et al.   PLoS One

Compensatory anti-inflammatory response syndrome

(2008) Jean-Marc Cavaillon et al.   THROMBOSIS AND HAEMOSTASIS

Use of Procalcitonin to Shorten Antibiotic Treatment Duration in Septic Patients

(2007) Vandack Nobre et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Procalcitonin predicts patients at low risk of death from community-acquired pneumonia across all CRB-65 classes

(2007) S. Kruger et al.   EUROPEAN RESPIRATORY JOURNAL

Host–pathogen interactions in sepsis

(2007) Tom van der Poll et al.   LANCET INFECTIOUS DISEASES

Persisting elevation of C-reactive protein after pancreatic resections can indicate developing inflammatory complications

(2007) Thilo Welsch et al.   SURGERY