Article
Multidisciplinary Sciences
Leilei Zang, Yanmei Song, Yanhua Tian, Ning Hu
Summary: The study demonstrated that PHACTR1 promotes the mobility of papillary thyroid carcinoma (PTC) cells and plays a role in the carcinogenesis of PTC. PHACTR1 regulates the formation of F-actin, which determines the mobility of PTC cells. Therefore, PHACTR1 has the potential to be a biomarker for predicting prognosis and targeted therapy in PTC.
Article
Medicine, Research & Experimental
Guodong Liu, Xiwu Ouyang, Liansheng Gong, Lei Yao, Shiqing Liu, Jiarong Li, Qi Zhang, Yao Xiao
Summary: The study reveals the crucial role of circ-PRKAR1B in liver cancer progression, promoting cancer advancement through the miR-432-5p/E2F3 pathway. Clinical data and animal experiments further confirm the significance of this newly identified signaling.
MOLECULAR THERAPY-NUCLEIC ACIDS
(2021)
Article
Chemistry, Multidisciplinary
Dennis Frank, Jessica Christel Moussie, Svenja Ulferts, Lina Lorenzen, Carsten Schwan, Robert Grosse
Summary: Vesicle trafficking is important for tumor progression, and this study reveals the role of Formin-like 2 (FMNL2) in the trafficking and secretion of Angiopoietin-like 4 (ANGPTL4). The phosphorylation of FMNL2 by protein kinase C (PKC) downstream of transforming growth factor beta (TGF beta) is required for cancer cell invasion and ANGPTL4 vesicle trafficking and secretion. Additionally, super resolution microscopy shows that ANGPTL4 trafficking is actin-dependent, and FMNL2 polymerizes actin at ANGPTL4-containing vesicles, associated with Rab8a and myosin Vb. This mechanism may play an important role in regulating cancer cell metastasis and tumor progression.
Article
Biochemistry & Molecular Biology
Ze Zhang, Ruoyan Liu, Yafei Wang, Yun Wang, Yanjie Shuai, Chuangwu Ke, Rui Jin, Xudong Wang, Jingtao Luo
Summary: The study reveals that phosphorylation of MICAL2 at Tyr445 and Tyr463 by ARG mediates F-actin disassembly and promotes HNSCC progression.
Article
Biochemistry & Molecular Biology
Claudia Tito, Ilaria Genovese, Flavia Giamogante, Anna Benedetti, Selenia Miglietta, Lucia Barazzuol, Loredana Cristiano, Alessia Iaiza, Sabatino Carolini, Luciana De Angelis, Silvia Masciarelli, Stefania Annarita Nottola, Giuseppe Familiari, Vincenzo Petrozza, Mattia Lauriola, Luca Tamagnone, Andrea Ilari, Tito Cali, Hector H. Valdivia, Carmen R. Valdivia, Gianni Colotti, Francesco Fazi
Summary: This study elucidates a functional mechanism that links calcium homeostasis to EGFR signaling in cancer. Sorcin directly binds EGFR protein in a calcium-dependent fashion, regulating calcium homeostasis and controlling EGFR proteostasis and signaling. This promotes cancer cell proliferation, migration, invasion, epithelial-to-mesenchymal transition, malignant progression, and resistance to chemotherapeutic drugs. Sorcin can also enhance the effectiveness of EGFR-targeting therapies.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2023)
Article
Biotechnology & Applied Microbiology
Zhenying Ge, Tingxuan Gu, Lingge Zhang, Qingfang Fan, Li Ma, Na Fang
Summary: PRL-3, a tyrosine phosphatase, is associated with tumor metastasis and high expression in various cancers. It interacts with beta 3-tubulin and dephosphorylates it, leading to promotion of glioma cell migration and invasion. This suggests a potential role of PRL-3 in tumor metastasis through cytoskeleton assembly and enhanced cell migration.
Article
Oncology
Ha Hyung Moon, Nina-Naomi Kreis, Alexandra Friemel, Susanne Roth, Dorothea Schulte, Christine Solbach, Frank Louwen, Juping Yuan, Andreas Ritter
Summary: The microtubule cytoskeleton regulator MCAK plays a critical role in cell motility and migration by affecting the dynamics of actin-MT cytoskeleton and FA turnover, potentially promoting malignant progression and metastasis of tumor cells.
Article
Medicine, Research & Experimental
Yong-Li Wang, Dan Ren, Jin-Long Lu, He Jiang, Jia-Zhang Wei, Jiao Lan, Fei Liu, Shen-Hong Qu
Summary: In nasopharyngeal carcinoma (NPC), CREB1 and SRGN are increased while miR-148a-5p is decreased. Silencing of SRGN and CREB1, and miR-148a-5p overexpression represses NPC tumor progression. The authors show that CREB1 promotes SRGN expression by targeting its promoter. In NPC, FoxO1 binds to miR-148a-5p, and miR-148a-5p targets CREB1. FoxO1 knockdown abolishes the downregulation of CREB1 and SRGN induced by STAT3 silencing. In summary, STAT3 regulates SRGN and promotes the growth and metastasis of NPC through the FoxO1-miR-148a-5p-CREB1 axis.
LABORATORY INVESTIGATION
(2022)
Article
Cell Biology
Xi Chen, Qing-Qing Tan, Xin-Rui Tan, Shi-Jun Li, Xing-Xing Zhang
Summary: In NAFLD models, circ_0057558 was found to increase while miR-206 decreased. miR-206 directly inhibited lipogenesis and TG secretion by binding to ROCK1 3'-UTR, and circ_0057558 bound to miR-206 to de-repress ROCK1/AMPK signaling. Knockdown of circ_0057558 or overexpression of miR-206 inhibited lipogenesis and TG secretion. ROCK1 knockdown reversed the effects of circ_0057558 overexpression.
CELL DEATH & DISEASE
(2021)
Review
Biochemistry & Molecular Biology
Eleonora Sarantelli, Apostolis Mourkakis, Lefteris C. Zacharia, Andreas Stylianou, Vasiliki Gkretsi
Summary: As metastasis is a major cause of cancer-related deaths, understanding the cellular and molecular events involved in cancer cell migration and invasion is crucial for developing novel anti-metastatic therapies. Fascin-1, an actin-bundling protein, plays a fundamental role in cell migration processes. It is significantly elevated in most cancers and its high expression is associated with aggressive disease and poor prognosis. Recent studies show that Fascin-1 is critically involved in metastasis and suggest it as a promising target for anti-metastatic treatment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Hui Han, Shenkang Zhou, Gengzhen Chen, Yandi Lu, Hui Lin
Summary: This study found that ABAT is inactivated in liver cancer tissues and cells, and patients with low ABAT expression have a poor prognosis. Overexpression of ABAT inhibits cancer cell behaviors and tumor formation. Meanwhile, miR-183-5p is highly expressed in liver cancer tissues and cells, targeting and downregulating ABAT expression.
INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Ullas Chembazhi, Sushant Bangru, Mikel Hernaez, Auinash Kalsotra
Summary: The liver has a unique ability to regenerate in response to injuries, with a subset of hepatocytes reactivating early-postnatal-like gene expression program to proliferate and another population of metabolically active cells compensating for temporary deficits in liver function. The study also reveals the spatial and metabolic dynamics of hepatocyte proliferation after partial hepatectomy, with midlobular cells proliferating nearby while portal and central vein proximal hepatocytes remain metabolically active to preserve liver functions. Intercellular crosstalk and cellular reprogramming play a crucial role in balancing metabolic and proliferative requirements during liver regeneration.
Article
Cell Biology
Qian Liang, Yun Wang, Yingsi Lu, Qingqing Zhu, Wenlin Xie, Nannan Tang, Lifen Huang, Tailai An, Di Zhang, Anqi Yan, Shaoyu Liu, Liping Ye, Chengming Zhu
Summary: The study revealed the functional expression of RANK in human CRC cells and demonstrated that RANK induced the Ca2+-calcineurin/NFATC1-ACP5 axis in the regulation of CRC metastasis, that might be amenable to therapeutic targeting.
CELL DEATH & DISEASE
(2021)
Article
Biochemistry & Molecular Biology
Yan Qi, Mengjia Hu, Changhao Han, Jin Wang, Fang Chen, Hui Guo, Yuanting She, Meijuan Zhang, Jing Zhang, Zhongyue Zhao, Huan Xie, Song Wang, Mo Chen, Junping Wang, Dongfeng Zeng
Summary: Rho GTPase-activating protein 4 (ARHGAP4) is overexpressed in human acute myeloid leukemia (AML) patients and is associated with a poor prognosis. Knockdown of ARHGAP4 impairs viability and induces apoptosis in AML cells, while ARHGAP4 deletion impairs AML progression in vivo. The ARHGAP4/DRAM1 axis plays a crucial role in regulating AML progression.
Article
Biochemistry & Molecular Biology
Pegah Abdollahi, Esten N. Vandsemb, Samah Elsaadi, Lisa M. Rost, Rui Yang, Magnus A. Hjort, Trygve Andreassen, Kristine Misund, Tobias S. Slordahl, Torstein B. Ro, Anne-Marit Sponaas, Siver Moestue, Per Bruheim, Magne Borset
Summary: PRL-3, a cytokine-induced oncogenic phosphatase highly expressed in multiple myeloma cells, influences metabolism by promoting aerobic glycolysis, glucose uptake, and increasing levels of proteins regulating glycolysis and enzymes in the serine/glycine synthesis pathway. Important metabolic effects of PRL-3 are independent of its phosphatase activity, with glycine decarboxylase (GLDC) playing a significant role in PRL-3-induced aerobic glycolysis.
