Article
Biochemistry & Molecular Biology
Sei Yonezawa, Yasushi Kawasaki, Yasuhiro Natori, Akinori Sugiyama
Summary: Reducing lipid accumulation in the kidney can suppress the development of pathological conditions in kidney disease, such as inflammation and fibrosis.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2023)
Article
Cell Biology
Jing Yue, Kai Su, Guangxin Zhang, Jinghui Yang, Chengbi Xu, Xueshibojie Liu
Summary: Dihydrotanshinone (DIH) can regulate LPS-induced acute lung injury (ALI) in mice by inhibiting the NF-κB signaling pathway.
Article
Food Science & Technology
Jie Bai, Tao Yang, Yaping Zhou, Wei Xu, Shuai Han, Tianyi Guo, Lingfeng Zhu, Dandan Qin, Yi Luo, Zuomin Hu, Xiaoqi Wu, Feijun Luo, Bo Liu, Qinlu Lin
Summary: Changes in eating habits have led to a significant increase in obesity. Octacosanol has been found to reduce lipid levels in high-fat diet-induced obese mice by modulating lipid metabolism-related signal pathways.
Article
Virology
Yunlong Yang, Yizhuo Luo, Songqiang Yi, Qi Gao, Ting Gong, Yongzhi Feng, Dongdong Wu, Xiaoyu Zheng, Heng Wang, Guihong Zhang, Yankuo Sun
Summary: Porcine reproductive and respiratory syndrome (PRRS) is a respiratory disease caused by porcine reproductive and respiratory syndrome virus (PRRSV). This study found that lipid metabolism and lipid droplets (LDs) play important roles in PRRSV replication. The study explored the mechanisms through which LDs affect PRRSV replication, and revealed the significance of the NF-kappa B signaling pathway regulation and LD accumulation in PRRSV replication.
Article
Cell Biology
Wenfei Pan, Limei Deng, Haitao Wang, Vivien Ya-Fan Wang
Summary: The NF-kappa B family of dimeric transcription factors regulate various biological functions. A study has revealed that the atypical I kappa B protein, Bcl3, plays a crucial role in enhancing the population of the p52:p52 homodimer within the NF-kappa B family. Bcl3 competes with other NF-kappa B subunits for efficient p52:p52 homodimer formation, leading to the upregulation of target genes involved in cell proliferation, migration, and inflammation. The aberrant activation of Bcl3 and p52 contributes to cancer.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Gastroenterology & Hepatology
Suzhen Yang, Bing Xu, Yuying Han, MingZuo Jiang, Tingting Luo, Nan Wu, Jiayi Cao, Ying Zheng, Lin Shen, Wen Qin, Haitao Shi, Lei Dong
Summary: This study investigated the role of TAF15 in the progression of NASH and its underlying molecular mechanism. It was found that TAF15 was significantly increased in NASH models. TAF15 exacerbated NASH progression by promoting the transcriptional activation of FASN, interacting with p65, and activating the NF-κB signaling pathway.
LIVER INTERNATIONAL
(2023)
Article
Cell Biology
Lara Bideyan, Maykel Lopez Rodriguez, Christina Priest, John P. Kennelly, Yajing Gao, Alessandra Ferrari, Prashant Rajbhandari, An-Chieh Feng, Sergei G. Tevosian, Stephen T. Smale, Peter Tontonoz
Summary: In this study, the researchers investigated the role of GATA4 in adult liver metabolism and identified it as a transcriptional regulator of metabolism in the liver. They found that hepatic GATA4 plays a crucial role in the transcriptional control of hepatic and systemic lipid homeostasis.
GENES & DEVELOPMENT
(2022)
Article
Food Science & Technology
Hui Gao, Chunping Rao, Ruijuan Song, Shufen Han
Summary: The study demonstrated that oat fiber feeding can hinder the progression of atherosclerosis by affecting circulating oxysterols, alleviating hepatic inflammatory response, and targeting the TLR4/MyD88/NF-kB signaling pathway.
JOURNAL OF FUNCTIONAL FOODS
(2021)
Article
Food Science & Technology
Yue-Qiang Huang, Yi-Xi Tang, Bai-Hao Qiu, Milton Talukder, Xue-Nan Li, Jin-Long Li
Summary: DEHP exposure can cause liver damage in quails, resulting in lipid metabolism disorders and inflammatory response.
FOOD AND CHEMICAL TOXICOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Matthew Martin, Aishat Motolani, Hyeong-Geug Kim, Amy M. Collins, Faranak Alipourgivi, Jiamin Jin, Han Wei, Barry A. Wood, Yao-Ying Ma, X. Charlie Dong, Raghavendra G. Mirmira, Tao Lu
Summary: Dysregulation of metabolic functions in the liver affects the development of diabetes and metabolic disorders. The study identifies lysine demethylase 2A (KDM2A) as a negative regulator of nuclear factor (NF)-kappa B in the liver, with a crucial role in liver function. Through a liver-specific Kdm2a knockout mouse model, it is shown that KDM2A deficiency leads to liver dysfunction and increased inflammation.
Article
Endocrinology & Metabolism
Jessica Kain, Xiaolong Wei, Nihal A. Reddy, Andrew J. Price, Claire Woods, Irina M. Bochkis
Summary: The study revealed the crucial role of Foxa2 in regulating ligand-dependent binding of II nuclear hormone receptors FXR and LXRa, as well as the activation of gene expression. Foxa2 forms an interdependent DNA binding complex with the receptor during ligand binding, facilitating the activation of nuclear hormone receptors.
MOLECULAR METABOLISM
(2021)
Article
Veterinary Sciences
Qinghua Deng, Liyin Du, Yuming Zhang, Guowen Liu
Summary: Transition dairy cows often experience negative energy balance, insulin resistance, and inflammation. NEFAs can activate the NF-kappa B inflammatory signaling pathway through TLR4, influencing insulin resistance. Inhibitors of TLR4 can alleviate the inhibitory effects of NEFAs and reduce the activation of the inflammatory signaling pathway.
FRONTIERS IN VETERINARY SCIENCE
(2021)
Article
Pharmacology & Pharmacy
Panpan Chen, Rong Wang, Fangbin Liu, Shengnan Li, Yanqiu Gu, Lei Wang, Yongfang Yuan
Summary: Schizandrin C from Schisandra chinensis has been found to ameliorate liver fibrosis by regulating lipid metabolism and inflammation through nuclear factor kappa-B and p38/ERK MAPK signaling pathways, making it a potential drug for liver fibrosis.
FRONTIERS IN PHARMACOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Daniela Verzella, Jessica Cornice, Paola Arboretto, Davide Vecchiotti, Mauro Di Vito Nolfi, Daria Capece, Francesca Zazzeroni, Guido Franzoso
Summary: NF-kappa B pathway plays a crucial role in cancer, but there is no effective NF-kappa B inhibitor for treatment yet. Researchers are focusing on developing new drugs targeting upstream regulators or downstream effectors of the NF-kappa B signaling pathway.
Review
Chemistry, Medicinal
Rina Das, Dinesh Kumar Mehta, Meenakshi Dhanawat
Summary: Nuclear factor-kappa B (NF-kappa B) is a transcription factor that controls gene expression and plays a crucial role in regulating cell signaling. The constitutive activity of NF-kappa B signaling has been reported in various cancer cells, making it a desirable target for cancer treatment. Plant-derived compounds, such as flavonoids and polyphenols, have been evaluated as potential inhibitors of NF-kappa B signaling and have shown promising anticancer effects.
MINI-REVIEWS IN MEDICINAL CHEMISTRY
(2022)
Review
Chemistry, Multidisciplinary
Leyuan Xu, Qianming Bai, Xin Zhang, Hu Yang
JOURNAL OF CONTROLLED RELEASE
(2017)
Article
Urology & Nephrology
Tinika A. Montgomery, Leyuan Xu, Sherene Mason, Amirtha Chinnadurai, Chun Geun Lee, Jack A. Elias, Lloyd G. Cantley
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
(2017)
Article
Materials Science, Biomaterials
Leyuan Xu, Remy C. Cooper, Juan Wang, W. Andrew Yeudall, Hu Yang
ACS BIOMATERIALS SCIENCE & ENGINEERING
(2017)
Article
Materials Science, Biomaterials
Leyuan Xu, Remy C. Cooper, Juan Wang, W. Andrew Yeudall, Hu Yang
ACS BIOMATERIALS SCIENCE & ENGINEERING
(2017)
Article
Urology & Nephrology
Leyuan Xu, Diana Sharkey, Lloyd G. Cantley
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
(2019)
Article
Medicine, Research & Experimental
Jeremy Puthumana, Heather Thiessen-Philbrook, Leyuan Xu, Steven G. Coca, Amit X. Garg, Jonathan Himmelfarb, Pavan K. Bhatraju, T. Alp Ikizler, Edward D. Siew, Lorraine B. Ware, Kathleen D. Liu, Alan S. Go, James S. Kaufman, Paul L. Kimmel, Vernon M. Chinchilli, Lloyd G. Cantley, Chirag R. Parikh
Summary: The study found that levels of MCP-1 and YKL-40 measured at 3 months after hospitalization were associated with long-term risk of kidney failure, while UMOD levels were linked with decreased risk of kidney injury. Using a multimarker score provided better accuracy in predicting patients' risk of kidney disease progression compared to traditional clinical variables.
JOURNAL OF CLINICAL INVESTIGATION
(2021)
Article
Urology & Nephrology
Xiaojia Guo, Leyuan Xu, Heino Velazquez, Tian-Min Chen, Ryan M. Williams, Daniel A. Heller, Barbara Burtness, Robert Safirstein, Gary Desir
Summary: Kidney-targeted delivery of RNLS can prevent cisplatin-induced CKD by decreasing cell death and improving the viability of the renal proximal tubule.
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
(2022)
Article
Urology & Nephrology
Naomi S. Shin, Arnaud Marlier, Leyuan Xu, Natnael Doilicho, Daniel Linberg, Jiankan Guo, Lloyd G. Cantley
Summary: Inflammatory macrophages that infiltrate the kidney after injury transition to a reparative state characterized by the expression of multiple proteins, including Arg1. By studying mice lacking macrophage Arg1 expression, the researchers found that Arg1 plays a critical role in renal recovery by promoting renal epithelial cell proliferation. Enhancing Arg1 expression may improve renal recovery after kidney injury.
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
(2022)
Article
Urology & Nephrology
Hannah Melchinger, Frida Calderon-Gutierrez, Wassim Obeid, Leyuan Xu, Melissa M. Shaw, Randy L. Luciano, Michael Kuperman, Gilbert W. Moeckel, Michael Kashgarian, F. Perry Wilson, Chirag R. Parikh, Dennis G. Moledina
Summary: This study found a negative correlation between urine uromodulin and tubulointerstitial fibrosis, which was confirmed in both human and mouse models.
CLINICAL JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
(2022)
Article
Multidisciplinary Sciences
Leyuan Xu, Jiankan Guo, Dennis G. Moledina, Lloyd G. Cantley
Summary: Incomplete repair after acute kidney injury can lead to the development of chronic kidney disease, and this response is mediated by macrophages promoting a proinflammatory environment and progressive tubule injury.
NATURE COMMUNICATIONS
(2022)
Article
Medicine, Research & Experimental
Yumeng Wen, Leyuan Xu, Isabel Melchinger, Heather Thiessen-Philbrook, Dennis G. Moledina, Steven G. Coca, Chi-yuan Hsu, Alan S. Go, Kathleen D. Liu, Edward D. Siew, T. Alp Ikizler, Vernon M. Chinchilli, James S. Kaufman, Paul L. Kimmel, Jonathan Himmelfarb, Lloyd G. Cantley, Chirag R. Parikh
Summary: Long-term injury and inflammation after acute kidney injury (AKI) may lead to chronic kidney disease (CKD) progression. Study on 656 AKI patients found that changes in urine biomarkers (KIM-1, MCP-1) and plasma biomarker (TNFR1) were associated with increased risk of CKD, while changes in urine uromodulin were associated with reduced risk of CKD. The trajectories of these biological processes were also associated with kidney atrophy in mice after ischemic reperfusion injury (IRI).
Article
Urology & Nephrology
Steven Menez, Yumeng Wen, Leyuan Xu, Dennis G. Moledina, Heather Thiessen-Philbrook, David Hu, Wassim Obeid, Pavan K. Bhatraju, T. Alp Ikizler, Edward D. Siew, Vernon M. Chinchilli, Amit X. Garg, Alan S. Go, Kathleen D. Liu, James S. Kaufman, Paul L. Kimmel, Jonathan Himmelfarb, Steven G. Coca, Lloyd G. Cantley, Chirag R. Parikh
Summary: Urinary epidermal growth factor (EGF) may serve as a biomarker for tubular function and can be used to assess the risk of chronic kidney disease (CKD) after hospitalization. Higher urinary EGF concentrations three months post-discharge are associated with a reduced risk of major adverse kidney events (MAKE), such as CKD incidence, progression, or kidney failure.
KIDNEY INTERNATIONAL
(2023)
Article
Physiology
Naomi S. Shin, Arnaud Marlier, Leyuan Xu, TuKiet Lam, Lloyd G. Cantley, Jian-Kan Guo
Summary: This study provides detailed insights into the formation and resolution process of tubular casts in ischemically injured kidney, including the distribution of dead cell debris, the timing and location of cast formation, and the clearance mechanism.
AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY
(2022)
Review
Urology & Nephrology
Leyuan Xu
Summary: AKI is highly prevalent and lacks optimal therapy. Experimental studies show that immune responses play a central role in injury, repair, and fibrosis after AKI.
Article
Engineering, Biomedical
Leyuan Xu, W. Andrew Yeudall, Hu Yang
ACTA BIOMATERIALIA
(2017)