Article
Endocrinology & Metabolism
Franziska Lademann, Elena Tsourdi, Lorenz C. Hofbauer, Martina Rauner
Summary: Thyroid hormones regulate bone metabolism through the transporter protein MCT8. Knocking out the MCT8 gene in mice leads to both bone gain and bone loss, depending on the age of the mice. Young mice lacking MCT8 show increased trabecular bone at the spine, while adult mice show decreased trabecular bone in both the femur and vertebrae. Additionally, deleting MCT8 in osteoblasts and osteocytes has different effects on bone volume.
Article
Multidisciplinary Sciences
Annette J. J. Klomp, Ashley Plumb, Jacqueline B. B. Mehr, Deniz A. A. Madencioglu, Hsiang Wen, Aislinn J. J. Williams
Summary: Deletion of neuronal Ca(V)1.2 alters motor performance, acoustic startle reflex, and social behaviors in a sex-specific manner, while associative learning deficits generalize across sexes. Our data provide evidence for both sex-specific and sex-independent phenotypes related to neuronal expression of Ca(V)1.2.
SCIENTIFIC REPORTS
(2022)
Article
Multidisciplinary Sciences
Meiling Zhu, Ben-hua Sun, Erin Nevius, Jared Kaplan, Joao Pereira, Karl Insogna
Summary: CSF1 may play a significant role in mature osteoclasts, with c-fms being crucial in regulating the function of these cells.
Article
Endocrinology & Metabolism
Frank C. Ko, Sarah B. Jochum, Brittany M. Wilson, Amal Adra, Nikhil Patel, Hoomin Lee, Sherry Wilber, Maliha Shaikh, Christopher Forsyth, Ali Keshavarzian, Garth R. Swanson, D. Rick Sumner
Summary: This study found that multiple metabolic processes, including bone metabolism, are regulated by the circadian clock system. Both central and peripheral circadian signaling have been shown to regulate skeletal growth and homeostasis in mice. Disruption of central circadian rhythms has been associated with a decline in bone mineral density in humans, and disruption of clock genes in bone tissue leads to lower bone mass in mice. The study also demonstrated that deletion of the clock gene Bmal1 in colon epithelial cells leads to failure to acquire trabecular and cortical bone in male mice.
Article
Biochemistry & Molecular Biology
Xin Xu, Xiao-Qin Liu, Xin-Long Liu, Xu Wang, Wen-Di Zhang, Xiao-Fu Huang, Fang-Yue Jia, Peng Kong, Mei Han
Summary: Considerable evidence suggests that cognitive impairment is primarily a vascular disorder. The depletion of SM22 alpha in VSMCs contributes to their phenotypic switching and inflammation, but the role of VSMCs in cognitive impairment is still uncertain. This study shows a possible link between VSMC phenotypic switching and neurodegenerative diseases, supporting the idea of VSMCs and SM22 alpha as therapeutic targets in cognitive impairment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Medicine, Research & Experimental
Zongzhuang Wen, Haixia Zhu, Jing Wang, Bin Wu, Aizhen Zhang, Hui Zhao, Chenyang Song, Shuangyuan Liu, Yin Cheng, Hongxiang Wang, Jianyuan Li, Daqing Sun, Xiaolong Fu, Jiangang Gao, Min Liu
Summary: This study generated a germ cell-specific deletion mutant of the Hspa5 gene (Hspa5-cKO) using CRISPR/Cas9 technology and the Cre/Loxp system. Hspa5 knockout resulted in severe germ cell loss and vacuolar degeneration of seminiferous tubules, leading to complete arrest of spermatogenesis, testicular atrophy, and male infertility in adult mice. Single-cell RNA sequencing analysis further confirmed that HSPA5 is crucial for germ cell development.
Article
Endocrinology & Metabolism
Lina Lawenius, Hannah Collden, Karin Horkeby, Jianyao Wu, Louise Grahnemo, Liesbeth Vandenput, Claes Ohlsson, Klara Sjogren
Summary: Studies have shown that the probiotic mix L. Mix can protect bone in male mice by increasing bone mineral density and preventing bone loss. These bone protective effects are associated with increased levels of short-chain fatty acids in the cecal content of male mice.
JOURNAL OF ENDOCRINOLOGY
(2022)
Article
Cell Biology
Haixia Xu, Jiahua Guo, Wei Wu, Qiu Han, Yueru Huang, Yaling Wang, Cencen Li, Xiaofang Cheng, Pengpeng Zhang, Yongjie Xu
Summary: This study reveals that hnRNPK plays a crucial role in spermatogenesis and male fertility. HnRNPK is strongly expressed in the mouse testis and is mainly localized in the nucleus of germ cells. Depletion of hnRNPK in male germ cells leads to developmental abnormalities in the testis and infertility in males. The absence of hnRNPK in spermatocytes causes meiotic arrest and impairs the production of mature sperm.
Article
Neurosciences
Clemence Maupu, Julie Enderlin, Alexandre Igert, Myriam Oger, Stephane Auvin, Rahma Hassan-Abdi, Nadia Soussi-Yanicostas, Xavier Brazzolotto, Florian Nachon, Gregory Dal Bo, Nina Dupuis
Summary: Organophosphate pesticides and nerve agents can lead to seizures and neurodegeneration, resulting in neuroinflammation. This study identified distinct neuroinflammatory responses of microglia and astrocytes at different time points after induced seizures, highlighting the importance of targeting specific markers for treatment.
NEUROBIOLOGY OF DISEASE
(2021)
Article
Endocrinology & Metabolism
Daniela Schnyder, Giuseppe Albano, Patrycja Kucharczyk, Silvia Dolder, Mark Siegrist, Manuel Anderegg, Ganesh Pathare, Willy Hofstetter, Roland Baron, Daniel G. Fuster
Summary: Mutations in the SLC9A6 gene encoding NHE6 can lead to severe X-linked mental retardation, epilepsy, autism, and skeletal malformations in humans. Knocking out the NHE6 gene in mice caused reduced bone volume, trabecular number, and bone formation, associated with an increase in sclerostin expression.
Article
Biochemistry & Molecular Biology
Yu Chen, Yanbin Liu, Yangyang Zhang, Jiangming Yu, Liang Tang
Summary: Bone formation depends on osteoblasts derived from BMSCs. Gal-1 plays a crucial role in immunomodulation and has been shown to promote osteogenic differentiation of BMSCs through the activation of Lrp5 expression and Wnt/beta-catenin signaling pathway. Age-related decline in Gal-1 expression in aged mice is associated with attenuated osteogenic differentiation potential of BMSCs.
Article
Endocrinology & Metabolism
Lieve Verlinden, Stefanie Doms, Iris Janssens, Mark B. B. Meyer, J. Wesley Pike, Geert Carmeliet, Annemieke Verstuyf
Summary: Neuropilin 2 (NRP2) plays a role in bone homeostasis by regulating osteoblasts and osteoclasts. The expression of NRP2 in osteoblasts is induced by 1,25-dihydroxyvitamin D-3. Deletion of NRP2 in osteoblasts results in reduced bone mass, while deletion in osteoclasts does not have a bone phenotype.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Endocrinology & Metabolism
Jin-Ran Chen, Oxana P. Lazarenko, Michael L. Blackburn
Summary: This study investigated the role of GPR109A in gonadectomy-induced bone loss using mouse models. The results showed that global GPR109A gene deletion ameliorated the bone loss caused by gonadectomy.
Article
Multidisciplinary Sciences
Yuexia Wang, Khurts Shilagardi, Trunee Hsu, Kamsi O. Odinammadu, Takamitsu Maruyama, Wei Wu, Chyuan-Sheng Lin, Christopher B. Damoci, Eric D. Spear, Ji-Yeon Shin, Wei Hsu, Susan Michaelis, Howard J. Worman
Summary: Prelamin A, a farnesylated precursor of lamin A, can cause progeria syndrome when accumulated as progerin. Mutations in ZMPSTE24, the processing enzyme of prelamin A, can lead to progeroid disorders. This study generated a mouse model with permanently farnesylated prelamin A and found that these mice have extended lifespan and exhibit skeletal and nuclear defects during physiological aging.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Immunology
Shuoshuo Li, Yajin Liao, Yuan Dong, Xiaoheng Li, Jun Li, Yong Cheng, Jinbo Cheng, Zengqiang Yuan
Summary: The study revealed the critical role of microglial activation in PTSD, with an increase in microglia number and ratio post foot-shock exposure. Genetic/pharmacological depletion of microglia or minocycline treatment before exposure alleviated anxiety and contextual fear associated with PTSD.
JOURNAL OF NEUROINFLAMMATION
(2021)
Review
Oncology
Shinje Moon, Ka Hee Yi, Young Joo Park
Summary: This meta-analysis found that thyroid cancer treatment (including RAIT) does not increase the risk of adverse pregnancy outcomes for patients, and the results regarding miscarriage, preterm labor, and congenital anomalies are similar to those in the general population.
Review
Oncology
Ho-Ryun Won, Eonju Jeon, Jae Won Chang, Yea Eun Kang, Kunho Song, Sun Wook Kim, Dong Mee Lim, Tae Kwun Ha, Ki-Wook Chung, Hyo-Jeong Kim, Young Joo Park, Bon Seok Koo
Summary: There is insufficient evidence to support the effectiveness of post-operative maintenance of thyroid-stimulating hormone (TSH) levels below 2 mU/L in reducing recurrence in patients undergoing thyroid lobectomy for low-risk differentiated thyroid cancer (DTC). Further research is needed to clarify the impact of TSH maintenance in this patient population.
Letter
Endocrinology & Metabolism
Yoo Hyung Kim, Hyo-Cheol Kim, Yun Bin Lee, Samina Park, Eun-Jae Chung, Jin Chul Paeng, Young Joo Park
ENDOCRINOLOGY AND METABOLISM
(2022)
Article
Psychiatry
Ju-Yeon Jung, Seo-Eun Cho, Nambeom Kim, Chang-Ki Kang, Seung-Gul Kang
Summary: This study found a lower RSFC between the left habenula and cerebellum in patients with MDD, and reduced RSFC among numerous subcortical areas through ROI-to-ROI analysis. These findings on the neural circuitry of MDD may help deepen our understanding of depression.
FRONTIERS IN PSYCHIATRY
(2022)
Review
Endocrinology & Metabolism
Min-Kyoung Song, Serk In Park, Sun Wook Cho
Summary: Bone metastasis is a common site of spread for various solid tumors, leading to significant health problems and mortality in patients. One major challenge is the lack of biomarkers for early detection and monitoring of therapeutic responses. Current imaging techniques have limitations in detecting early lesions and accurately monitoring disease progression. Therefore, there is a need for the development of novel blood biomarkers. This review article provides an overview of the protein- and cell-based biomarkers that are currently used or under development for bone metastasis in clinical practice.
JOURNAL OF BONE AND MINERAL METABOLISM
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Hyobin Seo, Kwang Nam Jin, Ji Sang Park, Koung Mi Kang, Eun Kyung Lee, Ji Ye Lee, Roh-Eul Yoo, Young Joo Park, Ji-hoon Kim
Summary: This study evaluated the risk of thyroid cancer in a lung cancer screening population based on the presence of incidental thyroid nodules detected on low-dose chest computed tomography (LDCT). The results showed that the incidence of thyroid cancer was higher in the ITN-positive group compared to the ITN-negative group, but all cancers were papillary thyroid microcarcinomas (PTMCs). Therefore, thorough screening for thyroid incidentalomas may not be necessary in patients with a heavy smoking history.
Article
Nanoscience & Nanotechnology
Seong Uk Son, Eun-Kyung Lim, Soojin Jang, Jaewoo Lim, Seung Beom Seo, Taejoon Kang, Juyeon Jung, Seo Yeong Oh, Sun-Woo Yoon, Dongeun Yong, Jaejong Lee
Summary: The study developed a conductive thread-based immunosensor to easily detect airborne viruses, which is important in preventing the spread of infectious diseases.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Article
Chemistry, Applied
Soojin Jang, Seong Uk Son, Junseok Kim, Hyungjun Kim, Jaewoo Lim, Seung Beom Seo, Byunghoon Kang, Taejoon Kang, Juyeon Jung, Sungbaek Seo, Eun-Kyung Lim
Summary: A colorimetric sensor using PDA-based hydrogel beads has been developed to conveniently detect food spoilage. The sensor can visually confirm the presence of biogenic amines through color changes, providing an efficient and accurate method.
Article
Medicine, Research & Experimental
Chae Won Chung, Kyong Yeun Jung, Eun Hye Jung, Min Joung Lee, Young Joo Park, Jeong Kyu Lee, Hwa Young Ahn, Sun Wook Cho
Summary: This study aims to evaluate the therapeutic effect of selenium in mild-to-moderate Graves' ophthalmopathy (GO) in selenium-sufficient South Korea. The study will assess the treatment effectiveness through questionnaires and clinical evaluations to provide better treatment options.
Article
Endocrinology & Metabolism
Shinje Moon, Eun Kyung Lee, Hoonsung Choi, Sue K. Park, Young Joo Park
Summary: This study investigates the impact of ultra-sound screening on thyroid cancer outcomes. The findings suggest that early detection of thyroid cancer leads to better survival outcomes compared to symptomatic thyroid cancer.
ENDOCRINOLOGY AND METABOLISM
(2023)
Review
Endocrinology & Metabolism
Sun Wook Cho, Jung Hee Kim, Han Seok Choi, Hwa Young Ahn, Mee Kyoung Kim, Eun Jung Rhee
Summary: The Korean National Health Information Database (NHID) is a big data source that combines information from the National Health Insurance Service and health examinations. It is used for longitudinal studies and research on rare diseases, with data on cause and date of death provided by Statistics Korea. While research based on NHID has greatly increased in the field of endocrine disorders, there are limitations due to the data not being collected for research purposes and the need for operational definitions of diseases.
ENDOCRINOLOGY AND METABOLISM
(2023)
Article
Oncology
Hoon Young Suh, Hongyoon Choi, Sun Wook Cho, Jin Chul Paeng, Gi Jeong Cheon, Young Joo Park, Keon Wook Kang
Summary: Iodine and FDG uptakes are established methods in defining the biological properties of thyroid cancer. This study investigates the association between glucose metabolism in thyroid cancer and the tumor microenvironment (TME) using transcriptomic analyses. The results show that FDG uptake is positively correlated with the enrichment score of macrophages and glycolysis activity, and immune cells have higher levels of glucose transporters and glycolysis signatures, suggesting that FDG uptake mainly occurs in immune cells of the TME.
Article
Endocrinology & Metabolism
Hwa Young Ahn, Sun Wook Cho, Mi Young Lee, Young Joo Park, Bon Seok Koo, Hang-Seok Chang, Ka Hee Yi
Summary: This study investigated the changes in the incidence and treatment of hyperthyroidism in South Korea from 2003 to 2018. The study found that hyperthyroidism occurred more frequently in women than in men, and antithyroid drugs were the most commonly prescribed treatment. The study also found that hyperthyroid patients had a higher risk of atrial fibrillation or flutter, osteoporosis, and fractures at a younger age compared to the general population.
ENDOCRINOLOGY AND METABOLISM
(2023)
Article
Endocrinology & Metabolism
Sung Hye Kong, Jung Hee Kim, Man Young Park, Sang Wan Kim, Chan Soo Shin
Summary: The incidence of primary hyperparathyroidism patients who underwent parathyroidectomy has been increasing in Korea. Patients with complications, especially mood disorder, have an increased risk of mortality and cardiovascular and cerebrovascular events.
Article
Endocrinology & Metabolism
A. Ram Hong, Jae-Yeon Yang, Ji Yeon Lee, Joonho Suh, Yun-Sil Lee, Jung-Eun Kim, Sang Wan Kim
Summary: Reactivation of bone lining cells (BLCs) is modestly attenuated but reproducible during persistent administration of anti-sclerostin antibody (Scl-Ab). Serum levels of N-terminal procollagen type I (P1NP) appear to be an indicator of the impact of Scl-Ab on the conversion of BLCs into mature osteoblasts on periosteal bone surfaces, thus contributing to modeling-based bone formation.
CALCIFIED TISSUE INTERNATIONAL
(2022)