Review
Biochemistry & Molecular Biology
Vishal Khatri, Ramaswamy Kalyanasundaram
Summary: This review focuses on the association between IBD and gut inflammasome, as well as recent advances in research and therapeutic strategies for IBD, discussing inflammasomes and their components, outcomes from experimental animals and human studies, inflammasome inhibitors, and developments in inflammasome-targeted therapies for IBD.
Review
Biochemistry & Molecular Biology
HyunTaek Jung, Jae Seok Kim, Keum Hwa Lee, Kalthoum Tizaoui, Salvatore Terrazzino, Sarah Cargnin, Lee Smith, Ai Koyanagi, Louis Jacob, Han Li, Sung Hwi Hong, Dong Keon Yon, Seung Won Lee, Min Seo Kim, Paul Wasuwanich, Wikrom Karnsakul, Jae Il Shin, Andreas Kronbichler
Summary: Inflammatory bowel disease (IBD) is a chronic inflammatory disease of the gastrointestinal tract that mainly affects young people. Recent studies have shown that microRNAs (miRNAs) play an important role in the pathogenesis, diagnosis, and treatment of IBD.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2021)
Article
Gastroenterology & Hepatology
Uma Mahadevan, Millie D. Long, Sunanda Kane, Abhik Roy, Marla C. Dubinsky, Bruce E. Sands, Russell D. Cohen, Christina D. Chambers, William J. Sandborn
Summary: The study found that exposure to biologic, thiopurine, or combination therapy during pregnancy did not increase adverse maternal or fetal outcomes, and these treatments can be continued throughout pregnancy for women with IBD to maintain disease control.
Article
Medicine, General & Internal
Silvia Salvatori, Francesco Baldassarre, Michelangela Mossa, Giovanni Monteleone
Summary: Long COVID is common in patients with inflammatory bowel diseases (IBD), with fatigue being the most frequent symptom. It does not influence the frequency of IBD relapses, but is more prevalent in female patients.
JOURNAL OF CLINICAL MEDICINE
(2021)
Review
Gastroenterology & Hepatology
Thomas M. Goodsall, Tran M. Nguyen, Claire E. Parker, Christopher Ma, Jane M. Andrews, Vipul Jairath, Robert Bryant
Summary: The study systematically identified ultrasound scoring indices for assessing inflammatory bowel disease activity, with common components including bowel wall thickness, colour Doppler imaging, and bowel wall stratification. The correlation between ultrasound indices and reference standards, as well as sensitivity, specificity, accuracy, and other properties, varied within certain ranges. However, reliability and responsiveness data were limited, and most studies were rated with unclear or high risk of bias.
JOURNAL OF CROHNS & COLITIS
(2021)
Review
Medicine, General & Internal
Katarzyna Akutko, Andrzej Stawarski
Summary: Inflammatory bowel diseases (IBD) are chronic inflammatory diseases of the digestive tract with periods of remission and relapses. The etiopathogenesis is not fully understood, leading to only symptomatic treatment. There is a constant need to search for new high safety profile therapies for IBD.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Gastroenterology & Hepatology
Miikka Hoyhtya, Katri Korpela, Schahzad Saqib, Sofia Junkkari, Eija Nissila, Anne Nikkonen, Evgenia Dikareva, Anne Salonen, Willem M. de Vos, Kaija-Leena Kolho
Summary: This study aimed to investigate the absolute abundances of gut microbiota in relation to the response to induction therapy with infliximab in pediatric inflammatory bowel disease. The results showed that the treatment responsive group had a higher absolute abundance of Bifidobacteriales and a lower absolute abundance of Actinomycetales compared to the nonresponders. However, the level of inflammation according to fecal calprotectin showed no statistically significant association with the absolute abundances of fecal microbiota. The results on relative abundances differed from the absolute abundances.
INFLAMMATORY BOWEL DISEASES
(2023)
Review
Biotechnology & Applied Microbiology
Guihua Chen, Jun Shen
Summary: Inflammatory bowel disease (IBD) is a global disease with high morbidity and medical costs. Early diagnosis and intervention are crucial for controlling its progression.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2021)
Article
Gastroenterology & Hepatology
Jurij Hanzel, Peter Bossuyt, Valerie Pittet, Mark Samaan, Monika Tripathi, Wladyslawa Czuber-Dochan, Johan Burisch, Salvatore Leone, Roberto Saldana, Filip Baert, Uri Kopylov, Susanna Jaghult, Michel Adamina, Naila Arebi, Krisztina Gecse
Summary: This study aimed to develop a core outcome set for real-world studies in adult patients with inflammatory bowel disease (IBD). Candidate outcomes and outcome measures were identified through a systematic review and a modified Delphi consensus process. The international panel agreed on the final core outcome set, which will facilitate the synthesis and generation of real-world evidence.
JOURNAL OF CROHNS & COLITIS
(2023)
Editorial Material
Gastroenterology & Hepatology
Catherine Le Berre, Laurent Peyrin-Biroulet
Summary: The SPIRIT consensus group has agreed that the ultimate therapeutic goal in both CD and UC is to prevent disease impact on patients' lives, including health-related quality of life, disability, and fecal incontinence, as well as prevent complications in the short and long term, such as bowel damage, surgeries, disease extension, extraintestinal manifestations, and dysplasia or cancer. These recommendations will need to be validated in clinical studies before being implemented in disease-modification trials.
Article
Multidisciplinary Sciences
Ryan W. Gan, Diana Sun, Amanda R. Tatro, Shirley Cohen-Mekelburg, Wyndy L. Wiitala, Ji Zhu, Akbar K. Waljee
Summary: This study replicated a machine-learning model's ability to predict acute exacerbations of inflammatory bowel disease (IBD) in a nationally representative cohort, with the random forest model outperforming the logistic regression model.
Review
Medicine, General & Internal
Elisabetta Antonelli, Gabrio Bassotti, Marta Tramontana, Katharina Hansel, Luca Stingeni, Sandro Ardizzone, Giovanni Genovese, Angelo Valerio Marzano, Giovanni Maconi
Summary: This review summarizes the dermatologic manifestations occurring in patients with inflammatory bowel diseases, including specific manifestations, cutaneous disorders associated with IBDs, reactive mucocutaneous manifestations of IBDs, mucocutaneous conditions secondary to treatment, and manifestations due to nutritional malabsorption. An accurate dermatological examination is crucial in all IBD patients, especially in candidates to biologic therapies where drug-induced cutaneous reactions may be clinically relevant.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Medicine, General & Internal
Anastasia Katsoula, Georgios Axiaris, Afroditi Mpitouli, Maria Palatianou, Angeliki Christidou, Nikolaos Dimitriadis, Andreas Nakos, Ploutarchos Pastras, Panagiotis Kourkoulis, Pantelis Karatzas, Miltiadis Moutzoukis, Charalampos Zlatinoudis, Athanasios Philippidis, Anastasia Kourikou, Georgios Kokkotis, Antonios Gklavas, Angeliki Machaira, Aikaterini Mantaka, Persefoni Talimtzi, Evaggelia Anagnostopoulou, Ioannis E. Koutroubakis, Ioannis Papaconstantinou, Georgios Bamias, Spilios Manolakopoulos, Nicoletta Mathou, Konstantina Paraskeva, Andreas Protopappas, Eftychia Tsironi, Konstantinos H. H. Katsanos, Dimitrios K. K. Christodoulou, Georgios Papatheodoridis, Georgios Michalopoulos, Georgios Theocharis, Christos Triantos, Ioannis Pachiadakis, Konstantinos Soufleris, Nikolaos Viazis, Gerassimos J. Mantzaris, Georgios Tribonias, Maria Tzouvala, Angeliki Theodoropoulou, Konstantinos Karmiris, Evanthia Zampeli, Spyridon Michopoulos, Anna-Bettina Haidich, Olga Giouleme
Summary: The aim of this study was to validate the content of IBD-Disk in a Greek cohort of IBD patients. The results showed good correlation and consistency between the scores of IBD-Disk and IBD-DI at baseline and follow-up. Female gender and extraintestinal manifestations were significantly associated with a higher IBD-Disk total score. Therefore, the Greek version of IBD-Disk was proven to be a reliable and valid tool for assessing IBD-related disability.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Gastroenterology & Hepatology
Jee Hyun Kim, Chang-Myung Oh, Jun Hwan Yoo
Summary: Obesity is common in patients with inflammatory bowel disease (IBD), especially in newly developed countries. It has been suggested that 15%-40% of IBD patients are obese, and obesity may play a role in the development of IBD. Dysfunction of mesenteric fat can worsen the inflammation in Crohn's disease and lead to the formation of strictures or fistulas. Additionally, obesity can affect the course of the disease and the response to treatment in IBD. As a result, obesity control is being proposed as a novel management approach for IBD, and this review aims to discuss the impact of obesity on IBD treatment outcomes and the current status of pharmacologic or surgical anti-obesity treatments in IBD patients.
WORLD JOURNAL OF GASTROENTEROLOGY
(2023)
Article
Gastroenterology & Hepatology
Vu Q. Nguyen, Fabiano Celio, Maithili Chitnavis, Mohammad Shakhatreh, Jeffry Katz, Fabio Cominelli, Amitabh Chak, Paul Yeaton
Summary: This study examined the role of EUS in distinguishing between Crohn's disease and ulcerative colitis, finding that it can be used to diagnose active and inactive disease by measuring colon wall layer thickness and assessing transmural disease activity.
GASTROINTESTINAL ENDOSCOPY
(2023)
Article
Oncology
Jerry D. Monroe, Daniel Fraher, Xiaoqian Huang, Natalie A. Mellett, Peter J. Meikle, Andrew J. Sinclair, Seth T. Lirette, Nita J. Maihle, Zhiyuan Gong, Yann Gibert
Summary: The study found that induction of xmrk, Myc, and xmrk/Myc led to different stages of HCC. Lipid deposition and class levels generally increased during tumor progression, but triglyceride levels decreased. Myc may control early HCC stage lipid species levels in double transgenics, while xmrk may take over in later stages.
CANCER & METABOLISM
(2022)
Review
Cardiac & Cardiovascular Systems
Soloman Saleh, Jacob George, Katharine A. Kott, Peter J. Meikle, Gemma A. Figtree
Summary: Cardiovascular disease is a leading cause of death worldwide, and its diagnosis and quantification are significant health issues. Emerging cardiovascular biomarkers have shown great promise in predicting and treating the disease. However, there are challenges in translating these biomarkers into clinical practice.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Medicine, General & Internal
Sartaj Ahmad Mir, Li Chen, Satvika Burugupalli, Bo Burla, Shanshan Ji, Adam Alexander T. Smith, Kothandaraman Narasimhan, Adaikalavan Ramasamy, Karen Mei-Ling Tan, Kevin Huynh, Corey Giles, Ding Mei, Gerard Wong, Fabian Yap, Kok Hian Tan, Fiona Collier, Richard Saffery, Peter Vuillermin, Anne K. Bendt, David Burgner, Anne-Louise Ponsonby, Yung Seng Lee, Yap Seng Chong, Peter D. Gluckman, Johan G. Eriksson, Peter J. Meikle, Markus R. Wenk, Neerja Karnani
Summary: This study provides comprehensive insights into the changes in lipid levels during pregnancy and early childhood, as well as their association with obesity risk. The findings suggest that the lipidomic profiles in pregnant and non-pregnant women, as well as in offspring at birth and at 6 years of age, are influenced by adiposity. The study also highlights the overlap in the circulating lipid phenotype of obesity risk between children and adults, with a larger number of lipids associated with BMI in adults.
Review
Biochemistry & Molecular Biology
Alexandra D. George, Satvika Burugupalli, Sudip Paul, Toby Mansell, David Burgner, Peter J. Meikle
Summary: Evidence suggests that breastfeeding plays a critical role in protecting infants against obesity and inflammation. The unique lipid composition of human milk may be a key factor.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Cardiac & Cardiovascular Systems
Kunal P. Verma, Michael Inouye, Peter J. Meikle, Stephen J. Nicholls, Melinda J. Carrington, Thomas H. Marwick
Summary: Risk factor-based models are inadequate in estimating risk for specific populations, especially younger individuals. Personalized risk prediction tools, such as coronary artery calcium scoring and polygenic risk scores, hold potential to improve risk assessment. A multidimensional approach to risk prediction offers precise risk estimation and the opportunity for targeted prevention and early identification of high-risk individuals.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Wei Wu, Qun Lu, Shan Ma, Jin-Chan Du, Kevin Huynh, Thy Duong, Zhang-Da Pang, Daniel Donner, Peter J. Meikle, Xiu-Ling Deng, Xiao-Jun Du
Summary: Using an isoproterenol-induced mouse model of Takotsubo syndrome (TTS), we investigated the role of the O-adrenoceptors (OAR)-Hippo signaling pathway in mediating mitochondrial dysfunction. Our findings demonstrate that activation of OAR stimulates the Hippo pathway, which leads to mitochondrial dysfunction characterized by energy insufficiency and increased reactive oxygen species.
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
(2023)
Article
Endocrinology & Metabolism
Guillaume Treiber, Alice Guilleux, Kevin Huynh, Oriane Bonfanti, Ania Flaus-Furmaniuk, David Couret, Natalie Mellet, Celine Bernard, Nathalie Le-Moullec, Berenice Doray, Isabelle Jeru, Jean-Christophe Maiza, Bhoopendrasing Domun, Muriel Cogne, Olivier Meilhac, Corinne Vigouroux, Peter J. Meikle, Estelle Nobecourt
Summary: The study investigated glucose tolerance, insulin response, and metabolic markers in FPLD2 patients, revealing a high prevalence of diabetes and prediabetes. Early diagnosis and treatment are necessary.
DIABETES & METABOLISM
(2023)
Review
Biology
Aaron W. Jurrjens, Marcus M. Seldin, Corey Giles, Peter J. Meikle, Brian G. Drew, Anna C. Calkin
Summary: Cardiometabolic diseases result from genetic, environmental, and lifestyle factors and identifying those at high risk is challenging. Systems genetics, using population-based approaches, can elucidate the genetic and environmental causes of these diseases. Mouse genetic reference panels provide a complementary approach to human genome-wide association studies, allowing for controlled investigation of genetic and phenotypic variation. Integrating multi-omics data from human and mouse populations can advance our understanding of cardiometabolic diseases.
Article
Biochemistry & Molecular Biology
Dantong Zhu, Stephen T. Vernon, Zac D'Agostino, Jingqin Wu, Corey Giles, Adam S. Chan, Katharine A. Kott, Michael P. Gray, Alireza Gholipour, Owen Tang, Habtamu B. Beyene, Ellis Patrick, Stuart M. Grieve, Peter J. Meikle, Gemma A. Figtree, Jean Y. H. Yang
Summary: The current CAD risk scores based on traditional risk factors often fail individuals. We aim to identify lipidomic biomarkers using non-invasive imaging technology and advanced lipidomic measurement to enable intervention before cardiovascular events.
Article
Nutrition & Dietetics
Paige F. van der Pligt, Konsita Kuswara, Sarah A. Mcnaughton, Gavin Abbott, Sheikh Mohammed Shariful Islam, Kevin Huynh, Peter J. Meikle, Aya Mousa, Stacey J. Ellery
Summary: This study aimed to assess the relationship between early pregnancy maternal diet quality and maternal plasma lipids and indicators of cardiometabolic health. The results showed that maternal diet quality was inversely associated with multiple plasma triglycerides. This study provides novel insights into the relationship between diet quality, lipid biomarkers, and cardiometabolic health during pregnancy.
EUROPEAN JOURNAL OF NUTRITION
(2023)
Article
Gastroenterology & Hepatology
Ying Li, Bhagirath Chaurasia, M. Mahidur Rahman, Vincent Kaddai, J. Alan Maschek, Jordan A. Berg, Joseph L. Wilkerson, Ziad S. Mahmassani, James Cox, Peng Wei, Peter J. Meikle, Donald Atkinson, Liping Wang, Annelise M. Poss, Mary C. Playdon, Trevor S. Tippetts, Esraa M. Mousa, Kesara Nittayaboon, Pon Velayutham Anandh Babu, Micah J. Drummond, Hans Clevers, James A. Shayman, Yoshio Hirabayashi, William L. Holland, Jared Rutter, Bruce A. Edgar, Scott A. Summers
Summary: This study found that ceramides, as sphingolipid compounds, are associated with alimentary tract cancers. They function as signals of nutritional excess and can alter stem cell behaviors to influence cancer risk. The study also discovered that sphingolipid-producing enzymes are up-regulated in intestinal adenomas, leading to increased proliferation of intestinal progenitors through the stimulation of peroxisome-proliferator activated receptor-alpha and induction of fatty acid binding protein-1.
Article
Cell Biology
Hyo Lee, Aimee J. Aylward, Richard Pearse II, Alexandra M. Lish, Yi-Chen Hsieh, Zachary M. Augur, Courtney R. Benoit, Vicky Chou, Allison Knupp, Cheryl Pan, Srilakshmi Goberdhan, Duc M. Duong, Nicholas T. Seyfried, David A. Bennett, Mariko F. Taga, Kevin Huynh, Matthias Arnold, Peter J. Meikle, Philip L. De Jager, Vilas Menon, Jessica E. Young, Tracy L. Young-Pearse
Summary: SORL1 plays an important role in the pathogenesis of Alzheimer's disease. Loss of SORL1 affects neurons and astrocytes the most and leads to a reduction in apolipoprotein E (APOE) and clusterin (CLU), altered lipid profiles, and tau phenotypes in neurons. The study also identifies a link between SORL1, APOE, and CLU levels in neurons and implicates transforming growth factor β/SMAD signaling in SORL1 function.
Article
Multidisciplinary Sciences
Ebru Boslem, Saskia Reibe, Rodrigo Carlessi, Benoit Smeuninx, Surafel Tegegne, Casey L. Egan, Emma Mclennan, Lauren V. Terry, Max Nobis, Andre Mu, Cameron Nowell, Neil Horadagoda, Natalie A. Mellett, Paul Timpson, Matthew Jones, Elena Denisenko, Alistair R. R. Forrest, Janina E. E. Tirnitz-Parker, Peter J. Meikle, Stefan Rose-John, Michael Karin, Mark A. Febbraio
Summary: The incidence of hepatocellular carcinoma (HCC) is increasing due to obesity-related nonalcoholic steatohepatitis (NASH). In a mouse model mimicking NASH-driven HCC, activation of endoplasmic reticulum stress and inflammation was observed in hepatocytes. Treatment with an ER stress inhibitor and an anti-inflammatory drug reversed NASH and reduced NASH-driven HCC.
Article
Medicine, General & Internal
Taeho Jo, Junpyo Kim, Paula Bice, Kevin Huynh, Tingting Wang, Matthias Arnold, Peter J. Meikle, Corey Giles, Rima Kaddurah-Daouk, Andrew J. Saykin, Kwangsik Nho
Summary: This study introduces the Circular-Sliding Window Association Test (c-SWAT) to improve the classification accuracy in predicting Alzheimer's Disease (AD) using serum-based metabolomics data. The results show that c-SWAT is effective in improving classification accuracy and in identifying key lipids associated with AD.
Article
Medical Laboratory Technology
Olga Vvedenskaya, Michal Holcapek, Michael Vogeser, Kim Ekroos, Peter J. Meikle, Anne K. Bendt
Summary: Lipid metabolites have significant clinical potential beyond triglycerides and cholesterol, but standardization of mass spectrometry-based workflows is necessary for routine clinical applications. The International Lipidomics Society and its Clinical Lipidomics Interest Group were formed to bridge the gap between professionals and address workflow harmonization issues.
JOURNAL OF MASS SPECTROMETRY AND ADVANCES IN THE CLINICAL LAB
(2022)
