Article
Medicine, Research & Experimental
Itam Ako Hogan, Yu-Cheng Kuo, Asmau N. Abubakar, Bashir Lawal, Abdulhakeem R. Agboola, Halimat Yusuf Lukman, Sunday Amos Onikanni, Femi Olawale, Adewale Oluwaseun Fadaka, Yunusa O. Ibrahim, Shukurat B. Babalola, Gaber El -Saber Batiha, Sarah M. Albogami, Mohammed Alorabi, Michel De Waard, Hsu-Shan Huang
Summary: The present study evaluated the potential protective effects of Tridax procumbens methanolic extract on an experimentally induced type 2 diabetes rat model. The results showed that the extract significantly restored alterations in blood glucose levels, body weight loss, insulin levels, and pancreatic histology in diabetic rats. Additionally, the extract improved dyslipidemia, serum biochemical alterations, and full blood count distortion in diabetic rats. It also enhanced antioxidant status and reduced proinflammatory mediators in the brain of diabetic rats. However, it failed to attenuate certain changes in the brain. In conclusion, Tridax procumbens methanolic extract shows promise as an alternative therapeutic option for managing diabetic complications.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Review
Nutrition & Dietetics
Liu-Hong Shen, Lei Fan, Yue Zhang, Ying-Kun Zhu, Xiao-Lan Zong, Guang-Neng Peng, Sui-Zhong Cao
Summary: Placenta extract contains biologically active substances that have anti-inflammatory, antioxidation, and liver-protective effects.
Article
Engineering, Chemical
Wesam Al-Amarat, Mohammad H. Abukhalil, Osama Y. Althunibat, Manal A. Alfwuaires, Mashael M. Alnamshan, Amany Alqosaibi, Ahmad F. Ahmeda, Emadeldin M. Kamel, Hany H. Arab, Ayman M. Mahmoud
Summary: Galangin ameliorates hyperglycemia, glucose intolerance, oxidative stress, inflammation, and apoptosis, and enhances antioxidants and Nrf2/HO-1 signaling in diabetic rats.
Article
Biochemistry & Molecular Biology
Yin Qin, Ruyan Fan, Yingxin Liu, Shuyi Qiu, Lu Wang
Summary: This study investigated the liver protective effect of Rubus corchorifolius fruit extract (RCE) on mice with high-fat-diet-induced NAFLD and explored the potential mechanisms through transcriptomics and metabolomics analysis. The results showed that RCE contains polyphenolic compounds and has a modulatory effect on oxidative stress and inflammatory responses in the liver. Additionally, RCE intervention significantly affected metabolic pathways associated with glycolipid metabolism. Therefore, intake of RCE may be an effective strategy to alleviate liver damage.
Article
Biochemistry & Molecular Biology
Natalia S. S. Guimaraes, Vyctoria S. Ramos, Laura F. L. Prado-Souza, Rayssa M. Lopes, Gabriel S. Arini, Luis G. P. Feitosa, Ricardo R. Silva, Iseli L. Nantes, Debora C. Damasceno, Norberto P. Lopes, Tiago Rodrigues
Summary: The study found that rosemary is an aromatic herb with antimicrobial and antioxidant activities, which can be used as a condiment and in folk medicine. The study also found that a rosemary extract can protect liver mitochondria from oxidative damage in vitro and have antioxidant and hepatoprotective effects in vivo. These findings highlight the potent antioxidant activity of rosemary and its potential health benefits.
Article
Agriculture, Dairy & Animal Science
Bemela Mawulom Tokofai, Kokou Idoh, Oyegunle Emmanuel Oke, Amegnona Agbonon
Summary: The study demonstrated that Vernonia amygdalina extract has hepatoprotective effects on poultry, reducing the adverse effects of carbon tetrachloride-induced liver damage. The aqueous extract at a dose of 100 mg/kg body weight showed a moderate hepatoprotective effect by reducing serum AST levels.
Article
Biochemistry & Molecular Biology
Xin Yan, Yu Wang, Xue-Yang Ren, Xiao-Yun Liu, Jia-Mu Ma, Ruo-Lan Song, Xiu-Huan Wang, Ying Dong, A-Xiang Yu, Qi-Qi Fan, Jing Wei, Gai-Mei She
Summary: The study showed that Thymus quinquecostatus Celak extract has hepatoprotective effects against ALD by improving gut barrier function, modulating gut microbiota, suppressing inflammatory response, and reducing ROS production in the liver.
Article
Agriculture, Dairy & Animal Science
Wei-Yu Yeh, Yi-Ling Lin, Wen-Yuan Yang, Chung-Hsi Chou, Yi-Hsieng Samuel Wu, Yi-Chen Chen
Summary: This study highlights the potential benefits of chicken-liver hydrolysate (CLH) in improving glucose homeostasis and cognitive decline in diabetic mice. CLH supplementation lowered blood glucose levels, enhanced antioxidant capacities, improved memory and cognitive behavior, and reduced neuron damage and deposition caused by diabetes. These findings suggest that CLH could have therapeutic potential for insulin resistance and cognitive decline in hyperglycemia.
Article
Medicine, Research & Experimental
Alaaeldin Ahmed Hamza, Gehan Hussein Heeba, Salsabil Hamza, Ali Abdalla, Amr Amin
Summary: The study demonstrates that ginger has chemo-preventive effects against liver cancer by reducing carcinogenic changes, inducing apoptosis, and protecting the liver from oxidative and inflammatory damage. Ginger also inhibits cell proliferation and promotes cell death, showcasing its potential as a natural preventive agent for liver cancer.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Food Science & Technology
Milos M. Dordevic, Anja Tolic, Jovana Rajic, Mirjana Mihailovic, Jelena Arambasic Jovanovic, Aleksandra Uskokovic, Nevena Grdovic, Marija B. Dordevic, Danijela Misic, Branislav Siler, Melita Vidakovic, Svetlana Dinic
Summary: This study investigated the hepato- and reno-protective effects of methanol extract of Centaurium erythraea Rafn (CEE) in STZ-diabetic rats. The results showed that CEE improved liver and kidney functionality and had antioxidant effects in diabetic rats.
JOURNAL OF FUNCTIONAL FOODS
(2022)
Article
Food Science & Technology
Ivonne Peugnet-Gonzalez, Sandra Luz Martinez-Hernandez, Manuel Enrique Avila-Blanco, David Alejandro Hernandez-Marin, Jose Roberto Macias-Perez, Liseth Rubi Aldaba-Muruato, Teodulo Quezada-Tristan, Joaquin Sosa-Ramirez, Gloria Stephanie Villa-Jaimes, Javier Ventura-Juarez, Martin Munoz-Ortega, David Ibarra-Martinez
Summary: The study found that watercress extract can prevent liver fibrosis induced by CCl4 through its antioxidant and hepatoprotective effects. Watercress extract can improve steatosis and fibrosis, increase IL-10 expression, and regulate the expression of fibrogenic markers.
JOURNAL OF FUNCTIONAL FOODS
(2023)
Article
Engineering, Environmental
Lujia Huang, Xiaoquan Guo, Pei Liu, Yulan Zhao, Cong Wu, Changming Zhou, Cheng Huang, Guyue Li, Yu Zhuang, Sufang Cheng, Huabin Cao, Caiying Zhang, Zheng Xu, Xin Liu, Guoliang Hu, Ping Liu
Summary: The study found that acute DDVP poisoning has serious effects on the brain tissue of broilers, causing hyperglycemia, oxidative stress, brain edema, and neuronal mitochondrial damage. DDVP also significantly altered neurotransmitter secretion, energy metabolism, and amino acid metabolism. Additionally, various metabolites were significantly correlated with blood glucose, oxidative stress biomarkers, and brain injury pathology.
JOURNAL OF HAZARDOUS MATERIALS
(2022)
Article
Biochemistry & Molecular Biology
Ewa Florek, Marta Szukalska, Katarzyna Markiewicz, Izabela Miechowicz, Justyna Gornowicz-Porowska, Anna Jelinska, Joanna Kasprzyk-Pochopien, Joanna Nawrot, Agnieszka Sobczak, Malgorzata Horoszkiewicz, Wojciech Piekoszewski, Gerard Nowak
Summary: The extract from the leaves of Cynara scolymus L. has been found to have a high antioxidative potential and exhibits protective and regenerative effects on the liver, making it beneficial for reducing hepatocellular damage caused by xenobiotics.
Article
Cell Biology
Mohammad Shamsul Ola
Summary: This study examined ROS generation and antioxidant enzyme activities in diabetic rat retinas under various conditions, highlighting a potential decrease in ROS generation and glucose oxidation rate in the short-term hyperglycemic state. However, an increase in ROS formation was observed in diabetic retinas compared to controls in vivo, indicating non-mitochondrial sources may play a significant role in ROS generation in diabetic retinas.
Article
Biochemistry & Molecular Biology
Giulia Matacchione, Debora Valli, Andrea Silvestrini, Angelica Giuliani, Jacopo Sabbatinelli, Chiara Giordani, Sofia Coppari, Maria Rita Rippo, Maria Cristina Albertini, Fabiola Olivieri
Summary: Chronic hyperglycemia, a diagnostic biomarker of Type 2 Diabetes Mellitus (T2DM), promotes oxidative stress and proinflammatory signals, which contribute to cellular senescence. Despite extensive research, the synergistic anti-inflammatory and antioxidant effects of natural compounds in senescent cells and hyperglycemic conditions have not been confirmed. In this study, a mixture of natural compounds significantly decreased the expression of inflammatory markers in both young and replicative senescent cells, suggesting a senomorphic activity. This research highlights the potential of nutraceuticals as adjuvant supplements to counteract proinflammatory and pro-oxidative signals induced by hyperglycemia and senescence.
Article
Biochemistry & Molecular Biology
Bertan Boran Bayrak, Pelin Arda-Pirincci, Sehnaz Bolkent, Refiye Yanardag
Summary: The study showed that zinc sulfate can reverse the effects of ethanol-induced cell proliferation and oxidative damage in tongue tissues of rats, indicating its therapeutic potential in such conditions.
BIOLOGICAL TRACE ELEMENT RESEARCH
(2022)
Article
Medicine, Research & Experimental
Irem Hersek, M. Kutay Koroglu, Busra Coskunlu, Busra Ertas, Goksel Sener, Feriha Ercan
Summary: This study aimed to investigate the effects of apocynin (APC), an inhibitor of NADPH oxidase (NOX), on testicular cytotoxicity induced by high-fat diet (HF). The results showed that HF caused significant changes in serum lipid and hormone levels. It also induced oxidative stress in the testis, leading to abnormalities in sperm parameters and testicular morphology. However, treatment with APC improved these alterations by regulating the oxidant/antioxidant balance.
CLINICAL AND EXPERIMENTAL HEALTH SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Ali Sen, Dilek Ozbeyli, Kerem Terali, Fatih Goger, Aybeniz Yildirim, Busra Ertas, Ahmet Dogan, Leyla Bitis, Goksel Sener
Summary: The study evaluated the therapeutic effect of an active ethanol extract from Rubus tereticaulis leaves against colitis. Major compounds were purified from the extract through bioassay-directed isolation. The rats treated with the extract showed significantly reduced macroscopic scores, colon wet weights, myeloperoxidase activity, malondialdehyde levels, and increased glutathione levels. Kaempferol-3-O-beta-D-glucuronide and quercetin-3-O-beta-D-glucuronide were identified as the major compounds and were found to have anti-inflammatory and antioxidant activity. Quinic acid, 5-caffeoylquinic acid, quercetin pentoside, quercetin glucoside, quercetin3-O-beta-D-glucuronide, kaempferol-3-O-beta-D-glucuronide, and kaempferol rutinoside were also detected in the extract. The study highlights the potential use of the extract as a natural alternative for colitis treatment.
CHEMICO-BIOLOGICAL INTERACTIONS
(2023)
Article
Biochemistry & Molecular Biology
Onur Ertik, Goksel Sener, Refiye Yanardag
Summary: In this study, the effects of prolonged melatonin administration on liver parameters of diabetic rats were examined. The results showed that melatonin treatment prevented the distortion of liver biochemical parameters. This indicates the potential protective effect of melatonin on liver tissue in diabetic conditions.
JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY
(2023)
Article
Gastroenterology & Hepatology
Seren Ede, Dilek Özbeyli, Omer Erdogn, Ozge Cevik, Fatma Kanpalta, Feriha Ercan, Refiye Yanardag, Ozlem Sacan, Onur Ertik, Meral Yuksel, Goksel Senerg
Summary: This study aimed to investigate the possible protective effects of parsley extract (Petroselinum Crispum; PC) against oxidative liver damage caused by bile obstruction in rats. The results showed that PC treatment decreased AST and ALT levels which increased with bile duct ligation (BDL), and oxidant damage parameters also decreased with this treatment. The study concluded that PC extract could be a potential therapeutic agent against liver fibrosis and further studies are needed.
ARAB JOURNAL OF GASTROENTEROLOGY
(2023)
Article
Pharmacology & Pharmacy
Caglar Macit, Dilek Ozbeyli, Ozge Cevik, Melisa Cetin, Goksel Sener, Sevil Ozkan
Summary: This study investigated the protective effects of bitter melon extract against methotrexate-induced nephrotoxicity. The results showed that bitter melon significantly reversed kidney damage caused by methotrexate, indicating its potential as a protective agent.
CURRENT DRUG THERAPY
(2023)
Article
Endocrinology & Metabolism
Onur Ertik, Bertan Boran Bayrak, Goksel Sener, Refiye Yanardag
Summary: The study aimed to investigate the effect of Melatonin (Mel) and/or insulin treatment on oxidative liver and pancreatic injuries in diabetic rats. The results showed that Melatonin or Melatonin + insulin treatment could improve the deteriorated oxidant/antioxidant system in the liver and pancreatic tissues of diabetic rats under long-term oxidative stress conditions.
JOURNAL OF DIABETES AND METABOLIC DISORDERS
(2023)
Article
Biochemistry & Molecular Biology
Ali Sen, Busra Ertas, Ozge Cevik, Aybeniz Yildirim, Damla Gokceoglu Kayali, Dilek Akakin, Leyla Bitis, Goksel Sener
Summary: The effects of Cotinus coggygria ethanol extract (CCE) on colonic structure and inflammation in acetic acid-induced ulcerative colitis in rats were investigated. CCE was found to have a significant protective effect against colonic damage and a potential anti-inflammatory activity by regulating cytokine levels. Additionally, CCE exhibited strong antioxidant activity and a high content of polyphenolic compounds. These findings suggest that CCE could be a promising novel therapy for ulcerative colitis.
APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY
(2023)
Article
Nutrition & Dietetics
Elif Tufan, Guezin Goksun Sivas, Begum Gurel-Gokmen, Suemeyye Yilmaz-Karaoglu, Ercan Dursun, Esin Caliskan-Ak, Aleyna Muhan, Dilek Ozbeyli, Goeksel Sener, Tugba Tunali-Akbay
Summary: This study aimed to evaluate the effects of whey proteins on MTX-induced liver and kidney damage. The results showed that whey protein administration significantly reduced the damage caused by MTX in the liver and kidney due to its antioxidant properties.
BRITISH JOURNAL OF NUTRITION
(2023)
Article
Biochemistry & Molecular Biology
Onur Ertik, Seren Ede Pazarbasi, Goksel Sener, Ozlem Sacan, Refiye Yanardag
Summary: Alzheimer's disease is a neurodegenerative disease that affects the quality of life and causes metabolic defects and tissue damage. This study found that parsley extract has therapeutic effects on lens tissues in an experimental AD model by reducing oxidative stress. This may be due to the phenolic and flavonoid-rich content of parsley extract.
CHEMISTRY & BIODIVERSITY
(2023)
Article
Medicine, General & Internal
Nagehan Ozyilmaz Yay, Nurdan Bulbul Ayci, Rumeysa Keles Kaya, Ali Sen, Goksel Sener, Feriha Ercan
Summary: The study aimed to investigate the protective effects of Myrtus communis L. extract on high fat-diet induced heart and aorta damage by evaluating oxidative stress and the endothelial nitric oxide system (eNOS). The results demonstrated that the extract improved the heart and aorta damage caused by high fat-diet by enhancing the oxidant/antioxidant balance, increasing nitric oxide levels, and reducing oxidative stress and inflammatory cells.
MARMARA MEDICAL JOURNAL
(2023)
Article
Medicine, Research & Experimental
Merve Acikel Elmas, Ozlem Bingol Ozakpinar, Meltem Kolgazi, Goksel Sener, Feriha Ercan
Summary: The aim of this study was to evaluate the ameliorative effects of swimming training on renal and bladder damage caused by a high-fat diet. The results showed that swimming training could reverse the histological damage and altered oxidative stress parameters, suggesting its potential role in regulating oxidative stress.
CLINICAL AND EXPERIMENTAL HEALTH SCIENCES
(2022)
Article
Pharmacology & Pharmacy
Burcin Alev-Tuzuner, Nevin Genc-Kahraman, Hazal Ipekci, Unsal Veli Ustundag, Tugba Tunali-Akbay, Ebru Emekli-Alturfan, Goksel Sener, Aysen Yarat
Summary: Exercise and caloric restriction have impacts on improving metabolic risk factors. This study investigated the changes in the brain after exercise and/or caloric restriction in a rat model of metabolic syndrome induced by a high fructose diet. The results showed that the combination of exercise and caloric restriction (MeS+EXCR) had the best effect in reducing brain tissue damage and improving antioxidant levels.
JOURNAL OF RESEARCH IN PHARMACY
(2022)
Article
Pharmacology & Pharmacy
Busra Erta, Betul Okuyan, Ali Sen, Feriha Ercan, Huseyin Onel, Fatih Goger, Goksel Sener
Summary: The present study evaluated the curative effect of Cotinus coggygria leaves on burn injury and investigated its anti-inflammatory and antioxidant activity. The results showed that Cotinus coggygria leaves can reduce the increased levels of serum cytokines and promote the repair and restoration of damaged tissues to normal levels.
JOURNAL OF RESEARCH IN PHARMACY
(2022)
Article
Biology
Sule Arslan, Ozan Ozcan, Begum Gurel-Gokmen, Zatiye Ayca Cevikelli-Yakut, Halil Ibrahim Saygi, Ali Sen, Fatih Goger, Gozde Erkanli-Senturk, Goksel Sener, Tugba Tunali-Akbay
Summary: This study investigated the effects of myrtle leaf extract on heart, kidney, and aorta tissues in experimental renovascular hypertension. The results showed that myrtle leaf extract administration could decrease increased blood pressure and restore impaired tissues. Therefore, myrtle leaf extract may be considered as an alternative antihypertensive treatment for preventing oxidative stress-induced damage in renovascular hypertension.
Article
Cell Biology
Abril Alondra Barrientos-Bonilla, Paola Belem Pensado-Guevara, Abraham Puga-Olguin, Rasajna Nadella, Aurora del Carmen Sanchez-Garcia, Laura Mireya Zavala-Flores, Arnulfo Villanueva-Olivo, Iliana Tamara Cibrian-Llanderal, Maria de Jesus Rovirosa-Hernandez, Daniel Hernandez-Baltazar
Summary: This study evaluated the impact of BrdU on liver function and found that multiple injections of BrdU did not induce hepatocellular damage.
Article
Cell Biology
Pan Zhang, Qun Feng, Wenxiao Chen, Xizhuang Bai
Summary: It was found that catalpol antagonizes LPS-mediated inflammation and suppressive osteoblast differentiation by inhibiting inflammation and promoting osteoblast differentiation. This finding contributes to a better understanding of the pathogenesis of osteoporosis.
