Progress with the use of monoclonal antibodies for the treatment of systemic lupus erythematosus

Prospective observational single-centre cohort study to evaluate the effectiveness of treating lupus nephritis with rituximab and mycophenolate mofetil but no oral steroids

(2013) Marie B Condon et al.   ANNALS OF THE RHEUMATIC DISEASES

A phase 1b clinical trial evaluating sifalimumab, an anti-IFN-α monoclonal antibody, shows target neutralisation of a type I IFN signature in blood of dermatomyositis and polymyositis patients

(2013) Brandon W Higgs et al.   ANNALS OF THE RHEUMATIC DISEASES

Efficacy and safety of epratuzumab in patients with moderate/severe active systemic lupus erythematosus: results from EMBLEM, a phase IIb, randomised, double-blind, placebo-controlled, multicentre study

(2013) Daniel J Wallace et al.   ANNALS OF THE RHEUMATIC DISEASES

Comparison of Alternative Primary Outcome Measures for Use in Lupus Nephritis Clinical Trials

(2013) David Wofsy et al.   ARTHRITIS AND RHEUMATISM

Efficacy and Safety of Ocrelizumab in Active Proliferative Lupus Nephritis: Results From a Randomized, Double-Blind, Phase III Study

(2013) Eduardo F. Mysler et al.   ARTHRITIS AND RHEUMATISM

Sifalimumab, a Human Anti-Interferon-α Monoclonal Antibody, in Systemic Lupus Erythematosus: A Phase I Randomized, Controlled, Dose-Escalation Study

(2013) Michelle Petri et al.   ARTHRITIS AND RHEUMATISM

Targeting the complement system in systemic lupus erythematosus and other diseases

(2013) Maria-Louise Barilla-LaBarca et al.   CLINICAL IMMUNOLOGY

Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of Anti-TWEAK Monoclonal Antibody in Patients With Rheumatoid Arthritis

(2013) Nicolas Wisniacki et al.   CLINICAL THERAPEUTICS

Complement therapy in atypical haemolytic uraemic syndrome (aHUS)

(2013) Edwin K.S. Wong et al.   MOLECULAR IMMUNOLOGY

The identification of a novel splicing mutation in C1qB in a Japanese family with C1q deficiency: a case report

(2013) Yousuke Higuchi et al.   Pediatric Rheumatology

Suppression of soluble T cell-associated proteins by an anti-interferon-  monoclonal antibody in adult patients with dermatomyositis or polymyositis

(2013) X. Guo et al.   RHEUMATOLOGY

Efficacy and safety of epratuzumab in patients with moderate/severe flaring systemic lupus erythematosus: results from two randomized, double-blind, placebo-controlled, multicentre studies (ALLEVIATE) and follow-up

(2013) Daniel J. Wallace et al.   RHEUMATOLOGY

Efficacy and Safety of Abatacept in Lupus Nephritis: A Twelve-Month, Randomized, Double-Blind Study

(2013) Richard Furie et al.   Arthritis & Rheumatology

Impact of anti-interleukin-6 receptor blockade on circulating T and B cell subsets in patients with systemic lupus erythematosus

(2012) Yuko Shirota et al.   ANNALS OF THE RHEUMATIC DISEASES

Belimumab in the treatment of systemic lupus erythematosus: high disease activity predictors of response

(2012) Ronald F van Vollenhoven et al.   ANNALS OF THE RHEUMATIC DISEASES

Safety and pharmacodynamics of rontalizumab in patients with systemic lupus erythematosus: Results of a phase I, placebo-controlled, double-blind, dose-escalation study

(2012) Jacqueline M. McBride et al.   ARTHRITIS AND RHEUMATISM

Efficacy and safety of rituximab in patients with active proliferative lupus nephritis: The lupus nephritis assessment with rituximab study

(2012) Brad H. Rovin et al.   ARTHRITIS AND RHEUMATISM

Abatacept for lupus nephritis: Alternative definitions of complete response support conflicting conclusions

(2012) David Wofsy et al.   ARTHRITIS AND RHEUMATISM

Successful Use of Interleukin 6 Antagonist Tocilizumab in a Patient With Refractory Cutaneous Lupus and Urticarial Vasculitis

(2012) Ashima Makol et al.   JCR-JOURNAL OF CLINICAL RHEUMATOLOGY

Induction of severe systemic lupus erythematosus by TNF blockade and response to anti–IL-6 strategy

(2012) Sabine Adler et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Taming lupus—a new understanding of pathogenesis is leading to clinical advances

(2012) Zheng Liu et al.   NATURE MEDICINE

Eculizumab for the Treatment of Dense-Deposit Disease

(2012) Marina Vivarelli et al.   NEW ENGLAND JOURNAL OF MEDICINE

Tocilizumab for treating refractory haemolytic anaemia in a patient with systemic lupus erythematosus

(2012) F. J. Garcia-Hernandez et al.   RHEUMATOLOGY

Atacicept in combination with MMF and corticosteroids in lupus nephritis: results of a prematurely terminated trial

(2012) Ellen M Ginzler et al.   ARTHRITIS RESEARCH & THERAPY

Safety profile and clinical activity of sifalimumab, a fully human anti-interferon   monoclonal antibody, in systemic lupus erythematosus: a phase I, multicentre, double-blind randomised study

(2011) J. T. Merrill et al.   ANNALS OF THE RHEUMATIC DISEASES

B cell biomarkers of rituximab responses in systemic lupus erythematosus

(2011) Edward M. Vital et al.   ARTHRITIS AND RHEUMATISM

A phase III, randomized, placebo-controlled study of belimumab, a monoclonal antibody that inhibits B lymphocyte stimulator, in patients with systemic lupus erythematosus

(2011) Richard Furie et al.   ARTHRITIS AND RHEUMATISM

Efficacy of rituximab in 164 patients with biopsy-proven lupus nephritis: Pooled data from European cohorts

(2011) Cándido Díaz-Lagares et al.   AUTOIMMUNITY REVIEWS

Molecular basis of hereditary C1q deficiency—revisited: identification of several novel disease-causing mutations

(2011) L Schejbel et al.   GENES AND IMMUNITY

Tumor Necrosis Factor-Like Weak Inducer of Apoptosis (TWEAK) Mediates p38 Mitogen-Activated Protein Kinase Activation and Signal Transduction in Peripheral Blood Mononuclear Cells from Patients with Lupus Nephritis

(2011) Liu Zhi-Chun et al.   INFLAMMATION

Netting Neutrophils Induce Endothelial Damage, Infiltrate Tissues, and Expose Immunostimulatory Molecules in Systemic Lupus Erythematosus

(2011) E. Villanueva et al.   JOURNAL OF IMMUNOLOGY

Efficacy and safety of belimumab in patients with active systemic lupus erythematosus: a randomised, placebo-controlled, phase 3 trial

(2011) Sandra V Navarra et al.   LANCET

Rituximab induces a rapid and sustained remission in Colombian patients with severe and refractory systemic lupus erythematosus

(2011) LF Pinto et al.   LUPUS

Are autoantibodies the targets of B-cell-directed therapy?

(2011) David S. Pisetsky et al.   Nature Reviews Rheumatology

Gene expression of TWEAK/Fn14 and IP-10/CXCR3 in glomerulus and tubulointerstitium of patients with lupus nephritis

(2011) JIANXIN LU et al.   NEPHROLOGY

Neutrophils Activate Plasmacytoid Dendritic Cells by Releasing Self-DNA-Peptide Complexes in Systemic Lupus Erythematosus

(2011) R. Lande et al.   Science Translational Medicine

Netting Neutrophils Are Major Inducers of Type I IFN Production in Pediatric Systemic Lupus Erythematosus

(2011) G. S. Garcia-Romo et al.   Science Translational Medicine

Rates of, and risk factors for, severe infections in patients with systemic autoimmune diseases receiving biological agents off-label

(2011) Cándido Díaz-Lagares et al.   ARTHRITIS RESEARCH & THERAPY

The efficacy and safety of abatacept in patients with non-life-threatening manifestations of systemic lupus erythematosus: Results of a twelve-month, multicenter, exploratory, phase IIb, randomized, double-blind, placebo-controlled trial

(2010) J. T. Merrill et al.   ARTHRITIS AND RHEUMATISM

Safety and efficacy of rituximab in systemic lupus erythematosus: Results from 136 patients from the French autoimmunity and rituximab registry

(2010) Benjamin Terrier et al.   ARTHRITIS AND RHEUMATISM

Tocilizumab in systemic lupus erythematosus: Data on safety, preliminary efficacy, and impact on circulating plasma cells from an open-label phase I dosage-escalation study

(2010) Gabor G. Illei et al.   ARTHRITIS AND RHEUMATISM

Treatment of systemic lupus erythematosus with epratuzumab

(2010) Pawel Traczewski et al.   BRITISH JOURNAL OF CLINICAL PHARMACOLOGY

B cells as therapeutic targets in SLE

(2010) Iñaki Sanz et al.   Nature Reviews Rheumatology

Long-term efficacy and safety of rituximab in refractory and relapsing systemic lupus erythematosus

(2010) F. Catapano et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

Rituximab versus Cyclophosphamide for ANCA-Associated Vasculitis

(2010) John H. Stone et al.   NEW ENGLAND JOURNAL OF MEDICINE

Rituximab versus Cyclophosphamide in ANCA-Associated Renal Vasculitis

(2010) Rachel B. Jones et al.   NEW ENGLAND JOURNAL OF MEDICINE

Eculizumab and Renal Transplantation in a Patient with CAPS

(2010) Bonnie E. Lonze et al.   NEW ENGLAND JOURNAL OF MEDICINE

Systemic lupus erythematosus and its ABCs (APRIL/BLyS complexes)

(2010) William Stohl   ARTHRITIS RESEARCH & THERAPY

B-lymphocyte stimulator/a proliferation-inducing ligand heterotrimers are elevated in the sera of patients with autoimmune disease and are neutralized by atacicept and B cell maturation antigen-immunoglobulin

(2010) Stacey R Dillon et al.   ARTHRITIS RESEARCH & THERAPY

TWEAK and its receptor Fn14 in the synovium of patients with rheumatoid arthritis compared to psoriatic arthritis and its response to tumour necrosis factor blockade

(2009) A W R van Kuijk et al.   ANNALS OF THE RHEUMATIC DISEASES

A retrospective seven-year analysis of the use of B cell depletion therapy in systemic lupus erythematosus at university college london hospital: The first fifty patients

(2009) Tim Y.-T. Lu et al.   ARTHRITIS AND RHEUMATISM

Efficacy and safety of rituximab in moderately-to-severely active systemic lupus erythematosus: The randomized, double-blind, phase ii/iii systemic lupus erythematosus evaluation of rituximab trial

(2009) Joan T. Merrill et al.   ARTHRITIS AND RHEUMATISM

Etanercept-associated SLE with lupus nephritis

(2009) A Neradová et al.   LUPUS

Rituximab is an effective treatment for lupus nephritis and allows a reduction in maintenance steroids

(2009) R. Pepper et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

Renal damage is the most important predictor of mortality within the damage index: data from LUMINA LXIV, a multiethnic US cohort

(2009) M. I. Danila et al.   RHEUMATOLOGY

Adverse events and efficacy of TNF-  blockade with infliximab in patients with systemic lupus erythematosus: long-term follow-up of 13 patients

(2009) M. Aringer et al.   RHEUMATOLOGY

Understanding the Epidemiology and Progression of Systemic Lupus Erythematosus

(2009) Guillermo J. Pons-Estel et al.   SEMINARS IN ARTHRITIS AND RHEUMATISM

Progressive multifocal leucoencephalopathy in the rheumatic diseases: assessing the risks of biological immunosuppressive therapies

(2008) L. H. Calabrese et al.   ANNALS OF THE RHEUMATIC DISEASES

Efficacy and safety of TNF-blocker therapy in systemic lupus erythematosus

(2008) Martin Aringer et al.   Expert Opinion On Drug Safety

Changing Patterns in Mortality and Disease Outcomes for Patients with Systemic Lupus Erythematosus

(2008) Murray B. Urowitz et al.   JOURNAL OF RHEUMATOLOGY

The role of tumor necrosis factor-alpha in systemic lupus erythematosus

(2008) Martin Aringer et al.   ARTHRITIS RESEARCH & THERAPY