Are autoantibodies the targets of B-cell-directed therapy?

Efficacy and safety of belimumab in patients with active systemic lupus erythematosus: a randomised, placebo-controlled, phase 3 trial

(2011) Sandra V Navarra et al.   LANCET

Long-lived autoreactive plasma cells drive persistent autoimmune inflammation

(2011) Falk Hiepe et al.   Nature Reviews Rheumatology

TLR9 Regulates TLR7- and MyD88-Dependent Autoantibody Production and Disease in a Murine Model of Lupus

(2010) Kevin M. Nickerson et al.   JOURNAL OF IMMUNOLOGY

TLR recognition of self nucleic acids hampers glucocorticoid activity in lupus

(2010) Cristiana Guiducci et al.   NATURE

Rituximab versus Cyclophosphamide for ANCA-Associated Vasculitis

(2010) John H. Stone et al.   NEW ENGLAND JOURNAL OF MEDICINE

Atacicept: targeting B cells in multiple sclerosis

(2010) Hans-Peter Hartung et al.   Therapeutic Advances in Neurological Disorders

Effect of long-term belimumab treatment on b cells in systemic lupus erythematosus: Extension of a phase II, double-blind, placebo-controlled, dose-ranging study

(2009) Annett M. Jacobi et al.   ARTHRITIS AND RHEUMATISM

Immunization responses in rheumatoid arthritis patients treated with rituximab: Results from a controlled clinical trial

(2009) Clifton O. Bingham et al.   ARTHRITIS AND RHEUMATISM

Efficacy and safety of rituximab in moderately-to-severely active systemic lupus erythematosus: The randomized, double-blind, phase ii/iii systemic lupus erythematosus evaluation of rituximab trial

(2009) Joan T. Merrill et al.   ARTHRITIS AND RHEUMATISM

New approaches of B-cell-directed therapy: beyond rituximab

(2009) Thomas Dörner et al.   CURRENT OPINION IN RHEUMATOLOGY

Baseline autoantibody profiles predict normalization of complement and anti-dsDNA autoantibody levels following Rituximab treatment in systemic lupus erythematosus

(2009) GW Tew et al.   LUPUS

Concentration of antibodies to extractable nuclear antigens and disease activity in systemic lupus erythematosus

(2009) S Agarwal et al.   LUPUS

B cells in autoimmunity

(2009) Thomas Dörner et al.   ARTHRITIS RESEARCH & THERAPY

Anti-DNA antibodies in the pathogenesis of lupus nephritis — The emerging mechanisms

(2008) Susan Yung et al.   AUTOIMMUNITY REVIEWS

T Cell-Independent and Toll-like Receptor-Dependent Antigen-Driven Activation of Autoreactive B Cells

(2008) Robin A. Herlands et al.   IMMUNITY

The proteasome inhibitor bortezomib depletes plasma cells and protects mice with lupus-like disease from nephritis

(2008) Kirsten Neubert et al.   NATURE MEDICINE

B-Cell Depletion with Rituximab in Relapsing–Remitting Multiple Sclerosis

(2008) Stephen L. Hauser et al.   NEW ENGLAND JOURNAL OF MEDICINE

Serum and Cerebrospinal Fluid Autoantibodies in Patients with Neuropsychiatric Lupus Erythematosus. Implications for Diagnosis and Pathogenesis

(2008) Hilda Fragoso-Loyo et al.   PLoS One