Article
Medicine, Research & Experimental
Dan Xu, Swati Bhattacharyya, Wenxia Wang, Igal Ifergan, Ming-Yi Alice Chiang Wong, Daniele Procissi, Anjana Yeldandi, Swarna Bale, Roberta Goncalves Marangoni, Craig Horbinski, Stephen D. Miller, John Varga
Summary: Systemic sclerosis (SSc) is a chronic orphan disease with a poorly understood pathogenesis. We have found that monocytes and macrophages expressing the scavenger receptor MARCO play a significant role in chronic inflammation and fibrosis in SSc. Treatment with PLG nanoparticles could effectively reduce skin and lung inflammation and fibrosis. In vitro, PLG nanoparticles inhibited TGF-dependent fibrotic responses.
Article
Cell Biology
Frances S. Li, Kathryn S. Carpentier, David W. Hawman, Cormac J. Lucas, Stephanie E. Ander, Heinz Feldmann, Thomas E. Morrison
Summary: Arboviruses are a public health threat, and this study demonstrates the role of the scavenger receptor MARCO in efficiently clearing alphaviruses from circulation. MARCO promotes binding and internalization of CHIKV, ONNV, and RRV in vitro. The species-specific effects of MARCO on CHIKV internalization suggest a potential role in determining the host's ability to amplify or clear the virus.
Article
Multidisciplinary Sciences
M. Clement, J. L. Forbester, M. Marsden, P. Sabberwal, M. S. Sommerville, D. Wellington, S. Dimonte, S. Clare, K. Harcourt, Z. Yin, L. Nobre, R. Antrobus, B. Jin, M. Chen, S. Makvandi-Nejad, J. A. Lindborg, S. M. Strittmatter, M. P. Weekes, R. J. Stanton, T. Dong, I. R. Humphreys
Summary: IFITM3 restricts viral pathogenesis by regulating Nogo-B-mediated inflammatory response, not only in response to cytomegalovirus but also to influenza and SARS-CoV-2.
NATURE COMMUNICATIONS
(2022)
Article
Medicine, Research & Experimental
Tao Sun, Chunxue Wei, Daoyong Wang, Xuxu Wang, Jiao Wang, Yuqing Hu, Xiaohua Mao
Summary: mascRNA plays a crucial role in regulating innate immune responses by inhibiting pro-inflammatory signaling pathways and promoting antiviral signaling pathways, with potential therapeutic implications in immune-related diseases.
Article
Oncology
Yui Yamazaki, Hidenori Wake, Takashi Nishinaka, Omer Faruk Hatipoglu, Keyue Liu, Masahiro Watanabe, Takao Toyomura, Shuji Mori, Tadashi Yoshino, Masahiro Nishibori, Hideo Takahashi
Summary: The study suggests that scavenger receptors CD36, CD163, and LOX-1, along with the RAGE receptor, work together to mediate toxic AGE-induced facilitation of angiogenesis.
EXPERIMENTAL CELL RESEARCH
(2021)
Article
Immunology
Raissa Timmerman, Ella A. Zuiderwijk-Sick, Jeffrey J. Bajramovic
Summary: TLR-induced signaling triggers inflammatory responses, and the P2Y6 receptor enhances pro-inflammatory cytokine levels, especially in microglia. Through transcriptome analysis, P2Y6 signaling amplifies pro-inflammatory responses in microglia by regulating the expression of target genes through modulation of transcription factors. Additionally, inhibition of P2Y6 signaling strongly induces heat shock protein expression. These findings shed new light on the specific pro-inflammatory role of P2Y6 signaling in neuroinflammation and may provide novel approaches to control brain inflammatory responses.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Nutrition & Dietetics
Adrian D. Friedrich, Juliana Leoni, Mariela L. Paz, Daniel H. Gonzalez Maglio
Summary: Lipoteichoic acid (LTA) from different Gram-positive bacterial sources has varying immune effects. Lacticaseibacillus rhamnosus GG LTA (LGG-LTA) oral administration reduces UVB-induced immunosuppression and skin tumor development in mice. In this study, the immunomodulatory effects of LGG-LTA on dendritic cells (DC) and T cells were evaluated in vitro and in the gut-associated lymphoid tissue (GALT). The results showed that LGG-LTA activated DC and T cells, promoting Th1-biased immune response after oral LTA administration.
Article
Cell Biology
Naveen Sharma, Ajay Suresh Akhade, Sana Ismaeel, Ayub Qadri
Summary: TLRs recognize conserved pathogen associated molecular patterns and generate innate immune responses. Collaborating proteins can sense microbial ligands and promote inflammatory responses. Host lipids amplify TLR-induced cellular responses and represent a novel pathway for enhancing innate immunity and inflammation.
JOURNAL OF LEUKOCYTE BIOLOGY
(2021)
Article
Immunology
Fernando Bandeira Sulczewski, Larissa Alves Martino, Davi Salles, Marcio Massao Yamamoto, Daniela Santoro Rosa, Silvia Beatriz Boscardin
Summary: In this study, the researchers investigated the role of the STAT3 signaling pathway in the ability of different types of dendritic cells to prime CD4(+) T cell responses. They found that STAT3 signaling pathway regulates the function of cDC1 to promote Th1 and Th1-like Tfh cell responses, but does not control the ability of cDC2 to promote Tfh cell responses.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Physiology
Sabin Bhandari, Anett Kristin Larsen, Peter McCourt, Bard Smedsrod, Karen Kristine Sorensen
Summary: This review outlines the blood clearance function of liver sinusoidal endothelial cells (LSECs) in both health and disease, highlighting their high-affinity receptors and intracellular vesicle transport system. It also discusses the similarities and differences between LSECs and specialized scavenger endothelial cells (SECs) in various vascular beds and vertebrate classes. The activity of LSECs and other SECs helps to maintain blood and tissue homeostasis by efficiently clearing large molecules and nanoparticles, but this process may also result in unwanted uptake of nanomedicines and biologics.
FRONTIERS IN PHYSIOLOGY
(2021)
Article
Environmental Sciences
Miki Kuroiwa, Shin-Ichiro Yamaguchi, Yoshinobu Kato, Arisa Hori, Saori Toyoura, Mai Nakahara, Nobuyuki Morimoto, Masafumi Nakayama
Summary: Our study demonstrates that the receptor Tim4 mediates the interaction between macrophages and microplastics through aromatic-aromatic interactions. It is involved in the engulfment of PS microplastics and MWCNTs, and disrupts the process of efferocytosis. These findings suggest that chronic exposure to large amounts of PS microplastics may lead to chronic inflammation and autoimmune diseases.
SCIENCE OF THE TOTAL ENVIRONMENT
(2023)
Article
Multidisciplinary Sciences
Kazuki Tawaratsumida, Vanessa Redecke, Ruiqiong Wu, Jeeba Kuriakose, Jill J. Bouchard, Tanja Mittag, Brian K. Lohman, Ashutosh Mishra, Anthony A. High, Hans Haecker
Summary: This study identifies a key regulatory mechanism for IRF family members controlling TLR biology. It reveals that LYN phosphorylates and degrades IRFs, thereby controlling IRF activity. Additionally, it shows that CSK regulates LYN activity by recruiting it into the TLR signaling complex and activating its catalytic activity.
Article
Multidisciplinary Sciences
Carlos E. Rivera, Yulai Zhou, Daniel P. Chupp, Hui Yan, Amanda D. Fisher, Raphael Simon, Hong Zan, Zhenming Xu, Paolo Casali
Summary: Maturation of antibody responses involves B cell Toll-like receptor (TLR) coengagement with B cell receptor (BCR), leading to various processes including somatic hypermutation (SHM), class-switch DNA recombination (CSR), plasma cell differentiation, and memory B cell generation. TLR-BCR coengagement requires linkage of TLR and BCR ligands, and it can induce mature antibody responses and protective antibodies against microbial pathogens, such as Escherichia coli and Salmonella Typhi-murium, without T cell help.
Article
Engineering, Biomedical
Rakibul Islam, Mohammad Mirazul Islam, Per H. Nilsson, Camilla Mohlin, Kjersti Thorvaldsen Hagen, Eleftherios Paschalis, Russell L. Woods, Sabuj Chandra Bhowmick, Claes H. Dohlman, Terje Espevik, James Chodosh, Miguel Gonzalez-Andrades, Tom Eirik Mollnes
Summary: Inadequate donor cornea supply has led to increased interest in corneal xenotransplantation, but innate immune responses remain a significant barrier. This study demonstrates the potential of blocking C5 and CD14 to inhibit porcine cornea-induced innate immune responses, offering promising therapeutic potential for overcoming immunological barriers in pig-to-human corneal xenotransplantation.
ACTA BIOMATERIALIA
(2021)
Article
Cell Biology
Qian Wang, Zhaoyang Chen, Junjie Guo, Xiaoping Peng, Zeqi Zheng, Hang Chen, Haibo Liu, Yuanji Ma, Jianbing Zhu
Summary: Our study found that atorvastatin-induced tDCs have a beneficial effect on post-infarction cardiomyocyte apoptosis and myocardial fibrosis, reducing inflammatory cell infiltration and inhibiting oxidative stress, likely through suppression of TLR-4/NF-kappa B activation.
INFLAMMATION RESEARCH
(2023)
Article
Cell Biology
Caitlin C. Zebley, Rama S. Akondy, Benjamin A. Youngblood, Haydn T. Kissick
Summary: The pool of memory CD8 T cells consists of highly specialized subpopulations of cells with both shared and distinct functions. Current research on T-cell memory focuses on how these subpopulations arise, how the cells are maintained over the host's lifespan, and how they protect the host against reinfection. However, the use of surface markers to define and study these memory T-cell subsets is proving to be inadequate, and there is a need for an updated definition using the epigenetic state of cells to better characterize the functional capacity of CD8 memory T-cell subsets.
COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY
(2022)
Meeting Abstract
Oncology
Mehmet Asim Bilen, Yuan Liu, Bassel Nazha, Jacqueline T. Brown, Adeboya O. Osunkoya, Sierra Williams, Wilena Session, Lauren Beth Yantorni, Greta Russler, Sarah Caulfield, Shreyas S. Joshi, Vikram M. Narayan, Christopher Paul Filson, Kenneth Ogan, Omer Kucuk, Bradley Curtis Carthon, Haydn Kissick, Viraj A. Master
JOURNAL OF CLINICAL ONCOLOGY
(2022)
Meeting Abstract
Oncology
Gregory E. Sanda, Julie M. Shabto, Subir Goyal, Yuan Liu, Dylan J. Martini, Bassel Nazha, Jacqueline T. Brown, Lauren Beth Yantorni, Greta Russler, Sarah Caulfield, Shreyas S. Joshi, Vikram M. Narayan, Haydn Kissick, Kenneth Ogan, Viraj A. Master, Bradley Curtis Carthon, Omer Kucuk, Mehmet Asim Bilen
JOURNAL OF CLINICAL ONCOLOGY
(2022)
Article
Oncology
Amir Ishaq Khan, Sarah P. Psutka, Dattatraya H. Patil, Gordon Hong, Milton A. Williams, Mehmet A. Bilen, Aarti Sekhar, Haydn T. Kissick, Vikram M. Narayan, Shreyas S. Joshi, Kenneth Ogan, Viraj A. Master
Summary: Sarcopenia and high systemic inflammation are independently associated with poor OS after CN, providing potential use in preoperative risk stratification.
Article
Oncology
Bindu Varghese, Lydia Lynch, Lianne E. Vriend, Dobrin Draganov, Justice M. Clark, Haydn T. Kissick, Sharlin Varghese, Martin G. Sanda, Glenn Dranoff, M. Simo Arredouani, Steven P. Balk, Mark A. Exley
Summary: By adding α GC to a tumor cell vaccine, the therapeutic effect against prostate cancer can be enhanced. In a therapeutic model, mice treated with the combination vaccine showed prolonged survival and tumor inhibition. Mechanistic studies revealed that GM-CSF and iNKT cells in the vaccine played a crucial role in anti-tumor immune responses.
CANCER IMMUNOLOGY IMMUNOTHERAPY
(2022)
Editorial Material
Oncology
Haydn Kissick, Rafi Ahmed
Summary: In this article, Belk et al. conducted an in vitro CRISPR screen to identify genes that regulate CD8(+) T cell exhaustion. They discovered several genes related to epigenetic modification and demonstrated that eliminating Arid1a enables CD8(+) T cells to retain their proliferative and cytotoxic function in vivo, resulting in improved anti-tumor activity.
Article
Oncology
Jennifer Wilkinson Carlisle, Caroline S. Jansen, Maria Andrea Cardenas, Ewelina Sobierajska, Adriana Moon Reyes, Rachel Greenwald, Luke Del Balzo, Nataliya Prokhnevska, Omer Kucuk, Bradley C. Carthon, Patrick Connor Mullane, Adeboye Osunkoya, Deborah Baumgarten, Fares Hosseinzadeh, Scott Wilkinson, Ross Lake, Adam G. Sowalsky, Yuan Liu, Viraj A. Master, Mehmet A. Bilen, Haydn Kissick
Summary: This study identifies potential immunological biomarkers that can predict therapeutic response in patients with advanced renal cell carcinoma (RCC). Assessing changes in T cells in the peripheral blood and tumor microenvironment, the researchers found that patients with the highest increase in specific activated T cells had the best antitumor immune response and clinical benefit.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2022)
Article
Immunology
Nataliya Prokhnevska, Maria A. Cardenas, Rajesh M. Valanparambil, Ewelina Sobierajska, Benjamin G. Barwick, Caroline Jansen, Adriana Reyes Moon, Petra Gregorova, Luke delBalzo, Rachel Greenwald, Mehmet Asim Bilen, Mehrdad Alemozaffar, Shreyas Joshi, Cara Cimmino, Christian Larsen, Viraj Master, Martin Sanda, Haydn Kissick
Summary: Improvements in tumor immunotherapies rely on understanding the T cell response to tumors. By studying tumor-draining lymph nodes (TDLNs), it was discovered that activated CD8+ T cells in TDLNs shared characteristics with stem-like cells in tumors. These TDLN cells were revealed to be precursors of tumor-resident stem-like CD8+ T cells. Murine tumor models showed that tumor-specific CD8+ T cells were activated in TDLNs and later differentiated into effector cells in the tumor with co-stimulation.
Article
Virology
Amanda L. Gill, William H. Hudson, Rajesh M. Valanparambil, Eunseon Ahn, Donald J. McGuire, Andreas Wieland, Daniel T. McManus, Haydn T. Kissick, Rama S. Akondy, Rafi Ahmed
Summary: A better understanding of long-lived memory CD8 T cell differentiation is necessary due to increased demand for novel vaccination strategies. Using a mouse model of acute LCMV infection, we conducted an in-depth, longitudinal analysis of memory CD8 T cell subsets, examining their phenotype, transcriptional programming, and anatomical location in the spleen. We characterized a comprehensive memory phenotype associated with higher CD28 expression and found distinct localization programs within the spleen for memory subsets. These findings suggest that memory formation and survival may be influenced by location, emphasizing the importance of considering memory phenotypes and their trafficking for robust memory responses following vaccination.
JOURNAL OF VIROLOGY
(2023)
Article
Oncology
Gregory E. Sanda, Julie M. Shabto, Subir Goyal, Yuan Liu, Dylan J. Martini, Bassel Nazha, Jacqueline T. Brown, Lauren B. Yantorni, Greta Anne Russler, Sarah Caulfield, Shreyas S. Joshi, Vikram M. Narayan, Haydn Kissick, Kenneth Ogan, Viraj A. Master, Bradley C. Carthon, Omer Kucuk, Mehmet Asim Bilen
Summary: A retrospective study investigated the relationship between immune-related adverse events (irAEs) and clinical outcomes in patients with advanced urothelial cancer who received immune checkpoint inhibitor therapy. The results showed that patients with irAEs, especially dermatologic irAEs, had significantly improved overall survival (OS), progression-free survival (PFS), and clinical benefit (CB).
Meeting Abstract
Oncology
Brendan L. C. Kinney, Connor Parrish, Vikash Kansal, Zachary S. Buchwald, Haydn T. Kissick, Amy Y. Chen, Nicole C. Schmitt
Meeting Abstract
Oncology
Jimmy Patel, Amber Draper, Yena Woo, Layla Dhabaan, Pretesh Patel, Ashesh Jani, Bradley Carthon, Viraj Master, Haydn Kissick, Mehmet Bilen, Zachary Buchwald, David Qian
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2022)
Meeting Abstract
Oncology
Guillermo Rangel RIvera, Connor Dwyer, Hannah Knochelmann, Aubrey Smith, Anna Cole, Megan Wyatt, Chrystal Paulos, Jessica Thaxton, Shikhar Mehrotra, Haydn Kissick, Mark Rubinstein, Gregory Lesinski
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2022)
Meeting Abstract
Oncology
Eric J. Miller, Carrie Q. Sun, Petra Gregorova, Edgars Jecs, Yesim Altas Tahirovic, Robert J. Wilson, Huy H. Nguyen, Savita K. Sharma, Perry Bartsch, Zachary Sticher, Levi Moellering, Priscilla Davidson, Ryan Jajosky, Michael D'Erasmo, Manohar Saindane, Zafer Sahin, Nicholas S. Akins, Alexander A. Kolykhalov, Lawrence Wilson, Rebecca S. Arnold, John A. Petros, Haydn Kissick, Lingjie Xu, Yi Jiang, Dennis C. Liotta
Meeting Abstract
Immunology
Nataliya Prokhnevska, Maria A. Cardenas, Rajesh Valanparambil, Ewelina Sobierajska, Caroline Jansen, Viraj Master, Martin Sanda, Haydn Kissick
JOURNAL OF IMMUNOLOGY
(2022)