Molecular mechanism and cellular function of MHCII ubiquitination

Distinct Contributions of Aire and Antigen-Presenting-Cell Subsets to the Generation of Self-Tolerance in the Thymus

(2014) Justin S.A. Perry et al.   IMMUNITY

Cutting Edge: Antigen-Specific Thymocyte Feedback Regulates Homeostatic Thymic Conventional Dendritic Cell Maturation

(2014) N. A. Spidale et al.   JOURNAL OF IMMUNOLOGY

Costimulation via the tumor-necrosis factor receptor superfamily couples TCR signal strength to the thymic differentiation of regulatory T cells

(2014) Shawn A Mahmud et al.   NATURE IMMUNOLOGY

Ubiquitin in the immune system

(2013) Julia Zinngrebe et al.   EMBO REPORTS

Loss of MHC II ubiquitination inhibits the activation and differentiation of CD4 T cells

(2013) Rikiya Ishikawa et al.   INTERNATIONAL IMMUNOLOGY

MARCH1-mediated MHCII ubiquitination promotes dendritic cell selection of natural regulatory T cells

(2013) Jaehak Oh et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Antigen-Specific Induced T Regulatory Cells Impair Dendritic Cell Function via an IL-10/MARCH1-Dependent Mechanism

(2013) G. Chattopadhyay et al.   JOURNAL OF IMMUNOLOGY

Kaposi’s Sarcoma-Associated Herpesvirus K3 and K5 Proteins Down Regulate Both DC-SIGN and DC-SIGNR

(2013) Sabine M. Lang et al.   PLoS One

Internalizing MHC class II-peptide complexes are ubiquitinated in early endosomes and targeted for lysosomal degradation

(2013) K. Furuta et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Autoreactive thymic B cells are efficient antigen-presenting cells of cognate self-antigens for T cell negative selection

(2013) J. Perera et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

MHC Class II Antigen Presentation by Dendritic Cells Regulated through Endosomal Sorting

(2013) T. ten Broeke et al.   Cold Spring Harbor Perspectives in Biology

Ubiquitin-Binding Proteins: Decoders of Ubiquitin-Mediated Cellular Functions

(2012) Koraljka Husnjak et al.   Annual Review of Biochemistry

Decisions About Dendritic Cells: Past, Present, and Future

(2012) Ralph M. Steinman   Annual Review of Immunology

A Broad Range of Self-Reactivity Drives Thymic Regulatory T Cell Selection to Limit Responses to Self

(2012) Hyang-Mi Lee et al.   IMMUNITY

Structural Requirements for Recognition of Major Histocompatibility Complex Class II by Membrane-associated RING-CH (MARCH) Protein E3 Ligases

(2012) Martin Jahnke et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

B cell survival, surface BCR and BAFFR expression, CD74 metabolism, and CD8−dendritic cells require the intramembrane endopeptidase SPPL2A

(2012) Hannes Bergmann et al.   JOURNAL OF EXPERIMENTAL MEDICINE

The intramembrane protease SPPL2a promotes B cell development and controls endosomal traffic by cleavage of the invariant chain

(2012) Janna Schneppenheim et al.   JOURNAL OF EXPERIMENTAL MEDICINE

The intramembrane protease Sppl2a is required for B cell and DC development and survival via cleavage of the invariant chain

(2012) Daniel R. Beisner et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Autoregulation of MARCH1 Expression by Dimerization and Autoubiquitination

(2012) M.-C. Bourgeois-Daigneault et al.   JOURNAL OF IMMUNOLOGY

MHC class II distribution in dendritic cells and B cells is determined by ubiquitin chain length

(2012) J. K. Ma et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Strong CD28 costimulation suppresses induction of regulatory T cells from naive precursors through Lck signaling

(2011) K. Semple et al.   BLOOD

CD83 increases MHC II and CD86 on dendritic cells by opposing IL-10–driven MARCH1-mediated ubiquitination and degradation

(2011) Lina E. Tze et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Ubiquitination of CD86 Is a Key Mechanism in Regulating Antigen Presentation by Dendritic Cells

(2011) G. Baravalle et al.   JOURNAL OF IMMUNOLOGY

SCIMP, a Transmembrane Adaptor Protein Involved in Major Histocompatibility Complex Class II Signaling

(2011) P. Draber et al.   MOLECULAR AND CELLULAR BIOLOGY

Human cytomegalovirus decreases constitutive transcription of MHC class II genes in mature Langerhans cells by reducing CIITA transcript levels

(2011) Andrew W. Lee et al.   MOLECULAR IMMUNOLOGY

Intracellular MHC class II molecules promote TLR-triggered innate immune responses by maintaining activation of the kinase Btk

(2011) Xingguang Liu et al.   NATURE IMMUNOLOGY

A role for interleukin-2 trans-presentation in dendritic cell–mediated T cell activation in humans, as revealed by daclizumab therapy

(2011) Simone C Wuest et al.   NATURE MEDICINE

Ubiquitin-Dependent Control of Class II MHC Localization Is Dispensable for Antigen Presentation and Antibody Production

(2011) Annette M. McGehee et al.   PLoS One

What Has the Study of the K3 and K5 Viral Ubiquitin E3 Ligases Taught Us about Ubiquitin-Mediated Receptor Regulation?

(2011) Jessica M. Boname et al.   Viruses-Basel

What Determines the Specificity and Outcomes of Ubiquitin Signaling?

(2010) Fumiyo Ikeda et al.   CELL

Ubiquitin Makes Its Mark on Immune Regulation

(2010) Barbara A. Malynn et al.   IMMUNITY

Regulatory T-cell differentiation versus clonal deletion of autoreactive thymocytes

(2010) Gerald Wirnsberger et al.   IMMUNOLOGY AND CELL BIOLOGY

Dendritic Cell Activation Prevents MHC Class II Ubiquitination and Promotes MHC Class II Survival Regardless of the Activation Stimulus

(2010) Even Walseng et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Stress-Regulated Targeting of the NKG2D Ligand Mult1 by a Membrane-Associated RING-CH Family E3 Ligase

(2010) T. J. Nice et al.   JOURNAL OF IMMUNOLOGY

Functional Redundancy between Thymic CD8 + and Sirp + Conventional Dendritic Cells in Presentation of Blood-Derived Lysozyme by MHC Class II Proteins

(2010) D. F. Atibalentja et al.   JOURNAL OF IMMUNOLOGY

Cutting Edge: Hematopoietic-Derived APCs Select Regulatory T Cells in Thymus

(2010) E. Roman et al.   JOURNAL OF IMMUNOLOGY

Ubiquitination regulates MHC class II-peptide complex retention and degradation in dendritic cells

(2010) E. Walseng et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

RING Domain E3 Ubiquitin Ligases

(2009) Raymond J. Deshaies et al.   Annual Review of Biochemistry

The HLA-DRα Chain Is Modified by Polyubiquitination

(2009) Nicolas Lapaque et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cutting Edge: Requirement of MARCH-I-Mediated MHC II Ubiquitination for the Maintenance of Conventional Dendritic Cells

(2009) M. Ohmura-Hoshino et al.   JOURNAL OF IMMUNOLOGY

Thymus-Blood Protein Interactions Are Highly Effective in Negative Selection and Regulatory T Cell Induction

(2009) D. F. Atibalentja et al.   JOURNAL OF IMMUNOLOGY

Ubiquitylation in innate and adaptive immunity

(2009) Vijay G. Bhoj et al.   NATURE

Ubiquitin-binding domains — from structures to functions

(2009) Ivan Dikic et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

MHC II in Dendritic Cells is Targeted to Lysosomes or T Cell-Induced Exosomes Via Distinct Multivesicular Body Pathways

(2009) Sonja I. Buschow et al.   TRAFFIC

Interleukin-10-induced MARCH1 mediates intracellular sequestration of MHC class II in monocytes

(2008) Jacques Thibodeau et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

A Two-Step Process for Thymic Regulatory T Cell Development

(2008) Chan-Wang Joaquim Lio et al.   IMMUNITY

MHC class II structural requirements for the association with Igα/β, and signaling of calcium mobilization and cell death

(2008) Lei Jin et al.   IMMUNOLOGY LETTERS

Down-regulation of NKG2D and NKp80 ligands by Kaposi's sarcoma-associated herpesvirus K5 protects against NK cell cytotoxicity

(2008) M. Thomas et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

MHC class II stabilization at the surface of human dendritic cells is the result of maturation-dependent MARCH I down-regulation

(2008) A. De Gassart et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Dendritic cells in the thymus contribute to T-regulatory cell induction

(2008) A. I. Proietto et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA