Article
Engineering, Environmental
Qi Tang, Chongpeng Qiu, You Zhang, Xuefeng Zhang, Zihui Yuan, Hailu Tan, Lei Wang, Cornelis F. de Hoop, Jinqiu Qi, Xingyan Huang
Summary: A novel nanocellulose/alum/chitosan/polyethyleneimine biohybrid aerogel (NACPBA) beads adsorbent was successfully prepared for diclofenac sodium (DS) removal from wastewater. The adsorbent showed high adsorption capacity and removal efficiency, and could maintain good adsorption performance through regeneration cycles. The adsorption mechanism was mainly governed by electrostatic attractions and hydrogen bond interactions.
JOURNAL OF POLYMERS AND THE ENVIRONMENT
(2023)
Article
Chemistry, Physical
Kyung Hee Park, Yeon Woo Choi, Heejoo Ryu, Hyoung Jae Lee, Jae-Hak Moon, Ho-Jun Song, Yeong-Joon Park
Summary: This study developed improved multi-component beads for controlled and sustained delivery of antibiotics. Single and multi-component beads were prepared using chitosan, calcium chloride, alginate, and citric acid, and the release of antibiotics was controlled by crosslinking. The crosslinked beads showed efficient sustained-release of gentamicin.
Article
Pharmacology & Pharmacy
Daniela Ailincai, Maricel Agop, Ioana Cristina Marinas, Andrei Zala, Stefan Andrei Irimiciuc, Lucian Dobreci, Tudor-Cristian Petrescu, Constantin Volovat
Summary: This study focused on modeling the release of diclofenac sodium salt from a hydrogel matrix based on PEGylated chitosan using Multifractal Theory of Motion. The findings suggest that the drug-release dynamics can be accurately described at both global and local scales by a fundamental spinor set composed of 2 x 2 matrices with real elements.
Article
Polymer Science
Denitsa Nikolova, Marin Simeonov, Christo Tzachev, Anton Apostolov, Lachezar Christov, Elena Vassileva
Summary: The study aimed to develop PECs based on chitosan and sodium alginate as a drug delivery system for sustained release of diclofenac sodium. Various techniques were used to investigate the structure and properties of the complexes and to assess drug entrapment efficiency and release profiles. The fibrillar form of the chitosan/alginate PECs was found to have specific control over diclofenac release, making them suitable for controlled drug delivery.
POLYMER INTERNATIONAL
(2022)
Article
Chemistry, Physical
Cesar Vinicius Toniciolli Rigueto, Mateus Torres Nazari, Marieli Rosseto, Lillian Avila Massuda, Ingridy Alessandretti, Jeferson Steffanello Piccin, Aline Dettmer
Summary: The RCTLW gelatin beads extracted from tannery wastes showed promising adsorption capacities for TYD and DCF, with maximum adsorption capacities of 263.13 and 36.65 mg.g(-1), respectively. The beads exhibited good regeneration potential, maintaining a capacity of around 100 mg.g(-1) with 45% regeneration after 10 cycles of use.
JOURNAL OF MOLECULAR LIQUIDS
(2021)
Article
Materials Science, Ceramics
Nga H. N. Do, Thinh H. Pham, Phung K. Le, Anh C. Ha
Summary: In this study, thermo-sensitive hydrogels made from chitosan and beta-glycerophosphate (GP) were used to post-load diclofenac sodium (DS) for temperature-controlled-release at inflammatory sites. The hydrogels showed sol-gel and swelling behaviors in response to temperature changes. The developed chitosan hydrogels had specific surface area, pore size, and pore volume within certain ranges. The hydrogels exhibited adaptive swelling to temperature changes and showed significantly improved DS loading capacity compared to previous studies.
JOURNAL OF SOL-GEL SCIENCE AND TECHNOLOGY
(2023)
Article
Polymer Science
Lu Wang, Xin Gang, Yu Xiao, Yi Ren, Jianhong Wang, Baolong Niu, Wenfeng Li
Summary: In this study, SA/CMCS-CuO composite microspheres were prepared by blending CMCS-CuO nanoparticles with the SA matrix. The characterization results showed molecular interaction between CMCS-CuO NPs and SA matrix. The addition of CMCS-CuO NPs decreased the swelling ratio and increased the time of maximum swelling ratio of gel microspheres. Cytotoxicity test, hemolysis test, and cell migration test demonstrated the good biocompatibility of the composite microspheres. Furthermore, the in vitro release experiments indicated the pH sensitivity of SA/CMCS-CuO composite microspheres and the prolonged release time of curcumin with the addition of CMCS-CuO NPs, suggesting potential applications in drug release.
EUROPEAN POLYMER JOURNAL
(2023)
Article
Biochemistry & Molecular Biology
Emine Bulut
Summary: The study focused on the preparation of ionically crosslinked beads as semi-interpenetrating polymer networks loaded with ibuprofen. The drug release behaviors and performance parameters of the beads were investigated and optimized for the best release conditions.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Environmental Sciences
Hao Li, Jin Wang, Yu Luo, Bo Bai, Fangli Cao
Summary: Chlorella was employed as a bio-based filler to prepare chitosan-chlorella hydrogel beads, which exhibited enhanced mechanical stability and sensitivity to external factors. The hydrogel beads with 40 wt% Chlorella reached the largest water absorption ratio of 42.92 g/g.
Article
Chemistry, Physical
Anna Jarosz, Oliwia Kapusta, Dorota Gugala-Fekner, Mariusz Barczak
Summary: The influence of agarose hydrogels containing citric acid on drug release was studied, and it was found that the citric acid content had significant effects on both drug release rate and mechanical properties. Due to their high biocompatibility, agarose hydrogels can be considered as safe and potential platforms for controlled drug release in biomedical applications.
Article
Pharmacology & Pharmacy
Ahmed M. Omer, Maha S. Ahmed, Gehan M. El-Subruiti, Randa E. Khalifa, Abdelazeem S. Eltaweil
Summary: Alg-CMCs@AmCs dual polyelectrolyte complexes were successfully employed as a pH-sensitive drug carrier for efficient encapsulation and release of diclofenac sodium. The developed microcapsules showed excellent stability and high encapsulation efficiency under colonic conditions, suggesting great potential for practical applications.
Article
Chemistry, Applied
Kemal Cetin, Adil Denizli
Summary: This study investigates the effects of environmental changes, such as pH and temperature, on drug release in the development of drug delivery systems. Microcryogels loaded with diclofenac sodium were used as drug delivery systems. The results show that drug release is lower in acidic environment compared to higher pH values, and the release rates are higher at inflammatory temperature compared to normal body temperature.
REACTIVE & FUNCTIONAL POLYMERS
(2022)
Article
Biochemistry & Molecular Biology
Karla Cisneros, Naisha Chowdhury, Emily Coleman, Tamanna Ferdous, Hengjie Su, Jessica A. Jennings, Joel D. Bumgardner, Tomoko Fujiwara
Summary: This study evaluates the effect of controlled release of simvastatin from 3D-printed triple-network hydrogels for osteogenic stimulation and characterizes their mechanical and biological properties as an implant. The tunable triple-network hydrogels loaded with simvastatin provide a potential therapeutic value for bone regeneration.
MACROMOLECULAR BIOSCIENCE
(2021)
Article
Chemistry, Applied
Esraa G. Arafa, Magdy W. Sabaa, Riham R. Mohamed, Emadeldin M. Kamel, Ali M. Elzanaty, Ayman M. Mahmoud, Omayma F. Abdel-Gawad
Summary: This study synthesized a superabsorbent hydrogel for controlled-release urea, which showed swelling, urea release, and antimicrobial properties suitable for efficient water management and economic and environmental benefits in agriculture.
CARBOHYDRATE POLYMERS
(2022)
Article
Engineering, Chemical
Qiang Sun, Xuebin Hu, Qiang He, Manli Sun, Liangliang Dai, Sarfaraz Khan, Huaili Zheng
Summary: This study achieved the spatiotemporal coagulation and degradation of diclofenac sodium under visible light irradiation by modifying TiO2 nanoparticles. The modified TiO2 nanoparticles showed activated photocatalytic activity and improved photocatalytic efficiency. Additionally, it was found that the coagulant could be directly reused multiple times.
JOURNAL OF THE TAIWAN INSTITUTE OF CHEMICAL ENGINEERS
(2022)