Using Microscale Thermophoresis to Characterize Hits from High-Throughput Screening: A European Lead Factory Perspective

Discovery of first-in-class reversible dual small molecule inhibitors against G9a and DNMTs in hematological malignancies

(2017) Edurne San José-Enériz et al.   Nature Communications

Six Biophysical Screening Methods Miss a Large Proportion of Crystallographically Discovered Fragment Hits: A Case Study

(2016) Johannes Schiebel et al.   ACS Chemical Biology

On the acquisition and analysis of microscale thermophoresis data

(2016) Thomas H. Scheuermann et al.   ANALYTICAL BIOCHEMISTRY

Avoiding Fluorescence Assay Interference—The Case for Diaphorase

(2016) Matthew D. Hall et al.   ASSAY AND DRUG DEVELOPMENT TECHNOLOGIES

How to Triage PAINS-Full Research

(2016) Jayme L. Dahlin et al.   ASSAY AND DRUG DEVELOPMENT TECHNOLOGIES

The ELF Honest Data Broker: informatics enabling public–private collaboration in a precompetitive arena

(2016) Guillaume Paillard et al.   DRUG DISCOVERY TODAY

Integrating biophysics with HTS-driven drug discovery projects

(2016) Rutger H.A. Folmer   DRUG DISCOVERY TODAY

Studying small molecule–aptamer interactions using MicroScale Thermophoresis (MST)

(2016) Clemens Entzian et al.   METHODS

Biophysics in drug discovery: impact, challenges and opportunities

(2016) Jean-Paul Renaud et al.   NATURE REVIEWS DRUG DISCOVERY

Small molecules, big targets: drug discovery faces the protein–protein interaction challenge

(2016) Duncan E. Scott et al.   NATURE REVIEWS DRUG DISCOVERY

One Question, Multiple Answers: Biochemical and Biophysical Screening Methods Retrieve Deviating Fragment Hit Lists

(2015) Johannes Schiebel et al.   ChemMedChem

The Joint European Compound Library: boosting precompetitive research

(2015) Jérémy Besnard et al.   DRUG DISCOVERY TODAY

The importance of triaging in determining the quality of output from high-throughput screening

(2015) Philip Jones et al.   Future Medicinal Chemistry

Mitigating risk in academic preclinical drug discovery

(2015) Jayme L. Dahlin et al.   NATURE REVIEWS DRUG DISCOVERY

Detection of secondary binding sites in proteins using fragment screening

(2015) R. Frederick Ludlow et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A novel method for the study of molecular interaction by using microscale thermophoresis

(2015) Yexuan Mao et al.   TALANTA

Novel microscale approaches for easy, rapid determination of protein stability in academic and commercial settings

(2014) Crispin G. Alexander et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

MicroScale Thermophoresis: Interaction analysis and beyond

(2014) Moran Jerabek-Willemsen et al.   JOURNAL OF MOLECULAR STRUCTURE

Chemistry: Chemical con artists foil drug discovery

(2014) Jonathan Baell et al.   NATURE

Allostery in Disease and in Drug Discovery

(2013) Ruth Nussinov et al.   CELL

Direct Detection of Antibody Concentration and Affinity in Human Serum Using Microscale Thermophoresis

(2012) Svenja Lippok et al.   ANALYTICAL CHEMISTRY

Label-Free Microscale Thermophoresis Discriminates Sites and Affinity of Protein-Ligand Binding

(2012) Susanne A. I. Seidel et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Protein Folding Drives Disulfide Formation

(2012) Pallav Kosuri et al.   CELL

Microscale thermophoresis quantifies biomolecular interactions under previously challenging conditions

(2012) Susanne A.I. Seidel et al.   METHODS

Protein–protein interaction inhibitors get into the groove

(2012) Asher Mullard   NATURE REVIEWS DRUG DISCOVERY

Metal Impurities Cause False Positives in High-Throughput Screening Campaigns

(2012) Johannes C. Hermann et al.   ACS Medicinal Chemistry Letters

Molecular Interaction Studies Using Microscale Thermophoresis

(2011) Moran Jerabek-Willemsen et al.   ASSAY AND DRUG DEVELOPMENT TECHNOLOGIES

A comparative study of fragment screening methods on the p38α kinase: new methods, new insights

(2011) Scott J. Pollack et al.   JOURNAL OF COMPUTER-AIDED MOLECULAR DESIGN

Ludwig–Soret effect in a linear temperature field: Theory and experiments for steady state distributions

(2011) Hyeyun Jung et al.   PHYSICS LETTERS A

Redox cycling compounds generate H2O2 in HTS buffers containing strong reducing reagents—real hits or promiscuous artifacts?

(2010) Paul A Johnston   CURRENT OPINION IN CHEMICAL BIOLOGY

Affinity-based, biophysical methods to detect and analyze ligand binding to recombinant proteins: Matching high information content with high throughput

(2010) Geoff A. Holdgate et al.   JOURNAL OF STRUCTURAL BIOLOGY

Protein-binding assays in biological liquids using microscale thermophoresis

(2010) Christoph J. Wienken et al.   Nature Communications

Biophysical techniques for ligand screening and drug design

(2009) Jean-Paul Renaud et al.   CURRENT OPINION IN PHARMACOLOGY

Promiscuous Aggregate-Based Inhibitors Promote Enzyme Unfolding

(2009) Kristin E. D. Coan et al.   JOURNAL OF MEDICINAL CHEMISTRY

Fluorescence Spectroscopic Profiling of Compound Libraries

(2008) Anton Simeonov et al.   JOURNAL OF MEDICINAL CHEMISTRY