The importance of triaging in determining the quality of output from high-throughput screening

Tracing Binding Modes in Hit-to-Lead Optimization: Chameleon-Like Poses of Aspartic Protease Inhibitors

(2015) Maren Kuhnert et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

The Joint European Compound Library: boosting precompetitive research

(2015) Jérémy Besnard et al.   DRUG DISCOVERY TODAY

Promiscuous 2-Aminothiazoles (PrATs): A Frequent Hitting Scaffold

(2015) Shane M. Devine et al.   JOURNAL OF MEDICINAL CHEMISTRY

Academic drug discovery within the United Kingdom: a reassessment

(2015) Emma Shanks et al.   NATURE REVIEWS DRUG DISCOVERY

2014 FDA drug approvals

(2015) Asher Mullard   NATURE REVIEWS DRUG DISCOVERY

The essential roles of chemistry in high-throughput screening triage

(2014) Jayme L Dahlin et al.   Future Medicinal Chemistry

Chemistry: Chemical con artists foil drug discovery

(2014) Jonathan Baell et al.   NATURE

Rhodanine hydrolysis leads to potent thioenolate mediated metallo-β-lactamase inhibition

(2014) Jürgen Brem et al.   Nature Chemistry

UK academic drug discovery

(2013) Cathy Tralau-Stewart et al.   NATURE REVIEWS DRUG DISCOVERY

Big pharma screening collections: more of the same or unique libraries? The AstraZeneca–Bayer Pharma AG case

(2012) Thierry Kogej et al.   DRUG DISCOVERY TODAY

Finding the sweet spot: the role of nature and nurture in medicinal chemistry

(2012) Michael M. Hann et al.   NATURE REVIEWS DRUG DISCOVERY

Diagnosing the decline in pharmaceutical R&D efficiency

(2012) Jack W. Scannell et al.   NATURE REVIEWS DRUG DISCOVERY

Metal Impurities Cause False Positives in High-Throughput Screening Campaigns

(2012) Johannes C. Hermann et al.   ACS Medicinal Chemistry Letters

US academic drug discovery

(2011) Stephen Frye et al.   NATURE REVIEWS DRUG DISCOVERY

Impact of high-throughput screening in biomedical research

(2011) Ricardo Macarron et al.   NATURE REVIEWS DRUG DISCOVERY

Profiling the NIH Small Molecule Repository for Compounds That Generate H2O2 by Redox Cycling in Reducing Environments

(2010) Karina M. Soares et al.   ASSAY AND DRUG DEVELOPMENT TECHNOLOGIES