One Question, Multiple Answers: Biochemical and Biophysical Screening Methods Retrieve Deviating Fragment Hit Lists

Tracing Binding Modes in Hit-to-Lead Optimization: Chameleon-Like Poses of Aspartic Protease Inhibitors

(2015) Maren Kuhnert et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Thermodynamic signatures of fragment binding: Validation of direct versus displacement ITC titrations

(2015) Eggert Rühmann et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

A three-stage biophysical screening cascade for fragment-based drug discovery

(2013) Ellene H Mashalidis et al.   Nature Protocols

Integrated biophysical approach to fragment screening and validation for fragment-based lead discovery

(2013) H. L. Silvestre et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

High-Throughput Interrogation of Ligand Binding Mode Using a Fluorescence-Based Assay

(2012) Paweł Śledź et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Fragment-Based Approaches in Drug Discovery and Chemical Biology

(2012) Duncan E. Scott et al.   BIOCHEMISTRY

Microscale thermophoresis quantifies biomolecular interactions under previously challenging conditions

(2012) Susanne A.I. Seidel et al.   METHODS

Molecular Interaction Studies Using Microscale Thermophoresis

(2011) Moran Jerabek-Willemsen et al.   ASSAY AND DRUG DEVELOPMENT TECHNOLOGIES

Experimental and Computational Active Site Mapping as a Starting Point to Fragment-Based Lead Discovery

(2011) Jürgen Behnen et al.   ChemMedChem

A Small Nonrule of 3 Compatible Fragment Library Provides High Hit Rate of Endothiapepsin Crystal Structures with Various Fragment Chemotypes

(2011) Helene Köster et al.   JOURNAL OF MEDICINAL CHEMISTRY

A Fragment-Based Approach to Identifying Ligands for Riboswitches

(2010) Liuhong Chen et al.   ACS Chemical Biology

Fragment Screening by Surface Plasmon Resonance

(2010) Iva Navratilova et al.   ACS Medicinal Chemistry Letters

Recent progress in fragment-based lead discovery

(2009) Michèle N Schulz et al.   CURRENT OPINION IN PHARMACOLOGY

NMR methods in fragment screening: theory and a comparison with other biophysical techniques

(2009) Claudio Dalvit   DRUG DISCOVERY TODAY

From fragment to clinical candidate—a historical perspective

(2009) Gianni Chessari et al.   DRUG DISCOVERY TODAY

Native MS: an ’ESI‚ way to support structure- and fragment-based drug discovery

(2009) Valerie Vivat Hannah et al.   Future Medicinal Chemistry

Fragment-based lead generation: identification of seed fragments by a highly efficient fragment screening technology

(2009) Lars Neumann et al.   JOURNAL OF COMPUTER-AIDED MOLECULAR DESIGN

Direct optical detection in fragment-based screening

(2008) Florian Pröll et al.   ANALYTICAL AND BIOANALYTICAL CHEMISTRY

Recent Developments in Fragment-Based Drug Discovery

(2008) Miles Congreve et al.   JOURNAL OF MEDICINAL CHEMISTRY