Prediction of off-target activities for the end-to-end design of CRISPR guide RNAs
Published 2018 View Full Article
- Home
- Publications
- Publication Search
- Publication Details
Title
Prediction of off-target activities for the end-to-end design of CRISPR guide RNAs
Authors
Keywords
-
Journal
Nature Biomedical Engineering
Volume 2, Issue 1, Pages 38-47
Publisher
Springer Nature
Online
2018-01-09
DOI
10.1038/s41551-017-0178-6
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- Examination of CRISPR/Cas9 design tools and the effect of target site accessibility on Cas9 activity
- (2017) Ciaran M. Lee et al. EXPERIMENTAL PHYSIOLOGY
- Mapping the genomic landscape of CRISPR–Cas9 cleavage
- (2017) Peter Cameron et al. NATURE METHODS
- CIRCLE-seq: a highly sensitive in vitro screen for genome-wide CRISPR–Cas9 nuclease off-targets
- (2017) Shengdar Q Tsai et al. NATURE METHODS
- Genome-scale measurement of off-target activity using Cas9 toxicity in high-throughput screens
- (2017) David W. Morgens et al. Nature Communications
- CRISPR-DO for genome-wide CRISPR design and optimization
- (2016) Jian Ma et al. BIOINFORMATICS
- Genome-wide target specificities of CRISPR-Cas9 nucleases revealed by multiplex Digenome-seq
- (2016) Daesik Kim et al. GENOME RESEARCH
- High-fidelity CRISPR–Cas9 nucleases with no detectable genome-wide off-target effects
- (2016) Benjamin P. Kleinstiver et al. NATURE
- Optimized sgRNA design to maximize activity and minimize off-target effects of CRISPR-Cas9
- (2016) John G Doench et al. NATURE BIOTECHNOLOGY
- Genome-wide specificities of CRISPR-Cas Cpf1 nucleases in human cells
- (2016) Benjamin P Kleinstiver et al. NATURE BIOTECHNOLOGY
- Genome-wide analysis reveals specificities of Cpf1 endonucleases in human cells
- (2016) Daesik Kim et al. NATURE BIOTECHNOLOGY
- CHOPCHOP v2: a web tool for the next generation of CRISPR genome engineering
- (2016) Kornel Labun et al. NUCLEIC ACIDS RESEARCH
- CRISPR Screens Provide a Comprehensive Assessment of Cancer Vulnerabilities but Generate False-Positive Hits for Highly Amplified Genomic Regions
- (2016) D. M. Munoz et al. Cancer Discovery
- Genomic Copy Number Dictates a Gene-Independent Cell Response to CRISPR/Cas9 Targeting
- (2016) A. J. Aguirre et al. Cancer Discovery
- Sequence determinants of improved CRISPR sgRNA design
- (2015) Han Xu et al. GENOME RESEARCH
- In vivo genome editing using Staphylococcus aureus Cas9
- (2015) F. Ann Ran et al. NATURE
- Unbiased detection of off-target cleavage by CRISPR-Cas9 and TALENs using integrase-defective lentiviral vectors
- (2015) Xiaoling Wang et al. NATURE BIOTECHNOLOGY
- CRISPRscan: designing highly efficient sgRNAs for CRISPR-Cas9 targeting in vivo
- (2015) Miguel A Moreno-Mateos et al. NATURE METHODS
- Unraveling CRISPR-Cas9 genome engineering parameters via a library-on-library approach
- (2015) Raj Chari et al. NATURE METHODS
- Digenome-seq: genome-wide profiling of CRISPR-Cas9 off-target effects in human cells
- (2015) Daesik Kim et al. NATURE METHODS
- Cas9-chromatin binding information enables more accurate CRISPR off-target prediction
- (2015) Ritambhara Singh et al. NUCLEIC ACIDS RESEARCH
- Ensembl 2016
- (2015) Andrew Yates et al. NUCLEIC ACIDS RESEARCH
- Identification of potential drug targets for tuberous sclerosis complex by synthetic screens combining CRISPR-based knockouts with RNAi
- (2015) Benjamin E. Housden et al. Science Signaling
- Identification of potential drug targets for tuberous sclerosis complex by synthetic screens combining CRISPR-based knockouts with RNAi
- (2015) Benjamin E. Housden et al. Science Signaling
- CCTop: An Intuitive, Flexible and Reliable CRISPR/Cas9 Target Prediction Tool
- (2015) Manuel Stemmer et al. PLoS One
- Cas-OFFinder: a fast and versatile algorithm that searches for potential off-target sites of Cas9 RNA-guided endonucleases
- (2014) S. Bae et al. BIOINFORMATICS
- Rational design of highly active sgRNAs for CRISPR-Cas9–mediated gene inactivation
- (2014) John G Doench et al. NATURE BIOTECHNOLOGY
- GUIDE-seq enables genome-wide profiling of off-target cleavage by CRISPR-Cas nucleases
- (2014) Shengdar Q Tsai et al. NATURE BIOTECHNOLOGY
- Genome-wide detection of DNA double-stranded breaks induced by engineered nucleases
- (2014) Richard L Frock et al. NATURE BIOTECHNOLOGY
- E-CRISP: fast CRISPR target site identification
- (2014) Florian Heigwer et al. NATURE METHODS
- CRISPR/Cas9 systems have off-target activity with insertions or deletions between target DNA and guide RNA sequences
- (2014) Y. Lin et al. NUCLEIC ACIDS RESEARCH
- COSMID: A Web-based Tool for Identifying and Validating CRISPR/Cas Off-target Sites
- (2014) Thomas J Cradick et al. Molecular Therapy-Nucleic Acids
- DNA targeting specificity of RNA-guided Cas9 nucleases
- (2013) Patrick D Hsu et al. NATURE BIOTECHNOLOGY
- Nucleotide-resolution DNA double-strand break mapping by next-generation sequencing
- (2013) Nicola Crosetto et al. NATURE METHODS
- Genetic Screens in Human Cells Using the CRISPR-Cas9 System
- (2013) Tim Wang et al. SCIENCE
- FLASH assembly of TALENs for high-throughput genome editing
- (2012) Deepak Reyon et al. NATURE BIOTECHNOLOGY
- Integrative annotation of chromatin elements from ENCODE data
- (2012) Michael M. Hoffman et al. NUCLEIC ACIDS RESEARCH
Find Funding. Review Successful Grants.
Explore over 25,000 new funding opportunities and over 6,000,000 successful grants.
ExploreFind the ideal target journal for your manuscript
Explore over 38,000 international journals covering a vast array of academic fields.
Search