Identification of potential drug targets for tuberous sclerosis complex by synthetic screens combining CRISPR-based knockouts with RNAi
Published 2015 View Full Article
- Home
- Publications
- Publication Search
- Publication Details
Title
Identification of potential drug targets for tuberous sclerosis complex by synthetic screens combining CRISPR-based knockouts with RNAi
Authors
Keywords
-
Journal
Science Signaling
Volume 8, Issue 393, Pages rs9-rs9
Publisher
American Association for the Advancement of Science (AAAS)
Online
2015-09-09
DOI
10.1126/scisignal.aab3729
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- Myc and mRNA capping
- (2015) Sianadh Dunn et al. Biochimica et Biophysica Acta-Gene Regulatory Mechanisms
- Combining Genetic Perturbations and Proteomics to Examine Kinase-Phosphatase Networks in Drosophila Embryos
- (2014) Richelle Sopko et al. DEVELOPMENTAL CELL
- Estradiol and mTORC2 cooperate to enhance prostaglandin biosynthesis and tumorigenesis in TSC2-deficient LAM cells
- (2014) Chenggang Li et al. JOURNAL OF EXPERIMENTAL MEDICINE
- ZNF300P1 Encodes a lincRNA that regulates cell polarity and is epigenetically silenced in type II epithelial ovarian cancer
- (2014) Brian Gloss et al. Molecular Cancer
- Rational design of highly active sgRNAs for CRISPR-Cas9–mediated gene inactivation
- (2014) John G Doench et al. NATURE BIOTECHNOLOGY
- ProteomeXchange provides globally coordinated proteomics data submission and dissemination
- (2014) Juan A Vizcaíno et al. NATURE BIOTECHNOLOGY
- Microhomology-based choice of Cas9 nuclease target sites
- (2014) Sangsu Bae et al. NATURE METHODS
- RNAi screening comes of age: improved techniques and complementary approaches
- (2014) Stephanie E. Mohr et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- Efficient chromosomal gene modification with CRISPR/cas9 and PCR-based homologous recombination donors in cultured Drosophila cells
- (2014) R. Bottcher et al. NUCLEIC ACIDS RESEARCH
- Highly Specific Contractions of a Single CAG/CTG Trinucleotide Repeat by TALEN in Yeast
- (2014) Guy-Franck Richard et al. PLoS One
- Optimization of Genome Engineering Approaches with the CRISPR/Cas9 System
- (2014) Kai Li et al. PLoS One
- Enhanced Specificity and Efficiency of the CRISPR/Cas9 System with Optimized sgRNA Parameters in Drosophila
- (2014) Xingjie Ren et al. Cell Reports
- DNA copy number evolution in Drosophila cell lines
- (2014) Hangnoh Lee et al. GENOME BIOLOGY
- A simplified and efficient germline-specific CRISPR/Cas9 system forDrosophilagenomic engineering
- (2013) Zachary L Sebo et al. FLY
- Genome Engineering of Drosophila with the CRISPR RNA-Guided Cas9 Nuclease
- (2013) Scott J. Gratz et al. GENETICS
- Highly Efficient Genome Modifications Mediated by CRISPR/Cas9 in Drosophila
- (2013) Z. Yu et al. GENETICS
- Autophagy-Dependent Metabolic Reprogramming Sensitizes TSC2-Deficient Cells to the Antimetabolite 6-Aminonicotinamide
- (2013) Andrey A. Parkhitko et al. MOLECULAR CANCER RESEARCH
- CAS9 transcriptional activators for target specificity screening and paired nickases for cooperative genome engineering
- (2013) Prashant Mali et al. NATURE BIOTECHNOLOGY
- DNA targeting specificity of RNA-guided Cas9 nucleases
- (2013) Patrick D Hsu et al. NATURE BIOTECHNOLOGY
- High-throughput profiling of off-target DNA cleavage reveals RNA-programmed Cas9 nuclease specificity
- (2013) Vikram Pattanayak et al. NATURE BIOTECHNOLOGY
- High-frequency off-target mutagenesis induced by CRISPR-Cas nucleases in human cells
- (2013) Yanfang Fu et al. NATURE BIOTECHNOLOGY
- Efficient generation of large-scale genome-modified mice using gRNA and CAS9 endonuclease
- (2013) Wataru Fujii et al. NUCLEIC ACIDS RESEARCH
- Efficient multiplex biallelic zebrafish genome editing using a CRISPR nuclease system
- (2013) Li-En Jao et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Optimized gene editing technology for Drosophila melanogaster using germ line-specific Cas9
- (2013) X. Ren et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- RNA-Guided Human Genome Engineering via Cas9
- (2013) P. Mali et al. SCIENCE
- Genome-Scale CRISPR-Cas9 Knockout Screening in Human Cells
- (2013) Ophir Shalem et al. SCIENCE
- Genetic Screens in Human Cells Using the CRISPR-Cas9 System
- (2013) Tim Wang et al. SCIENCE
- Multiplex Genome Engineering Using CRISPR/Cas Systems
- (2013) L. Cong et al. SCIENCE
- Highly Efficient Targeted Mutagenesis of Drosophila with the CRISPR/Cas9 System
- (2013) Andrew R. Bassett et al. Cell Reports
- Mutagenesis and homologous recombination in Drosophila cell lines using CRISPR/Cas9
- (2013) A. R. Bassett et al. Biology Open
- TBC1D7 Is a Third Subunit of the TSC1-TSC2 Complex Upstream of mTORC1
- (2012) Christian C. Dibble et al. MOLECULAR CELL
- Efficient TALEN-mediated gene knockout in livestock
- (2012) D. F. Carlson et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Use and Abuse of RNAi to Study Mammalian Gene Function
- (2012) W. G. Kaelin SCIENCE
- A Programmable Dual-RNA-Guided DNA Endonuclease in Adaptive Bacterial Immunity
- (2012) M. Jinek et al. SCIENCE
- The cyclin-dependent kinase PITSLRE/CDK11 is required for successful autophagy
- (2011) Simon Wilkinson et al. Autophagy
- A Protein Complex Network of Drosophila melanogaster
- (2011) K.G. Guruharsha et al. CELL
- Stringent Analysis of Gene Function and Protein-Protein Interactions Using Fluorescently Tagged Genes
- (2011) R. A. Neumuller et al. GENETICS
- Genome-scale RNAi on living-cell microarrays identifies novel regulators of Drosophila melanogaster TORC1-S6K pathway signaling
- (2011) R. A. Lindquist et al. GENOME RESEARCH
- Mapping of signaling networks through synthetic genetic interaction analysis by RNAi
- (2011) Thomas Horn et al. NATURE METHODS
- Efficacy and Safety of Sirolimus in Lymphangioleiomyomatosis
- (2011) Francis X. McCormack et al. NEW ENGLAND JOURNAL OF MEDICINE
- Inference of RhoGAP/GTPase regulation using single-cell morphological data from a combinatorial RNAi screen
- (2010) O. Nir et al. GENOME RESEARCH
- Everolimus for Subependymal Giant-Cell Astrocytomas in Tuberous Sclerosis
- (2010) Darcy A. Krueger et al. NEW ENGLAND JOURNAL OF MEDICINE
- Rapamycin-Insensitive Up-Regulation ofMMP2and Other Genes in Tuberous Sclerosis Complex 2–Deficient Lymphangioleiomyomatosis-Like Cells
- (2009) Po-Shun Lee et al. AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY
- Direct Response to Notch Activation: Signaling Crosstalk and Incoherent Logic
- (2009) A. Krejci et al. Science Signaling
- The TSC1–TSC2 complex: a molecular switchboard controlling cell growth
- (2008) Jingxiang Huang et al. BIOCHEMICAL JOURNAL
- Sirolimus for Angiomyolipoma in Tuberous Sclerosis Complex or Lymphangioleiomyomatosis
- (2008) John J. Bissler et al. NEW ENGLAND JOURNAL OF MEDICINE
Add your recorded webinar
Do you already have a recorded webinar? Grow your audience and get more views by easily listing your recording on Peeref.
Upload NowAsk a Question. Answer a Question.
Quickly pose questions to the entire community. Debate answers and get clarity on the most important issues facing researchers.
Get Started