Developing an Irreversible Inhibitor of Human DDAH-1, an Enzyme Upregulated in Melanoma

Transport of asymmetric dimethylarginine (ADMA) by cationic amino acid transporter 2 (CAT2), organic cation transporter 2 (OCT2) and multidrug and toxin extrusion protein 1 (MATE1)

(2013) Joachim Strobel et al.   AMINO ACIDS

Molecular Pathways: Inflammation-Associated Nitric-Oxide Production as a Cancer-Supporting Redox Mechanism and a Potential Therapeutic Target

(2013) E. A. Grimm et al.   CLINICAL CANCER RESEARCH

Peptidylarginine deiminase inhibition is immunomodulatory and vasculoprotective in murine lupus

(2013) Jason S. Knight et al.   JOURNAL OF CLINICAL INVESTIGATION

Targeting Nitric Oxide Signaling with nNOS Inhibitors As a Novel Strategy for the Therapy and Prevention of Human Melanoma

(2012) Zhen Yang et al.   ANTIOXIDANTS & REDOX SIGNALING

Endogenous Nitric Oxide Synthase Inhibitors in the Biology of Disease

(2012) Ben Caplin et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Genetic and Pharmacological Inhibition of Dimethylarginine Dimethylaminohydrolase 1 Is Protective in Endotoxic Shock

(2012) Manasi Nandi et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Alanine-Glyoxylate Aminotransferase-2 Metabolizes Endogenous Methylarginines, Regulates NO, and Controls Blood Pressure

(2012) Ben Caplin et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Inhibition of peptidyl-arginine deiminases reverses protein-hypercitrullination and disease in mouse models of multiple sclerosis

(2012) M. A. Moscarello et al.   Disease Models & Mechanisms

Development and Use of Clickable Activity Based Protein Profiling Agents for Protein Arginine Deiminase 4

(2011) Jessica L. Slack et al.   ACS Chemical Biology

Dimethylarginine Dimethylaminohydrolase-1 Is the Critical Enzyme for Degrading the Cardiovascular Risk Factor Asymmetrical Dimethylarginine

(2011) Xinli Hu et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Designing modulators of dimethylarginine dimethylaminohydrolase (DDAH): A focus on selectivity over arginase

(2011) Juerke Kotthaus et al.   JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY

The therapeutic potential of targeting endogenous inhibitors of nitric oxide synthesis

(2011) James Leiper et al.   NATURE REVIEWS DRUG DISCOVERY

The Role of Dimethylarginine Dimethylaminohydrolase in Idiopathic Pulmonary Fibrosis

(2011) S. S. Pullamsetti et al.   Science Translational Medicine

Characterization of C-Alkyl Amidines as Bioavailable Covalent Reversible Inhibitors of Human DDAH-1

(2010) Matthew Lluis et al.   ChemMedChem

Reactive oxygen and nitrogen species regulate inducible nitric oxide synthase function shifting the balance of nitric oxide and superoxide production

(2009) Jian Sun et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Developing Dual and Specific Inhibitors of Dimethylarginine Dimethylaminohydrolase-1 and Nitric Oxide Synthase: Toward a Targeted Polypharmacology To Control Nitric Oxide

(2009) Yun Wang et al.   BIOCHEMISTRY

Vascular Endothelial-Specific Dimethylarginine Dimethylaminohydrolase-1–Deficient Mice Reveal That Vascular Endothelium Plays an Important Role in Removing Asymmetric Dimethylarginine

(2009) Xinli Hu et al.   CIRCULATION

Role of Dimethylarginine Dimethylaminohydrolases in the Regulation of Endothelial Nitric Oxide Production

(2009) Arthur J. Pope et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A Click Chemistry Mediatedin VivoActivity Probe for Dimethylarginine Dimethylaminohydrolase

(2009) Yun Wang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Regulation of eNOS-Derived Superoxide by Endogenous Methylarginines†

(2008) Lawrence J. Druhan et al.   BIOCHEMISTRY

Structure–activity relationship of novel and known inhibitors of human dimethylarginine dimethylaminohydrolase-1: Alkenyl-amidines as new leads

(2008) Jürke Kotthaus et al.   BIOORGANIC & MEDICINAL CHEMISTRY