Genomic and immune heterogeneity are associated with differential responses to therapy in melanoma

CT Textural Analysis of Large Primary Renal Cell Carcinomas: Pretreatment Tumor Heterogeneity Correlates With Histologic Findings and Clinical Outcomes

(2016) Meghan G. Lubner et al.   AMERICAN JOURNAL OF ROENTGENOLOGY

Varying Mutational Alterations in Multiple Primary Melanomas

(2016) Friederike Egberts et al.   JOURNAL OF MOLECULAR DIAGNOSTICS

The genomic landscape of cutaneous melanoma

(2016) Tongwu Zhang et al.   Pigment Cell & Melanoma Research

Radiomics: Images Are More than Pictures, They Are Data

(2016) Robert J. Gillies et al.   RADIOLOGY

Heterogeneity and clinical significance of ESR1 mutations in ER-positive metastatic breast cancer patients receiving fulvestrant

(2016) Jill M. Spoerke et al.   Nature Communications

Genomic heterogeneity of multiple synchronous lung cancer

(2016) Yu Liu et al.   Nature Communications

Analysis of Immune Signatures in Longitudinal Tumor Samples Yields Insight into Biomarkers of Response and Mechanisms of Resistance to Immune Checkpoint Blockade

(2016) P.-L. Chen et al.   Cancer Discovery

Distinct clinical patterns and immune infiltrates are observed at time of progression on targeted therapy versus immune checkpoint blockade for melanoma

(2016) Zachary A. Cooper et al.   OncoImmunology

Non-genomic and Immune Evolution of Melanoma Acquiring MAPKi Resistance

(2015) Willy Hugo et al.   CELL

Unfolding the Mutational Landscape of Human Melanoma

(2015) Diwakar Davar et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

ibex: An open infrastructure software platform to facilitate collaborative work in radiomics

(2015) Lifei Zhang et al.   MEDICAL PHYSICS

The Genetic Evolution of Melanoma from Precursor Lesions

(2015) A. Hunter Shain et al.   NEW ENGLAND JOURNAL OF MEDICINE

Co-Evolution of Somatic Variation in Primary and Metastatic Colorectal Cancer May Expand Biopsy Indications in the Molecular Era

(2015) Richard Kim et al.   PLoS One

Phylogenetic analyses of melanoma reveal complex patterns of metastatic dissemination

(2015) J. Zachary Sanborn et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Neoantigens in cancer immunotherapy

(2015) T. N. Schumacher et al.   SCIENCE

Tumor Heterogeneity and Lesion-Specific Response to Targeted Therapy in Colorectal Cancer

(2015) M. Russo et al.   Cancer Discovery

Genome-wide mutation profiles of colorectal tumors and associated liver metastases at the exome and transcriptome levels

(2015) Byungho Lim et al.   Oncotarget

CT texture analysis in colorectal liver metastases: A better way than size and volume measurements to assess response to chemotherapy?

(2015) Sheng-Xiang Rao et al.   United European Gastroenterology Journal

Imaging Intratumor Heterogeneity: Role in Therapy Response, Resistance, and Clinical Outcome

(2014) J. P. B. O'Connor et al.   CLINICAL CANCER RESEARCH

PD-1 blockade induces responses by inhibiting adaptive immune resistance

(2014) Paul C. Tumeh et al.   NATURE

Genetic Basis for Clinical Response to CTLA-4 Blockade in Melanoma

(2014) Alexandra Snyder et al.   NEW ENGLAND JOURNAL OF MEDICINE

Comparative Genomic Analysis of Primary and Synchronous Metastatic Colorectal Cancers

(2014) Sun Young Lee et al.   PLoS One

Clonal Architectures and Driver Mutations in Metastatic Melanomas

(2014) Li Ding et al.   PLoS One

The Continuum of Cancer Immunosurveillance: Prognostic, Predictive, and Mechanistic Signatures

(2013) Jérôme Galon et al.   IMMUNITY

Ultra-deep T cell receptor sequencing reveals the complexity and intratumour heterogeneity of T cell clones in renal cell carcinomas

(2013) Marco Gerlinger et al.   JOURNAL OF PATHOLOGY

Mutational heterogeneity in cancer and the search for new cancer-associated genes

(2013) Michael S. Lawrence et al.   NATURE

Signatures of mutational processes in human cancer

(2013) Ludmil B. Alexandrov et al.   NATURE

Acquired Resistance and Clonal Evolution in Melanoma during BRAF Inhibitor Therapy

(2013) H. Shi et al.   Cancer Discovery

A Landscape of Driver Mutations in Melanoma

(2012) Eran Hodis et al.   CELL

CTLA-4 Blockade with Ipilimumab: Long-term Follow-up of 177 Patients with Metastatic Melanoma

(2012) P. A. Prieto et al.   CLINICAL CANCER RESEARCH

Assessment of tumor heterogeneity by CT texture analysis: Can the largest cross-sectional area be used as an alternative to whole tumor analysis?

(2012) Francesca Ng et al.   EUROPEAN JOURNAL OF RADIOLOGY

BRAF/NRASMutation Frequencies Among Primary Tumors and Metastases in Patients With Melanoma

(2012) Maria Colombino et al.   JOURNAL OF CLINICAL ONCOLOGY

Radiomics: the process and the challenges

(2012) Virendra Kumar et al.   MAGNETIC RESONANCE IMAGING

Intratumor Heterogeneity and Branched Evolution Revealed by Multiregion Sequencing

(2012) Marco Gerlinger et al.   NEW ENGLAND JOURNAL OF MEDICINE

Safety, Activity, and Immune Correlates of Anti–PD-1 Antibody in Cancer

(2012) Suzanne L. Topalian et al.   NEW ENGLAND JOURNAL OF MEDICINE

Improved Survival with Vemurafenib in Melanoma with BRAF V600E Mutation

(2011) Paul B. Chapman et al.   NEW ENGLAND JOURNAL OF MEDICINE

Improved Survival with Ipilimumab in Patients with Metastatic Melanoma

(2010) F. Stephen Hodi et al.   NEW ENGLAND JOURNAL OF MEDICINE

Accurate approximation method for prediction of class I MHC affinities for peptides of length 8, 10 and 11 using prediction tools trained on 9mers

(2008) C. Lundegaard et al.   BIOINFORMATICS

New response evaluation criteria in solid tumours: Revised RECIST guideline (version 1.1)

(2008) E.A. Eisenhauer et al.   EUROPEAN JOURNAL OF CANCER

The immunologic constant of rejection

(2008) Ena Wang et al.   TRENDS IN IMMUNOLOGY