Sex-Dependent Effects of Developmental Lead Exposure on the Brain

Associations between prenatal lead exposure and birth outcomes: Modification by sex and GSTM1/GSTT1 polymorphism

(2018) Dirga Kumar Lamichhane et al.   SCIENCE OF THE TOTAL ENVIRONMENT

Maternal stress modifies the effect of exposure to lead during pregnancy and 24-month old children's neurodevelopment

(2017) Marcela Tamayo y Ortiz et al.   ENVIRONMENT INTERNATIONAL

Genome-wide gene by lead exposure interaction analysis identifies UNC5D as a candidate gene for neurodevelopment

(2017) Zhaoxi Wang et al.   Environmental Health

Statistical Approaches for Estimating Sex-Specific Effects in Endocrine Disruptors Research

(2017) Jessie P. Buckley et al.   ENVIRONMENTAL HEALTH PERSPECTIVES

Interaction of sex chromosome complement, gonadal hormones and neuronal steroid synthesis on the sexual differentiation of mammalian neurons

(2017) Maria Julia Cambiasso et al.   JOURNAL OF NEUROGENETICS

Incorporating sex as a biological variable in neuroscience: what do we gain?

(2017) Margaret M. McCarthy et al.   NATURE REVIEWS NEUROSCIENCE

Neuroimmunology and neuroepigenetics in the establishment of sex differences in the brain

(2017) Margaret M. McCarthy et al.   NATURE REVIEWS NEUROSCIENCE

Prenatal stress and epigenetics

(2017) L. Cao-Lei et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

Sex- and brain region- specific effects of prenatal stress and lead exposure on permissive and repressive post-translational histone modifications from embryonic development through adulthood

(2017) G. Varma et al.   NEUROTOXICOLOGY

Data relating to prenatal lead exposure and child IQ at 4 and 8 years old in the Avon Longitudinal Study of Parents and Children

(2017) Caroline M. Taylor et al.   NEUROTOXICOLOGY

Sex-specific effects of developmental lead exposure on the immune-neuroendocrine network

(2017) Jane Kasten-Jolly et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

A Drosophila model for toxicogenomics: Genetic variation in susceptibility to heavy metal exposure

(2017) Shanshan Zhou et al.   PLoS Genetics

New Perspectives on Genomic Imprinting, an Essential and Multifaceted Mode of Epigenetic Control in the Developing and Adult Brain

(2016) Julio D. Perez et al.   Annual Review of Neuroscience

Cellular and molecular mechanisms of sexual differentiation in the mammalian nervous system

(2016) Nancy G. Forger et al.   FRONTIERS IN NEUROENDOCRINOLOGY

Genome-wide association studies and epigenome-wide association studies go together in cancer control

(2016) Mukesh Verma   Future Oncology

Sex differences in DNA methylation and expression in zebrafish brain: a test of an extended ‘male sex drive’ hypothesis

(2016) Aniruddha Chatterjee et al.   GENE

A general theory of sexual differentiation

(2016) Arthur P. Arnold   JOURNAL OF NEUROSCIENCE RESEARCH

The organizing actions of adolescent gonadal steroid hormones on brain and behavioral development

(2016) Kalynn M. Schulz et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

Sex-dependent effects of lead and prenatal stress on post-translational histone modifications in frontal cortex and hippocampus in the early postnatal brain

(2016) Jay S. Schneider et al.   NEUROTOXICOLOGY

Subcortical gray matter changes in transgender subjects after long-term cross-sex hormone administration

(2016) Rene Seiger et al.   PSYCHONEUROENDOCRINOLOGY

Effects of low level lead exposure on associative learning and memory in the rat: Influences of sex and developmental timing of exposure

(2016) D.W. Anderson et al.   TOXICOLOGY LETTERS

A Mouse Model of X-linked Intellectual Disability Associated with Impaired Removal of Histone Methylation

(2016) Shigeki Iwase et al.   Cell Reports

Chronic early life lead (Pb2+) exposure alters presynaptic vesicle pools in hippocampal synapses

(2016) Sara Rose Guariglia et al.   BMC Pharmacology & Toxicology

Progressive Reduction in Cortical Thickness as Psychosis Develops: A Multisite Longitudinal Neuroimaging Study of Youth at Elevated Clinical Risk

(2015) Tyrone D. Cannon et al.   BIOLOGICAL PSYCHIATRY

Lead Exposure during Early Human Development and DNA Methylation of Imprinted Gene Regulatory Elements in Adulthood

(2015) Yue Li et al.   ENVIRONMENTAL HEALTH PERSPECTIVES

Lead exposure induces changes in 5-hydroxymethylcytosine clusters in CpG islands in human embryonic stem cells and umbilical cord blood

(2015) Arko Sen et al.   Epigenetics

Epigenetics and sex differences in the brain: A genome-wide comparison of histone-3 lysine-4 trimethylation (H3K4me3) in male and female mice

(2015) Erica Y. Shen et al.   EXPERIMENTAL NEUROLOGY

Mutations in the intellectual disability gene KDM5C reduce protein stability and demethylase activity

(2015) Emily Brookes et al.   HUMAN MOLECULAR GENETICS

Influence of environmental exposure on human epigenetic regulation

(2015) C. J. Marsit   JOURNAL OF EXPERIMENTAL BIOLOGY

Sex- and tissue-specific methylome changes in brains of mice perinatally exposed to lead

(2015) Francisco Javier Sánchez-Martín et al.   NEUROTOXICOLOGY

Immobility in the forced swim test is adaptive and does not reflect depression

(2015) Marc L. Molendijk et al.   PSYCHONEUROENDOCRINOLOGY

Olfactory recognition memory is disrupted in young mice with chronic low-level lead exposure

(2015) Mayra Gisel Flores-Montoya et al.   TOXICOLOGY LETTERS

Early life lead exposure causes gender-specific changes in the DNA methylation profile of DNA extracted from dried blood spots

(2015) Arko Sen et al.   Epigenomics

Noncanonical Genomic Imprinting Effects in Offspring

(2015) Paul J. Bonthuis et al.   Cell Reports

Sex differences in animal models of psychiatric disorders

(2014) N Kokras et al.   BRITISH JOURNAL OF PHARMACOLOGY

Transient Neuroprotection by SRY Upregulation in Dopamine Cells Following Injury in Males

(2014) Daniel P. Czech et al.   ENDOCRINOLOGY

KDM5C mutational screening among males with intellectual disability suggestive of X-Linked inheritance and review of the literature

(2014) Thainá Fernandez Gonçalves et al.   European Journal of Medical Genetics

Environmental Exposure to Lead (Pb) and Variations in Its Susceptibility

(2014) Jina Kim et al.   JOURNAL OF ENVIRONMENTAL SCIENCE AND HEALTH PART C-ENVIRONMENTAL CARCINOGENESIS & ECOTOXICOLOGY REVIEWS

Tracing the long-term legacy of childhood lead exposure: A review of three decades of the Port Pirie Cohort study

(2014) Amelia K. Searle et al.   NEUROTOXICOLOGY

Sex-dependent impacts of low-level lead exposure and prenatal stress on impulsive choice behavior and associated biochemical and neurochemical manifestations

(2014) Hiromi I. Weston et al.   NEUROTOXICOLOGY

DNA Methyl Transferase (DNMT) Gene Polymorphisms Could Be a Primary Event in Epigenetic Susceptibility to Schizophrenia

(2014) Koramannil Radha Saradalekshmi et al.   PLoS One

Genetic Diversity Influences the Response of the Brain to Developmental Lead Exposure

(2014) Jay S. Schneider et al.   TOXICOLOGICAL SCIENCES

Lead Exposure Disrupts Global DNA Methylation in Human Embryonic Stem Cells and Alters Their Neuronal Differentiation

(2014) Marie-Claude Senut et al.   TOXICOLOGICAL SCIENCES

MeCP2: the long trip from a chromatin protein to neurological disorders

(2014) Juan Ausió et al.   TRENDS IN MOLECULAR MEDICINE

The effects of perinatal testosterone exposure on the DNA methylome of the mouse brain are late-emerging

(2014) Negar M Ghahramani et al.   Biology of Sex Differences

Minireview: Conversing With Chromatin: The Language of Nuclear Receptors

(2013) Simon C. Biddie et al.   MOLECULAR ENDOCRINOLOGY

Rearing environment, sex and developmental lead exposure modify gene expression in the hippocampus of behaviorally naïve animals

(2013) D.W. Anderson et al.   NEUROCHEMISTRY INTERNATIONAL

Prospective associations between childhood low-level lead exposure and adult mental health problems: The Port Pirie cohort study

(2013) Alexander C. McFarlane et al.   NEUROTOXICOLOGY

Modifying roles of glutathione S-transferase polymorphisms on the association between cumulative lead exposure and cognitive function

(2013) Ki-Do Eum et al.   NEUROTOXICOLOGY

The Nature of Nurture: Refining the Definition of the Exposome

(2013) Gary W. Miller et al.   TOXICOLOGICAL SCIENCES

Gender differences in the neurotoxicity of metals in children

(2013) Sabrina Llop et al.   TOXICOLOGY

DNA Methylation Signatures in Development and Aging of the Human Prefrontal Cortex

(2012) Shusuke Numata et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Dosage Compensation of the Sex Chromosomes

(2012) Christine M. Disteche   Annual Review of Genetics

Understanding the Sexome: Measuring and Reporting Sex Differences in Gene Systems

(2012) Arthur P. Arnold et al.   ENDOCRINOLOGY

Prenatal Lead Levels, Plasma Amyloid β Levels, and Gene Expression in Young Adulthood

(2012) Maitreyi Mazumdar et al.   ENVIRONMENTAL HEALTH PERSPECTIVES

Sexual differentiation in the developing mouse brain: contributions of sex chromosome genes

(2012) J. T. Wolstenholme et al.   GENES BRAIN AND BEHAVIOR

Glutathione Is a Key Player in Metal-Induced Oxidative Stress Defenses

(2012) Marijke Jozefczak et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Association of Glutathione S-transferase genes (GSTM1 and GSTT1) polymorphisms with hypertension in lead-exposed workers

(2012) Byung-Kook Lee et al.   Molecular & Cellular Toxicology

Genome-wide association studies in mice

(2012) Jonathan Flint et al.   NATURE REVIEWS GENETICS

Developmental lead effects on behavior and brain gene expression in male and female BALB/cAnNTac mice

(2012) Jane Kasten-Jolly et al.   NEUROTOXICOLOGY

Effects of Developmental Lead Exposure on the Hippocampal Transcriptome: Influences of Sex, Developmental Period, and Lead Exposure Level

(2012) Jay S Schneider et al.   TOXICOLOGICAL SCIENCES

Dysregulation of BDNF-TrkB Signaling in Developing Hippocampal Neurons by Pb2+: Implications for an Environmental Basis of Neurodevelopmental Disorders

(2012) Kirstie H. Stansfield et al.   TOXICOLOGICAL SCIENCES

Influence of developmental lead exposure on expression of DNA methyltransferases and methyl cytosine-binding proteins in hippocampus

(2012) J.S. Schneider et al.   TOXICOLOGY LETTERS

Epigenetics of early-life lead exposure and effects on brain development

(2012) Marie-Claude Senut et al.   Epigenomics

Histone Deacetylation during Brain Development Is Essential for Permanent Masculinization of Sexual Behavior

(2011) Ken Ichi Matsuda et al.   ENDOCRINOLOGY

Genes that escape from X inactivation

(2011) Joel B. Berletch et al.   HUMAN GENETICS

Environmental chemical exposures and human epigenetics

(2011) Lifang Hou et al.   INTERNATIONAL JOURNAL OF EPIDEMIOLOGY

Hypothalamic Ahi1 Mediates Feeding Behavior through Interaction with 5-HT2CReceptor

(2011) Hao Wang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Differential Effect of Postnatal Lead Exposure on Gene Expression in the Hippocampus and Frontal Cortex

(2011) J. S. Schneider et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

Sex Difference in the Expression of DNA Methyltransferase 3a in the Rat Amygdala During Development

(2011) M. H. Kolodkin et al.   JOURNAL OF NEUROENDOCRINOLOGY

A critical role for IGF-II in memory consolidation and enhancement

(2011) Dillon Y. Chen et al.   NATURE

Reframing sexual differentiation of the brain

(2011) Margaret M McCarthy et al.   NATURE NEUROSCIENCE

Epigenetic Underpinnings of Developmental Sex Differences in the Brain

(2011) Bridget M. Nugent et al.   NEUROENDOCRINOLOGY

Modification by the genes ALAD and VDR of lead-induced cognitive effects in children

(2011) Natalia Pawlas et al.   NEUROTOXICOLOGY

Sex-based differences in gene expression in hippocampus following postnatal lead exposure

(2011) J.S. Schneider et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Lead exposure suppressed ALAD transcription by increasing methylation level of the promoter CpG islands

(2011) Chunping Li et al.   TOXICOLOGY LETTERS

Epigenetic regulation of autosomal gene expression by sex chromosomes

(2011) Patrick J. Wijchers et al.   TRENDS IN GENETICS

The end of gonad-centric sex determination in mammals

(2011) Arthur P. Arnold   TRENDS IN GENETICS

Neurotoxic Effects and Biomarkers of Lead Exposure: A Review

(2011) T. Sanders et al.   REVIEWS ON ENVIRONMENTAL HEALTH

Genetics of Early Onset Cognitive Impairment

(2010) Hans Hilger Ropers   Annual Review of Genomics and Human Genetics

Lifetime Consequences of Combined Maternal Lead and Stress

(2010) Deborah A. Cory-Slechta et al.   BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY

Histone modifications proposed to regulate sexual differentiation of brain and behavior

(2010) Khatuna Gagnidze et al.   BIOESSAYS

Sex Differences in Epigenetic Regulation of the Estrogen Receptor-α Promoter within the Developing Preoptic Area

(2010) Joseph R. Kurian et al.   ENDOCRINOLOGY

Developmental and Hormone-Induced Epigenetic Changes to Estrogen and Progesterone Receptor Genes in Brain Are Dynamic across the Life Span

(2010) Jaclyn M. Schwarz et al.   ENDOCRINOLOGY

Sex differences in histone modifications in the neonatal mouse brain

(2010) Houng-Wei Tsai et al.   Epigenetics

Gene expression patterns in the hippocampus and amygdala of endogenous depression and chronic stress models

(2010) B M Andrus et al.   MOLECULAR PSYCHIATRY

Estrogen Actions in the Brain and the Basis for Differential Action in Men and Women: A Case for Sex-Specific Medicines

(2010) G. E. Gillies et al.   PHARMACOLOGICAL REVIEWS

High-Resolution Analysis of Parent-of-Origin Allelic Expression in the Mouse Brain

(2010) C. Gregg et al.   SCIENCE

Sex-Specific Parent-of-Origin Allelic Expression in the Mouse Brain

(2010) C. Gregg et al.   SCIENCE

Effect of the delta-aminolevulinic acid dehydratase gene polymorphism on renal and neurobehavioral function in workers exposed to lead in China

(2010) Ai Gao et al.   SCIENCE OF THE TOTAL ENVIRONMENT

Enhanced Learning Deficits in Female Rats Following Lifetime Pb Exposure Combined with Prenatal Stress

(2010) Deborah A. Cory-Slechta et al.   TOXICOLOGICAL SCIENCES

Blood Lead Levels and Major Depressive Disorder, Panic Disorder, and Generalized Anxiety Disorder in US Young Adults

(2009) Maryse F. Bouchard et al.   ARCHIVES OF GENERAL PSYCHIATRY

Gender specific differences in neurodevelopmental effects of prenatal exposure to very low-lead levels: The prospective cohort study in three-year olds

(2009) Wieslaw Jedrychowski et al.   EARLY HUMAN DEVELOPMENT

Epigenetic Regulation of Estrogen Receptor α Gene Expression in the Mouse Cortex during Early Postnatal Development

(2009) Jenne M. Westberry et al.   ENDOCRINOLOGY

Influence of Prenatal Lead Exposure on Genomic Methylation of Cord Blood DNA

(2009) J. Richard Pilsner et al.   ENVIRONMENTAL HEALTH PERSPECTIVES

The Mothers and Children’s Environmental Health (MOCEH) study

(2009) Byung-Mi Kim et al.   EUROPEAN JOURNAL OF EPIDEMIOLOGY

Back to the future: The organizational–activational hypothesis adapted to puberty and adolescence

(2009) Kalynn M. Schulz et al.   HORMONES AND BEHAVIOR

The Epigenetics of Sex Differences in the Brain

(2009) M. M. McCarthy et al.   JOURNAL OF NEUROSCIENCE

Sexual dimorphism in environmental epigenetic programming

(2009) Anne Gabory et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Spatial working memory learning in young male and female rats: Involvement of different limbic system regions revealed by cytochrome oxidase activity

(2009) Magdalena Méndez-López et al.   NEUROSCIENCE RESEARCH

Lead and cognitive function in ALAD genotypes in the third National Health and Nutrition Examination Survey

(2009) Edward F. Krieg et al.   NEUROTOXICOLOGY AND TERATOLOGY

Transcription Factors in Long-Term Memory and Synaptic Plasticity

(2009) Cristina M. Alberini   PHYSIOLOGICAL REVIEWS

Very low lead exposures and children??s neurodevelopment

(2008) David C Bellinger   CURRENT OPINION IN PEDIATRICS

Mecp2 Organizes Juvenile Social Behavior in a Sex-Specific Manner

(2008) J. R. Kurian et al.   JOURNAL OF NEUROSCIENCE

Interaction of the δ-Aminolevulinic Acid Dehydratase Polymorphism and Lead Burden on Cognitive Function: The VA Normative Aging Study

(2008) Pradeep Rajan et al.   JOURNAL OF OCCUPATIONAL AND ENVIRONMENTAL MEDICINE

CNS effects of developmental Pb exposure are enhanced by combined maternal and offspring stress

(2008) M.B. Virgolini et al.   NEUROTOXICOLOGY

Sex-Specific Expression of the X-Linked Histone Demethylase Gene Jarid1c in Brain

(2008) Jun Xu et al.   PLoS One

Sex steroids and brain structure in pubertal boys and girls

(2008) Jiska S. Peper et al.   PSYCHONEUROENDOCRINOLOGY

Alterations in glucocorticoid negative feedback following maternal Pb, prenatal stress and the combination: A potential biological unifying mechanism for their corresponding disease profiles

(2008) A. Rossi-George et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Decreased Brain Volume in Adults with Childhood Lead Exposure

(2008) Kim M Cecil et al.   PLOS MEDICINE

Association of Prenatal and Childhood Blood Lead Concentrations with Criminal Arrests in Early Adulthood

(2008) John Paul Wright et al.   PLOS MEDICINE