Article
Environmental Sciences
Zuo Wang, Haiyu Zhao, Yanyi Xu, Jianing Zhao, Zan Song, Yi Bi, Yang Li, Xianyong Lan, Chuanying Pan, Nicholas S. Foulkes, Shengxiang Zhang
Summary: Lead-induced neurotoxicity has been extensively studied, but the connection between early-life lead exposure and abnormal neurobehavior in juveniles and adults is still unclear. Using a zebrafish model, this study found that early-life exposure to lead caused neurologic damage and defective neurobehavior, with affected vitality and social behavior in juvenile and adult fish. The modulation of key genes and neuronal density changes may contribute to the observed neurobehavioral disorders.
SCIENCE OF THE TOTAL ENVIRONMENT
(2022)
Article
Immunology
Ruo-Xi Chen, Meng-Di Dai, Qing-Zhao Zhang, Mei-Ping Lu, Mei-Lin Wang, Min Yin, Xin-Jie Zhu, Zhong-Fei Wu, Zheng-Dong Zhang, Lei Cheng
Summary: This study explored the genetic association of allergic rhinitis (AR) with single nucleotide polymorphisms (SNPs) in the Toll-like receptor (TLR) signaling pathway. It found that genetic polymorphisms in TLR2 and CD14, as well as gene-gene interactions, were associated with susceptibility to AR in this Han Chinese population. However, the results regarding gene-environment interactions were limited.
JOURNAL OF INFLAMMATION RESEARCH
(2022)
Review
Chemistry, Inorganic & Nuclear
Ke Chen, Si Sun, Junying Wang, Xiao-Dong Zhang
Summary: The central nervous system is crucial for human health, and the treatment of CNS diseases is essential. Artificial enzymes offer high stability and catalytic activity, showing great potential for treating neuroinflammation and other disorders.
COORDINATION CHEMISTRY REVIEWS
(2021)
Article
Oncology
Xiuli Wang, Christian Huynh, Ryan Urak, Lihong Weng, Miriam Walter, Laura Lim, Vibhuti Vyas, Wen-Chung Chang, Brenda Aguilar, Alfonso Brito, Aniee Sarkissian, N. Achini Bandara, Lu Yang, Jinhui Wang, Xiwei Wu, Jianying Zhang, Saul J. Priceman, Hong Qin, Larry W. Kwak, Lihua E. Budde, Sandra H. Thomas, Mary C. Clark, Leslie Popplewell, Tanya Siddiqi, Christine E. Brown, Stephen J. Forman
Summary: The study demonstrated that intracerebroventricular (ICV) delivery of CD19-CAR T cells had activity against both CNS and systemic lymphomas in a mouse model, suggesting a valuable new strategy for treating B-cell malignancies with CNS involvement.
CANCER IMMUNOLOGY RESEARCH
(2021)
Review
Chemistry, Multidisciplinary
Meihua Luo, Leo Kit Cheung Lee, Bo Peng, Chung Hang Jonathan Choi, Wing Yin Tong, Nicolas H. Voelcker
Summary: Central nervous system diseases, such as Alzheimer's diseases, Parkinson's diseases, brain tumors, Huntington's disease, and stroke, are difficult to treat using conventional molecular drugs. Gene therapies have emerged as versatile therapeutics with the potential to prevent and treat these diseases. However, the efficient and safe in vivo delivery of gene therapies remains a major challenge, which can be addressed by exploring non-viral nanomedicines.
Article
Oncology
Iside Alessi, Anna Maria Caroleo, Luca de Palma, Angela Mastronuzzi, Stefano Pro, Giovanna Stefania Colafati, Alessandra Boni, Nicoletta Della Vecchia, Margherita Velardi, Melania Evangelisti, Alessia Carboni, Andrea Carai, Luciana Vinti, Massimiliano Valeriani, Antonino Reale, Pasquale Parisi, Umberto Raucci
Summary: The purpose of this review is to describe the central nervous system side effects in the treatment of pediatric cancer patients. The major neurotoxicities arising from traditional chemotherapy, radiotherapy, biologic therapy, and immunotherapy are discussed. These side effects can significantly impact the quality of life and may occur during the treatment or even years later. As early detection and more effective anticancer therapies extend the survival of cancer patients, treatment-related CNS toxicity becomes increasingly vital.
Article
Education, Scientific Disciplines
Chunbao Mo, Tingyu Mai, Jiansheng Cai, Haoyu He, Huaxiang Lu, Xu Tang, Quanhui Chen, Xia Xu, Chuntao Nong, Shuzhen Liu, Dechan Tan, Qiumei Liu, Min Xu, You Li, Zhiyong Zhang, Jian Qin
Summary: The study found no significant association between TFEB polymorphism and FLD susceptibility, but identified interactions with smoking, body mass index, and alcohol intake as factors influencing the risk of FLD.
Article
Immunology
Ying Zhang, Changfeng Zhang, Jin Zhou, Jingren Zhang, Xiaochen Chen, Jia Chen, Pu Wang, Xiuli Sun, Xiaoyan Lou, Wei Qi, Liqing Kang, Lei Yu, Depei Wu, Caixia Li
Summary: This is the first report of a patient with isolated CNS-MM treated using BCMA-CART therapy. The study showed that intravenously administered BCMA-CART cells trafficked into the cerebrospinal fluid, eradicated tumor cells, and induced severe but reversible neurological adverse events. This research suggests that BCMA-CART therapy can be considered as an alternative option for isolated CNS-MM.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Multidisciplinary Sciences
Santhosh Sethuramanujam, Akihiro Matsumoto, Geoff deRosenroll, Benjamin Murphy-Baum, J. Michael McIntosh, Miao Jing, Yulong Li, David Berson, Keisuke Yonehara, Gautam B. Awatramani
Summary: The study reveals that acetylcholine signals are transmitted through a rapid co-activation mechanism, activating receptors on multiple neurons surrounding the release site. Additionally, while acetylcholine signals are direction-selective locally, they do not show global directionality, facilitating information transfer at a local scale.
NATURE COMMUNICATIONS
(2021)
Review
Immunology
Wenjie Zhang, Yuan Chen, Hui Pei
Summary: C1q is an essential component of the complement system, performing non-specific immune functions and playing a crucial role in immune homeostasis and normal physiological functions. In the developing central nervous system, C1q is involved in synapse formation, pruning, and the development of neuronal networks. C1q has a close relationship with microglia and astrocytes and may contribute to the development of CNS disorders. Clinical trials are already underway for CNS disorders, highlighting the potential therapeutic target of C1q.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Behavioral Sciences
Diego Gomes Candido Reis, Debora Levy, Luis Alberto de Padua Covas Lage, Hebert Fabricio Culler, Vanderson Rocha, Sergio Paulo Bydlowski, Maria Claudia Nogueira Zerbini, Juliana Pereira
Summary: Overexpression of MYC and MGMT were found to be prognostic markers associated with unfavorable clinical outcomes in PCNSL-DLBCL patients. Age > 60 years and moderate/high IELSG score were also linked to worse prognosis.
BRAIN AND BEHAVIOR
(2021)
Review
Biochemistry & Molecular Biology
Bowen Jia, Jing Li, Yiting Song, Chengliang Luo
Summary: Ferroptosis is a form of iron-dependent regulated cell death characterized by iron-dependent lipid peroxidation and has been implicated in various diseases, including nervous system diseases and injuries. ACSL4, a member of the ACSLs family, is involved in the regulation of arachidonic acid and eicosapentaenoic acid, leading to ferroptosis. Understanding the molecular mechanisms of ACSL4-mediated ferroptosis will contribute to the development of new treatment strategies for these diseases or injuries.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Benedetta Russo, Marika Menduni, Patrizia Borboni, Fabiana Picconi, Simona Frontoni
Summary: This review discusses the role of the autonomic nervous system in obesity and insulin-resistance, highlighting the bi-directional effects of related mechanisms, and exploring the neural, hormonal, and nutritional mechanisms involved. Leptin is emphasized for its crucial role in appetite regulation, glucose homeostasis, and energy expenditure.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Medicine, General & Internal
Xin He, Xiaotong Fan, Yongzhi Shan, Xinrui Ji, Lan Su, Yaming Wang
Summary: In this study, next-generation sequencing was used to investigate the genomic profile of primary central nervous system lymphoma (PCNSL). The most common mutation type and mutated genes in PCNSL were identified. Enrichment analysis revealed the involvement of mutated genes in various pathways and functional protein activities. This study provides insights into the molecular mechanisms of PCNSL and potential targets for diagnosis and precision medicine.
Article
Environmental Sciences
Wudi Hao, Xiaoying Zhu, Ziyue Liu, Yushuai Song, Shengwen Wu, Xiaobo Lu, Jinghua Yang, Cuihong Jin
Summary: This study found that aluminum exposure can induce pyroptosis and neurotoxicity, causing adverse effects on the nervous system. DDX3X plays a role in determining cell survival or death by regulating the NLRP3 pyroptosis pathway or stress granules. Excessive activation of microglia may damage neurons and worsen nerve injury.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2023)
Review
Environmental Sciences
Karolina Czerwinska, Pawel Gac, Rafal Poreba, Grzegorz Mazur, Krystyna Pawlas
Summary: This study presents the differences between occupational and para-occupational diseases in Polish law, highlighting the significance of cardiovascular diseases (CVDs) in relation to work and the prevalence of cardiovascular risk factors in workplaces. The research underscores the impact of the work environment on cardiovascular diseases and suggests a shift in perspective towards focusing on work-related factors affecting people's health.
ANNALS OF AGRICULTURAL AND ENVIRONMENTAL MEDICINE
(2021)
Article
Clinical Neurology
Helena Martynowicz, Karolina Czerwinska, Anna Wojakowska, Lidia Januszewska, Iwona Markiewicz-Gorka, Mieszko Wieckiewicz, Grzegorz Mazur, Krystyna Pawlas, Rafal Poreba, Pawel Gac
Summary: This study found a relationship between blood renalase concentration and the severity of OSA, which may impact the development of hypertension in OSA patients. A negative correlation was observed between renalase and AHI in hypertensives, and other factors such as BMI and gender were independently associated with higher AHI.
SLEEP AND BREATHING
(2021)
Article
Biochemistry & Molecular Biology
Mateusz Lejawa, Kamila Osadnik, Tadeusz Osadnik, Natalia Pawlas
Summary: This study found associations between oxidative stress, metabolic health, and telomere length in both healthy and unhealthy individuals. Total oxidation status, total antioxidant capacity, and telomere length were significantly linked with metabolically unhealthy obesity. The findings suggest that obesity can lead to telomere shortening through metabolic disturbances and oxidative stress associated with MetS. Further research is needed to explore these pathways in young individuals with different metabolic health statuses.
Review
Environmental Sciences
Pawel Gac, Karolina Czerwinska, Piotr Macek, Aleksandra Jaremkow, Grzegorz Mazur, Krystyna Pawlas, Rafal Poreba
Summary: Research has highlighted the role of trace elements such as selenium and zinc in cardiovascular health, with some studies suggesting potential impact on cardiovascular morphology and function. However, there is currently no scientific evidence supporting supplementation of these trace elements for preventing cardiovascular diseases, highlighting the need for further research in this area.
ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY
(2021)
Article
Cell Biology
Grzegorz K. Jakubiak, Kamila Osadnik, Mateusz Lejawa, Slawomir Kasperczyk, Tadeusz Osadnik, Natalia Pawlas
Summary: The study revealed significant differences in oxidative stress parameters between metabolically unhealthy obese individuals and young volunteers with normal body weight, providing insights into the relationship between obesity and oxidative stress.
OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
(2021)
Article
Biochemistry & Molecular Biology
Grzegorz K. Jakubiak, Kamila Osadnik, Mateusz Lejawa, Tadeusz Osadnik, Marcin Golawski, Piotr Lewandowski, Natalia Pawlas
Summary: Metabolic syndrome is the coexistence of factors that increase the risk for type 2 diabetes and cardiovascular disease, and it is associated with oxidative stress. Among the components of metabolic syndrome, obesity and insulin resistance show the strongest association with oxidative stress.
Article
Environmental Sciences
Iwona Markiewicz-Gorka, Malgorzata Chowaniec, Helena Martynowicz, Anna Wojakowska, Aleksandra Jaremkow, Grzegorz Mazur, Piotr Wiland, Krystyna Pawlas, Rafal Poreba, Pawel Gac
Summary: This study found an association between cadmium exposure and the risk of developing or exacerbating symptoms of inflammatory arthritis (IA). High levels of blood cadmium were linked to an increased risk of IA, as well as elevated levels of oxidative damage marker and cyclooxygenase-2, and frequent consumption of offal. Cadmium exposure was also related to disease symptoms onset in IA patients, decreased levels of anti-inflammatory interleukin 10, and increased disease activity.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2022)
Article
Environmental Sciences
Agata Maria Kawalec, Krystyna Pawlas
Summary: The study aimed to investigate the relationship between socioeconomic factors and chosen parameters of burns in children. The results indicated that single parenthood, fathers' age, and having multiple children in the family were associated with the severity of burns, type of treatment, and length of hospitalization for children.
ANNALS OF AGRICULTURAL AND ENVIRONMENTAL MEDICINE
(2022)
Review
Pharmacology & Pharmacy
Tadeusz Osadnik, Marcin Golawski, Piotr Lewandowski, Jakub Morze, Kamila Osadnik, Natalia Pawlas, Mateusz Lejawa, Grzegorz K. Jakubiak, Agnieszka Mazur, Lucas Schwingschackl, Mariusz Gasior, Maciej Banach
Summary: Hypercholesterolemia is responsible for an estimated 2.6 million deaths worldwide. Non-adherence to statin therapy is mainly due to statin-associated muscle symptoms. Nutraceuticals are prescribed as an alternative, and this study aimed to assess their efficacy in lowering LDL-C and improving lipid profile.
PHARMACOLOGICAL RESEARCH
(2022)
Article
Medicine, Legal
Paulina Wachholz, Rafal Skowronek, Natalia Pawlas
Summary: This study investigates the use of cerebrospinal fluid (CSF) collected from the spinal canal for determining ethyl alcohol content in post-mortem cases. The results show a strong positive correlation between blood ethanol concentration and CSF ethanol concentration. The findings suggest that CSF can be an alternative biological specimen for assessing ethyl alcohol intoxication status.
FORENSIC SCIENCE MEDICINE AND PATHOLOGY
(2023)
Article
Chemistry, Analytical
Paulina Wachholz, Rafal Celinski, Beata Bujak-Gizycka, Rafal Skowronek, Natalia Pawlas
Summary: This article presents a case of death caused by alpha-PiHP, a popular cathinone derivative. The analysis of toxicological results, autopsy, histopathological findings, and crime-scene information confirmed fatal intoxication with alpha-PiHP as the cause of death. Alpha-PiHP and its metabolite (OH-alpha-PiHP) were detected and quantified in various postmortem materials, making this the first case of determination of these substances in postmortem specimens. The authors believe that a database of alpha-PiHP and its metabolite concentrations can be useful in interpreting fatal cases.
JOURNAL OF ANALYTICAL TOXICOLOGY
(2023)
Review
Nutrition & Dietetics
Marcin Delijewski, Aleksandra Barton, Beata Maksym, Natalia Pawlas
Summary: Iron is a crucial transition metal in physiological processes, but it can also be toxic due to its involvement in free radical formation. Impaired iron metabolism leads to iron deficiency, anemia, and iron overload, with different prevalences in transplant patients. Limited knowledge exists on iron metabolism in lung graft recipients and donors, complicated further by the potential impact of drugs. This overview highlights the importance of understanding iron turnover in transplant patients and assessing drug effects on iron metabolism for perioperative treatment in transplantology.
Article
Public, Environmental & Occupational Health
Frantiska Hruba, Milena Cerna, Chunying Chen, Florencia Harari, Milena Horvat, Kvetoslava Koppova, Andrea Krskova, Jawhar Laamech, Yu-feng Li, Lina Loefmark, Thomas Lundh, Badiaa Lyoussi, Darja Mazej, Josko Osredkar, Krystyna Pawlas, Natalia Pawlas, Adam Prokopowicz, Gerda Rentschler, Janja Snoj Tratnik, Johan Sommar, Vera Spevackova, Zdravko Spiric, Staffan Skerfving, Ingvar A. Bergdahl
Summary: The study aimed to evaluate regional differences in blood levels of toxic elements in children and identify factors associated with exposure. The findings revealed that children living in certain areas were at a higher risk of exposure to toxic elements.
INTERNATIONAL JOURNAL OF OCCUPATIONAL MEDICINE AND ENVIRONMENTAL HEALTH
(2023)
Article
Environmental Sciences
Fallah Hashemi, Lori Hoepner, Farahnaz Soleimani Hamidinejad, Daniela Haluza, Sima Afrashteh, Alireza Abbasi, Elma Omeragic, Belma Imamovic, Narin A. Rasheed, Taqi M. J. Taher, Fitri Kurniasari, Dhuha Youssef Wazqar, Ozge Ceren Apali, Ayca Demir Yildirim, Bo Zhao, Zaruhi Kalikyan, Cui Guo, Andrea Chong Valbuena, Magdalena Mititelu, Carolina Martinez Pando, Maria Saridi, Aikaterini Toska, Magalys Lopez Cuba, Precious Kwablah Kwadzokpui, Niguse Tadele, Tohfa Nasibova, Stefanie Harsch, Luvsan Munkh-Erdene, Wafaa Menawi, Efi Evangelou, Antoniya Dimova, Dimitar Marinov, Teodora Dimitrova, Anna Shalimova, Howieda Fouly, Anna Suraya, Juliana Pereira da Silva Faquim, Bouadil Oumayma, Maria Antonieta Annunziato, Rezarta Lalo, Evridiki Papastavrou, Anju D. Ade, Susanna Caminada, Svetlana Stojkov, Carmen Gloria Narvaez, Lutendo Sylvia Mudau, Ines Rassas, Daphnee Michel, Nur Sema Kaynar, Sehar Iqbal, Halla Elshwekh, Irin Hossain, Sadeq AL-Fayyadh, Aniuta Sydorchuk, Dua'a M. H. Alnusairat, Asli Mohamed Abdullahi, Neelam Iqbal, Apsara Pandey, Brenda Gomez-Gomez, Aysenur Gunaydin Akyildiz, Elena Morosan, Daniella Dwarica, Gantuya Dorj, Sumaya Yusuf Hasan, Noha M. Al-Shdayfat, Bojana Knezevic, Wendy Valladares, Cecilia Severi, Sofia Cuba Fuentes, Sofia Augusto, Elizaveta Sidorova, Anita Dewi Moelyaningrum, Tafaul Alawad, Atiqa Khalid, Nafisa M. K. Elehamer, Anna Mihaylova, Oxana Tsigengagel, Aziza Menouni, Agnieszka Wojtecka, Rozita Hod, Yusuf Banke Idayat, Khadija Othman, Rim M. Harfouch, Tsonco Paunov, Meruyert Omar, Nana Christine Benderli, Globila Nurika, Sana Amjad, Salma Elnoamany, Fatma Elesrigy, Marwa Mamdouh Shaban, Domenica Acevedo-Lopez, Maria Kartashova, Atika Khalaf, Sabah Abdullah Jaafar, Taisir A. Kadhim, Nada Ab Hweissa, Yulong Teng, Fatima E. Mohammed, Thayahlini Sasikumar, Christabel Nangandu Hikaambo, Aditi Kharat, Ulyana Lyamtseva, Maya Arfan Aldeeb, Natalia Pawlas, Lkhagvasuren Khorolsuren, Roopeshwaree Pallavi Koonjul, Halima Boubacar Mainassara, Priyanka Chahal, Rose W. Wangeci, Ainur B. Kumar, Irina Zamora-Corrales, Stella Gracy, Maimouna Mahamat, Jakub Adamczyk, Haliza Abdul Rahman, Lolita Matiashova, Omneya Ezzat Elsherif, Nazdar E. Alkhateeb, Yamile Aleaga, Shima Bahrami, Shaimaa Rahem Al-salihy, Paula Cabrera-Galeana, Mladena Lalic-Popovic, Eugenie Brown-Myrie, Divya Bhandari, Cinderella Akbar Mayaboti, Svetlana Stanisic, Sanda Kreitmayer Pestic, Muhammed Yunus Bektay, Haleama Al Sabbah, Saber Hashemi, Bouchetara Assia, Anne-Sophie Merritt, Zhian Ramzi, Himawatee Baboolal, Juman Isstaif, Rula Shami, Rahma Saad, Temwanani Nyirongo, Mohammad Hoseini
Summary: COVID-19 has raised concerns about the adverse effects of sanitizers and disinfectants on human health. This study assessed the global health effects of these products and found that detergents, alcohol-based substances, and chlorinated compounds were the most prevalent chemical agents. Skin and respiratory effects were the most frequently reported health issues. The study highlights the need for increased awareness programs about the potential side effects of sanitizers and disinfectants during viral epidemics.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2023)
Review
Environmental Sciences
Grzegorz K. Jakubiak, Natalia Pawlas, Grzegorz Cieslar, Agata Stanek
Summary: Diabetes mellitus is a strong risk factor for cardiovascular diseases, particularly in patients with PAD where restenosis is influenced by multiple factors. The treatment options for atherosclerotic cardiovascular diseases are limited, with restenosis posing a challenge to long-term effectiveness.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2021)
