Article
Oncology
Chi Cui, Yaru Duan, Cuipeng Qiu, Peng Wang, Guiying Sun, Hua Ye, Liping Dai, Zhuo Han, Chunhua Song, Kaijuan Wang, Jianxiang Shi, Jianying Zhang
Summary: Autoantibodies against tumor-associated antigens are potential biomarkers for cancer detection. A proteomic chip approach identified 11 candidate tumor-associated antigens for gastric cancer, and a diagnostic model based on anti-NRAS, anti-MFGE8, anti-PTP4A1, and anti-RRAS2 autoantibodies showed optimal performance in distinguishing gastric cancer cases from healthy controls. This approach is effective in cancer detection and can aid in accurate diagnosis.
FRONTIERS IN ONCOLOGY
(2021)
Article
Oncology
Huimin Wang, Xiaoang Yang, Guiying Sun, Qian Yang, Chi Cui, Xiao Wang, Hua Ye, Liping Dai, Jianxiang Shi, Jianying Zhang, Peng Wang
Summary: The study demonstrates that the anti-GNA11 autoantibody has potential as a new serological marker in the diagnosis of ESCC. It can distinguish ESCC patients from normal controls with high diagnostic performance in clinical subgroups. The expression of GNA11 can differentiate ESCC tissues from para-tumor tissues, and the mRNA expression of GNA11 varies between ESCC patients and normal controls.
FRONTIERS IN ONCOLOGY
(2021)
Article
Immunology
Cuipeng Qiu, Yaru Duan, Bofei Wang, Jianxiang Shi, Peng Wang, Hua Ye, Liping Dai, Jianying Zhang, Xiao Wang
Summary: The study found a positive correlation between the high expression of PDLIM1 autoantibodies in OC patients and high expression of PDLIM1 in tissues, indicating the potential of autoantibodies against PDLIM1 as a novel serological biomarker for OC, serving as a complementary measure to CA125 and improving the accuracy of OC detection.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Immunology
Yue Zhao, Alexey Baldin, Orkhan Isayev, Jens Werner, Andrey A. Zamyatnin, Alexandr Bazhin
Summary: Cancer vaccines utilize the host's immune system specificity to eliminate tumor cells, with antigen selection and application playing a critical role in efficacy. Tumor-associated antigens and tumor-specific antigens have different characteristics and applications in vaccine development.
Review
Immunology
Jitian Li, Bo Qin, Manyu Huang, Yan Ma, Dongsheng Li, Wuyin Li, Zhiping Guo
Summary: Osteosarcoma is the most common malignant bone tumor in childhood and adolescence, with a poor prognosis. Anti-tumor-associated antigens autoantibodies in sera may serve as serological biomarkers for early cancer detection and provide new insights into the molecular and cellular biology of cancers.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Genetics & Heredity
Reihaneh Alsadat Mahmoudian, Maharati Amirhosein, Parvaneh Mahmoudian, Fatemeh Fardi Golyan, Leila Mokhlessi, Mina Maftooh, Majid Khazaei, Mohammadreza Nassiri, Seyed Mahdi Hassanian, Majid Ghayour-Mobarhan, Gordon Ferns, Soodabeh Shahidsales, Amir Avan
Summary: Gastric cancer is a leading cause of mortality globally and presents challenges in diagnosis, prognosis, and therapy. Cancer-testis antigens (CTAs) have been identified as potential biomarkers and targets for cancer immunotherapy. Numerous studies have reported the dysregulation of CTAs in gastric cancer, and clinical trials have been conducted to evaluate their immunotherapeutic potential.
Review
Biochemistry & Molecular Biology
Karim Rihawi, Angela Dalia Ricci, Alessandro Rizzo, Stefano Brocchi, Giovanni Marasco, Luigi Vincenzo Pastore, Fabiola Lorena Rojas Llimpe, Rita Golfieri, Matteo Renzulli
Summary: Gastric cancer is the fifth most commonly diagnosed cancer worldwide, with poor prognosis in advanced stage patients despite improvements in treatment. Research efforts have focused on identifying novel therapeutic targets, with the tumor microenvironment emerging as a potential target. Various agents and strategies targeting the TME are currently being evaluated in preclinical and clinical studies.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Oncology
Hugo de Jonge, Luisa Iamele, Maristella Maggi, Greta Pessino, Claudia Scotti
Summary: Cancer is a leading cause of death worldwide, making early detection crucial for effective treatment. Auto-antibodies, circulating antibodies specific for tumor cells, have the potential to impact tumor growth and may be utilized for cancer management. However, their significance and role in cancer progression still require further research.
Article
Biotechnology & Applied Microbiology
Jijun Yu, Luoxuan Wang, Xiangya Kong, Yang Cao, Mengmeng Zhang, Zhaolin Sun, Yang Liu, Jing Wang, Beifen Shen, Xiaochen Bo, Jiannan Feng
Summary: Cancer vaccines have gained attention for their performance in preclinical and clinical settings. However, there is a need for improvement in predicting neoantigens. This study collected verified cancer antigen peptides and discussed the role of each dataset in algorithm improvement. A platform was designed for exploring cancer antigens.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Article
Oncology
Takahiro Ishii, Ayako Suzuki, Takeshi Kuwata, Shoshi Hisamitsu, Hiroko Hashimoto, Yuuki Ohara, Kazuyoshi Yanagihara, Shuichi Mitsunaga, Takayuki Yoshino, Takahiro Kinoshita, Atsushi Ochiai, Kohei Shitara, Genichiro Ishii
Summary: This study evaluated the impact of drug-exposed CAFs on the growth and migration ability of drug-exposed GC cells, showing that CAFs promoted the migration and invasion of GC cells and higher residual CAFs were associated with increased lymphovascular invasion and recurrence rate. RNA-seq analysis identified gp130 derived from CAFs as a potential factor contributing to enhanced migration of GC cells following drug treatment.
Article
Immunology
Xin Qing, Wenjing Xu, Shengli Liu, Zhencheng Chen, Chunping Ye, Yewei Zhang
Summary: This study systematically assessed the association between angiogenesis and gastric cancer (GC). The authors identified two molecular subtypes and determined the correlation between angiogenesis-associated genes mutations, clinicopathological characteristics, prognosis, immune cell infiltration, and tumor microenvironment. They established an AAG_score for predicting overall survival (OS) and created a reliable nomogram for clinical viability. The study provides insights into the characteristics of TME and potential immunotherapy strategies in GC.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Cell Biology
Hui Sun, Xu Wang, Xin Wang, Midie Xu, Weiqi Sheng
Summary: Despite progress in cancer treatment, gastric cancer (GC) still has a poor prognosis. Recent research has shown that the malignant behavior of cancer is not only caused by tumor cells, but also mediated by the activity of cancer stroma and regulated by molecular networks in the tumor microenvironment (TME). Cancer-associated fibroblasts (CAFs) are abundant in the stroma and play a significant role in the malignant development of GC. CAFs can modulate the biological properties of tumor cells through various mechanisms, affecting the initiation and progression of GC. However, there is heterogeneity in the cellular origins, phenotypes, and functions of CAFs in the TME of GC, and the molecular mechanisms are not well understood.
CELL DEATH & DISEASE
(2022)
Article
Oncology
Yu Xu, Wenjing Zhang, Tingting Xia, Yuliang Liu, Zhoukui Bi, Liang Guo, Weijia Xie, Ying Xiang, Zhi Xu, Zubin Yu, Yafei Li, Li Bai
Summary: This study confirmed the diagnostic value of 7 tumor-associated autoantibodies (AABs) for lung cancer and explored the potential improvement in diagnostic value by combining them with 7 traditional tumor-associated antigens (TAs).
FRONTIERS IN ONCOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Eun Young Kim, Jamshid Abdul-Ghafar, Yosep Chong, Kwangil Yim
Summary: This study evaluated the prognostic role and relationship between tumor-associated neutrophils (TANs) and tumor-stroma ratio (TSR) in gastric cancer. The results showed that high-grade CD15-positive, cN2 in the tumor center, and TSR were significantly associated with poor disease-free survival. Additionally, cN2 in the tumor center showed a positive correlation with TSR.
Article
Genetics & Heredity
Weihong Xie, Guiying Sun, Jicun Zhu, Huimin Wang, Zhuo Han, Peng Wang
Summary: The study found that anti-POSTN and anti-TIMP1 autoantibodies may serve as potential biomarkers for the diagnosis of esophageal squamous cell carcinoma (ESCC).
FRONTIERS IN GENETICS
(2022)
Article
Chemistry, Organic
Yitao Duan, Peiyuan Yao, Yuncheng Du, Jinhui Feng, Qiaqing Wu, Dunming Zhu
BEILSTEIN JOURNAL OF ORGANIC CHEMISTRY
(2015)
Article
Biochemistry & Molecular Biology
Yitao Duan, Peiyuan Yao, Xi Chen, Xiangtao Liu, Rui Zhang, Jinhui Feng, Qiaqing Wu, Dunming Zhu
JOURNAL OF MOLECULAR CATALYSIS B-ENZYMATIC
(2015)
Article
Biochemistry & Molecular Biology
Chao Han, Peiyuan Yao, Jing Yuan, Yitao Duan, Jinhui Feng, Min Wang, Qiaqing Wu, Dunming Zhu
JOURNAL OF MOLECULAR CATALYSIS B-ENZYMATIC
(2015)
Article
Biochemistry & Molecular Biology
Yitao Duan, Zhe Wang, Wei Wu, Zhenjiang Fang, He Huang
BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY
(2012)
Article
Biochemistry & Molecular Biology
Jinhan Wang, Yitao Duan, Dexian Zhi, Guangqiang Li, Liwen Wang, Hongmei Zhang, Lichao Gu, Haihua Ruan, Kunsheng Zhang, Qiang Liu, Shiming Li, Chi-Tang Ho, Hui Zhao
CELL BIOCHEMISTRY AND BIOPHYSICS
(2014)
Article
Chemistry, Multidisciplinary
Duan YiTao, Yao PeiYuan, Ren Jie, Han Chao, Li Qian, Yuan Jing, Feng JinHui, Wu QiaQing, Zhu DunMing
SCIENCE CHINA-CHEMISTRY
(2014)
Article
Chemistry, Physical
Guangyue Li, Jie Ren, Peiyuan Yao, Yitao Duan, Hailing Zhang, Qiaqing Wu, Jinhui Feng, Peter C. K. Lau, Dunming Zhu
Article
Oncology
Huiping Chen, Xiujuan Wu, Yitao Duan, Dexian Zhi, Min Zou, Zhihong Zhao, Xiaojun Zhang, Xiaoang Yang, Jianying Zhang
Article
Microbiology
Yitao Duan, Huihui Gao, Liyang Zheng, Shuangqing Liu, Yang Cao, Siyuan Zhu, Zhenzhe Wu, Hongqiang Ren, Daqing Mao, Yi Luo
FRONTIERS IN MICROBIOLOGY
(2020)
Article
Medicine, Research & Experimental
Meiqi Zhao, Chuanai Chen, Zhoujie Yuan, Wenwen Li, Mohan Zhang, Nailing Cui, Yitao Duan, Xiaoqian Zhang, Peng Zhang
Summary: The study demonstrated that dietary supplementation of B. subtilis can restore gut microbiota homeostasis, alleviate alcohol-induced liver injury, decrease endotoxin translocation, reduce hepatic inflammation, and improve liver function.
EXPERIMENTAL AND THERAPEUTIC MEDICINE
(2021)
Article
Ecology
Peng Zhang, Daqing Mao, Huihui Gao, Liyang Zheng, Zeyou Chen, Yuting Gao, Yitao Duan, Jianhua Guo, Yi Luo, Hongqiang Ren
Summary: The study revealed that evolutionary adaptation of plasmid-carrying bacteria in an antibiotic-influenced environment facilitated colonization of the murine gut by the bacteria and transfer of plasmids to gut bacteria. The evolved strains exhibited phenotypic alterations, enhanced bacterial growth, biofilm formation capability, and decreased plasmid fitness cost, which were attributed to chromosomal mutations and transcriptional modifications. Upregulated genes, such as type 1 fimbrial-protein pilus and surface adhesin genes, were responsible for the enhanced biofilm-forming capacity, while efflux pump genes and plasmid-harboring genes showed differential transcriptional regulation.
Article
Infectious Diseases
Yitao Duan, Shuangqing Liu, Yuting Gao, Peng Zhang, Daqing Mao, Yi Luo
Summary: Macrolides can activate the transcription of the msr(E)-mph(E) operon through the involvement of HNS and CRP. The operon was found to exist widely in diverse species of bacteria, with Acinetobacter baumannii, Klebsiella pneumoniae, Escherichia coli, and Proteus mirabilis being the main carriers. These bacteria were primarily isolated from human clinical samples and had a wide geographical distribution.
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
(2022)
Article
Engineering, Environmental
Peng Zhang, Liyang Zheng, Yitao Duan, Yuting Gao, Huihui Gao, Daqing Mao, Yi Luo
Summary: The study revealed that TCS can cause liver injury by disturbing lipid metabolism and dysbiosis of gut microbiota. TCS also increases intestinal permeability, contributing to liver damage. The research provides new insights into the health impact of TCS on the human body.
JOURNAL OF HAZARDOUS MATERIALS
(2022)
Article
Chemistry, Medicinal
Yi-Tao Duan, Xiao-Ang Yang, Lian-Ying Fang, Jin-Han Wang, Qiang Liu