Anti-Cancer Auto-Antibodies: Roles, Applications and Open Issues

Evaluation of paraneoplastic antigens reveals TRIM21 autoantibodies as biomarker for early detection of ovarian cancer in combination with autoantibodies to NY-ESO-1 and TP53

(2020) Laura C. Hurley et al.   Cancer Biomarkers

Identification of tumor-associated antigens with diagnostic ability of colorectal cancer by in-depth immunomic and seroproteomic analysis

(2020) María Garranzo-Asensio et al.   Journal of Proteomics

Integration of IgA and IgG Autoantigens Improves Performance of Biomarker Panels for Early Diagnosis of Lung Cancer

(2020) Jianbo Pan et al.   MOLECULAR & CELLULAR PROTEOMICS

MUCIN-4 (MUC4) is a novel tumor antigen in pancreatic cancer immunotherapy

(2020) Shailendra K. Gautam et al.   SEMINARS IN IMMUNOLOGY

Measuring serum human epididymis secretory protein autoantibody as an early biomarker of lung cancer

(2020) Bin Yang et al.   Translational Cancer Research

Antibodies Against Hypothalamus and Pituitary Gland in Childhood-Onset Brain Tumors and Pituitary Dysfunction

(2020) Giuseppa Patti et al.   Frontiers in Endocrinology

Proteome Profiling Uncovers an Autoimmune Response Signature That Reflects Ovarian Cancer Pathogenesis

(2020) Makoto Kobayashi et al.   Cancers

Clinical significance of Kelch-like protein 11 antibodies

(2020) Estibaliz Maudes et al.   Neurology-Neuroimmunology & Neuroinflammation

Tumor-associated antigens and their antibodies in the screening, diagnosis, and monitoring of esophageal cancers

(2020) Abhilash Perisetti et al.   EUROPEAN JOURNAL OF GASTROENTEROLOGY & HEPATOLOGY

Tumor-associated autoantibodies in combination with alpha-fetoprotein for detection of early stage hepatocellular carcinoma

(2020) Christopher Welberry et al.   PLoS One

Serum p53 antibody: useful for detecting gastric cancer but not for predicting prognosis after surgery

(2020) Yoko Oshima et al.   SURGERY TODAY

Detection of circulating natural antibodies against CD25, MUC1, and VEGFR1 for early diagnosis of non‐small cell lung cancer

(2020) Siqi Liu et al.   FEBS Open Bio

Immunological Bases of Paraneoplastic Cerebellar Degeneration and Therapeutic Implications

(2020) Lidia Yshii et al.   Frontiers in Immunology

Cancer-testis Antigen FATE1 Expression in Adrenocortical Tumors Is Associated with A Pervasive Autoimmune Response and Is A Marker of Malignancy in Adult, but Not Children, ACC

(2020) Mabrouka Doghman-Bouguerra et al.   Cancers

Six autoantibodies as potential serum biomarkers of hepatocellular carcinoma: A prospective multicenter study

(2020) Rei Okada et al.   INTERNATIONAL JOURNAL OF CANCER

Serum anti‐p53 autoantibodies in angiosarcoma

(2020) Mihoko Kiyohara et al.   JOURNAL OF DERMATOLOGY

Paraneoplastic cerebellar degeneration in a patient with breast cancer associated with carbonic anhydrase–related protein VIII autoantibodies

(2020) Angeliki Prevezianou et al.   JOURNAL OF NEUROIMMUNOLOGY

Clinical impact of preoperative serum p53 antibody titers in 1487 patients with surgically treated esophageal squamous cell carcinoma: a multi-institutional study

(2020) Suzuki Takashi et al.   Esophagus

Serological Biomarkers for Early Detection of Hepatocellular Carcinoma: A Focus on Autoantibodies against Tumor-Associated Antigens Encoded by Cancer Driver Genes

(2020) Keyan Wang et al.   Cancers

Extracellular Vesicles Mediate B Cell Immune Response and Are a Potential Target for Cancer Therapy

(2020) Taketo Kato et al.   Cells

Identification and Validation of Novel Serum Autoantibody Biomarkers for Early Detection of Colorectal Cancer and Advanced Adenoma

(2020) Hejing Wang et al.   Frontiers in Oncology

Systematic review of observational studies reporting antiphospholipid antibodies in patients with solid tumors

(2020) Noha Abdel-Wahab et al.   Blood Advances

Anti- RI antibody associated progressive supranuclear palsy like presentation in a patient with breast carcinoma

(2020) Aastha Takkar et al.   JOURNAL OF NEUROIMMUNOLOGY

Novel Survivin Peptides Screened With Computer Algorithm Induce Cytotoxic T Lymphocytes With Higher Cytotoxic Efficiency to Cancer Cells

(2020) Qiuqiang Chen et al.   Frontiers in Molecular Biosciences

New Assay System Elecsys Anti-p53 to Detect Serum Anti-p53 Antibodies in Esophageal Cancer Patients and Colorectal Cancer Patients: Multi-institutional Study

(2020) Satoshi Yajima et al.   ANNALS OF SURGICAL ONCOLOGY

Tumor-educated B cells selectively promote breast cancer lymph node metastasis by HSPA4-targeting IgG

(2019) Yan Gu et al.   NATURE MEDICINE

Diagnostic value of multiple tumor-associated autoantibodies in lung cancer

(2019) Rui Zhang et al.   OncoTargets and Therapy

Paraneoplastic autoimmunity and small-cell lung cancer: Neurological and serological accompaniments

(2019) Anastasia Zekeridou et al.   Thoracic Cancer

Autoantibody against 14-3-3 zeta: a serological marker in detection of gastric cancer

(2019) Jiejie Qin et al.   JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY

Whole genome-derived tiled peptide arrays detect pre-diagnostic autoantibody signatures in non-small cell lung cancer

(2019) Yuanqing Yan et al.   CANCER RESEARCH

Mitochondrial autoimmunity and MNRR1 in breast carcinogenesis

(2019) Siddhesh Aras et al.   BMC CANCER

Using recursive partitioning approach to select tumor‐associated antigens in immunodiagnosis of gastric adenocarcinoma

(2019) Jiejie Qin et al.   CANCER SCIENCE

Serum anti‑GAPDH autoantibody levels reflect the severity of cervical lesions: A potential serum biomarker for cervical cancer screening

(2019) Mei Xu et al.   Oncology Letters

Kelch-like Protein 11 Antibodies in Seminoma-Associated Paraneoplastic Encephalitis

(2019) Caleigh Mandel-Brehm et al.   NEW ENGLAND JOURNAL OF MEDICINE

Antiphospholipid antibodies and antiphospholipid syndrome in cancer: Uninvited guests in troubled times

(2019) Md. Asiful Islam   SEMINARS IN CANCER BIOLOGY

MGMT autoantibodies as a potential prediction of recurrence and treatment response biomarker for glioma patients

(2019) Haibin Wu et al.   Cancer Medicine

High-throughput assessment of the antibody profile in ovarian cancer ascitic fluids

(2019) Frank Antony et al.   OncoImmunology

Enhancement of diagnostic performance in lung cancers by combining CEA and CA125 with autoantibodies detection

(2019) Ruochuan Zang et al.   OncoImmunology

B Cells as an Immune-Regulatory Signature in Ovarian Cancer

(2019) Gupta et al.   Cancers

A panel of autoantibodies against tumor-associated antigens in the early immunodiagnosis of lung cancer

(2019) Di Jiang et al.   IMMUNOBIOLOGY

Review of emerging biomarkers in head and neck squamous cell carcinoma in the era of immunotherapy and targeted therapy

(2019) Jason Chia‐Hsun Hsieh et al.   HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK

Discovering novel lung cancer associated antigens and the utilization of their autoantibodies in detection of lung cancer

(2019) Lu Pei et al.   IMMUNOBIOLOGY

The global burden of urinary bladder cancer: an update

(2019) Anke Richters et al.   WORLD JOURNAL OF UROLOGY

Establishment and validation of an immunodiagnostic model for prediction of breast cancer

(2019) Cuipeng Qiu et al.   OncoImmunology

Circulating biomarkers for the detection of tumor recurrence in the postsurgical follow-up of differentiated thyroid carcinoma

(2019) Luca Giovanella   CURRENT OPINION IN ONCOLOGY

Changing pattern of tumor markers in recurrent colorectal cancer patients before surgery to recurrence: serum p53 antibodies, CA19-9 and CEA

(2019) Mitsunori Ushigome et al.   International Journal of Clinical Oncology

Autoantibodies against tumor‐associated antigens combined with microRNAs in detecting esophageal squamous cell carcinoma

(2019) Guiying Sun et al.   Cancer Medicine

Longitudinal autoantibody responses against tumor-associated antigens decrease in breast cancer patients according to treatment modality

(2018) Rick L. Evans et al.   BMC CANCER

Early detection of hepatocellular carcinoma using autoantibody profiles from a panel of tumor-associated antigens

(2018) James A. Koziol et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Antinuclear antibodies and cancer: A literature review

(2018) Alexandru Vlagea et al.   CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY

Multi-panel assay of serum autoantibodies in colorectal cancer

(2018) Mitsunori Ushigome et al.   International Journal of Clinical Oncology

Cost-effectiveness of an autoantibody test (EarlyCDT-Lung) as an aid to early diagnosis of lung cancer in patients with incidentally detected pulmonary nodules

(2018) John Edelsberg et al.   PLoS One

Identification of six serum antigens and autoantibodies for the detection of early stage epithelial ovarian carcinoma by bioinformatics analysis and liquid chip analysis

(2018) Yupeng Zou et al.   Oncology Letters

Deregulated PP1α phosphatase activity towards MAPK activation is antagonized by a tumor suppressive failsafe mechanism

(2018) Ming Chen et al.   Nature Communications

Serum anti-TOPO48 autoantibody as a biomarker for early diagnosis and prognosis in patients with esophageal squamous cell carcinoma

(2018) Jian-bo Zhang et al.   Clinics and Research in Hepatology and Gastroenterology

A diagnostic autoantibody signature for primary cutaneous melanoma

(2018) Pauline Zaenker et al.   Oncotarget

NY-ESO-1 Based Immunotherapy of Cancer: Current Perspectives

(2018) Remy Thomas et al.   Frontiers in Immunology

Using a panel of multiple tumor-associated antigens to enhance autoantibody detection for immunodiagnosis of gastric cancer

(2018) Shuaibing Wang et al.   OncoImmunology

Tumor-infiltrating lymphocytes and serum anti-p53 autoantibody in HER2-positive breast cancer treated with neoadjuvant chemotherapy.

(2018) Eriko Tokunaga et al.   JOURNAL OF CLINICAL ONCOLOGY

Detection of autoantibodies against cancer-testis antigens in non-small cell lung cancer

(2018) Dijana Djureinovic et al.   LUNG CANCER

Epidemiology and Demographics of the Head and Neck Cancer Population

(2018) Natasha Cohen et al.   Oral and Maxillofacial Surgery Clinics of North America

Combined detection of serum autoantibodies as diagnostic biomarkers in esophagogastric junction adenocarcinoma

(2018) Yi-Wei Xu et al.   Gastric Cancer

Autoimmunity and Cancer, the Paradox Comorbidities Challenging Therapy in the Context of Preexisting Autoimmunity

(2018) Julio C. Valencia et al.   JOURNAL OF INTERFERON AND CYTOKINE RESEARCH

Biomarkers in Lung Cancer Screening: Achievements, Promises, and Challenges

(2018) Luis M. Seijo et al.   Journal of Thoracic Oncology

Systematic review: Tumor-associated antigen autoantibodies and ovarian cancer early detection

(2017) Renée Turzanski Fortner et al.   GYNECOLOGIC ONCOLOGY

Autoantibody biomarkers for the detection of serous ovarian cancer

(2017) Benjamin A. Katchman et al.   GYNECOLOGIC ONCOLOGY

Ovarian cancer early detection by circulating CA125 in the context of anti-CA125 autoantibody levels: Results from the EPIC cohort

(2017) Renée T. Fortner et al.   INTERNATIONAL JOURNAL OF CANCER

Autoimmune diseases and breast cancer risk by tumor hormone-receptor status among elderly women

(2017) Catherine Schairer et al.   INTERNATIONAL JOURNAL OF CANCER

Autoantibody Signature Enhances the Positive Predictive Power of Computed Tomography and Nodule-Based Risk Models for Detection of Lung Cancer

(2017) Pierre P. Massion et al.   Journal of Thoracic Oncology

Identification of 14–3-3ζ as a potential biomarker in gastric cancer by proteomics-based analysis

(2017) Xin-Xin Liu et al.   Molecular Medicine Reports

Antigen presentation profiling reveals recognition of lymphoma immunoglobulin neoantigens

(2017) Michael S. Khodadoust et al.   NATURE

CpG-based immunotherapy impairs antitumor activity of BRAF inhibitors in a B-cell-dependent manner

(2017) L Huang et al.   ONCOGENE

Current modalities in cancer immunotherapy: Immunomodulatory antibodies, CARs and vaccines

(2017) Jason Lohmueller et al.   PHARMACOLOGY & THERAPEUTICS

Serum levels of anti‑sperm‑associated antigen 9 antibody are elevated in patients with hepatocellular carcinoma

(2017) Biqiong Ren et al.   Oncology Letters

Mutational and putative neoantigen load predict clinical benefit of adoptive T cell therapy in melanoma

(2017) Martin Lauss et al.   Nature Communications

Identification of novel serum autoantibodies against EID3 in non-functional pancreatic neuroendocrine tumors

(2017) Koji Hontani et al.   Oncotarget

Circulating GRP78 antibodies from ovarian cancer patients: a promising tool for cancer cell targeting drug delivery system?

(2017) Kylie Van Hoesen et al.   Oncotarget

Evaluation of autoantibody signatures in meningioma patients using human proteome arrays

(2017) Shabarni Gupta et al.   Oncotarget

Epitope mapping of spontaneous autoantibodies to anaplastic lymphoma kinase (ALK) in non-small cell lung cancer

(2017) Mark M. Awad et al.   Oncotarget

The cancer-testis antigen, sperm protein 17, a new biomarker and immunological target in head and neck squamous cell carcinoma

(2017) Christopher A. Schutt et al.   Oncotarget

Use of autoantibodies against tumor-associated antigens as serum biomarkers for primary screening of cervical cancer

(2017) Yingji Jin et al.   Oncotarget

Anti-NY-ESO-1 autoantibody may be a tumor marker for intrahepatic cholangiocarcinoma

(2017) Zhen Zhang et al.   Oncotarget

Early detection of lung cancer by using an autoantibody panel in Chinese population

(2017) Shengxiang Ren et al.   OncoImmunology

Oesophageal cancer

(2017) Elizabeth C. Smyth et al.   Nature Reviews Disease Primers

Central Nervous System Cancers

(2017) Louis Burt Nabors et al.   Journal of the National Comprehensive Cancer Network

SCS macrophages suppress melanoma by restricting tumor-derived vesicle-B cell interactions

(2016) F. Pucci et al.   SCIENCE

An Autoimmune Response Signature Associated with the Development of Triple-Negative Breast Cancer Reflects Disease Pathogenesis

(2015) H. Katayama et al.   CANCER RESEARCH

Mechanisms of human autoimmunity

(2015) Michael D. Rosenblum et al.   JOURNAL OF CLINICAL INVESTIGATION

NY-ESO-1 autoantibody as a tumor-specific biomarker for esophageal cancer: screening in 1969 patients with various cancers

(2015) Yoko Oshima et al.   JOURNAL OF GASTROENTEROLOGY

Mutational landscape determines sensitivity to PD-1 blockade in non-small cell lung cancer

(2015) N. A. Rizvi et al.   SCIENCE

Clinicopathological significance of matrix metalloproteinase-7 protein expression in esophageal cancer: a meta-analysis

(2015) Bin Yang et al.   Drug Design Development and Therapy

Autoantibody Profiling of Glioma Serum Samples to Identify Biomarkers Using Human Proteome Arrays

(2015) Parvez Syed et al.   Scientific Reports

B Cells Regulate Macrophage Phenotype and Response to Chemotherapy in Squamous Carcinomas

(2014) Nesrine I. Affara et al.   CANCER CELL

Achievements and challenges of adoptive T cell therapy with tumor-infiltrating or blood-derived lymphocytes for metastatic melanoma: what is needed to achieve standard of care?

(2014) Inge Marie Svane et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Systematic review: Serum autoantibodies in the early detection of gastric cancer

(2014) Simone Werner et al.   INTERNATIONAL JOURNAL OF CANCER

Genetic Basis for Clinical Response to CTLA-4 Blockade in Melanoma

(2014) Alexandra Snyder et al.   NEW ENGLAND JOURNAL OF MEDICINE

Serum Biomarkers in Head and Neck Squamous Cell Cancer

(2014) Nadine M. Kaskas et al.   JAMA Otolaryngology-Head & Neck Surgery

Audit of the autoantibody test, EarlyCDT®-Lung, in 1600 patients: An evaluation of its performance in routine clinical practice

(2013) James R. Jett et al.   LUNG CANCER

Cancer Genome Landscapes

(2013) B. Vogelstein et al.   SCIENCE

Clinical utility of anti-p53auto-antibody: Systematic review and focus on colorectal cancer

(2013) Aravind Suppiah   WORLD JOURNAL OF GASTROENTEROLOGY

Decreased breast cancer risk in systemic lupus erythematosus: the search for a genetic basis continues

(2012) S Bernatsky et al.   LUPUS

Application of a High Throughput Method of Biomarker Discovery to Improvement of the EarlyCDT®-Lung Test

(2012) Isabel K. Macdonald et al.   PLoS One

EarlyCDT®-Lung test: improved clinical utility through additional autoantibody assays

(2012) Caroline J. Chapman et al.   TUMOR BIOLOGY

EarlyCDT-Lung: An Immunobiomarker Test as an Aid to Early Detection of Lung Cancer

(2011) Stephen Lam et al.   Cancer Prevention Research

PD-1 Blockade by CT-011, Anti-PD-1 Antibody, Enhances Ex Vivo T-cell Responses to Autologous Dendritic Cell/Myeloma Fusion Vaccine

(2011) Jacalyn Rosenblatt et al.   JOURNAL OF IMMUNOTHERAPY

Clinical validation of an autoantibody test for lung cancer

(2010) P. Boyle et al.   ANNALS OF ONCOLOGY

Correlation of the autoantibody response to the ALK oncoantigen in pediatric anaplastic lymphoma kinase-positive anaplastic large cell lymphoma with tumor dissemination and relapse risk

(2010) K. Ait-Tahar et al.   BLOOD

Angiosarcoma: State of the art and perspectives

(2010) Nicolas Penel et al.   CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY

Trastuzumab in combination with chemotherapy versus chemotherapy alone for treatment of HER2-positive advanced gastric or gastro-oesophageal junction cancer (ToGA): a phase 3, open-label, randomised controlled trial

(2010) Yung-Jue Bang et al.   LANCET

Molecular and immunological aspects of p53 and p53-autoantibodies in head and neck squamous cell carcinoma

(2009) Cordes   ONCOLOGY REPORTS

Anti-Ma and anti-Ta associated paraneoplastic neurological syndromes: 22 newly diagnosed patients and review of previous cases

(2008) L A Hoffmann et al.   JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY

Proteomics-Based Identification of HSP60 as a Tumor-Associated Antigen in Early Stage Breast Cancer and Ductal Carcinomain situ

(2008) C. Desmetz et al.   JOURNAL OF PROTEOME RESEARCH