The Interleukin-23/Interleukin-17 Axis Links Adaptive and Innate Immunity in Psoriasis

Pustular psoriasis and related pustular skin diseases

(2018) H. Bachelez   BRITISH JOURNAL OF DERMATOLOGY

The genetic basis for most patients with pustular skin disease remains elusive

(2018) R. Mössner et al.   BRITISH JOURNAL OF DERMATOLOGY

HLA-Cw6 and psoriasis

(2018) L. Chen et al.   BRITISH JOURNAL OF DERMATOLOGY

Unopposed IL-36 Activity Promotes Clonal CD4 + T-Cell Responses with IL-17A Production in Generalized Pustular Psoriasis

(2018) Akiko Arakawa et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Determinants of Patient’s Global Assessment of Disease Activity and Physician’s Global Assessment of Disease Activity in patients with rheumatoid arthritis: A post hoc analysis of overall and Japanese results from phase 3 clinical trials

(2018) Yuko Kaneko et al.   Modern Rheumatology

Sexy again: the renaissance of neutrophils in psoriasis

(2017) Michael P. Schön et al.   EXPERIMENTAL DERMATOLOGY

Dissecting human ILC heterogeneity: more than just three subsets

(2017) Yannick Simoni et al.   IMMUNOLOGY

Psoriasis pathogenesis and the development of novel targeted immune therapies

(2017) Jason E. Hawkes et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

IL-1 and IL-36 are dominant cytokines in generalized pustular psoriasis

(2017) Andrew Johnston et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

JAK inhibition as a therapeutic strategy for immune and inflammatory diseases

(2017) Daniella M. Schwartz et al.   NATURE REVIEWS DRUG DISCOVERY

Anti-interleukin and interleukin therapies for psoriasis: current evidence and clinical usefulness

(2017) Ya-Chu Tsai et al.   Therapeutic Advances in Musculoskeletal Disease

Mutually enhancing anti-inflammatory activities of dimethyl fumarate and NF-κB inhibitors - implications for dose-sparing combination therapies

(2016) Anna-Carina Hund et al.   EXPERIMENTAL DERMATOLOGY

Pathogenese der Psoriasis vulgaris

(2016) K. Schäkel et al.   HAUTARZT

c-Rel in Epidermal Homeostasis: A Spotlight on c-Rel in Cell Cycle Regulation

(2016) Verena N. Lorenz et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Downregulation of RUNX3 moderates the frequency of Th17 and Th22 cells in patients with psoriasis

(2016) DANDAN FU et al.   Molecular Medicine Reports

Interleukin-23-Independent IL-17 Production Regulates Intestinal Epithelial Permeability

(2015) Jacob S. Lee et al.   IMMUNITY

Th17 Cell Pathway in Human Immunity: Lessons from Genetics and Therapeutic Interventions

(2015) Dhavalkumar D. Patel et al.   IMMUNITY

The immunogenetics of Psoriasis: A comprehensive review

(2015) Jamie L. Harden et al.   JOURNAL OF AUTOIMMUNITY

Melanocyte antigen triggers autoimmunity in human psoriasis

(2015) Akiko Arakawa et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Identification of Two Loci Associated with Generalized Pustular Psoriasis

(2015) Zheng Zhang et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Palmoplantar Pustular Psoriasis Is Associated with Missense Variants in CARD14 , but Not with Loss-of-Function Mutations in IL36RN in European Patients

(2015) Rotraut Mössner et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Psoriasis

(2015) Wolf-Henning Boehncke et al.   LANCET

Inhibition of PAD4 activity is sufficient to disrupt mouse and human NET formation

(2015) Huw D Lewis et al.   Nature Chemical Biology

The burgeoning family of unconventional T cells

(2015) Dale I Godfrey et al.   NATURE IMMUNOLOGY

IL-12 and IL-23 cytokines: from discovery to targeted therapies for immune-mediated inflammatory diseases

(2015) Michele W L Teng et al.   NATURE MEDICINE

Phase 3 Studies Comparing Brodalumab with Ustekinumab in Psoriasis

(2015) Mark Lebwohl et al.   NEW ENGLAND JOURNAL OF MEDICINE

A Phase 2 Trial of Guselkumab versus Adalimumab for Plaque Psoriasis

(2015) Kenneth B. Gordon et al.   NEW ENGLAND JOURNAL OF MEDICINE

A New Initiative on Precision Medicine

(2015) Francis S. Collins et al.   NEW ENGLAND JOURNAL OF MEDICINE

IL-4 abrogates TH17 cell-mediated inflammation by selective silencing of IL-23 in antigen-presenting cells

(2015) Emmanuella Guenova et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Highly Focused Antigen Receptor Repertoire Characterizes γδ T Cells That are Poised to Make IL-17 Rapidly in Naive Animals

(2015) Yu-Ling Wei et al.   Frontiers in Immunology

Expression of CCL20 and Its Corresponding Receptor CCR6 Is Enhanced in Active Inflammatory Bowel Disease, and TLR3 Mediates CCL20 Expression in Colonic Epithelial Cells

(2015) Helene Kolstad Skovdahl et al.   PLoS One

AP1S3 Mutations Are Associated with Pustular Psoriasis and Impaired Toll-like Receptor 3 Trafficking

(2014) Niovi Setta-Kaffetzi et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Immunology of Psoriasis

(2014) Michelle A. Lowes et al.   Annual Review of Immunology

Th17 and regulatory T cell balance in autoimmune and inflammatory diseases

(2014) Mélissa Noack et al.   AUTOIMMUNITY REVIEWS

Innate mucosal-associated invariant T (MAIT) cells are activated in inflammatory bowel diseases

(2014) N.-E. Serriari et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Fine mapping of eight psoriasis susceptibility loci

(2014) Sayantan Das et al.   EUROPEAN JOURNAL OF HUMAN GENETICS

The plot thickens while the scope broadens: a holistic view on IL-17 in psoriasis and other inflammatory disorders

(2014) Michael P. Schön   EXPERIMENTAL DERMATOLOGY

Cellular sources of IL-17 in psoriasis: a paradigm shift?

(2014) Romy R. M. C. Keijsers et al.   EXPERIMENTAL DERMATOLOGY

Induction of IL-17+ T Cell Trafficking and Development by IFN- : Mechanism and Pathological Relevance in Psoriasis

(2014) I. Kryczek et al.   JOURNAL OF IMMUNOLOGY

IL-23 Promotes Maintenance but Not Commitment to the Th17 Lineage

(2014) G. L. Stritesky et al.   JOURNAL OF IMMUNOLOGY

Mucosal-Associated Invariant T Cell Deficiency in Systemic Lupus Erythematosus

(2014) Young-Nan Cho et al.   JOURNAL OF IMMUNOLOGY

Novel Role of the Antimicrobial Peptide LL-37 in the Protection of Neutrophil Extracellular Traps against Degradation by Bacterial Nucleases

(2014) Ariane Neumann et al.   Journal of Innate Immunity

A New Player on the Psoriasis Block: IL-17A- and IL-22-Producing Innate Lymphoid Cells

(2014) Nicole L. Ward et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

CARD14 c.526G>C (p.Asp176His) Is a Significant Risk Factor for Generalized Pustular Psoriasis with Psoriasis Vulgaris in the Japanese Cohort

(2014) Kazumitsu Sugiura et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

The IL-17A-Producing CD8 + T-Cell Population in Psoriatic Lesional Skin Comprises Mucosa-Associated Invariant T Cells and Conventional T Cells

(2014) Marcel B.M. Teunissen et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Th17 cells and Tregs : unlikely allies

(2014) Xin Chen et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Interleukin 17A: Toward a new understanding of psoriasis pathogenesis

(2014) Charles W. Lynde et al.   JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY

Nociceptive sensory neurons drive interleukin-23-mediated psoriasiform skin inflammation

(2014) Lorena Riol-Blanco et al.   NATURE

Secukinumab in Plaque Psoriasis — Results of Two Phase 3 Trials

(2014) Richard G. Langley et al.   NEW ENGLAND JOURNAL OF MEDICINE

The antimicrobial peptide LL37 is a T-cell autoantigen in psoriasis

(2014) Roberto Lande et al.   Nature Communications

A Myeloperoxidase-Containing Complex Regulates Neutrophil Elastase Release and Actin Dynamics during NETosis

(2014) Kathleen D. Metzler et al.   Cell Reports

The New Insight into the Role of Antimicrobial Proteins-Alarmins in the Immunopathogenesis of Psoriasis

(2014) A. Batycka-Baran et al.   Journal of Immunology Research

VWF-mediated leukocyte recruitment with chromatin decondensation by PAD4 increases myocardial ischemia/reperfusion injury in mice

(2013) A. S. Savchenko et al.   BLOOD

Characterization of skin-resident T cells using a crawl-out method and flow cytometry

(2013) Jacqueline Poot et al.   EXPERIMENTAL DERMATOLOGY

Jakpot! New small molecules in autoimmune and inflammatory diseases

(2013) Kamran Ghoreschi et al.   EXPERIMENTAL DERMATOLOGY

Oral vitamin D increases the frequencies of CD38+human B cells and ameliorates IL-17-producing T cells

(2013) Gennadiy Drozdenko et al.   EXPERIMENTAL DERMATOLOGY

 -Defensin 2 and 3 Promote the Uptake of Self or CpG DNA, Enhance IFN-  Production by Human Plasmacytoid Dendritic Cells, and Promote Inflammation

(2013) P. Tewary et al.   JOURNAL OF IMMUNOLOGY

IL-17 and TNF Synergistically Modulate Cytokine Expression while Suppressing Melanogenesis: Potential Relevance to Psoriasis

(2013) Claire Q.F. Wang et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

c-Rel Downregulation Affects Cell Cycle Progression of Human Keratinocytes

(2013) Verena N. Lorenz et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Characterization of Innate Lymphoid Cells in Human Skin and Blood Demonstrates Increase of NKp44+ ILC3 in Psoriasis

(2013) Federica Villanova et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

In Vivo Induction of Cutaneous Inflammation Results in the Accumulation of Extracellular Trap-Forming Neutrophils Expressing RORγt and IL-17

(2013) Romy R.M.C Keijsers et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Involvement of IL-9 in Th17-Associated Inflammation and Angiogenesis of Psoriasis

(2013) Tej Pratap Singh et al.   PLoS One

Rare and Common Variants in CARD14, Encoding an Epidermal Regulator of NF-kappaB, in Psoriasis

(2012) Catherine T. Jordan et al.   AMERICAN JOURNAL OF HUMAN GENETICS

S100A8 and S100A9 are messengers in the crosstalk between epidermis and dermis modulating a psoriatic milieu in human skin

(2012) Young Lee et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Apremilast mechanism of action and application to psoriasis and psoriatic arthritis

(2012) Peter Schafer   BIOCHEMICAL PHARMACOLOGY

Endocytosis of soluble immune complexes leads to their clearance by Fc RIIIB but induces neutrophil extracellular traps via Fc RIIA in vivo

(2012) K. Chen et al.   BLOOD

Neutrophil extracellular traps mediate transfer of cytoplasmic neutrophil antigens to myeloid dendritic cells toward ANCA induction and associated autoimmunity

(2012) S. Sangaletti et al.   BLOOD

Rorγt+ innate lymphocytes and γδ T cells initiate psoriasiform plaque formation in mice

(2012) Stanislav Pantelyushin et al.   JOURNAL OF CLINICAL INVESTIGATION

Improvement of Psoriasis after Tonsillectomy Is Associated with a Decrease in the Frequency of Circulating T Cells That Recognize Streptococcal Determinants and Homologous Skin Determinants

(2012) R. H. Thorleifsdottir et al.   JOURNAL OF IMMUNOLOGY

T Lymphocyte Priming by Neutrophil Extracellular Traps Links Innate and Adaptive Immune Responses

(2012) K. Tillack et al.   JOURNAL OF IMMUNOLOGY

Vitamin D Analog Calcipotriol Suppresses the Th17 Cytokine–Induced Proinflammatory S100 “Alarmins” Psoriasin (S100A7) and Koebnerisin (S100A15) in Psoriasis

(2012) Zuzana Hegyi et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Requirements for NADPH oxidase and myeloperoxidase in neutrophil extracellular trap formation differ depending on the stimulus

(2012) Heather Parker et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Identification of 15 new psoriasis susceptibility loci highlights the role of innate immunity

(2012) Lam C Tsoi et al.   NATURE GENETICS

Crosstalk between neutrophils, B-1a cells and plasmacytoid dendritic cells initiates autoimmune diabetes

(2012) Julien Diana et al.   NATURE MEDICINE

Brodalumab, an Anti–Interleukin-17–Receptor Antibody for Psoriasis

(2012) Kim A. Papp et al.   NEW ENGLAND JOURNAL OF MEDICINE

Anti–Interleukin-17 Monoclonal Antibody Ixekizumab in Chronic Plaque Psoriasis

(2012) Craig Leonardi et al.   NEW ENGLAND JOURNAL OF MEDICINE

Downregulation of endothelial adhesion molecules by dimethylfumarate, but not monomethylfumarate, and impairment of dynamic lymphocyte-endothelial cell interactions

(2011) Katrin Wallbrecht et al.   EXPERIMENTAL DERMATOLOGY

Patients with palmoplantar pustulosis have increased IL-17 and IL-22 levels both in the lesion and serum

(2011) Masamoto Murakami et al.   EXPERIMENTAL DERMATOLOGY

The Multitasking Organ: Recent Insights into Skin Immune Function

(2011) Paola Di Meglio et al.   IMMUNITY

Human slan (6-sulfo LacNAc) dendritic cells are inflammatory dermal dendritic cells in psoriasis and drive strong Th17/Th1 T-cell responses

(2011) Anja Hänsel et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Fumarates improve psoriasis and multiple sclerosis by inducing type II dendritic cells

(2011) Kamran Ghoreschi et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Mast Cells and Neutrophils Release IL-17 through Extracellular Trap Formation in Psoriasis

(2011) A. M. Lin et al.   JOURNAL OF IMMUNOLOGY

Cathelicidin Antimicrobial Peptide LL-37 in Psoriasis Enables Keratinocyte Reactivity against TLR9 Ligands

(2011) Shin Morizane et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Neutrophils Activate Plasmacytoid Dendritic Cells by Releasing Self-DNA-Peptide Complexes in Systemic Lupus Erythematosus

(2011) R. Lande et al.   Science Translational Medicine

Myeloperoxidase is required for neutrophil extracellular trap formation: implications for innate immunity

(2010) K. D. Metzler et al.   BLOOD

Primary human keratinocytes efficiently induce IL-1-dependent IL-17 in CCR6+ T cells

(2010) Philipp Muhr et al.   EXPERIMENTAL DERMATOLOGY

Activated endothelial cells induce neutrophil extracellular traps and are susceptible to NETosis-mediated cell death

(2010) Anurag Kumar Gupta et al.   FEBS LETTERS

Neutrophil elastase and myeloperoxidase regulate the formation of neutrophil extracellular traps

(2010) Venizelos Papayannopoulos et al.   JOURNAL OF CELL BIOLOGY

Halting angiogenesis by non-viral somatic gene therapy alleviates psoriasis and murine psoriasiform skin lesions

(2010) John R. Zibert et al.   JOURNAL OF CLINICAL INVESTIGATION

8-Methoxypsoralen Plus Ultraviolet A Therapy Acts via Inhibition of the IL-23/Th17 Axis and Induction of Foxp3+ Regulatory T Cells Involving CTLA4 Signaling in a Psoriasis-Like Skin Disorder

(2010) T. P. Singh et al.   JOURNAL OF IMMUNOLOGY

A Subpopulation of CD163-Positive Macrophages Is Classically Activated in Psoriasis

(2010) Judilyn Fuentes-Duculan et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Integrative Responses to IL-17 and TNF-α in Human Keratinocytes Account for Key Inflammatory Pathogenic Circuits in Psoriasis

(2010) Andrea Chiricozzi et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Generation of pathogenic TH17 cells in the absence of TGF-β signalling

(2010) Kamran Ghoreschi et al.   NATURE

Activation of the Raf-MEK-ERK pathway is required for neutrophil extracellular trap formation

(2010) Abdul Hakkim et al.   Nature Chemical Biology

The Toll-like receptor 4 ligands Mrp8 and Mrp14 are crucial in the development of autoreactive CD8+ T cells

(2010) Karin Loser et al.   NATURE MEDICINE

Comparison of Ustekinumab and Etanercept for Moderate-to-Severe Psoriasis

(2010) Christopher E.M. Griffiths et al.   NEW ENGLAND JOURNAL OF MEDICINE

Restoration of NET formation by gene therapy in CGD controls aspergillosis

(2009) M. Bianchi et al.   BLOOD

From interleukin-23 to T-helper 17 cells: human T-helper cell differentiation revisited

(2009) Katia Boniface et al.   IMMUNOLOGICAL REVIEWS

Janus kinases in immune cell signaling

(2009) Kamran Ghoreschi et al.   IMMUNOLOGICAL REVIEWS

Psoriasis – eine systemische Entzündung: Klinik, Pathogenese und Therapieziele

(2009) Wolf-Henning Boehncke et al.   JOURNAL DER DEUTSCHEN DERMATOLOGISCHEN GESELLSCHAFT

Effective treatment of psoriasis with etanercept is linked to suppression of IL-17 signaling, not immediate response TNF genes

(2009) Lisa C. Zaba et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Histone hypercitrullination mediates chromatin decondensation and neutrophil extracellular trap formation

(2009) Yanming Wang et al.   JOURNAL OF CELL BIOLOGY

Self-RNA–antimicrobial peptide complexes activate human dendritic cells through TLR7 and TLR8

(2009) Dipyaman Ganguly et al.   JOURNAL OF EXPERIMENTAL MEDICINE

The IL-23/Th17 Axis in the Immunopathogenesis of Psoriasis

(2009) Antonella Di Cesare et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

The interleukin 23 receptor is essential for the terminal differentiation of interleukin 17–producing effector T helper cells in vivo

(2009) Mandy J McGeachy et al.   NATURE IMMUNOLOGY

Psoriasis

(2009) Frank O. Nestle et al.   NEW ENGLAND JOURNAL OF MEDICINE

Efalizumab in the treatment of psoriasis: mode of action, clinical indications, efficacy, and safety

(2008) Michael P. Schön   CLINICS IN DERMATOLOGY

Psoriasis Vulgaris Lesions Contain Discrete Populations of Th1 and Th17 T Cells

(2008) Michelle A. Lowes et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY