Therapeutic Potential of Invariant Natural Killer T Cells in Autoimmunity

Myeloid-derived suppressor cells coming of age

(2018) Filippo Veglia et al.   NATURE IMMUNOLOGY

Natural Killer T Cells in Cancer Immunotherapy

(2017) Shiny Nair et al.   Frontiers in Immunology

Natural Killer T Cells: An Ecological Evolutionary Developmental Biology Perspective

(2017) Amrendra Kumar et al.   Frontiers in Immunology

Development of invariant natural killer T cells

(2016) Laurent Gapin   CURRENT OPINION IN IMMUNOLOGY

Innate-like functions of natural killer T cell subsets result from highly divergent gene programs

(2016) Isaac Engel et al.   NATURE IMMUNOLOGY

How colonization by microbiota in early life shapes the immune system

(2016) Thomas Gensollen et al.   SCIENCE

Tissue-Specific Distribution of iNKT Cells Impacts Their Cytokine Response

(2015) You Jeong Lee et al.   IMMUNITY

Natural killer T cells in multiple sclerosis and its animal model, experimental autoimmune encephalomyelitis

(2015) Luc Van Kaer et al.   IMMUNOLOGY

The Response of CD1d-Restricted Invariant NKT Cells to Microbial Pathogens and Their Products

(2015) Luc Van Kaer et al.   Frontiers in Immunology

Regulatory role of natural killer T cells in diabetes

(2015) Celine Tard et al.   Biomedical Journal

A Single Subset of Dendritic Cells Controls the Cytokine Bias of Natural Killer T Cell Responses to Diverse Glycolipid Antigens

(2014) Pooja Arora et al.   IMMUNITY

IL-10–producing NKT10 cells are a distinct regulatory invariant NKT cell subset

(2014) Duygu Sag et al.   JOURNAL OF CLINICAL INVESTIGATION

Cutting Edge: Nonglycosidic CD1d Lipid Ligands Activate Human and Murine Invariant NKT Cells

(2014) J. D. Silk et al.   JOURNAL OF IMMUNOLOGY

Ligand-Dependent Induction of Noninflammatory Dendritic Cells by Anergic Invariant NKT Cells Minimizes Autoimmune Inflammation

(2014) J. Wang et al.   JOURNAL OF IMMUNOLOGY

Activation of Invariant NKT Cells Ameliorates Experimental Ocular Autoimmunity by A Mechanism Involving Innate IFN-  Production and Dampening of the Adaptive Th1 and Th17 Responses

(2014) R. S. Grajewski et al.   JOURNAL OF IMMUNOLOGY

Cutting Edge: Programmed Death-1/Programmed Death Ligand 1 Interaction Regulates the Induction and Maintenance of Invariant NKT Cell Anergy

(2014) W.-S. Chang et al.   JOURNAL OF IMMUNOLOGY

 -Galactosylceramide but Not Phenyl-Glycolipids Induced NKT Cell Anergy and IL-33-Mediated Myeloid-Derived Suppressor Cell Accumulation via Upregulation of egr2/3

(2014) J.-R. Huang et al.   JOURNAL OF IMMUNOLOGY

Regulatory iNKT cells lack expression of the transcription factor PLZF and control the homeostasis of Treg cells and macrophages in adipose tissue

(2014) Lydia Lynch et al.   NATURE IMMUNOLOGY

Activated Invariant NKT Cells Control Central Nervous System Autoimmunity in a Mechanism That Involves Myeloid-Derived Suppressor Cells

(2013) V. V. Parekh et al.   JOURNAL OF IMMUNOLOGY

Therapeutic manipulation of natural killer (NK) T cells in autoimmunity: are we close to reality?

(2012) Y. Simoni et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Activation of Invariant NKT Cells in Early Phase of Experimental Autoimmune Encephalomyelitis Results in Differentiation of Ly6Chi Inflammatory Monocyte to M2 Macrophages and Improved Outcome

(2012) L. Denney et al.   JOURNAL OF IMMUNOLOGY

Activation of Invariant NKT Cells with Glycolipid Ligand α-Galactosylceramide Ameliorates Glucose-6-Phosphate Isomerase Peptide-Induced Arthritis

(2012) Masanobu Horikoshi et al.   PLoS One

Targeting NKT cells and PD-L1 pathway results in augmented anti-tumor responses in a melanoma model

(2011) Kevin Durgan et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Stimulation of a shorter duration in the state of anergy by an invariant natural killer T cell agonist enhances its efficiency of protection from type 1 diabetes

(2011) R. Tohn et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Brief Treatment with iNKT Cell Ligand α-Galactosylceramide Confers a Long-term Protection Against Lupus

(2011) Jun-Qi Yang et al.   JOURNAL OF CLINICAL IMMUNOLOGY

Identification of Bcl-6-dependent follicular helper NKT cells that provide cognate help for B cell responses

(2011) Pheh-Ping Chang et al.   NATURE IMMUNOLOGY

Invariant natural killer T cells: bridging innate and adaptive immunity

(2010) Luc Van Kaer et al.   CELL AND TISSUE RESEARCH

High doses of α-galactosylceramide potentiate experimental autoimmune encephalomyelitis by directly enhancing Th17 response

(2010) Gaochao Qian et al.   CELL RESEARCH

Attenuation of invariant Natural Killer T-cell anergy induction through intradermal delivery of α-galactosylceramide

(2010) Hetty J. Bontkes et al.   CLINICAL IMMUNOLOGY

Invariant NK T cells: potential for immunotherapeutic targeting with glycolipid antigens

(2010) Luc Van Kaer et al.   Immunotherapy

Invariant NKT cells modulate the suppressive activity of IL-10-secreting neutrophils differentiated with serum amyloid A

(2010) Carmela De Santo et al.   NATURE IMMUNOLOGY

Molecular mechanisms regulating myeloid-derived suppressor cell differentiation and function

(2010) Thomas Condamine et al.   TRENDS IN IMMUNOLOGY

IL-17 and Th17 Cells

(2009) Thomas Korn et al.   Annual Review of Immunology

Natural Killer T Cells and Autoimmune Disease

(2009) Lan Wu et al.   CURRENT MOLECULAR MEDICINE

Cutting Edge: CD28 Engagement Releases Antigen-Activated Invariant NKT Cells from the Inhibitory Effects of PD-1

(2009) J. Wang et al.   JOURNAL OF IMMUNOLOGY

PD-1/PD-L Blockade Prevents Anergy Induction and Enhances the Anti-Tumor Activities of Glycolipid-Activated Invariant NKT Cells

(2009) V. V. Parekh et al.   JOURNAL OF IMMUNOLOGY

Invariant NKT cells inhibit development of the Th17 lineage

(2009) L. T. Mars et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mechanisms of NKT cell anergy induction involve Cbl-b-promoted monoubiquitination of CARMA1

(2009) S. Kojo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Alpha-galactosylceramide is an effective mucosal adjuvant for repeated intranasal or oral delivery of HIV peptide antigens

(2009) Amy N. Courtney et al.   VACCINE

Nanoparticle formulated alpha-galactosylceramide activates NKT cells without inducing anergy

(2009) Prakash Thapa et al.   VACCINE

Role of Invariant Natural Killer T (iNKT) Cells in Systemic Lupus Erythematosus

(2008) Maria Godo et al.   CURRENT MEDICINAL CHEMISTRY

CD1d-restricted iNKT cells, the ‘Swiss-Army knife’ of the immune system

(2008) Jennifer L Matsuda et al.   CURRENT OPINION IN IMMUNOLOGY

Sustained activation and tumor targeting of NKT cells using a CD1d–anti-HER2–scFv fusion protein induce antitumor effects in mice

(2008) Kathrin Stirnemann et al.   JOURNAL OF CLINICAL INVESTIGATION