Invariant NK T cells: potential for immunotherapeutic targeting with glycolipid antigens

Regulatory Roles for NKT Cell Ligands in Environmentally Induced Autoimmunity

(2014) J. Vas et al.   JOURNAL OF IMMUNOLOGY

Ligand-Dependent Induction of Noninflammatory Dendritic Cells by Anergic Invariant NKT Cells Minimizes Autoimmune Inflammation

(2014) J. Wang et al.   JOURNAL OF IMMUNOLOGY

Activation of Invariant NKT Cells Ameliorates Experimental Ocular Autoimmunity by A Mechanism Involving Innate IFN-  Production and Dampening of the Adaptive Th1 and Th17 Responses

(2014) R. S. Grajewski et al.   JOURNAL OF IMMUNOLOGY

Rapid NKT Cell Responses Are Self-Terminating during the Course of Microbial Infection

(2014) A. Chiba et al.   JOURNAL OF IMMUNOLOGY

Cutting Edge: Programmed Death-1/Programmed Death Ligand 1 Interaction Regulates the Induction and Maintenance of Invariant NKT Cell Anergy

(2014) W.-S. Chang et al.   JOURNAL OF IMMUNOLOGY

α-Galactosylceramide as a Therapeutic Agent for PulmonaryMycobacterium tuberculosisInfection

(2010) Isabel Sada-Ovalle et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

In Vivo Protection Provided by a Synthetic New Alpha-Galactosyl Ceramide Analog against Bacterial and Viral Infections in Murine Models

(2010) K.-H. Lin et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Development of Spontaneous Anergy in Invariant Natural Killer T Cells in a Mouse Model of Dyslipidemia

(2010) Nicole A. Braun et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

An α-galactosylceramide C20:2 N-acyl variant enhances anti-inflammatory and regulatory T cell-independent responses that prevent type 1 diabetes

(2010) D. Ly et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Natural Killer T Cells within the Liver: Conductors of the Hepatic Immune Orchestra

(2010) Mark G. Swain   DIGESTIVE DISEASES

α-GalCer ameliorates listeriosis by accelerating infiltration of Gr-1+ cells into the liver

(2010) Masashi Emoto et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

The Hunt for iNKT Cell Antigens: α-Galactosidase-Deficient Mice to the Rescue?

(2010) Luc Van Kaer et al.   IMMUNITY

Lysosomal α-Galactosidase Controls the Generation of Self Lipid Antigens for Natural Killer T Cells

(2010) Alexandre Darmoise et al.   IMMUNITY

CD1d-Dependent B-Cell Help by NK-Like T Cells Leads to Enhanced and Sustained Production of Bacillus anthracis Lethal Toxin-Neutralizing Antibodies

(2010) T. S. Devera et al.   INFECTION AND IMMUNITY

Induction of Th1-biased cytokine production by  -carba-GalCer, a neoglycolipid ligand for NKT cells

(2010) T. Tashiro et al.   INTERNATIONAL IMMUNOLOGY

Secretion of IFN-  but Not IL-17 by CD1d-Restricted NKT Cells Enhances Rejection of Skin Grafts Expressing Epithelial Cell-Derived Antigen

(2010) S. R. Mattarollo et al.   JOURNAL OF IMMUNOLOGY

Plasticity of Invariant NKT Cell Regulation of Allergic Airway Disease Is Dependent on IFN-  Production

(2010) H. Matsuda et al.   JOURNAL OF IMMUNOLOGY

A CD1d-Dependent Antagonist Inhibits the Activation of Invariant NKT Cells and Prevents Development of Allergen-Induced Airway Hyperreactivity

(2010) Vincent Lombardi et al.   JOURNAL OF IMMUNOLOGY

Antigen-Specific Cytotoxicity by Invariant NKT Cells In Vivo Is CD95/CD178-Dependent and Is Correlated with Antigenic Potency

(2010) G. Wingender et al.   JOURNAL OF IMMUNOLOGY

Marine Drugs from Sponge-Microbe Association—A Review

(2010) Tresa Remya A. Thomas et al.   Marine Drugs

Design of a potent CD1d-binding NKT cell ligand as a vaccine adjuvant

(2010) X. Li et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Nasal vaccination with P6 outer membrane protein and α-galactosylceramide induces nontypeable Haemophilus influenzae-specific protective immunity associated with NKT cell activation and dendritic cell expansion in nasopharynx

(2010) Kenji Noda et al.   VACCINE

Invariant natural killer T cell-natural killer cell interactions dictate transplantation outcome after  -galactosylceramide administration

(2009) R. D. Kuns et al.   BLOOD

Combination therapy ofin vitro-expanded natural killer T cells and α-galactosylceramide-pulsed antigen-presenting cells in patients with recurrent head and neck carcinoma

(2009) Naoki Kunii et al.   CANCER SCIENCE

β-galactosylceramide alters invariant natural killer T cell function and is effective treatment for lupus

(2009) Sufi R. Morshed et al.   CLINICAL IMMUNOLOGY

Invariant Natural Killer T-Cell Control of Type 1 Diabetes: A Dendritic Cell Genetic Decision of a Silver Bullet or Russian Roulette

(2009) J. P. Driver et al.   DIABETES

Adaptability of the semi-invariant natural killer T-cell receptor towards structurally diverse CD1d-restricted ligands

(2009) William C Florence et al.   EMBO JOURNAL

Invariant NKT cells and CD1d+cells amass in human omentum and are depleted in patients with cancer and obesity

(2009) Lydia Lynch et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

How do natural killer T cells help B cells?

(2009) Mark L Lang   Expert Review of Vaccines

Kinetics and Cellular Site of Glycolipid Loading Control the Outcome of Natural Killer T Cell Activation

(2009) Jin S. Im et al.   IMMUNITY

Carbohydrate specificity of the recognition of diverse glycolipids by natural killer T cells

(2009) Dirk M. Zajonc et al.   IMMUNOLOGICAL REVIEWS

Activation of invariant NKT cells confers protection against Chlamydia trachomatis-induced arthritis

(2009) M. S. Bharhani et al.   INTERNATIONAL IMMUNOLOGY

The Mucosal Adjuvant Effect of α-Galactosylceramide for Induction of Protective Immunity to Sexually Transmitted Viral Infection

(2009) Madelene Lindqvist et al.   JOURNAL OF IMMUNOLOGY

Mechanisms for Glycolipid Antigen-Driven Cytokine Polarization by Vα14 i NKT Cells

(2009) Barbara A. Sullivan et al.   JOURNAL OF IMMUNOLOGY

Incorporation of NKT Cell-Activating Glycolipids Enhances Immunogenicity and Vaccine Efficacy of Mycobacterium bovis Bacillus Calmette-Guerin

(2009) M. M. Venkataswamy et al.   JOURNAL OF IMMUNOLOGY

PD-1/PD-L Blockade Prevents Anergy Induction and Enhances the Anti-Tumor Activities of Glycolipid-Activated Invariant NKT Cells

(2009) V. V. Parekh et al.   JOURNAL OF IMMUNOLOGY

A Phase I-II Study of  -Galactosylceramide-Pulsed IL-2/GM-CSF-Cultured Peripheral Blood Mononuclear Cells in Patients with Advanced and Recurrent Non-Small Cell Lung Cancer

(2009) S. Motohashi et al.   JOURNAL OF IMMUNOLOGY

Immunologic Glycosphingolipidomics and NKT Cell Development in Mouse Thymus

(2009) Yunsen Li et al.   JOURNAL OF PROTEOME RESEARCH

Mechanisms maintaining peripheral tolerance

(2009) Daniel L Mueller   NATURE IMMUNOLOGY

Invariant NKT cells inhibit development of the Th17 lineage

(2009) L. T. Mars et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Lysosomal recycling terminates CD1d-mediated presentation of short and polyunsaturated variants of the NKT cell lipid antigen  GalCer

(2009) L. Bai et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Combined NKT cell activation and influenza virus vaccination boosts memory CTL generation and protective immunity

(2009) C. Guillonneau et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Adjuvant activity mediated by iNKT cells

(2009) Shinichiro Fujii et al.   SEMINARS IN IMMUNOLOGY

Lipid and glycolipid antigens of CD1d-restricted natural killer T cells

(2009) Manjunatha M. Venkataswamy et al.   SEMINARS IN IMMUNOLOGY

Invariant natural killer T cells: innate-like T cells with potent immunomodulatory activities

(2009) L. Wu et al.   TISSUE ANTIGENS

Alpha-C-galactosylceramide as an adjuvant for a live attenuated influenza virus vaccine

(2009) Sarah A. Kopecky-Bromberg et al.   VACCINE

Recognition of Lyso-Phospholipids by Human Natural Killer T Lymphocytes

(2009) Lisa M. Fox et al.   PLOS BIOLOGY

Bacillus anthracis Lethal Toxin Disrupts TCR Signaling in CD1d-Restricted NKT Cells Leading to Functional Anergy

(2009) Sunil K. Joshi et al.   PLoS Pathogens

Clinical applications of natural killer T cell–based immunotherapy for cancer

(2008) Shinichiro Motohashi et al.   CANCER SCIENCE

CD1d-restricted iNKT cells, the ‘Swiss-Army knife’ of the immune system

(2008) Jennifer L Matsuda et al.   CURRENT OPINION IN IMMUNOLOGY

Glycolipid-activated NKT cells support the induction of persistent plasma cell responses and antibody titers

(2008) T. Scott Devera et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Activation of invariant NKT cells enhances the innate immune response and improves the disease course in influenza A virus infection

(2008) Ling‐Pei Ho et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Glycolipid ligands of invariant natural killer T cells as vaccine adjuvants

(2008) Sungjune Kim et al.   Expert Review of Vaccines

Widespread natural variation in murine natural killer T-cell number and function

(2008) Stacia L. Rymarchyk et al.   IMMUNOLOGY

Bacterial infection alters the kinetics and function of iNKT cell responses

(2008) Hak-Jong Choi et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Diverse cytokine production by NKT cell subsets and identification of an IL-17-producing CD4-NK1.1- NKT cell population

(2008) J. M. Coquet et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Enhancement of HIV DNA vaccine immunogenicity by the NKT cell ligand, α-galactosylceramide

(2008) Yaoxing Huang et al.   VACCINE

Humans Lack iGb3 Due to the Absence of Functional iGb3-Synthase: Implications for NKT Cell Development and Transplantation

(2008) Dale Christiansen et al.   PLOS BIOLOGY

Activation of Invariant NKT Cells Exacerbates Experimental Visceral Leishmaniasis

(2008) Amanda C. Stanley et al.   PLoS Pathogens