Modulation of Regulatory T Cell Activity by TNF Receptor Type II-Targeting Pharmacological Agents

Induction of Regulatory T Cells and Its Regulation with Insulin-like Growth Factor/Insulin-like Growth Factor Binding Protein-4 by Human Mesenchymal Stem Cells

(2017) Ippei Miyagawa et al.   JOURNAL OF IMMUNOLOGY

Locking TNFR2 to kill ovarian cancer

(2017) Leslie K. Ferrarelli   SCIENCE

Targeting TNFR2 with antagonistic antibodies inhibits proliferation of ovarian cancer cells and tumor-associated Tregs

(2017) Heather Torrey et al.   Science Signaling

Targeting TNFR2, an immune checkpoint stimulator and oncoprotein, is a promising treatment for cancer

(2017) Xin Chen et al.   Science Signaling

Targeting TNFR2 with antagonistic antibodies inhibits proliferation of ovarian cancer cells and tumor-associated Tregs

(2017) Heather Torrey et al.   Science Signaling

Targeting TNFR2, an immune checkpoint stimulator and oncoprotein, is a promising treatment for cancer

(2017) Xin Chen et al.   Science Signaling

Adalimumab in the Treatment of Immune-Mediated Diseases

(2017) G. Lapadula et al.   INTERNATIONAL JOURNAL OF IMMUNOPATHOLOGY AND PHARMACOLOGY

TNFR1 inhibition with a Nanobody protects against EAE development in mice

(2017) Sophie Steeland et al.   Scientific Reports

TNF-α priming enhances CD4 + FoxP3 + regulatory T-cell suppressive function in murine GVHD prevention and treatment

(2016) Antonio Pierini et al.   BLOOD

Control of GVHD by regulatory T cells depends on TNF produced by T cells and TNFR2 expressed by regulatory T cells

(2016) M. Leclerc et al.   BLOOD

Infliximab therapy balances regulatory T cells, tumour necrosis factor receptor 2 (TNFR2) expression and soluble TNFR2 in sarcoidosis

(2016) A. Verwoerd et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Exogenous TNFR2 activation protects from acute GvHD via host T reg cell expansion

(2016) Martin Chopra et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Anti-TNF drives regulatory T cell expansion by paradoxically promoting membrane TNF–TNF-RII binding in rheumatoid arthritis

(2016) Dao Xuan Nguyen et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Enhanced Requirement for TNFR2 in Graft Rejection Mediated by Low-Affinity Memory CD8+T Cells during Heterologous Immunity

(2016) Scott M. Krummey et al.   JOURNAL OF IMMUNOLOGY

Oligodendroglial TNFR2 Mediates Membrane TNF-Dependent Repair in Experimental Autoimmune Encephalomyelitis by Promoting Oligodendrocyte Differentiation and Remyelination

(2016) Pernille M. Madsen et al.   JOURNAL OF NEUROSCIENCE

Suppressive activity of human regulatory T cells is maintained in the presence of TNF

(2016) Bruno Zaragoza et al.   NATURE MEDICINE

Paradoxical effects of targeting TNF signalling in the treatment of autoimmunity

(2016) Xin Chen et al.   Nature Reviews Rheumatology

Essential protective role of tumor necrosis factor receptor 2 in neurodegeneration

(2016) Yun Dong et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Pretransplant Recipient Circulating CD4+CD127lo/− Tumor Necrosis Factor Receptor 2+ Regulatory T Cells

(2016) Minh-Tri J. P. Nguyen et al.   TRANSPLANTATION

Phenotypic screening reveals TNFR2 as a promising target for cancer immunotherapy

(2016) Geoffrey S. Williams et al.   Oncotarget

A TNFR2-Agonist Facilitates High Purity Expansion of Human Low Purity Treg Cells

(2016) Xuehui He et al.   PLoS One

Induction of Suppressor Cells and Increased Tumor Growth following Chronic Psychosocial Stress in Male Mice

(2016) Dominic Schmidt et al.   PLoS One

Expression of TNFR2 by regulatory T cells in peripheral blood is correlated with clinical pathology of lung cancer patients

(2015) Fan Yan et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

TNF Receptor-2 Facilitates an Immunosuppressive Microenvironment in the Liver to Promote the Colonization and Growth of Hepatic Metastases

(2015) B. Ham et al.   CANCER RESEARCH

Panobinostat for the Treatment of Multiple Myeloma

(2015) J. P. Laubach et al.   CLINICAL CANCER RESEARCH

Small Molecules as Anti-TNF Drugs

(2015) Victoria Richmond et al.   CURRENT MEDICINAL CHEMISTRY

IKKα is required for the homeostasis of regulatory T cells and for the expansion of both regulatory and effector CD4 T cells

(2015) Xin Chen et al.   FASEB JOURNAL

Tumor necrosis factor inhibitors: clinical utility in autoimmune diseases

(2015) Maria A.V. Willrich et al.   Translational Research

Blockade of TNF-α signaling benefits cancer therapy by suppressing effector regulatory T cell expansion

(2015) Li-Yuan Chang et al.   OncoImmunology

Thalidomide Regulation of NF-κB Proteins Limits Tregs Activity in Chronic Lymphocytic Leukemia

(2015) Katarzyna Skórka et al.   Advances in Clinical and Experimental Medicine

Lenalidomide-based maintenance therapy reduces TNF receptor 2 on CD4 T cells and enhances immune effector function in acute myeloid leukemia patients

(2014) Chindu Govindaraj et al.   AMERICAN JOURNAL OF HEMATOLOGY

Transient Ablation of Regulatory T cells Improves Antitumor Immunity in Colitis-Associated Colon Cancer

(2014) E. Pastille et al.   CANCER RESEARCH

Progranulin promotes tumour necrosis factor-induced proliferation of suppressive mouse CD4+ Foxp3+regulatory T cells

(2014) Ya Hu et al.   IMMUNOLOGY

Anti-TNF therapy: past, present and future

(2014) C. Monaco et al.   INTERNATIONAL IMMUNOLOGY

Cutting Edge: Expression of TNFR2 Defines a Maximally Suppressive Subset of Mouse CD4+CD25+FoxP3+ T Regulatory Cells: Applicability to Tumor-Infiltrating T Regulatory Cells

(2014) X. Chen et al.   JOURNAL OF IMMUNOLOGY

Cutting Edge: TNFR-Shedding by CD4+CD25+ Regulatory T Cells Inhibits the Induction of Inflammatory Mediators

(2014) G. J. D. van Mierlo et al.   JOURNAL OF IMMUNOLOGY

Effector T Cells Boost Regulatory T Cell Expansion by IL-2, TNF, OX40, and Plasmacytoid Dendritic Cells Depending on the Immune Context

(2014) Audrey Baeyens et al.   JOURNAL OF IMMUNOLOGY

Activated CD8+T Cells Induce Expansion of Vβ5+Regulatory T Cells via TNFR2 Signaling

(2014) Jara J. Joedicke et al.   JOURNAL OF IMMUNOLOGY

Costimulation via the tumor-necrosis factor receptor superfamily couples TCR signal strength to the thymic differentiation of regulatory T cells

(2014) Shawn A Mahmud et al.   NATURE IMMUNOLOGY

Progranulin Facilitates Conversion and Function of Regulatory T Cells under Inflammatory Conditions

(2014) Fanhua Wei et al.   PLoS One

TNF receptor 2 protects oligodendrocyte progenitor cells against oxidative stress

(2013) Olaf Maier et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Tumor necrosis factor receptor 2-dependent homeostasis of regulatory T cells as a player in TNF-induced experimental metastasis

(2013) Martin Chopra et al.   CARCINOGENESIS

Reducing TNF Receptor 2 + Regulatory T Cells via the Combined Action of Azacitidine and the HDAC Inhibitor, Panobinostat for Clinical Benefit in Acute Myeloid Leukemia Patients

(2013) Chindu Govindaraj et al.   CLINICAL CANCER RESEARCH

Impaired Th1 immunity in ovarian cancer patients is mediated by TNFR2+ Tregs within the tumor microenvironment

(2013) Chindu Govindaraj et al.   CLINICAL IMMUNOLOGY

Therapeutic polyclonal human CD8+ CD25+ Fox3+ TNFR2+ PD-L1+ regulatory cells induced ex-vivo

(2013) David A. Horwitz et al.   CLINICAL IMMUNOLOGY

Progranulin deficiency exaggerates, whereas progranulin-derived Atsttrin attenuates, severity of dermatitis in mice

(2013) Yun-Peng Zhao et al.   FEBS LETTERS

Astrocyte-specific activation of TNFR2 promotes oligodendrocyte maturation by secretion of leukemia inhibitory factor

(2013) Roman Fischer et al.   GLIA

TNFR2 Is Critical for the Stabilization of the CD4+Foxp3+ Regulatory T Cell Phenotype in the Inflammatory Environment

(2013) X. Chen et al.   JOURNAL OF IMMUNOLOGY

IL-2-Independent and TNF- -Dependent Expansion of V 5+ Natural Regulatory T Cells during Retrovirus Infection

(2013) L. Myers et al.   JOURNAL OF IMMUNOLOGY

Asymptomatic Plasmodial Infection Is Associated With Increased Tumor Necrosis Factor Receptor II–Expressing Regulatory T Cells and Suppressed Type 2 Immune Responses

(2013) Linda J. Wammes et al.   JOURNAL OF INFECTIOUS DISEASES

Progranulin Does Not Bind Tumor Necrosis Factor (TNF) Receptors and Is Not a Direct Regulator of TNF-Dependent Signaling or Bioactivity in Immune or Neuronal Cells

(2013) X. Chen et al.   JOURNAL OF NEUROSCIENCE

Thalidomide-analogue biology: immunological, molecular and epigenetic targets in cancer therapy

(2013) J Shortt et al.   ONCOGENE

Triptolide Downregulates Treg Cells and the Level of IL-10, TGF-β, and VEGF in Melanoma-Bearing Mice

(2013) Biao Liu et al.   PLANTA MEDICA

Homogeneous Expansion of Human T-Regulatory Cells Via Tumor Necrosis Factor Receptor 2

(2013) Yoshiaki Okubo et al.   Scientific Reports

TNFR2 Expression on CD25hiFOXP3+ T Cells Induced upon TCR Stimulation of CD4 T Cells Identifies Maximal Cytokine-Producing Effectors

(2013) Chindu Govindaraj et al.   Frontiers in Immunology

Regulation of PI-3-Kinase and Akt Signaling in T Lymphocytes and Other Cells by TNFR Family Molecules

(2013) Takanori So et al.   Frontiers in Immunology

Th17 cells are restrained by Treg cells via the inhibition of interleukin-6 in patients with rheumatoid arthritis responding to anti-tumor necrosis factor antibody therapy

(2012) Jenny L. McGovern et al.   ARTHRITIS AND RHEUMATISM

TNF α Signaling Beholds Thalidomide Saga: A Review of Mechanistic Role of TNF-α Signaling Under Thalidomide

(2012) Syamantak Majumder et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

Progranulin deficiency promotes neuroinflammation and neuron loss following toxin-induced injury

(2012) Lauren Herl Martens et al.   JOURNAL OF CLINICAL INVESTIGATION

TNF signaling drives myeloid-derived suppressor cell accumulation

(2012) Xueqiang Zhao et al.   JOURNAL OF CLINICAL INVESTIGATION

TNF-α impairs differentiation and function of TGF-β-induced Treg cells in autoimmune diseases through Akt and Smad3 signaling pathway

(2012) Qi Zhang et al.   Journal of Molecular Cell Biology

Class I histone deacetylase inhibition is a novel mechanism to target regulatory T cells in immunotherapy

(2012) Li Shen et al.   OncoImmunology

Crosstalk between regulatory T cells (Tregs) and myeloid derived suppressor cells (MDSCs) during melanoma growth

(2012) Taku Fujimura et al.   OncoImmunology

Transmembrane tumour necrosis factor is neuroprotective and regulates experimental autoimmune encephalomyelitis via neuronal nuclear factor-κB

(2011) Era Taoufik et al.   BRAIN

Natural but Not Inducible Regulatory T Cells Require TNF-  Signaling for In Vivo Function

(2011) W. J. Housley et al.   JOURNAL OF IMMUNOLOGY

Loss of function mutations in the progranulin gene are related to pro-inflammatory cytokine dysregulation in frontotemporal lobar degeneration patients

(2011) Paola Bossù et al.   Journal of Neuroinflammation

The Growth Factor Progranulin Binds to TNF Receptors and Is Therapeutic Against Inflammatory Arthritis in Mice

(2011) W. Tang et al.   SCIENCE

Increased thioredoxin-1 production in human naturally occurring regulatory T cells confers enhanced tolerance to oxidative stress

(2010) D. Mougiakakos et al.   BLOOD

Co-expression of TNFR2 and CD25 identifies more of the functional CD4+FOXP3+regulatory T cells in human peripheral blood

(2010) Xin Chen et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Pathogenic T cells have a paradoxical protective effect in murine autoimmune diabetes by boosting Tregs

(2010) Yenkel Grinberg-Bleyer et al.   JOURNAL OF CLINICAL INVESTIGATION

Expression of Costimulatory TNFR2 Induces Resistance of CD4+FoxP3- Conventional T Cells to Suppression by CD4+FoxP3+ Regulatory T Cells

(2010) X. Chen et al.   JOURNAL OF IMMUNOLOGY

Critical Role for TNF in the Induction of Human Antigen-Specific Regulatory T Cells by Tolerogenic Dendritic Cells

(2010) F. S. Kleijwegt et al.   JOURNAL OF IMMUNOLOGY

Significantly reduced regulatory T cell population in patients with untreated multiple myeloma

(2010) Ritu Gupta et al.   LEUKEMIA RESEARCH

TNF receptor 2 pathway: drug target for autoimmune diseases

(2010) Denise Faustman et al.   NATURE REVIEWS DRUG DISCOVERY

TNF RECEPTOR 2, NOT TNF RECEPTOR 1, ENHANCES MESENCHYMAL STEM CELL-MEDIATED CARDIAC PROTECTION FOLLOWING ACUTE ISCHEMIA

(2010) Megan L. Kelly et al.   SHOCK

Induction of Treg by monocyte-derived DC modulated by vitamin D3or dexamethasone: Differential role for PD-L1

(2009) Wendy W. J. Unger et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Thalidomide exerts distinct molecular antileukemic effects and combined thalidomide/fludarabine therapy is clinically effective in high-risk chronic lymphocytic leukemia

(2009) K Giannopoulos et al.   LEUKEMIA

Cyclophosphamide and cancer: golden anniversary

(2009) Ashkan Emadi et al.   Nature Reviews Clinical Oncology

Thalidomide for treatment of multiple myeloma: 10 years later

(2008) A. Palumbo et al.   BLOOD

Tumor eradication after cyclophosphamide depends on concurrent depletion of regulatory T cells: a role for cycling TNFR2-expressing effector-suppressor T cells in limiting effective chemotherapy

(2008) Robbert G. van der Most et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Regulatory T Cells and Immune Tolerance

(2008) Shimon Sakaguchi et al.   CELL

The suppressive effect of triptolide on chronic colitis and TNF-α/TNFR2 signal pathway in interleukin-10 deficient mice

(2008) Xiaowei Wei et al.   CLINICAL IMMUNOLOGY

TNF signaling inhibition in the CNS: implications for normal brain function and neurodegenerative disease

(2008) Melissa K McCoy et al.   Journal of Neuroinflammation

Tumor necrosis factor antagonist mechanisms of action: A comprehensive review

(2007) Daniel Tracey et al.   PHARMACOLOGY & THERAPEUTICS