Oncolytic Viral Therapy and the Immune System: A Double-Edged Sword Against Cancer

Neoadjuvant oncolytic virotherapy before surgery sensitizes triple-negative breast cancer to immune checkpoint therapy

(2018) Marie-Claude Bourgeois-Daigneault et al.   Science Translational Medicine

Intravenous delivery of oncolytic reovirus to brain tumor patients immunologically primes for subsequent checkpoint blockade

(2018) Adel Samson et al.   Science Translational Medicine

Frequency of regulatory T cells determines the outcome of the T-cell-engaging antibody blinatumomab in patients with B-precursor ALL

(2017) J Duell et al.   LEUKEMIA

Re-designing Interleukin-12 to enhance its safety and potential as an anti-tumor immunotherapeutic agent

(2017) Pengju Wang et al.   Nature Communications

Oncolytic Immunotherapy: Conceptual Evolution, Current Strategies, and Future Perspectives

(2017) Zong Sheng Guo et al.   Frontiers in Immunology

Phase 1 study of intravenous administration of the chimeric adenovirus enadenotucirev in patients undergoing primary tumor resection

(2017) Rocio Garcia-Carbonero et al.   Journal for ImmunoTherapy of Cancer

Bispecific T cell engager (BiTE®) antibody constructs can mediate bystander tumor cell killing

(2017) Sandra L. Ross et al.   PLoS One

The Efficacy of Oncolytic Adenovirus Is Mediated by T-cell Responses against Virus and Tumor in Syrian Hamster Model

(2016) Xiaozhu Li et al.   CLINICAL CANCER RESEARCH

Macrophage response to oncolytic paramyxoviruses potentiates virus-mediated tumor cell killing

(2016) Darren Qiancheng Tan et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Prime-boost using separate oncolytic viruses in combination with checkpoint blockade improves anti-tumour therapy

(2016) E Ilett et al.   GENE THERAPY

Chronic Activation of Innate Immunity Correlates With Poor Prognosis in Cancer Patients Treated With Oncolytic Adenovirus

(2016) Kristian Taipale et al.   MOLECULAR THERAPY

Manipulating TLR Signaling Increases the Anti-tumor T Cell Response Induced by Viral Cancer Therapies

(2016) Juan J. Rojas et al.   Cell Reports

Oncolytic Viruses: Therapeutics With an Identity Crisis

(2016) Caroline J. Breitbach et al.   EBioMedicine

Talimogene Laherparepvec Improves Durable Response Rate in Patients With Advanced Melanoma

(2015) Robert H.I. Andtbacka et al.   JOURNAL OF CLINICAL ONCOLOGY

B7H6-Specific Bispecific T Cell Engagers Lead to Tumor Elimination and Host Antitumor Immunity

(2015) Ming-Ru Wu et al.   JOURNAL OF IMMUNOLOGY

First oncolytic virus approved for melanoma immunotherapy

(2015) Jonathan Pol et al.   OncoImmunology

A Vaccinia Virus Armed with Interleukin-10 Is a Promising Therapeutic Agent for Treatment of Murine Pancreatic Cancer

(2014) L. S. Chard et al.   CLINICAL CANCER RESEARCH

Remission of Disseminated Cancer After Systemic Oncolytic Virotherapy

(2014) Stephen J. Russell et al.   MAYO CLINIC PROCEEDINGS

Cytokine Conditioning Enhances Systemic Delivery and Therapy of an Oncolytic Virus

(2014) Elizabeth Ilett et al.   MOLECULAR THERAPY

Myxoma Virus Expressing a Fusion Protein of Interleukin-15 (IL15) and IL15 Receptor Alpha Has Enhanced Antitumor Activity

(2014) Vesna Tosic et al.   PLoS One

A Novel Therapeutic Regimen to Eradicate Established Solid Tumors with an Effective Induction of Tumor-Specific Immunity

(2012) J. R. Tysome et al.   CLINICAL CANCER RESEARCH

Macrophage plasticity and polarization: in vivo veritas

(2012) Antonio Sica et al.   JOURNAL OF CLINICAL INVESTIGATION

Cell Carriage, Delivery, and Selective Replication of an Oncolytic Virus in Tumor in Patients

(2012) R. A. Adair et al.   Science Translational Medicine

Expressing human interleukin-15 from oncolytic vesicular stomatitis virus improves survival in a murine metastatic colon adenocarcinoma model through the enhancement of anti-tumor immunity

(2011) K B Stephenson et al.   CANCER GENE THERAPY

Internalization of Oncolytic Reovirus by Human Dendritic Cell Carriers Protects the Virus from Neutralization

(2011) E. J. Ilett et al.   CLINICAL CANCER RESEARCH

The Oncolytic Poxvirus JX-594 Selectively Replicates in and Destroys Cancer Cells Driven by Genetic Pathways Commonly Activated in Cancers

(2011) Kelley A Parato et al.   MOLECULAR THERAPY

Cancer Immunoediting: Integrating Immunity's Roles in Cancer Suppression and Promotion

(2011) R. D. Schreiber et al.   SCIENCE

Pharmacological Interventions for Improving Adenovirus Usage in Gene Therapy

(2010) Hidde J. Haisma et al.   MOLECULAR PHARMACEUTICS

Antitumoral Immune Response by Recruitment and Expansion of Dendritic Cells in Tumors Infected with Telomerase-Dependent Oncolytic Viruses

(2009) Edukulla Ramakrishna et al.   CANCER RESEARCH

Targeting the Intratumoral Dendritic Cells by the Oncolytic Adenoviral Vaccine Expressing RANTES Elicits Potent Antitumor Immunity

(2009) Natalia Lapteva et al.   JOURNAL OF IMMUNOTHERAPY

Macrophage Depletion Combined with Anticoagulant Therapy Increases Therapeutic Window of Systemic Treatment with Oncolytic Adenovirus

(2008) E. V. Shashkova et al.   CANCER RESEARCH

Induction of Immune Responses and Clinical Efficacy in a Phase II Trial of IDM-2101, a 10-Epitope Cytotoxic T-Lymphocyte Vaccine, in Metastatic Non–Small-Cell Lung Cancer

(2008) Minal Barve et al.   JOURNAL OF CLINICAL ONCOLOGY

Development of PEGylated adenovirus vector with targeting ligand

(2007) Yusuke Eto et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS