Enteral siRNA delivery technique for therapeutic gene silencing in the liver via the lymphatic route

siRNA Conjugates Carrying Sequentially Assembled Trivalent N-Acetylgalactosamine Linked Through Nucleosides Elicit Robust Gene Silencing In Vivo in Hepatocytes

(2015) Shigeo Matsuda et al.   ACS Chemical Biology

DNA/RNA heteroduplex oligonucleotide for highly efficient gene silencing

(2015) Kazutaka Nishina et al.   Nature Communications

Chimeric Antisense Oligonucleotide Conjugated to α-Tocopherol

(2015) Tomoko Nishina et al.   Molecular Therapy-Nucleic Acids

Multivalent N-Acetylgalactosamine-Conjugated siRNA Localizes in Hepatocytes and Elicits Robust RNAi-Mediated Gene Silencing

(2014) Jayaprakash K. Nair et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Targeted delivery of antisense oligonucleotides to hepatocytes using triantennaryN-acetyl galactosamine improves potency 10-fold in mice

(2014) Thazha P. Prakash et al.   NUCLEIC ACIDS RESEARCH

Rational design of smart supramolecular assemblies for gene delivery: chemical challenges in the creation of artificial viruses

(2011) Kanjiro Miyata et al.   CHEMICAL SOCIETY REVIEWS

Progress Toward In Vivo Use of siRNAs-II

(2011) Garrett R Rettig et al.   MOLECULAR THERAPY

Efficacy and safety of more intensive lowering of LDL cholesterol: a meta-analysis of data from 170 000 participants in 26 randomised trials

(2010)   LANCET

Lipid-like materials for low-dose, in vivo gene silencing

(2010) K. T. Love et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Lipid Treatment Assessment Project 2

(2009) David D. Waters et al.   CIRCULATION

Orally delivered siRNA targeting macrophage Map4k4 suppresses systemic inflammation

(2009) Myriam Aouadi et al.   NATURE

Potential use of tight junction modulators to reversibly open membranous barriers and improve drug delivery

(2008) Mária A. Deli   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Molecular processes that handle — and mishandle — dietary lipids

(2008) Kevin Jon Williams   JOURNAL OF CLINICAL INVESTIGATION

Efficient In Vivo Delivery of siRNA to the Liver by Conjugation of α-Tocopherol

(2008) Kazutaka Nishina et al.   MOLECULAR THERAPY