Neferine Protects Endothelial Glycocalyx via Mitochondrial ROS in Lipopolysaccharide-Induced Acute Respiratory Distress Syndrome

Poor microcirculatory flow dynamics are associated with endothelial cell damage and glycocalyx shedding after traumatic hemorrhagic shock

(2018) David N. Naumann et al.   Journal of Trauma and Acute Care Surgery

Regulation and function of endothelial glycocalyx layer in vascular diseases

(2018) Irina Sieve et al.   VASCULAR PHARMACOLOGY

Poor microcirculatory flow dynamics are associated with endothelial cell damage and glycocalyx shedding after traumatic hemorrhagic shock

(2018) David N. Naumann et al.   Journal of Trauma and Acute Care Surgery

Protective Effect of Argan and Olive Oils against LPS-Induced Oxidative Stress and Inflammation in Mice Livers

(2017) Soufiane El Kamouni et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Neferine modulates IGF-1R/Nrf2 signaling in doxorubicin treated H9c2 cardiomyoblasts

(2017) Lohanathan Bharathi Priya et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Neferine Enhances the Antitumor Effect of Mitomycin-C in Hela Cells Through the Activation of p38-MAPK Pathway

(2017) Wassim Eid et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Neferine Potentiates the Antitumor Effect of Cisplatin in Human Lung Adenocarcinoma Cells Via a Mitochondria-Mediated Apoptosis Pathway

(2017) Kalai Selvi Sivalingam et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Therapeutic Restoration of Endothelial Glycocalyx in Sepsis

(2017) J.W. Song et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Linking Ventilator Injury-Induced Leak across the Blood-Gas Barrier to Derangements in Murine Lung Function

(2017) Bradford J. Smith et al.   Frontiers in Physiology

Ulinastatin attenuates pulmonary endothelial glycocalyx damage and inhibits endothelial heparanase activity in LPS-induced ARDS

(2016) Lipeng Wang et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Neferine prevents NF-κB translocation and protects muscle cells from oxidative stress and apoptosis induced by hypoxia

(2016) Rathinasamy Baskaran et al.   BIOFACTORS

Hyaluronidase 1 Deficiency Preserves Endothelial Function and Glycocalyx Integrity in Early Streptozotocin-Induced Diabetes

(2016) Sophie Dogné et al.   DIABETES

Amelioration of sepsis by TIE2 activation–induced vascular protection

(2016) Sangyeul Han et al.   Science Translational Medicine

The endothelial glycocalyx and its disruption, protection and regeneration: a narrative review

(2016) Ulf Schött et al.   Scandinavian Journal of Trauma Resuscitation & Emergency Medicine

Activation of AMPK attenuates LPS-induced acute lung injury by upregulation of PGC1α and SOD1

(2016) Guizuo Wang et al.   Experimental and Therapeutic Medicine

The Endothelial Glycocalyx: New Diagnostic and Therapeutic Approaches in Sepsis

(2016) Lukas Martin et al.   Biomed Research International

Endothelial Glycocalyx Damage is Associated with Leptospirosis Acute Kidney Injury

(2015) Alexandre Braga Libório et al.   AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE

Cyanidin-3-O-Glucoside Ameliorates Lipopolysaccharide-Induced Injury Both In Vivo and In Vitro Suppression of NF-κB and MAPK Pathways

(2015) Ming-Ming Ma et al.   INFLAMMATION

Endothelial Surface Glycocalyx Can Regulate Flow-Induced Nitric Oxide Production in Microvessels In Vivo

(2015) Wanyi Yen et al.   PLoS One

Novel regulators of endothelial barrier function

(2014) Dolly Mehta et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Matrix metalloproteinase 9-mediated shedding of syndecan 4 in response to tumor necrosis factor α: a contributor to endothelial cell glycocalyx dysfunction

(2014) Raina Ramnath et al.   FASEB JOURNAL

Schisantherin A protects lipopolysaccharide-induced acute respiratory distress syndrome in mice through inhibiting NF-κB and MAPKs signaling pathways

(2014) Ershun Zhou et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Modulation of Endothelial Glycocalyx Structure under Inflammatory Conditions

(2014) Hana Kolářová et al.   MEDIATORS OF INFLAMMATION

Sphingosine-1-phosphate protects endothelial glycocalyx by inhibiting syndecan-1 shedding

(2013) Ye Zeng et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

The Mechanisms and Physiological Relevance of Glycocalyx Degradation in Hepatic Ischemia/Reperfusion Injury

(2013) Rowan F. van Golen et al.   ANTIOXIDANTS & REDOX SIGNALING

Neferine, an alkaloid from lotus seed embryo, inhibits human lung cancer cell growth by MAPK activation and cell cycle arrest

(2013) Paramasivan Poornima et al.   BIOFACTORS

Reactive Oxygen Species Modulate the Barrier Function of the Human Glomerular Endothelial Glycocalyx

(2013) Anurag Singh et al.   PLoS One

Fresh Frozen Plasma Lessens Pulmonary Endothelial Inflammation and Hyperpermeability After Hemorrhagic Shock and Is Associated With Loss of Syndecan 1

(2013) Zhanglong Peng et al.   SHOCK

Neferine exerts its antithrombotic effect by inhibiting platelet aggregation and promoting dissociation of platelet aggregates

(2013) Ya-Jun Zhou et al.   THROMBOSIS RESEARCH

Mechanistic overview of reactive species-induced degradation of the endothelial glycocalyx during hepatic ischemia/reperfusion injury

(2012) Rowan F. van Golen et al.   FREE RADICAL BIOLOGY AND MEDICINE

The pulmonary endothelial glycocalyx regulates neutrophil adhesion and lung injury during experimental sepsis

(2012) Eric P Schmidt et al.   NATURE MEDICINE

Protective effect of neferine on endothelial cell nitric oxide production induced by lysophosphatidylcholine: the role of the DDAH–ADMA pathway

(2011) Zhen-Yu Peng et al.   CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY

Neferine, an alkaloid ingredient in lotus seed embryo, inhibits proliferation of human osteosarcoma cells by promoting p38 MAPK-mediated p21 stabilization

(2011) Xiyu Zhang et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Endothelial glycocalyx dysfunction in disease: albuminuria and increased microvascular permeability

(2011) Andrew HJ Salmon et al.   JOURNAL OF PATHOLOGY

Anti-amnesic activity of neferine with antioxidant and anti-inflammatory capacities, as well as inhibition of ChEs and BACE1

(2010) Hyun Ah Jung et al.   LIFE SCIENCES

Neferine, a bisbenzylisoquinline alkaloid attenuates bleomycin-induced pulmonary fibrosis

(2009) Libo Zhao et al.   EUROPEAN JOURNAL OF PHARMACOLOGY