Scutellarin Increases Cisplatin-Induced Apoptosis and Autophagy to Overcome Cisplatin Resistance in Non-small Cell Lung Cancer via ERK/p53 and c-met/AKT Signaling Pathways

Salvianolic acid A reverses cisplatin resistance in lung cancer A549 cells by targeting c-met and attenuating Akt/mTOR pathway

(2017) Xia-li Tang et al.   JOURNAL OF PHARMACOLOGICAL SCIENCES

Escin induces caspase-dependent apoptosis and autophagy through the ROS/p38 MAPK signalling pathway in human osteosarcoma cells in vitro and in vivo

(2017) Jian Zhu et al.   Cell Death & Disease

MiR-26 enhances chemosensitivity and promotes apoptosis of hepatocellular carcinoma cells through inhibiting autophagy

(2017) Fangfang Jin et al.   Cell Death & Disease

Inhibition of the PI3K/AKT/mTOR pathway activates autophagy and compensatory Ras/Raf/MEK/ERK signalling in prostate cancer

(2017) Dominika E. Butler et al.   Oncotarget

Tripchlorolide induces autophagy in lung cancer cells by inhibiting the PI3K/AKT/mTOR pathway and improves cisplatin sensitivity in A549/DDP cells

(2017) Li-Min Chen et al.   Oncotarget

Helicobacter pylori CagA Protein Negatively Regulates Autophagy and Promotes Inflammatory Response via c-Met-PI3K/Akt-mTOR Signaling Pathway

(2017) Na Li et al.   Frontiers in Cellular and Infection Microbiology

Enhancement of scutellarin oral delivery efficacy by vitamin B12-modified amphiphilic chitosan derivatives to treat type II diabetes induced-retinopathy

(2017) Jingnan Wang et al.   JOURNAL OF NANOBIOTECHNOLOGY

ABT-737 Synergizes with Cisplatin Bypassing Aberration of Apoptotic Pathway in Non-small Cell Lung Cancer

(2017) Eun Young Kim et al.   NEOPLASIA

Chk1 Inhibitor SCH900776 Effectively Potentiates the Cytotoxic Effects of Platinum-Based Chemotherapeutic Drugs in Human Colon Cancer Cells

(2017) Jarmila Herůdková et al.   NEOPLASIA

Transcriptome Sequencing Reveals Key Pathways and Genes Associated with Cisplatin Resistance in Lung Adenocarcinoma A549 Cells

(2017) Yani Fang et al.   PLoS One

Flavonoids of Rosa roxburghii Tratt exhibit radioprotection and anti-apoptosis properties via the Bcl-2(Ca2+)/Caspase-3/PARP-1 pathway

(2016) Ping Xu et al.   APOPTOSIS

Cancer statistics, 2016

(2016) Rebecca L. Siegel et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Cancer treatment and survivorship statistics, 2016

(2016) Kimberly D. Miller et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Scutellarin suppresses growth and causes apoptosis of human colorectal cancer cells by regulating the p53 pathway

(2016) Ning Yang et al.   Molecular Medicine Reports

Cucurbitacin-I induces hypertrophy in H9c2 cardiomyoblasts through activation of autophagy via MEK/ERK1/2 signaling pathway

(2016) Yao Wu et al.   TOXICOLOGY LETTERS

Autophagy and epithelial–mesenchymal transition: an intricate interplay in cancer

(2016) Mila Gugnoni et al.   Cell Death & Disease

Autophagy as an emerging therapy target for ovarian carcinoma

(2016) Lei Zhan et al.   Oncotarget

OSU-2S/Sorafenib Synergistic Antitumor Combination against Hepatocellular Carcinoma: The Role of PKCδ/p53

(2016) Hany A. Omar et al.   Frontiers in Pharmacology

Combination of chrysin and cisplatin promotes the apoptosis of Hep G2 cells by up-regulating p53

(2015) Xin Li et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Araguspongine C Induces Autophagic Death in Breast Cancer Cells through Suppression of c-Met and HER2 Receptor Tyrosine Kinase Signaling

(2015) Mohamed Akl et al.   Marine Drugs

Increased phosphorylation of ERK1/2 is associated with worse chemotherapeutic outcome and a poor prognosis in advanced lung adenocarcinoma

(2015) Ichiro Tsujino et al.   Medical Molecular Morphology

The role of PI3K/AKT/mTOR pathway in the modulation of autophagy and the clearance of protein aggregates in neurodegeneration

(2014) David Heras-Sandoval et al.   CELLULAR SIGNALLING

c-MET Inhibitors in the Treatment of Lung Cancer

(2014) Joanna Goździk-Spychalska et al.   CURRENT TREATMENT OPTIONS IN ONCOLOGY

Targeting RAS–ERK signalling in cancer: promises and challenges

(2014) Ahmed A. Samatar et al.   NATURE REVIEWS DRUG DISCOVERY

Angiogenin promotes tumoral growth and angiogenesis by regulating matrix metallopeptidase-2 expression via the ERK1/2 pathway

(2014) M Miyake et al.   ONCOGENE

MicroRNA 23b Regulates Autophagy Associated With Radioresistance of Pancreatic Cancer Cells

(2013) Peng Wang et al.   GASTROENTEROLOGY

Autophagy suppresses progression of K-ras-induced lung tumors to oncocytomas and maintains lipid homeostasis

(2013) J. Y. Guo et al.   GENES & DEVELOPMENT

Scutellarin inhibits the growth and invasion of human tongue squamous carcinoma through the inhibition of matrix metalloproteinase-2 and -9 and αvβ6 integrin

(2013) HAIXIA LI et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

Inhibition of c-Met promoted apoptosis, autophagy and loss of the mitochondrial transmembrane potential in oridonin-induced A549 lung cancer cells

(2013) Ying Liu et al.   JOURNAL OF PHARMACY AND PHARMACOLOGY

Wentilactone A as a novel potential antitumor agent induces apoptosis and G2/M arrest of human lung carcinoma cells and is mediated by HRas-GTP accumulation to excessively activate the Ras/Raf/ERK/p53-p21 pathway

(2013) C Lv et al.   Cell Death & Disease

Crizotinib for ALK-Rearranged Non-Small Cell Lung Cancer: A New Targeted Therapy for a New Target

(2012) L. Gandhi et al.   CLINICAL CANCER RESEARCH

Targeting the Hepatocyte Growth Factor–cMET Axis in Cancer Therapy

(2012) George R. Blumenschein et al.   JOURNAL OF CLINICAL ONCOLOGY

Interferon regulatory factor 4 binding protein is a novel p53 target gene and suppresses cisplatin-induced apoptosis of breast cancer cells

(2012) Mingzhen Yang et al.   Molecular Cancer

MET: a promising anticancer therapeutic target

(2012) Solange Peters et al.   Nature Reviews Clinical Oncology

Autophagy inhibitor Lys05 has single-agent antitumor activity and reproduces the phenotype of a genetic autophagy deficiency

(2012) Q. McAfee et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Molecular mechanisms of cisplatin resistance

(2011) L Galluzzi et al.   ONCOGENE

From basic research to clinical development of MEK1/2 inhibitors for cancer therapy

(2010) Christophe Frémin et al.   Journal of Hematology & Oncology

p53-Reactivating small molecules induce apoptosis and enhance chemotherapeutic cytotoxicity in head and neck squamous cell carcinoma

(2010) Jong-Lyel Roh et al.   ORAL ONCOLOGY

Mammalian autophagy: core molecular machinery and signaling regulation

(2009) Zhifen Yang et al.   CURRENT OPINION IN CELL BIOLOGY