Escin induces caspase-dependent apoptosis and autophagy through the ROS/p38 MAPK signalling pathway in human osteosarcoma cells in vitro and in vivo

Neferine augments therapeutic efficacy of cisplatin through ROS- mediated non-canonical autophagy in human lung adenocarcinoma (A549 cells)

(2017) Sivalingam Kalai Selvi et al.   FOOD AND CHEMICAL TOXICOLOGY

Inhibition of Autophagy Promotes Salinomycin-Induced Apoptosis via Reactive Oxygen Species-Mediated PI3K/AKT/mTOR and ERK/p38 MAPK-Dependent Signaling in Human Prostate Cancer Cells

(2017) Kwang-Youn Kim et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Escin induces apoptosis in human renal cancer cells through G2/M arrest and reactive oxygen species-modulated mitochondrial pathways

(2017) Sheau-Yun Yuan et al.   ONCOLOGY REPORTS

Eucalrobusone C suppresses cell proliferation and induces ROS-dependent mitochondrial apoptosis via the p38 MAPK pathway in hepatocellular carcinoma cells

(2017) Kai-Li Jian et al.   PHYTOMEDICINE

Oridonin induces autophagy via inhibition of glucose metabolism in p53-mutated colorectal cancer cells

(2017) Zhuo Yao et al.   Cell Death & Disease

RGD-modified oncolytic adenovirus-harboring shPKM2 exhibits a potent cytotoxic effect in pancreatic cancer via autophagy inhibition and apoptosis promotion

(2017) Yanni Xu et al.   Cell Death & Disease

Foot-and-mouth disease virus infection suppresses autophagy and NF-кB antiviral responses via degradation of ATG5-ATG12 by 3Cpro

(2017) Xuxu Fan et al.   Cell Death & Disease

Antiphospholipid antibodies enhance rat neonatal cardiomyocyte apoptosis in an in vitro hypoxia/reoxygenation injury model via p38 MAPK

(2017) Lauren T Bourke et al.   Cell Death & Disease

Endothelia-Targeting Protection by Escin in Decompression Sickness Rats

(2017) Kun Zhang et al.   Scientific Reports

The positive clinical therapeutically effects of Escin on advanced thyroid cancer

(2017) Jin-Yu Mei et al.   Cancer Medicine

Antiproliferative effect of β-escin - an in vitro study

(2016) Gabriela Mojžišová et al.   ACTA BIOCHIMICA POLONICA

Absence of autophagy promotes apoptosis by modulating the ROS-dependent RLR signaling pathway in classical swine fever virus-infected cells

(2016) Jingjing Pei et al.   Autophagy

Autophagy inhibition and mitochondrial remodeling join forces to amplify apoptosis in activation-induced cell death

(2016) Mauro Corrado et al.   Autophagy

GFRA1 promotes cisplatin-induced chemoresistance in osteosarcoma by inducing autophagy

(2016) Mihwa Kim et al.   Autophagy

Mir143-BBC3 cascade reduces microglial survival via interplay between apoptosis and autophagy: Implications for methamphetamine-mediated neurotoxicity

(2016) Yuan Zhang et al.   Autophagy

New anti-cancer molecules targeting HSPA5/BIP to induce endoplasmic reticulum stress, autophagy and apoptosis

(2016) Michaël Cerezo et al.   Autophagy

Advances in osteosarcoma stem cell research and opportunities for novel therapeutic targets

(2016) Guang-Ning Yan et al.   CANCER LETTERS

A new oridonin analog suppresses triple-negative breast cancer cells and tumor growth via the induction of death receptor 5

(2016) Jing Wu et al.   CANCER LETTERS

RAC2-P38 MAPK-dependent NADPH oxidase activity is associated with the resistance of quiescent cells to ionizing radiation

(2016) Hailong Pei et al.   CELL CYCLE

The role of pharmacogenetics in the treatment of osteosarcoma

(2016) Hanneke I. Vos et al.   DRUG DISCOVERY TODAY

Aromatic heterocyclic esters of podophyllotoxin exert anti-MDR activity in human leukemia K562/ADR cells via ROS/MAPK signaling pathways

(2016) Lei Zhang et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Rubicon inhibits autophagy and accelerates hepatocyte apoptosis and lipid accumulation in nonalcoholic fatty liver disease in mice

(2016) Satoshi Tanaka et al.   HEPATOLOGY

Simvastatin-Induced Apoptosis in Osteosarcoma Cells: A Key Role of RhoA-AMPK/p38 MAPK Signaling in Antitumor Activity

(2016) Walied A. Kamel et al.   MOLECULAR CANCER THERAPEUTICS

Molecular Mechanism for Cellular Response to β-Escin and Its Therapeutic Implications

(2016) Dominik Domanski et al.   PLoS One

β-escin selectively targets the glioblastoma-initiating cell population and reduces cell viability

(2016) Elizabeth Harford-Wright et al.   Oncotarget

Escin Ia suppresses the metastasis of triple-negative breast cancer by inhibiting epithelial-mesenchymal transition via down-regulating LOXL2 expression

(2016) Yuhui Wang et al.   Oncotarget

Downregulation of TFAM inhibits the tumorigenesis of non-small cell lung cancer by activating ROS-mediated JNK/p38MAPK signaling and reducing cellular bioenergetics

(2016) Deyao Xie et al.   Oncotarget

Salvianolic acid B, a novel autophagy inducer, exerts antitumor activity as a single agent in colorectal cancer cells

(2016) Zhao Jing et al.   Oncotarget

Peroxiredoxin II Negatively Regulates Lipopolysaccharide-Induced Osteoclast Formation and Bone Loss via JNK and STAT3

(2015) Hyojung Park et al.   ANTIOXIDANTS & REDOX SIGNALING

FGFR3/fibroblast growth factor receptor 3 inhibits autophagy through decreasing the ATG12–ATG5 conjugate, leading to the delay of cartilage development in achondroplasia

(2015) Xiaofeng Wang et al.   Autophagy

Erratum: Corrigendum: Selective killing of cancer cells by a small molecule targeting the stress response to ROS

(2015) Lakshmi Raj et al.   NATURE

Cell type-dependent ROS and mitophagy response leads to apoptosis or necroptosis in neuroblastoma

(2015) F Radogna et al.   ONCOGENE

β-escin reverses multidrug resistance through inhibition of the GSK3β/β-catenin pathway in cholangiocarcinoma

(2015) Gui-Li Huang   WORLD JOURNAL OF GASTROENTEROLOGY

MnSOD upregulation sustains the Warburg effect via mitochondrial ROS and AMPK-dependent signalling in cancer

(2015) Peter C. Hart et al.   Nature Communications

Rhus coriaria induces senescence and autophagic cell death in breast cancer cells through a mechanism involving p38 and ERK1/2 activation

(2015) Hussain El Hasasna et al.   Scientific Reports

Escin, a Novel Triterpene, Mitigates Chronic MPTP/p-Induced Dopaminergic Toxicity by Attenuating Mitochondrial Dysfunction, Oxidative Stress, and Apoptosis

(2014) Govindasamy Pushpavathi Selvakumar et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

Self-consumption: the interplay of autophagy and apoptosis

(2014) Guillermo Mariño et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Cytotoxic Effects of Escin on Human Castration-resistant Prostate Cancer Cells Through the Induction of Apoptosis and G2/M Cell Cycle Arrest

(2014) Songzhe Piao et al.   UROLOGY

Involvement of p38 in signal switching from autophagy to apoptosis via the PERK/eIF2α/ATF4 axis in selenite-treated NB4 cells

(2014) Q Jiang et al.   Cell Death & Disease

EGFR-Mediated Beclin 1 Phosphorylation in Autophagy Suppression, Tumor Progression, and Tumor Chemoresistance

(2013) Yongjie Wei et al.   CELL

Autophagy-Mediated Tumor Promotion

(2013) Jessie Yanxiang Guo et al.   CELL

Dual Programmed Cell Death Pathways Induced by p53 Transactivation Overcome Resistance to Oncolytic Adenovirus in Human Osteosarcoma Cells

(2013) J. Hasei et al.   MOLECULAR CANCER THERAPEUTICS

A tuberous sclerosis complex signalling node at the peroxisome regulates mTORC1 and autophagy in response to ROS

(2013) Jiangwei Zhang et al.   NATURE CELL BIOLOGY

Kinase crosstalk through beclin 1

(2013) Katharine H. Wrighton   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Control of apoptosis by the BCL-2 protein family: implications for physiology and therapy

(2013) Peter E. Czabotar et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Piperlongumine induces autophagy by targeting p38 signaling

(2013) Y Wang et al.   Cell Death & Disease

Escin augments the efficacy of gemcitabine through down-regulation of nuclear factor-κB and nuclear factor-κB-regulated gene products in pancreatic cancer both in vitro and in vivo

(2012) Yong-Wei Wang et al.   JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY

Common Musculoskeletal Tumors of Childhood and Adolescence

(2012) Carola A.S. Arndt et al.   MAYO CLINIC PROCEEDINGS

New targets and approaches in osteosarcoma

(2012) Jonathan Gill et al.   PHARMACOLOGY & THERAPEUTICS

The Apoptotic Effects of Escin in The H-RasTransformed 5RP7 Cell Line

(2012) G. Güney et al.   PHYTOTHERAPY RESEARCH

Addition of pamidronate to chemotherapy for the treatment of osteosarcoma

(2010) Paul A. Meyers et al.   CANCER

Regulation of autophagy by ROS: physiology and pathology

(2010) Ruth Scherz-Shouval et al.   TRENDS IN BIOCHEMICAL SCIENCES

Effect of β-escin sodium on endothelial cells proliferation, migration and apoptosis

(2008) Xu-Hua Wang et al.   VASCULAR PHARMACOLOGY