Advancing Stem Cell Models of Alpha-Synuclein Gene Regulation in Neurodegenerative Disease
Published 2018 View Full Article
- Home
- Publications
- Publication Search
- Publication Details
Title
Advancing Stem Cell Models of Alpha-Synuclein Gene Regulation in Neurodegenerative Disease
Authors
Keywords
-
Journal
Frontiers in Neuroscience
Volume 12, Issue -, Pages -
Publisher
Frontiers Media SA
Online
2018-04-09
DOI
10.3389/fnins.2018.00199
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- Therapeutic approaches to target alpha-synuclein pathology
- (2017) Patrik Brundin et al. EXPERIMENTAL NEUROLOGY
- Alpha-synuclein induces the unfolded protein response in Parkinson’s disease SNCA triplication iPSC-derived neurons
- (2017) Sabrina M Heman-Ackah et al. HUMAN MOLECULAR GENETICS
- α-synuclein aggregation and its modulation
- (2017) Dhiman Ghosh et al. INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
- Cellular Reprogramming Using Protein and Cell-Penetrating Peptides
- (2017) Bong Seo et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Homozygous alpha-synuclein p.A53V in familial Parkinson's disease
- (2017) Hiroyo Yoshino et al. NEUROBIOLOGY OF AGING
- Epigenetic approach to early-onset Parkinson’s disease: low methylation status of SNCA and PARK2 promoter regions
- (2017) Isil Ezgi Eryilmaz et al. NEUROLOGICAL RESEARCH
- Frontotemporal dementia as the presenting phenotype of p.A53T mutation carriers in the alpha-synuclein gene
- (2017) Anastasia Bougea et al. PARKINSONISM & RELATED DISORDERS
- β2-Adrenoreceptor is a regulator of the α-synuclein gene driving risk of Parkinson’s disease
- (2017) Shuchi Mittal et al. SCIENCE
- The Synucleinopathies: Twenty Years On
- (2017) Michel Goedert et al. Journal of Parkinsons Disease
- The Identification of Alpha-Synuclein as the First Parkinson Disease Gene
- (2017) Robert L. Nussbaum Journal of Parkinsons Disease
- Hypomethylation of intron1 of α-synuclein gene does not correlate with Parkinson’s disease
- (2017) Subhrangshu Guhathakurta et al. Molecular Brain
- Genetic Variants in SNCA and the Risk of Sporadic Parkinson’s Disease and Clinical Outcomes: A Review
- (2017) Clarissa Loureiro das Chagas Campêlo et al. Parkinsons Disease
- Interpreting Gene Expression Effects of Disease-Associated Variants: A Lesson from SNCA rs356168
- (2017) Omolara-Chinue Glenn et al. Frontiers in Genetics
- Maternal Modifiers and Parent-of-Origin Bias of the Autism-Associated 16p11.2 CNV
- (2016) Michael H. Duyzend et al. AMERICAN JOURNAL OF HUMAN GENETICS
- Midbrain-like Organoids from Human Pluripotent Stem Cells Contain Functional Dopaminergic and Neuromelanin-Producing Neurons
- (2016) Junghyun Jo et al. Cell Stem Cell
- Induced Pluripotent Stem Cells Meet Genome Editing
- (2016) Dirk Hockemeyer et al. Cell Stem Cell
- CRISPR Interference Efficiently Induces Specific and Reversible Gene Silencing in Human iPSCs
- (2016) Mohammad A. Mandegar et al. Cell Stem Cell
- The SSV Evaluation System: A Tool to Prioritize Short Structural Variants for Studies of Possible Regulatory and Causal Variants
- (2016) Robert Saul et al. HUMAN MUTATION
- Complex Effects of the ZSCAN21 Transcription Factor on Transcriptional Regulation of α-Synuclein in Primary Neuronal Cultures andin Vivo
- (2016) Georgia Dermentzaki et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- The rs3756063 polymorphism is associated with SNCA methylation in the Chinese Han population
- (2016) Yang Wei et al. JOURNAL OF THE NEUROLOGICAL SCIENCES
- Direct α-synuclein promoter transactivation by the tumor suppressor p53
- (2016) Eric Duplan et al. Molecular Neurodegeneration
- Parkinson-associated risk variant in distal enhancer of α-synuclein modulates target gene expression
- (2016) Frank Soldner et al. NATURE
- Engineered human pluripotent-stem-cell-derived intestinal tissues with a functional enteric nervous system
- (2016) Michael J Workman et al. NATURE MEDICINE
- Repurposing the CRISPR-Cas9 system for targeted DNA methylation
- (2016) Aleksandar Vojta et al. NUCLEIC ACIDS RESEARCH
- Autosomal dominant Parkinson's disease caused by SNCA duplications
- (2016) Takuya Konno et al. PARKINSONISM & RELATED DISORDERS
- DNA methylation changes atSNCAintron 1 in patients with dementia with Lewy bodies
- (2016) Yu Funahashi et al. PSYCHIATRY AND CLINICAL NEUROSCIENCES
- High-resolution interrogation of functional elements in the noncoding genome
- (2016) N. E. Sanjana et al. SCIENCE
- Systematic mapping of functional enhancer–promoter connections with CRISPR interference
- (2016) Charles P. Fulco et al. SCIENCE
- CRISPR Screens to Discover Functional Noncoding Elements
- (2016) Jason B. Wright et al. TRENDS IN GENETICS
- α-synuclein and p53 functional interplay in physiopathological contexts
- (2016) Cristine Alves da Costa et al. Oncotarget
- Role of microRNAs in the Regulation of α-Synuclein Expression: A Systematic Review
- (2016) Ariadna Recasens et al. Frontiers in Molecular Neuroscience
- Is Alpha-Synuclein Loss-of-Function a Contributor to Parkinsonian Pathology? Evidence from Non-human Primates
- (2016) Timothy J. Collier et al. Frontiers in Neuroscience
- Precision Modulation of Neurodegenerative Disease-Related Gene Expression in Human iPSC-Derived Neurons
- (2016) Sabrina Mahalia Heman-Ackah et al. Scientific Reports
- A cytosine-thymine (CT)-rich haplotype in intron 4 of SNCA confers risk for Lewy body pathology in Alzheimer's disease and affects SNCA expression
- (2015) Michael W. Lutz et al. Alzheimers & Dementia
- MicroRNA-214 participates in the neuroprotective effect of Resveratrol via inhibiting α-synuclein expression in MPTP-induced Parkinson’s disease mouse
- (2015) Zhao-Hui Wang et al. BIOMEDICINE & PHARMACOTHERAPY
- Generating iPSCs: Translating Cell Reprogramming Science into Scalable and Robust Biomanufacturing Strategies
- (2015) Marli Silva et al. Cell Stem Cell
- Distinct clinical and neuropathological features of G51D SNCA mutation cases compared with SNCA duplication and H50Q mutation
- (2015) Aoife P. Kiely et al. Molecular Neurodegeneration
- L-dopa increasesα-synuclein DNA methylation in Parkinson's disease patientsin vivoandin vitro
- (2015) Ina Schmitt et al. MOVEMENT DISORDERS
- Development of Passive Immunotherapies for Synucleinopathies
- (2015) Ann-Louise Bergström et al. MOVEMENT DISORDERS
- Multisystem Lewy body disease and the other parkinsonian disorders
- (2015) J William Langston et al. NATURE GENETICS
- CAUSEL: an epigenome- and genome-editing pipeline for establishing function of noncoding GWAS variants
- (2015) Sándor Spisák et al. NATURE MEDICINE
- DNA methylation levels of α-synuclein intron 1 in the aging brain
- (2015) Laura de Boni et al. NEUROBIOLOGY OF AGING
- A cell culture model for monitoring α-synuclein cell-to-cell transfer
- (2015) Juan F. Reyes et al. NEUROBIOLOGY OF DISEASE
- Transcriptional regulation of the α-synuclein gene in human brain tissue
- (2015) Steffen Brenner et al. NEUROSCIENCE LETTERS
- Elevated α-synuclein caused by SNCA gene triplication impairs neuronal differentiation and maturation in Parkinson's patient-derived induced pluripotent stem cells
- (2015) L M A Oliveira et al. Cell Death & Disease
- Four Copies of SNCA Responsible for Autosomal Dominant Parkinson’s Disease in Two Italian Siblings
- (2015) Rosangela Ferese et al. Parkinsons Disease
- Alpha-Synuclein Expression in the Oligodendrocyte Lineage: an In Vitro and In Vivo Study Using Rodent and Human Models
- (2015) Mehdi Djelloul et al. Stem Cell Reports
- Using iPS Cells toward the Understanding of Parkinson’s Disease
- (2015) Roger Torrent et al. Journal of Clinical Medicine
- Genetic variants and animal models in SNCA and Parkinson disease
- (2014) Hao Deng et al. AGEING RESEARCH REVIEWS
- The Genetics of Microdeletion and Microduplication Syndromes: An Update
- (2014) Corey T. Watson et al. Annual Review of Genomics and Human Genetics
- The Newly Discovered Parkinson’s Disease Associated Finnish Mutation (A53E) Attenuates α-Synuclein Aggregation and Membrane Binding
- (2014) Dhiman Ghosh et al. BIOCHEMISTRY
- Inhibition of miR-34b and miR-34c enhances α-synuclein expression in Parkinson's disease
- (2014) Savan Kabaria et al. FEBS LETTERS
- Genomic distribution and possible functions of DNA hydroxymethylation in the brain
- (2014) Lu Wen et al. GENOMICS
- The novel Parkinson's disease linked mutation G51D attenuates in vitro aggregation and membrane binding of -synuclein, and enhances its secretion and nuclear localization in cells
- (2014) M.-B. Fares et al. HUMAN MOLECULAR GENETICS
- Stem cell derived basal forebrain cholinergic neurons from Alzheimer’s disease patients are more susceptible to cell death
- (2014) Lishu Duan et al. Molecular Neurodegeneration
- Parkinson's disease correlates with promoter methylation in the α-synuclein gene
- (2014) Lasse Pihlstrøm et al. MOVEMENT DISORDERS
- Refining analyses of copy number variation identifies specific genes associated with developmental delay
- (2014) Bradley P Coe et al. NATURE GENETICS
- Large-scale meta-analysis of genome-wide association data identifies six new risk loci for Parkinson's disease
- (2014) Mike A Nalls et al. NATURE GENETICS
- A novel α-synuclein mutation A53E associated with atypical multiple system atrophy and Parkinson's disease-type pathology
- (2014) Petra Pasanen et al. NEUROBIOLOGY OF AGING
- Alpha-synuclein transcript isoforms in three different brain regions from Parkinson's disease and healthy subjects in relation to the SNCA rs356165/rs11931074 polymorphisms
- (2014) Lucía F. Cardo et al. NEUROSCIENCE LETTERS
- Pyrosequencing analysis of SNCA methylation levels in leukocytes from Parkinson's disease patients
- (2014) Yang Song et al. NEUROSCIENCE LETTERS
- Identification of Novel Regulatory Genes in Development of the Avian Reproductive Tracts
- (2014) Whasun Lim et al. PLoS One
- Higher Vulnerability and Stress Sensitivity of Neuronal Precursor Cells Carrying an Alpha-Synuclein Gene Triplication
- (2014) Adrian Flierl et al. PLoS One
- Pluripotent Stem Cells Derived From Mouse Primordial Germ Cells by Small Molecule Compounds
- (2014) Tohru Kimura et al. STEM CELLS
- DNA Methylation in Mammals
- (2014) E. Li et al. Cold Spring Harbor Perspectives in Biology
- A 6.4 Mb Duplication of the α-Synuclein Locus Causing Frontotemporal Dementia and Parkinsonism
- (2014) Eleanna Kara et al. JAMA Neurology
- α-Synucleinopathy associated with G51D SNCA mutation: a link between Parkinson’s disease and multiple system atrophy?
- (2013) Aoife P. Kiely et al. ACTA NEUROPATHOLOGICA
- G51D α-synuclein mutation causes a novel Parkinsonian-pyramidal syndrome
- (2013) Suzanne Lesage et al. ANNALS OF NEUROLOGY
- The Parkinson’s Disease-Associated H50Q Mutation Accelerates α-Synuclein Aggregation in Vitro
- (2013) Dhiman Ghosh et al. BIOCHEMISTRY
- Isogenic Human iPSC Parkinson’s Model Shows Nitrosative Stress-Induced Dysfunction in MEF2-PGC1α Transcription
- (2013) Scott D. Ryan et al. CELL
- Distinctive patterns of DNA methylation associated with Parkinson disease
- (2013) Eliezer Masliah et al. Epigenetics
- Clinical Significance of De Novo and Inherited Copy-Number Variation
- (2013) Anneke T. Vulto-van Silfhout et al. HUMAN MUTATION
- Modeling human neurological disorders with induced pluripotent stem cells
- (2013) Yoichi Imaizumi et al. JOURNAL OF NEUROCHEMISTRY
- Alpha-synuclein p.H50Q, a novel pathogenic mutation for Parkinson's disease
- (2013) Silke Appel-Cresswell et al. MOVEMENT DISORDERS
- Reprogramming human fibroblasts to pluripotency using modified mRNA
- (2013) Pankaj K Mandal et al. Nature Protocols
- A novel -synuclein missense mutation in Parkinson disease
- (2013) C. Proukakis et al. NEUROLOGY
- Methylation of α-synuclein and leucine-rich repeat kinase 2 in leukocyte DNA of Parkinson's disease patients
- (2013) Yu-yan Tan et al. PARKINSONISM & RELATED DISORDERS
- Clinical and neuroimaging features of patient with early-onset Parkinson's disease with dementia carrying SNCA p.G51D mutation
- (2013) Takayoshi Tokutake et al. PARKINSONISM & RELATED DISORDERS
- Identification and Rescue of -Synuclein Toxicity in Parkinson Patient-Derived Neurons
- (2013) C. Y. Chung et al. SCIENCE
- Pluripotent Stem Cells Induced from Mouse Somatic Cells by Small-Molecule Compounds
- (2013) P. Hou et al. SCIENCE
- Cellular reprogramming: a new approach to modelling Parkinson's disease
- (2012) Elizabeth M. Hartfield et al. BIOCHEMICAL SOCIETY TRANSACTIONS
- Alpha-Synuclein Posttranslational Modification and Alternative Splicing as a Trigger for Neurodegeneration
- (2012) Katrin Beyer et al. MOLECULAR NEUROBIOLOGY
- Alternative α-synuclein transcript usage as a convergent mechanism in Parkinson's disease pathology
- (2012) Herve Rhinn et al. Nature Communications
- Generation of Isogenic Pluripotent Stem Cells Differing Exclusively at Two Early Onset Parkinson Point Mutations
- (2011) Frank Soldner et al. CELL
- α-Synuclein Sequesters Dnmt1 from the Nucleus
- (2011) Paula Desplats et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Variant in the 3′ region of SNCA associated with Parkinson’s disease and serum α-synuclein levels
- (2011) Yacen Hu et al. JOURNAL OF NEUROLOGY
- Next-Generation Sequencing Reveals Regional Differences of the α-Synuclein Methylation State Independent of Lewy Body Disease
- (2011) L. de Boni et al. NEUROMOLECULAR MEDICINE
- SNCA Triplication Parkinson's Patient's iPSC-derived DA Neurons Accumulate α-Synuclein and Are Susceptible to Oxidative Stress
- (2011) Blake Byers et al. PLoS One
- Parkinson's disease induced pluripotent stem cells with triplication of the α-synuclein locus
- (2011) Michael J. Devine et al. Nature Communications
- Papp–Lantos inclusions and the pathogenesis of multiple system atrophy: an update
- (2010) Kurt A. Jellinger et al. ACTA NEUROPATHOLOGICA
- Consensus Statement: Chromosomal Microarray Is a First-Tier Clinical Diagnostic Test for Individuals with Developmental Disabilities or Congenital Anomalies
- (2010) David T. Miller et al. AMERICAN JOURNAL OF HUMAN GENETICS
- First appraisal of brain pathology owing to A30P mutant alpha-synuclein
- (2010) K Seidel et al. ANNALS OF NEUROLOGY
- SNCA Variant Associated With Parkinson Disease and Plasma α-Synuclein Level
- (2010) Ignacio F. Mata et al. ARCHIVES OF NEUROLOGY
- Post-transcriptional Regulation of α-Synuclein Expression by mir-7 and mir-153
- (2010) Epaminondas Doxakis JOURNAL OF BIOLOGICAL CHEMISTRY
- The effect of SNCA 3′ region on the levels of SNCA-112 splicing variant
- (2010) Jeanette J. McCarthy et al. NEUROGENETICS
- CpG Demethylation Enhances Alpha-Synuclein Expression and Affects the Pathogenesis of Parkinson's Disease
- (2010) Lumine Matsumoto et al. PLoS One
- Can cellular models revolutionize drug discovery in Parkinson's disease?
- (2009) Birgitt Schüle et al. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
- Molecular Pathology of Lewy Body Diseases
- (2009) Katrin Beyer et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- piggyBac transposition reprograms fibroblasts to induced pluripotent stem cells
- (2009) Knut Woltjen et al. NATURE
- Mechanisms of change in gene copy number
- (2009) P. J. Hastings et al. NATURE REVIEWS GENETICS
- A single nucleotide polymorphism in the 3′UTR of the SNCA gene encoding alpha-synuclein is a new potential susceptibility locus for Parkinson disease
- (2009) Sotiria Sotiriou et al. NEUROSCIENCE LETTERS
- Genetic Regulation of α-Synuclein mRNA Expression in Various Human Brain Tissues
- (2009) Colton Linnertz et al. PLoS One
- Repression of -synuclein expression and toxicity by microRNA-7
- (2009) E. Junn et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Genomic investigation of α-synuclein multiplication and parkinsonism
- (2008) Owen A. Ross et al. ANNALS OF NEUROLOGY
- Cerebellar α-synuclein levels are decreased in Parkinson’s disease and do not correlate with SNCA polymorphisms associated with disease in a Swedish material
- (2008) Marie Westerlund et al. FASEB JOURNAL
- GATA transcription factors directly regulate the Parkinson's disease-linked gene -synuclein
- (2008) C. R. Scherzer et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Genetic variability in the SNCA gene influences α-synuclein levels in the blood and brain
- (2007) Julia Fuchs et al. FASEB JOURNAL
Publish scientific posters with Peeref
Peeref publishes scientific posters from all research disciplines. Our Diamond Open Access policy means free access to content and no publication fees for authors.
Learn MoreBecome a Peeref-certified reviewer
The Peeref Institute provides free reviewer training that teaches the core competencies of the academic peer review process.
Get Started