Electro-Acupuncture Alleviates Chronic Unpredictable Stress-Induced Depressive- and Anxiety-Like Behavior and Hippocampal Neuroinflammation in Rat Model of Depression

An astroglial basis of major depressive disorder? An overview

(2017) Qian Wang et al.   GLIA

Activation of P2X7 receptor and NLRP3 inflammasome assembly in hippocampal glial cells mediates chronic stress-induced depressive-like behaviors

(2017) Na Yue et al.   Journal of Neuroinflammation

Deficits in cognitive flexibility induced by chronic unpredictable stress are associated with impaired glutamate neurotransmission in the rat medial prefrontal cortex

(2017) Julianne D. Jett et al.   NEUROSCIENCE

Electroacupuncture relieves depression-like symptoms in rats exposed to chronic unpredictable mild stress by activating ERK signaling pathway

(2017) Weidong Li et al.   NEUROSCIENCE LETTERS

Reversion of BDNF, Akt and CREB in Hippocampus of Chronic Unpredictable Stress Induced Rats: Effects of Phytochemical,Bacopa Monnieri

(2017) Somoday Hazra et al.   Psychiatry Investigation

Psychological Stress Activates the Inflammasome via Release of Adenosine Triphosphate and Stimulation of the Purinergic Type 2X7 Receptor

(2016) Masaaki Iwata et al.   BIOLOGICAL PSYCHIATRY

NLRP3 inflammasome activation mediates estrogen deficiency-induced depression- and anxiety-like behavior and hippocampal inflammation in mice

(2016) Yongjun Xu et al.   BRAIN BEHAVIOR AND IMMUNITY

Microglial dysfunction connects depression and Alzheimer’s disease

(2016) Luís Eduardo Santos et al.   BRAIN BEHAVIOR AND IMMUNITY

Fluoxetine Inhibits NLRP3 Inflammasome Activation: Implication in Depression

(2016) Ren-Hong Du et al.   INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY

Cytokines, brain-derived neurotrophic factor and C-reactive protein in bipolar I disorder – Results from a prospective study

(2016) Anne Sophie Jacoby et al.   JOURNAL OF AFFECTIVE DISORDERS

Neuroinflammatory Dynamics Underlie Memory Impairments after Repeated Social Defeat

(2016) Daniel B. McKim et al.   JOURNAL OF NEUROSCIENCE

Antidepressant effect of electroacupuncture regulates signal targeting in the brain and increases brain-derived neurotrophic factor levels

(2016) Dong-mei Duan et al.   Neural Regeneration Research

Density of GFAP-immunoreactive astrocytes is decreased in left hippocampi in major depressive disorder

(2016) J.A. Cobb et al.   NEUROSCIENCE

Electroacupuncture and cognitive behavioural therapy for sub-syndromal depression among undergraduates: a controlled clinical trial

(2016) Tianwei Guo et al.   Acupuncture in Medicine

How microglia kill neurons

(2015) Guy C. Brown et al.   BRAIN RESEARCH

Chronic corticosterone exposure reduces hippocampal astrocyte structural plasticity and induces hippocampal atrophy in mice

(2015) Huiyu Zhang et al.   NEUROSCIENCE LETTERS

l-Menthone confers antidepressant-like effects in an unpredictable chronic mild stress mouse model via NLRP3 inflammasome-mediated inflammatory cytokines and central neurotransmitters

(2015) Jinsong Xue et al.   PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR

Paroxetine suppresses recombinant human P2X7 responses

(2015) Phuong Dao-Ung et al.   Purinergic Signalling

Microglia activation regulates GluR1 phosphorylation in chronic unpredictable stress-induced cognitive dysfunction

(2015) Mingchao Liu et al.   STRESS-THE INTERNATIONAL JOURNAL ON THE BIOLOGY OF STRESS

Depression as a Microglial Disease

(2015) Raz Yirmiya et al.   TRENDS IN NEUROSCIENCES

NLRP3 Inflammasome Is Expressed and Functional in Mouse Brain Microglia but Not in Astrocytes

(2015) Audrey Gustin et al.   PLoS One

Microglial NLRP3 inflammasome activation mediates IL-1β-related inflammation in prefrontal cortex of depressive rats

(2014) Ying Pan et al.   BRAIN BEHAVIOR AND IMMUNITY

NLRP3 Inflammasome: A New Target in Major Depressive Disorder

(2014) Elísabet Alcocer-Gómez et al.   CNS Neuroscience & Therapeutics

The Alterations of IL-1Beta, IL-6, and TGF-Beta Levels in Hippocampal CA3 Region of Chronic Restraint Stress Rats after Electroacupuncture (EA) Pretreatment

(2014) Tianwei Guo et al.   Evidence-based Complementary and Alternative Medicine

Electroacupuncture Promotes Proliferation of Amplifying Neural Progenitors and Preserves Quiescent Neural Progenitors from Apoptosis to Alleviate Depressive-Like and Anxiety-Like Behaviours

(2014) Liu Yang et al.   Evidence-based Complementary and Alternative Medicine

Effects of Chronic Electroacupuncture on Depression- and Anxiety-Like Behaviors in Rats with Chronic Neuropathic Pain

(2014) Qian Li et al.   Evidence-based Complementary and Alternative Medicine

Iptakalim confers an antidepressant effect in a chronic mild stress model of depression through regulating neuro-inflammation and neurogenesis

(2014) Ming Lu et al.   INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY

NLRP3 Deficiency Ameliorates Neurovascular Damage in Experimental Ischemic Stroke

(2014) Fan Yang et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Inhibition of the NLRP3 inflammasome provides neuroprotection in rats following amygdala kindling-induced status epilepticus

(2014) Xiang-Fei Meng et al.   Journal of Neuroinflammation

P2X7 receptor: an emerging target in central nervous system diseases

(2014) Beáta Sperlágh et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Neuroendocrine and Cardiac Metabolic Dysfunction and NLRP3 Inflammasome Activation in Adipose Tissue and Pancreas following Chronic Spinal Cord Injury in the Mouse

(2013) Gregory E. Bigford et al.   ASN Neuro

Swimming exercise ameliorates depression-like behavior in chronically stressed rats: Relevant to proinflammatory cytokines and IDO activation

(2013) Weina Liu et al.   BEHAVIOURAL BRAIN RESEARCH

Electroacupuncture upregulates ERK signaling pathways and promotes adult hippocampal neural progenitors proliferation in a rat model of depression

(2013) Liu Yang et al.   BMC Complementary and Alternative Medicine

Involvement of Inflammasome Activation in Lipopolysaccharide-induced Mice Depressive-like Behaviors

(2013) Yi Zhang et al.   CNS Neuroscience & Therapeutics

Modulatory mechanisms controlling the NLRP3 inflammasome in inflammation: recent developments

(2013) Moritz Haneklaus et al.   CURRENT OPINION IN IMMUNOLOGY

Oligomeric amyloid β induces IL-1β processing via production of ROS: implication in Alzheimer’s disease

(2013) B Parajuli et al.   Cell Death & Disease

The inflammasome: Pathways linking psychological stress, depression, and systemic illnesses

(2012) Masaaki Iwata et al.   BRAIN BEHAVIOR AND IMMUNITY

Neuroimmunomodulation in unipolar depression: a focus on chronobiology and chronotherapeutics

(2012) Harris Eyre et al.   JOURNAL OF NEURAL TRANSMISSION

Effects of fluoxetine, tianeptine and olanzapine on unpredictable chronic mild stress-induced depression-like behavior in mice

(2012) Oguz Mutlu et al.   LIFE SCIENCES

A role for interleukin-1β in determining the lineage fate of embryonic rat hippocampal neural precursor cells

(2012) Holly F. Green et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

Microglia in the developing brain: A potential target with lifetime effects

(2012) G. Jean Harry et al.   NEUROTOXICOLOGY

Toll-like receptor (TLR) and inflammasome actions in the central nervous system

(2012) Richa Hanamsagar et al.   TRENDS IN IMMUNOLOGY

Unlocking mechanisms in interleukin-1β-induced changes in hippocampal neurogenesis—a role for GSK-3β and TLX

(2012) H F Green et al.   Translational Psychiatry

Evidence that Microglia Mediate the Neurobiological Effects of Chronic Psychological Stress on the Medial Prefrontal Cortex

(2011) M. Hinwood et al.   CEREBRAL CORTEX

Nuclear factor- B is a critical mediator of stress-impaired neurogenesis and depressive behavior

(2010) J. W. Koo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cytokines mediated inflammation and decreased neurogenesis in animal models of depression

(2010) Cai Song et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

Clomipramine treatment reversed the glial pathology in a chronic unpredictable stress-induced rat model of depression

(2009) Qiong Liu et al.   EUROPEAN NEUROPSYCHOPHARMACOLOGY

Cutting Edge: NF- B Activating Pattern Recognition and Cytokine Receptors License NLRP3 Inflammasome Activation by Regulating NLRP3 Expression

(2009) F. G. Bauernfeind et al.   JOURNAL OF IMMUNOLOGY

Region specific decrease in glial fibrillary acidic protein immunoreactivity in the brain of a rat model of depression

(2009) R.-D. Gosselin et al.   NEUROSCIENCE

Interleukin-1 receptor null mutant mice show decreased anxiety-like behavior and enhanced fear memory

(2009) Ja Wook Koo et al.   NEUROSCIENCE LETTERS

Associations of Depression With C-Reactive Protein, IL-1, and IL-6: A Meta-Analysis

(2009) M Bryant Howren et al.   PSYCHOSOMATIC MEDICINE

Repeated clomipramine treatment reversed the inhibition of cell proliferation in adult hippocampus induced by chronic unpredictable stress

(2008) Q Liu et al.   PHARMACOGENOMICS JOURNAL

IL-1 is an essential mediator of the antineurogenic and anhedonic effects of stress

(2008) J. W. Koo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

From inflammation to sickness and depression: when the immune system subjugates the brain

(2007) Robert Dantzer et al.   NATURE REVIEWS NEUROSCIENCE