Overactivated neddylation pathway in human hepatocellular carcinoma

A pathology atlas of the human cancer transcriptome

(2017) Mathias Uhlen et al.   SCIENCE

Down-regulation of the cyclin-dependent kinase inhibitor p57 is mediated by Jab1/Csn5 in hepatocarcinogenesis

(2016) Hui Guo et al.   HEPATOLOGY

Stabilization of HIF through inhibition of Cullin-2 neddylation is protective in mucosal inflammatory responses

(2015) Valerie F. Curtis et al.   FASEB JOURNAL

Aldolase B inhibits metastasis through Ten–Eleven Translocation 1 and serves as a prognostic biomarker in hepatocellular carcinoma

(2015) Qi-fei Tao et al.   Molecular Cancer

HuR Suppresses Fas Expression and Correlates with Patient Outcome in Liver Cancer

(2015) H. Zhu et al.   MOLECULAR CANCER RESEARCH

Neddylation inhibition impairs spine development, destabilizes synapses and deteriorates cognition

(2015) Annette M Vogl et al.   NATURE NEUROSCIENCE

Protein neddylation: beyond cullin–RING ligases

(2015) Radoslav I. Enchev et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Stabilization of LKB1 and Akt by neddylation regulates energy metabolism in liver cancer

(2015) Lucía Barbier-Torres et al.   Oncotarget

Regulation of cancer-related pathways by protein NEDDylation and strategies for the use of NEDD8 inhibitors in the clinic

(2014) Naima Abidi et al.   ENDOCRINE-RELATED CANCER

Neddylation plays an important role in the regulation of murine and human dendritic cell function

(2013) N. Mathewson et al.   BLOOD

Identification of NUB1 as a suppressor of mutant Huntingtin toxicity via enhanced protein clearance

(2013) Boxun Lu et al.   NATURE NEUROSCIENCE

Inhibition of a NEDD8 Cascade Restores Restriction of HIV by APOBEC3G

(2013) David J. Stanley et al.   PLoS Pathogens

The Nedd8-Activating Enzyme Inhibitor MLN4924 Induces Autophagy and Apoptosis to Suppress Liver Cancer Cell Growth

(2012) Z. Luo et al.   CANCER RESEARCH

Molecular Mechanisms Underlying Occult Hepatitis B Virus Infection

(2012) J. Samal et al.   CLINICAL MICROBIOLOGY REVIEWS

NCBI GEO: archive for functional genomics data sets—update

(2012) Tanya Barrett et al.   NUCLEIC ACIDS RESEARCH

NEDD8 Pathways in Cancer, Sine Quibus Non

(2011) Ian R. Watson et al.   CANCER CELL

Murine double minute 2 regulates Hu antigen R stability in human liver and colon cancer through NEDDylation

(2011) Nieves Embade et al.   HEPATOLOGY

A Unique Metastasis Gene Signature Enables Prediction of Tumor Relapse in Early-Stage Hepatocellular Carcinoma Patients

(2010) S. Roessler et al.   CANCER RESEARCH

Perturbation of Cullin Deneddylation via Conditional Csn8 Ablation Impairs the Ubiquitin–Proteasome System and Causes Cardiomyocyte Necrosis and Dilated Cardiomyopathy in Mice

(2010) Huabo Su et al.   CIRCULATION RESEARCH

Overexpression of aspartyl-(asparaginyl)-β-hydroxylase in hepatocellular carcinoma is associated with worse surgical outcome

(2010) Kui Wang et al.   HEPATOLOGY

Hepatocellular Carcinoma (HCC)

(2010) Peter Ferenci et al.   JOURNAL OF CLINICAL GASTROENTEROLOGY

An Altered Pattern of Liver Apolipoprotein A-I Isoforms Is Implicated in Male Chronic Hepatitis B Progression

(2009) Fu Yang et al.   JOURNAL OF PROTEOME RESEARCH

Correlation between expression of p53, p21/WAF1, and MDM2 proteins and their prognostic significance in primary hepatocellular carcinoma

(2009) Mei-Fang Zhang et al.   Journal of Translational Medicine

Overexpression of Jab1 in Hepatocellular Carcinoma and Its Inhibition by Peroxisome Proliferator-Activated Receptor  Ligands In vitro and In vivo

(2008) M.-C. Hsu et al.   CLINICAL CANCER RESEARCH

Epigenetic identification of ubiquitin carboxyl-terminal hydrolase L1 as a functional tumor suppressor and biomarker for hepatocellular carcinoma and other digestive tumors

(2008) Jun Yu et al.   HEPATOLOGY