Neurobiology of rodent self-grooming and its value for translational neuroscience

Learning From Animal Models of Obsessive-Compulsive Disorder

(2016) Patricia Monteiro et al.   BIOLOGICAL PSYCHIATRY

The Mouse Who Couldn't Stop Washing: Pathologic Grooming in Animals and Humans

(2016) Jamie D. Feusner et al.   CNS SPECTRUMS

Cross-Disorder Genome-Wide Analyses Suggest a Complex Genetic Relationship Between Tourette’s Syndrome and OCD

(2015) Dongmei Yu et al.   AMERICAN JOURNAL OF PSYCHIATRY

Translational neurobiology in Shank mutant mice - Model systems for neuropsychiatric disorders

(2015) Michael J. Schmeisser   ANNALS OF ANATOMY-ANATOMISCHER ANZEIGER

Developing better and more valid animal models of brain disorders

(2015) Adam Michael Stewart et al.   BEHAVIOURAL BRAIN RESEARCH

Modeling neuropsychiatric spectra to empower translational biological psychiatry

(2015) Allan V. Kalueff et al.   BEHAVIOURAL BRAIN RESEARCH

Repetitive grooming and sensorimotor abnormalities in an ephrin-A knockout model for Autism Spectrum Disorders

(2015) Rachel Wurzman et al.   BEHAVIOURAL BRAIN RESEARCH

A Corticostriatal Path Targeting Striosomes Controls Decision-Making under Conflict

(2015) Alexander Friedman et al.   CELL

Striatal circuits, habits, and implications for obsessive–compulsive disorder

(2015) Eric Burguière et al.   CURRENT OPINION IN NEUROBIOLOGY

DISSECTING OCD CIRCUITS: FROM ANIMAL MODELS TO TARGETED TREATMENTS

(2015) Susanne E. Ahmari et al.   DEPRESSION AND ANXIETY

Central amygdalar nucleus treated with orexin neuropeptides evoke differing feeding and grooming responses in the hamster

(2015) Raffaella Alò et al.   JOURNAL OF THE NEUROLOGICAL SCIENCES

Evidence against dopamine D1/D2 receptor heteromers

(2015) A L Frederick et al.   MOLECULAR PSYCHIATRY

Astroglial Glutamate Transporter Deficiency Increases Synaptic Excitability and Leads to Pathological Repetitive Behaviors in Mice

(2015) Tomomi Aida et al.   NEUROPSYCHOPHARMACOLOGY

Regulation of the mesocorticolimbic and mesostriatal dopamine systems by α-melanocyte stimulating hormone and agouti-related protein

(2015) Aaron G. Roseberry et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

Histidine decarboxylase knockout mice, a genetic model of Tourette syndrome, show repetitive grooming after induced fear

(2015) Meiyu Xu et al.   NEUROSCIENCE LETTERS

Targeted ablation of cholinergic interneurons in the dorsolateral striatum produces behavioral manifestations of Tourette syndrome

(2015) Meiyu Xu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Striatum: Where Skills and Habits Meet

(2015) Ann M. Graybiel et al.   Cold Spring Harbor Perspectives in Biology

The Role of Parental Cognitive, Behavioral, and Motor Profiles in Clinical Variability in Individuals With Chromosome 16p11.2 Deletions

(2015) Andres Moreno-De-Luca et al.   JAMA Psychiatry

Suppression of NMDA receptor function in mice prenatally exposed to valproic acid improves social deficits and repetitive behaviors

(2015) Jaeseung Kang et al.   Frontiers in Molecular Neuroscience

Transcriptional Consequences of 16p11.2 Deletion and Duplication in Mouse Cortex and Multiplex Autism Families

(2014) Ian Blumenthal et al.   AMERICAN JOURNAL OF HUMAN GENETICS

The NIMH Research Domain Criteria (RDoC) Project: Precision Medicine for Psychiatry

(2014) Thomas R. Insel   AMERICAN JOURNAL OF PSYCHIATRY

Parasites enhance self-grooming behaviour and information retention in humans

(2014) Pavol Prokop et al.   BEHAVIOURAL PROCESSES

Antagonistic Control of Social versus Repetitive Self-Grooming Behaviors by Separable Amygdala Neuronal Subsets

(2014) Weizhe Hong et al.   CELL

A Trial of D-Cycloserine to Treat Stereotypies in Older Adolescents and Young Adults With Autism Spectrum Disorder

(2014) Maria Urbano et al.   CLINICAL NEUROPHARMACOLOGY

Validation and implementation of a novel high-throughput behavioral phenotyping instrument for mice

(2014) Jesse Brodkin et al.   JOURNAL OF NEUROSCIENCE METHODS

Repetitive behaviors in the Shank1 knockout mouse model for autism spectrum disorder: Developmental aspects and effects of social context

(2014) A. Özge Sungur et al.   JOURNAL OF NEUROSCIENCE METHODS

Copy Number Variation in Obsessive-Compulsive Disorder and Tourette Syndrome: A Cross-Disorder Study

(2014) Lauren M. McGrath et al.   JOURNAL OF THE AMERICAN ACADEMY OF CHILD AND ADOLESCENT PSYCHIATRY

The 16p11.2 locus modulates brain structures common to autism, schizophrenia and obesity

(2014) A M Maillard et al.   MOLECULAR PSYCHIATRY

Clustering autism: using neuroanatomical differences in 26 mouse models to gain insight into the heterogeneity

(2014) J Ellegood et al.   MOLECULAR PSYCHIATRY

Basal ganglia subcircuits distinctively encode the parsing and concatenation of action sequences

(2014) Xin Jin et al.   NATURE NEUROSCIENCE

Decoding the contribution of dopaminergic genes and pathways to autism spectrum disorder (ASD)

(2014) Michael Nguyen et al.   NEUROCHEMISTRY INTERNATIONAL

Loss of glutamic acid decarboxylase (Gad67) in Gpr88-expressing neurons induces learning and social behavior deficits in mice

(2014) K. Zhang et al.   NEUROSCIENCE

Advancing the discovery of medications for autism spectrum disorder using new technologies to reveal social brain circuitry in rodents

(2014) Martien J. Kas et al.   PSYCHOPHARMACOLOGY

Working together: basal ganglia pathways in action selection

(2014) Danielle M. Friend et al.   TRENDS IN NEUROSCIENCES

Behavioral Abnormalities and Circuit Defects in the Basal Ganglia of a Mouse Model of 16p11.2 Deletion Syndrome

(2014) Thomas Portmann et al.   Cell Reports

Behavioral signatures related to genetic disorders in autism

(2014) Hilgo Bruining et al.   Molecular Autism

Effects of Environmental Enrichment on Repetitive Behaviors in the BTBR T+tf/J Mouse Model of Autism

(2013) Stacey Reynolds et al.   Autism Research

Repetitive behavior profile and supersensitivity to amphetamine in the C58/J mouse model of autism

(2013) Sheryl S. Moy et al.   BEHAVIOURAL BRAIN RESEARCH

Circuit-Selective Striatal Synaptic Dysfunction in the Sapap3 Knockout Mouse Model of Obsessive-Compulsive Disorder

(2013) Yehong Wan et al.   BIOLOGICAL PSYCHIATRY

d-Cycloserine improves sociability in the BTBR T+ Itpr3tf/J mouse model of autism spectrum disorders with altered Ras/Raf/ERK1/2 signaling

(2013) Jessica A. Burket et al.   BRAIN RESEARCH BULLETIN

The emerging role ofSHANKgenes in neuropsychiatric disorders

(2013) Audrey Guilmatre et al.   Developmental Neurobiology

The promising trajectory of autism therapeutics discovery

(2013) Jill L. Silverman et al.   DRUG DISCOVERY TODAY

Dopaminergic activity in Tourette syndrome and obsessive-compulsive disorder

(2013) Damiaan Denys et al.   EUROPEAN NEUROPSYCHOPHARMACOLOGY

Common and rare alleles of the serotonin transporter gene,SLC6A4, associated with Tourette's disorder

(2013) Pablo R. Moya et al.   MOVEMENT DISORDERS

The many faces of alpha-synuclein mutations

(2013) Meike Kasten et al.   MOVEMENT DISORDERS

DSM-5 and RDoC: progress in psychiatry research?

(2013) B. J. Casey et al.   NATURE REVIEWS NEUROSCIENCE

Acetylcholine Elevation Relieves Cognitive Rigidity and Social Deficiency in a Mouse Model of Autism

(2013) Golan Karvat et al.   NEUROPSYCHOPHARMACOLOGY

Context-dependent differences in grooming behavior among the NIH heterogeneous stock and the Roman high- and low-avoidance rats

(2013) C. Estanislau et al.   NEUROSCIENCE RESEARCH

Behavioral Characterization of A53T Mice Reveals Early and Late Stage Deficits Related to Parkinson’s Disease

(2013) Katrina L. Paumier et al.   PLoS One

Neuroimaging Evidence of Major Morpho-Anatomical and Functional Abnormalities in the BTBR T+TF/J Mouse Model of Autism

(2013) Luca Dodero et al.   PLoS One

Double deletion of melanocortin 4 receptors and SAPAP3 corrects compulsive behavior and obesity in mice

(2013) P. Xu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Developing zebrafish models of autism spectrum disorder (ASD)

(2013) Adam Michael Stewart et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

Assessing behavioural and cognitive domains of autism spectrum disorders in rodents: current status and future perspectives

(2013) Martien J. Kas et al.   PSYCHOPHARMACOLOGY

Optogenetic Stimulation of Lateral Orbitofronto-Striatal Pathway Suppresses Compulsive Behaviors

(2013) E. Burguiere et al.   SCIENCE

Repeated Cortico-Striatal Stimulation Generates Persistent OCD-Like Behavior

(2013) S. E. Ahmari et al.   SCIENCE

Partitioning the Heritability of Tourette Syndrome and Obsessive Compulsive Disorder Reveals Differences in Genetic Architecture

(2013) Lea K. Davis et al.   PLoS Genetics

High-throughput screening of stem cell therapy for globoid cell leukodystrophy using automated neurophenotyping of twitcher mice

(2012) Brittni A. Scruggs et al.   BEHAVIOURAL BRAIN RESEARCH

Autism-related behavioral abnormalities in synapsin knockout mice

(2012) Barbara Greco et al.   BEHAVIOURAL BRAIN RESEARCH

Shedding Light on Brain Circuits

(2012) Thomas R. Insel et al.   BIOLOGICAL PSYCHIATRY

Alterations in grooming activity and syntax in heterozygous SERT and BDNF knockout mice: The utility of behavior-recognition tools to characterize mutant mouse phenotypes

(2012) Evan J. Kyzar et al.   BRAIN RESEARCH BULLETIN

Anxiolytic effect of clonazepam in female rats: Grooming microstructure and elevated plus maze tests

(2012) Maurício S. Nin et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Reduced Excitatory Neurotransmission and Mild Autism-Relevant Phenotypes in Adolescent Shank3 Null Mutant Mice

(2012) M. Yang et al.   JOURNAL OF NEUROSCIENCE

Autistic-like social behaviour in Shank2-mutant mice improved by restoring NMDA receptor function

(2012) Hyejung Won et al.   NATURE

Inactivation of the bed nucleus of the stria terminalis suppresses the innate fear responses of rats induced by the odor of cat urine

(2012) H.-Y. Xu et al.   NEUROSCIENCE

The effect of intra-nucleus accumbens administration of allopregnanolone on δ and γ2 GABAA receptor subunit mRNA expression in the hippocampus and on depressive-like and grooming behaviors in rats

(2012) Maurício S. Nin et al.   PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR

Potential translational targets revealed by linking mouse grooming behavioral phenotypes to gene expression using public databases

(2012) Andrew Roth et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

Negative Allosteric Modulation of the mGluR5 Receptor Reduces Repetitive Behaviors and Rescues Social Deficits in Mouse Models of Autism

(2012) J. L. Silverman et al.   Science Translational Medicine

Towards high-throughput phenotyping of complex patterned behaviors in rodents: Focus on mouse self-grooming and its sequencing

(2011) Evan Kyzar et al.   BEHAVIOURAL BRAIN RESEARCH

Reverse-translational biomarker validation of Abnormal Repetitive Behaviors in mice: An illustration of the 4P's modeling approach

(2011) Joseph P. Garner et al.   BEHAVIOURAL BRAIN RESEARCH

Evaluation of the anxiolytic-like effects of clomipramine in two rat strains with different anxiety vulnerability (Wistar and Wistar-Kyoto rats)

(2011) Gabriela Rogel-Salazar et al.   BEHAVIOURAL PHARMACOLOGY

Synaptic dysfunction and abnormal behaviors in mice lacking major isoforms of Shank3

(2011) Xiaoming Wang et al.   HUMAN MOLECULAR GENETICS

Differential Electrophysiological Changes in Striatal Output Neurons in Huntington's Disease

(2011) V. M. Andre et al.   JOURNAL OF NEUROSCIENCE

Neurobiology of Tourette Syndrome: Current Status and Need for Further Investigation

(2011) R. J. Felling et al.   JOURNAL OF NEUROSCIENCE

Discovering imaging endophenotypes for major depression

(2011) G Hasler et al.   MOLECULAR PSYCHIATRY

Shank3 mutant mice display autistic-like behaviours and striatal dysfunction

(2011) João Peça et al.   NATURE

Social Deficits and Perseverative Behaviors, but not Overt Aggression, in MAO-A Hypomorphic Mice

(2011) Marco Bortolato et al.   NEUROPSYCHOPHARMACOLOGY

Basal Ganglia Disorders Associated with Imbalances in the Striatal Striosome and Matrix Compartments

(2011) Jill R. Crittenden et al.   Frontiers in Neuroanatomy

Past, Present, and Future of the Pathophysiological Model of the Basal Ganglia

(2011) José A. Obeso et al.   Frontiers in Neuroanatomy

Family-based genetic association study of DLGAP3 in Tourette Syndrome

(2010) Jacquelyn Crane et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS

Social peers rescue autism-relevant sociability deficits in adolescent mice

(2010) Mu Yang et al.   Autism Research

The effects of chronic social defeat stress on mouse self-grooming behavior and its patterning

(2010) Ashley Denmark et al.   BEHAVIOURAL BRAIN RESEARCH

Dopamine receptor modulation of repetitive grooming actions in the rat: Potential relevance for Tourette syndrome

(2010) Jennifer L. Taylor et al.   BRAIN RESEARCH

Hematopoietic Origin of Pathological Grooming in Hoxb8 Mutant Mice

(2010) Shau-Kwaun Chen et al.   CELL

Cholinergic Abnormalities in Autism

(2010) Stephen I. Deutsch et al.   CLINICAL NEUROPHARMACOLOGY

Investigating SAPAP3 variants in the etiology of obsessive-compulsive disorder and trichotillomania in the South African white population

(2010) Leigh Boardman et al.   COMPREHENSIVE PSYCHIATRY

Motor and cognitive stereotypies in the BTBR T+tf/J mouse model of autism

(2010) B. L. Pearson et al.   GENES BRAIN AND BEHAVIOR

Slitrk5 deficiency impairs corticostriatal circuitry and leads to obsessive-compulsive–like behaviors in mice

(2010) Sergey V Shmelkov et al.   NATURE MEDICINE

Nutritional up-regulation of serotonin paradoxically induces compulsive behavior

(2010) Brett D. Dufour et al.   NUTRITIONAL NEUROSCIENCE

Refining psychiatric genetics: from ‘mouse psychiatry’ to understanding complex human disorders

(2009) Justin L. LaPorte et al.   BEHAVIOURAL PHARMACOLOGY

Mouse models of Huntington's disease and methodological considerations for therapeutic trials

(2009) Robert J. Ferrante   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Association of SLC6A4 variants with obsessive-compulsive disorder in a large multicenter US family study

(2009) E Voyiaziakis et al.   MOLECULAR PSYCHIATRY

Repetitive Self-Grooming Behavior in the BTBR Mouse Model of Autism is Blocked by the mGluR5 Antagonist MPEP

(2009) Jill L Silverman et al.   NEUROPSYCHOPHARMACOLOGY

Conserved role for the serotonin transporter gene in rat and mouse neurobehavioral endophenotypes

(2009) A.V. Kalueff et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

Sapap3and pathological grooming in humans: Results from the OCD collaborative genetics study

(2008) O.J. Bienvenu et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS

Habits, Rituals, and the Evaluative Brain

(2008) Ann M. Graybiel   Annual Review of Neuroscience

Cerebral Amyloid Angiopathy and Parenchymal Amyloid Deposition in Transgenic Mice Expressing the Danish Mutant Form of Human BRI2

(2008) Ruben Vidal et al.   BRAIN PATHOLOGY

Multiple rare SAPAP3 missense variants in trichotillomania and OCD

(2008) S Züchner et al.   MOLECULAR PSYCHIATRY

Targeting the murine serotonin transporter: insights into human neurobiology

(2008) Dennis L. Murphy et al.   NATURE REVIEWS NEUROSCIENCE

How the serotonin story is being rewritten by new gene-based discoveries principally related to SLC6A4, the serotonin transporter gene, which functions to influence all cellular serotonin systems

(2008) Dennis L. Murphy et al.   NEUROPHARMACOLOGY

Striatal dopamine D2 receptor availability in OCD with and without comorbid social anxiety disorder: preliminary findings

(2007) Franklin R. Schneier et al.   DEPRESSION AND ANXIETY