Inhibition of the acetyltransferase NAT10 normalizes progeric and aging cells by rebalancing the Transportin-1 nuclear import pathway
出版年份 2018 全文链接
标题
Inhibition of the acetyltransferase NAT10 normalizes progeric and aging cells by rebalancing the Transportin-1 nuclear import pathway
作者
关键词
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出版物
Science Signaling
Volume 11, Issue 537, Pages eaar5401
出版商
American Association for the Advancement of Science (AAAS)
发表日期
2018-07-04
DOI
10.1126/scisignal.aar5401
参考文献
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注意:仅列出部分参考文献,下载原文获取全部文献信息。- Prelamin A impairs 53BP1 nuclear entry by mislocalizing NUP153 and disrupting the Ran gradient
- (2016) Andrew M. Cobb et al. AGING CELL
- NAT10 regulates p53 activation through acetylating p53 at K120 and ubiquitinating Mdm2
- (2016) Xiaofeng Liu et al. EMBO REPORTS
- Signaling pathway activation drift during aging: Hutchinson-Gilford Progeria Syndrome fibroblasts are comparable to normal middle-age and old-age cells
- (2015) Alexander M. Aliper et al. Aging-US
- Nup153 Recruits the Nup107-160 Complex to the Inner Nuclear Membrane for Interphasic Nuclear Pore Complex Assembly
- (2015) Benjamin Vollmer et al. DEVELOPMENTAL CELL
- Yeast Kre33 and human NAT10 are conserved 18S rRNA cytosine acetyltransferases that modify tRNAs assisted by the adaptor Tan1/THUMPD1
- (2015) Sunny Sharma et al. NUCLEIC ACIDS RESEARCH
- limma powers differential expression analyses for RNA-sequencing and microarray studies
- (2015) Matthew E. Ritchie et al. NUCLEIC ACIDS RESEARCH
- Impact of Farnesylation Inhibitors on Survival in Hutchinson-Gilford Progeria Syndrome
- (2014) Leslie B. Gordon et al. CIRCULATION
- Human NAT10 Is an ATP-dependent RNA Acetyltransferase Responsible forN4-Acetylcytidine Formation in 18 S Ribosomal RNA (rRNA)
- (2014) Satoshi Ito et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- A pathway linking oxidative stress and the Ran GTPase system in progeria
- (2014) Sutirtha Datta et al. MOLECULAR BIOLOGY OF THE CELL
- Chemical Inhibition of NAT10 Corrects Defects of Laminopathic Cells
- (2014) D. Larrieu et al. SCIENCE
- Sirtuins: guardians of mammalian healthspan
- (2014) William Giblin et al. TRENDS IN GENETICS
- The Hallmarks of Aging
- (2013) Carlos López-Otín et al. CELL
- hnRNP A1: The Swiss Army Knife of Gene Expression
- (2013) Jacques Jean-Philippe et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Defective nuclear import of Tpr in Progeria reflects the Ran sensitivity of large cargo transport
- (2013) Chelsi J. Snow et al. JOURNAL OF CELL BIOLOGY
- Resveratrol Rescues SIRT1-Dependent Adult Stem Cell Decline and Alleviates Progeroid Features in Laminopathy-Based Progeria
- (2012) Baohua Liu et al. Cell Metabolism
- Integrative Genome-wide Analysis Reveals Cooperative Regulation of Alternative Splicing by hnRNP Proteins
- (2012) Stephanie C. Huelga et al. Cell Reports
- The Defective Nuclear Lamina in Hutchinson-Gilford Progeria Syndrome Disrupts the Nucleocytoplasmic Ran Gradient and Inhibits Nuclear Localization of Ubc9
- (2011) J. B. Kelley et al. MOLECULAR AND CELLULAR BIOLOGY
- Protein Tpr is required for establishing nuclear pore-associated zones of heterochromatin exclusion
- (2010) Sandra Krull et al. EMBO JOURNAL
- hALP, A Novel Transcriptional U Three Protein (t-UTP), Activates RNA Polymerase I Transcription by Binding and Acetylating the Upstream Binding Factor (UBF)
- (2010) Ruirui Kong et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Defective Lamin A-Rb Signaling in Hutchinson-Gilford Progeria Syndrome and Reversal by Farnesyltransferase Inhibition
- (2010) Jackleen Marji et al. PLoS One
- Nuclear Pore Proteins Nup153 and Megator Define Transcriptionally Active Regions in the Drosophila Genome
- (2010) Juan M. Vaquerizas et al. PLoS Genetics
- Transportin Regulates Major Mitotic Assembly Events: From Spindle to Nuclear Pore Assembly
- (2009) Corine K. Lau et al. MOLECULAR BIOLOGY OF THE CELL
- lumi: a pipeline for processing Illumina microarray
- (2008) P. Du et al. BIOINFORMATICS
- Phenotype and Course of Hutchinson–Gilford Progeria Syndrome
- (2008) Melissa A. Merideth et al. NEW ENGLAND JOURNAL OF MEDICINE
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