Cyclic di-AMP-mediated interaction between Mycobacterium tuberculosis ΔcnpB and macrophages implicates a novel strategy for improving BCG vaccination

Mycobacterial ESX-1 secretion system mediates host cell lysis through bacterium contact-dependent gross membrane disruptions

(2017) William H. Conrad et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Control of potassium homeostasis is an essential function of the second messenger cyclic di-AMP inBacillus subtilis

(2017) Jan Gundlach et al.   Science Signaling

Recombinant BCG Expressing ESX-1 of Mycobacterium marinum Combines Low Virulence with Cytosolic Immune Signaling and Improved TB Protection

(2017) Matthias I. Gröschel et al.   Cell Reports

Control of potassium homeostasis is an essential function of the second messenger cyclic di-AMP inBacillus subtilis

(2017) Jan Gundlach et al.   Science Signaling

Inhibition of innate immune cytosolic surveillance by an M. tuberculosis phosphodiesterase

(2016) Ruchi Jain Dey et al.   Nature Chemical Biology

The Mechanism for Type I Interferon Induction by Mycobacterium tuberculosis is Bacterial Strain-Dependent

(2016) Kirsten E. Wiens et al.   PLoS Pathogens

Substrates Control Multimerization and Activation of the Multi-Domain ATPase Motor of Type VII Secretion

(2015) Oren S. Rosenberg et al.   CELL

The PAMP c-di-AMP Is Essential for Listeria monocytogenes Growth in Rich but Not Minimal Media due to a Toxic Increase in (p)ppGpp

(2015) Aaron T. Whiteley et al.   Cell Host & Microbe

Mycobacterium tuberculosis Meets the Cytosol: The Role of cGAS in Anti-mycobacterial Immunity

(2015) Laleh Majlessi et al.   Cell Host & Microbe

The Cytosolic Sensor cGAS Detects Mycobacterium tuberculosis DNA to Induce Type I Interferons and Activate Autophagy

(2015) Robert O. Watson et al.   Cell Host & Microbe

Mycobacterium tuberculosis Differentially Activates cGAS- and Inflammasome-Dependent Intracellular Immune Responses through ESX-1

(2015) Ruth Wassermann et al.   Cell Host & Microbe

Cyclic GMP-AMP Synthase Is an Innate Immune DNA Sensor for Mycobacterium tuberculosis

(2015) Angela C. Collins et al.   Cell Host & Microbe

Cyclic di-AMP mediates biofilm formation

(2015) Xian Peng et al.   MOLECULAR MICROBIOLOGY

A bacterial cyclic dinucleotide activates the cytosolic surveillance pathway and mediates innate resistance to tuberculosis

(2015) Bappaditya Dey et al.   NATURE MEDICINE

Cytosolic Access of Mycobacterium tuberculosis: Critical Impact of Phagosomal Acidification Control and Demonstration of Occurrence In Vivo

(2015) Roxane Simeone et al.   PLoS Pathogens

Successive Intramuscular Boosting with IFN-Alpha ProtectsMycobacterium bovisBCG-Vaccinated Mice againstM. lepraemuriumInfection

(2015) G. G. Guerrero et al.   Biomed Research International

Listeria monocytogenes induces IFN  expression through an IFI16-, cGAS- and STING-dependent pathway

(2014) K. Hansen et al.   EMBO JOURNAL

Type I IFN signaling triggers immunopathology in tuberculosis-susceptible mice by modulating lung phagocyte dynamics

(2014) Anca Dorhoi et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Detection of cyclic di-AMP using a competitive ELISA with a unique pneumococcal cyclic di-AMP binding protein

(2014) Adam J. Underwood et al.   JOURNAL OF MICROBIOLOGICAL METHODS

Deletion of the cyclic di-AMP phosphodiesterase gene (cnpB) inMycobacterium tuberculosisleads to reduced virulence in a mouse model of infection

(2014) Jun Yang et al.   MOLECULAR MICROBIOLOGY

Two-Step Synthesis and Hydrolysis of Cyclic di-AMP in Mycobacterium tuberculosis

(2014) Kasi Manikandan et al.   PLoS One

The Mucosal Adjuvant Cyclic di-AMP Exerts Immune Stimulatory Effects on Dendritic Cells and Macrophages

(2014) Ivana Škrnjug et al.   PLoS One

Intranasal Delivery of Influenza rNP Adjuvanted with c-di-AMP Induces Strong Humoral and Cellular Immune Responses and Provides Protection against Virus Challenge

(2014) Maria Victoria Sanchez et al.   PLoS One

STING-Dependent Type I IFN Production Inhibits Cell-Mediated Immunity to Listeria monocytogenes

(2014) Kristina A. Archer et al.   PLoS Pathogens

Listeria monocytogenes MDR transporters are involved in LTA synthesis and triggering of innate immunity during infection

(2014) Keren Tadmor et al.   Frontiers in Cellular and Infection Microbiology

Two DHH Subfamily 1 Proteins in Streptococcus pneumoniae Possess Cyclic Di-AMP Phosphodiesterase Activity and Affect Bacterial Growth and Virulence

(2013) Y. Bai et al.   JOURNAL OF BACTERIOLOGY

Pan-viral specificity of IFN-induced genes reveals new roles for cGAS in innate immunity

(2013) John W. Schoggins et al.   NATURE

Systematic identification of conserved bacterial c-di-AMP receptor proteins

(2013) R. M. Corrigan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

STING-Dependent Recognition of Cyclic di-AMP Mediates Type I Interferon Responses during Chlamydia trachomatis Infection

(2013) J. R. Barker et al.   mBio

Cyclic di-AMP Is Critical for Listeria monocytogenes Growth, Cell Wall Homeostasis, and Establishment of Infection

(2013) C. E. Witte et al.   mBio

Mycobacterium Tuberculosis Activates the DNA-Dependent Cytosolic Surveillance Pathway within Macrophages

(2012) Paolo S. Manzanillo et al.   Cell Host & Microbe

ESX-1-mediated translocation to the cytosol controls virulence of mycobacteria

(2012) Diane Houben et al.   CELLULAR MICROBIOLOGY

Listeria monocytogenes Strain-Specific Impairment of the TetR Regulator Underlies the Drastic Increase in Cyclic di-AMP Secretion and Beta Interferon-Inducing Ability

(2012) Takeshi Yamamoto et al.   INFECTION AND IMMUNITY

Hyperinduction of Host Beta Interferon by a Listeria monocytogenes Strain Naturally Overexpressing the Multidrug Efflux Pump MdrT

(2012) Kierstyn T. Schwartz et al.   INFECTION AND IMMUNITY

Cyclic Di-AMP Homeostasis inBacillus subtilis

(2012) Felix M. P. Mehne et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mycobacterium tuberculosisESAT-6 Exhibits a Unique Membrane-interacting Activity That Is Not Found in Its Ortholog from Non-pathogenicMycobacterium smegmatis

(2012) Joaquin De Leon et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Dynamic Roles of Type I and Type II IFNs in Early Infection with Mycobacterium tuberculosis

(2012) L. Desvignes et al.   JOURNAL OF IMMUNOLOGY

The helicase DDX41 recognizes the bacterial secondary messengers cyclic di-GMP and cyclic di-AMP to activate a type I interferon immune response

(2012) Kislay Parvatiyar et al.   NATURE IMMUNOLOGY

Innate sensing of bacterial cyclic dinucleotides: more than just STING

(2012) Andrew G Bowie   NATURE IMMUNOLOGY

Mycobacterium tuberculosis Rv3586 (DacA) Is a Diadenylate Cyclase That Converts ATP or ADP into c-di-AMP

(2012) Yinlan Bai et al.   PLoS One

Phagosomal Rupture by Mycobacterium tuberculosis Results in Toxicity and Host Cell Death

(2012) Roxane Simeone et al.   PLoS Pathogens

Methicillin Resistance Alters the Biofilm Phenotype and Attenuates Virulence in Staphylococcus aureus Device-Associated Infections

(2012) Clarissa Pozzi et al.   PLoS Pathogens

Loss of Function of the GdpP Protein Leads to Joint β-Lactam/Glycopeptide Tolerance in Staphylococcus aureus

(2011) J. M. Griffiths et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Two DHH Subfamily 1 Proteins Contribute to Pneumococcal Virulence and Confer Protection against Pneumococcal Disease

(2011) L. E. Cron et al.   INFECTION AND IMMUNITY

Mycobacterium tuberculosis Triggers Host Type I IFN Signaling To Regulate IL-1  Production in Human Macrophages

(2011) A. Novikov et al.   JOURNAL OF IMMUNOLOGY

MPYS Is Required for IFN Response Factor 3 Activation and Type I IFN Production in the Response of Cultured Phagocytes to Bacterial Second Messengers Cyclic-di-AMP and Cyclic-di-GMP

(2011) L. Jin et al.   JOURNAL OF IMMUNOLOGY

Dysregulation of serine biosynthesis contributes to the growth defect of a Mycobacterium tuberculosis crp mutant

(2011) Guangchun Bai et al.   MOLECULAR MICROBIOLOGY

Analysis of the role of Bacillus subtilis σM in β-lactam resistance reveals an essential role for c-di-AMP in peptidoglycan homeostasis

(2011) Yun Luo et al.   MOLECULAR MICROBIOLOGY

STING is a direct innate immune sensor of cyclic di-GMP

(2011) Dara L. Burdette et al.   NATURE

Bis-(3′,5′)-cyclic dimeric adenosine monophosphate: Strong Th1/Th2/Th17 promoting mucosal adjuvant

(2011) Thomas Ebensen et al.   VACCINE

c-di-AMP Is a New Second Messenger in Staphylococcus aureus with a Role in Controlling Cell Size and Envelope Stress

(2011) Rebecca M. Corrigan et al.   PLoS Pathogens

A mecA-Negative Strain of Methicillin-Resistant Staphylococcus aureus with High-Level  -Lactam Resistance Contains Mutations in Three Genes

(2010) R. Banerjee et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

TheN-Ethyl-N-Nitrosourea-InducedGoldenticketMouse Mutant Reveals an Essential Function ofStingin theIn VivoInterferon Response toListeria monocytogenesand Cyclic Dinucleotides

(2010) John-Demian Sauer et al.   INFECTION AND IMMUNITY

Intranasal Poly-IC treatment exacerbates tuberculosis in mice through the pulmonary recruitment of a pathogen-permissive monocyte/macrophage population

(2010) Lis R.V. Antonelli et al.   JOURNAL OF CLINICAL INVESTIGATION

c-di-AMP Secreted by Intracellular Listeria monocytogenes Activates a Host Type I Interferon Response

(2010) J. J. Woodward et al.   SCIENCE

NOD2, RIP2 and IRF5 Play a Critical Role in the Type I Interferon Response to Mycobacterium tuberculosis

(2009) Amit K. Pandey et al.   PLoS Pathogens

cAMP levels withinMycobacterium tuberculosisandMycobacterium bovisBCG increase upon infection of macrophages

(2008) Guangchun Bai et al.   FEMS IMMUNOLOGY AND MEDICAL MICROBIOLOGY

IFN-β improves BCG immunogenicity by acting on DC maturation

(2008) Elena Giacomini et al.   JOURNAL OF LEUKOCYTE BIOLOGY

MPYS, a Novel Membrane Tetraspanner, Is Associated with Major Histocompatibility Complex Class II and Mediates Transduction of Apoptotic Signals

(2008) L. Jin et al.   MOLECULAR AND CELLULAR BIOLOGY

Structural Biochemistry of a Bacterial Checkpoint Protein Reveals Diadenylate Cyclase Activity Regulated by DNA Recombination Intermediates

(2008) Gregor Witte et al.   MOLECULAR CELL

Great Times for Small Molecules: c-di-AMP, a Second Messenger Candidate in Bacteria and Archaea

(2008) U. Romling   Science Signaling