Article
Endocrinology & Metabolism
Sonia Sanchez-Bezanilla, Rebecca J. Hood, Lyndsey E. Collins-Praino, Renee J. Turner, Frederick R. Walker, Michael Nilsson, Lin Kooi Ong
Summary: The study found that cognitive function remains impaired post-stroke, while there is modest spontaneous motor recovery over an 84-day period. Reduced neuronal loss and decreased neuroinflammation in the peri-infarct region may explain the spontaneous motor recovery, whereas persistent neuronal loss with increased neuroinflammation and amyloid-beta accumulation in the hippocampus likely contribute to the persistent cognitive dysfunction.
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
(2021)
Article
Immunology
Jing Nie, Yuan Fang, Ying Chen, Aisikeer Aidina, Qi Qiu, Lu Zhao, Xiang Liu, Lin Sun, Yun Li, Chuwen Zhong, Yuan Li, Xia Li
Summary: This study investigated the differences and similarities of peripheral inflammatory parameters in late-life depression (LLD) and amnestic mild cognitive impairment (aMCI). The results showed increased IL-6 levels in the plasma of LLD patients and decreased levels of chemokines (CXCL11 and CCL13), which were associated with abnormal cognitive function and depression scores. A novel model based on proinflammatory cytokines and brief screening tests showed fair accuracy in discriminating between LLD and aMCI.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Neurosciences
Wei Zhou, Mengmeng Hu, Jingrong Hu, Zhiyun Du, Qing Su, Zhangmin Xiang
Summary: The study demonstrates that luteolin can alleviate LPS-induced cognitive impairment by protecting neurons through inhibiting the overproduction of inflammatory cytokines. This finding suggests the potential application of luteolin in therapeutic research of neuroinflammation-related neurodegenerative diseases.
NEUROTOXICITY RESEARCH
(2021)
Article
Medicine, Research & Experimental
Lamis I. Alotayk, Maha A. Aldubayan, Sattam K. Alenezi, Md Jamir Anwar, Ahmad H. Alhowail
Summary: Chemotherapeutic agents commonly used for treating various cancers often lead to chemobrain, which is characterized by difficulties in learning and memory processes that can persist for years. This study used a rat model of neuroinflammation to evaluate cognitive function after treatment with these agents and assess the possible involvement of thyroid toxicity in chemotherapy-induced cognitive dysfunction.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Review
Clinical Neurology
Abir A. Rahman, Narayanappa Amruta, Emmanuel Pinteaux, Gregory J. Bix
Summary: Stroke is a major cause of death and disability globally, but therapeutic options are limited. Neurogenesis induced by stroke injury is of therapeutic interest. Understanding the interplay between neuroinflammation and neurogenesis is crucial for future stroke therapy development.
TRANSLATIONAL STROKE RESEARCH
(2021)
Article
Multidisciplinary Sciences
Arina Ponomarenko, Anna A. Tyrtyshnaia, Evgeny A. Pislyagin, Inessa Dyuizen, Ruslan M. Sultanov, Igor Manzhulo
Summary: The results of this study demonstrate that DHEA has the potential to promote cognitive recovery in rats with mild traumatic brain injury by inhibiting pro-inflammatory microglial cells activity, reducing levels of pro-inflammatory markers, and increasing production of anti-inflammatory cells and antioxidant enzymes. This suggests that DHEA has a complex effect on neuroinflammation processes, highlighting its therapeutic potential.
SCIENTIFIC REPORTS
(2021)
Review
Endocrinology & Metabolism
Mandeep Kaur, Saurabh Sharma
Summary: Stroke is the second leading cause of death in developed countries, and it is also the primary cause of disability and cognitive impairment. Multiple factors, such as age, family history, hypertension, and diabetes, contribute to the risk of cognitive impairment and dementia after stroke. Recent research has revealed complex cellular changes and molecular mechanisms associated with stroke-related cognitive impairment.
METABOLIC BRAIN DISEASE
(2022)
Article
Cell Biology
Shengliang Peng, Yun Yu, Juan Li, Danling Jiang, Guohai Xu, Lidong Wu, Jialing Hu
Summary: Neuroinflammation plays a crucial role in the development of cognitive impairment. In this study, a lentiviral vector Hsp22 was used for intracerebroventricular injection pretreatment, and LPS was used to induce cognitive impairment in mice. The results showed that Hsp22 overexpression attenuated microglial activation, inflammatory responses, and apoptosis, and improved cognitive impairment in mice. These findings suggest that Hsp22 overexpression could be a potential therapeutic approach for treating cognitive impairment.
Article
Biochemistry & Molecular Biology
Giovanni Cirillo, Roberta Pepe, Mattia Siciliano, Domenico Ippolito, Dario Ricciardi, Manuela de Stefano, Daniela Buonanno, Danilo Atripaldi, Salvatore Abbadessa, Brunella Perfetto, Minoo Sharbafshaaer, Giovanna Sepe, Simona Bonavita, Alessandro Iavarone, Vincenzo Todisco, Michele Papa, Gioacchino Tedeschi, Sabrina Esposito, Francesca Trojsi
Summary: This study evaluated the effects of bilateral rTMS on plasmatic levels of MMPs and TIMPs, as well as cognitive performances, in MCI patients. The results showed that rTMS treatment reduced MMP1, -9, and -10 levels, increased TIMP1 and TIMP2 levels, and improved visuospatial performances in MCI patients.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Immunology
Lingling Xiao, Liang Li, Jingcong Huang, Yuting Luan, Jiaying Pan, Yun Gai, Zhenyu Xu
Summary: Salidroside (SAL) has been shown to have protective effects against neuroinflammation and cognitive impairment in a septic encephalopathy mice model (SEMM) through promoting autophagy.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Sandesh P. Kamdi, Amit Raval, Kartik T. Nakhate
Summary: The study demonstrated that phloridzin can protect mice from LPS-induced memory impairments and neuroinflammation, possibly through mechanisms involving antioxidant, anti-inflammatory, and enhanced cholinergic signaling activity.
Review
Biochemistry & Molecular Biology
Aleksandra Kaliszewska, Joseph Allison, Matteo Martini, Natalia Arias
Summary: Aging is a major contributor to cognitive decline, with mitochondrial dysfunction closely linked to cognitive impairment. Nutrition plays a crucial role in determining mitochondrial functioning, and dietary choices can help counteract cognitive decline in late adulthood.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Virology
Yu Fu, Irene Lorrai, Barry Zorman, Daniele Mercatelli, Chase Shankula, Jorge Marquez Gaytan, Celine Lefebvre, Giordano de Guglielmo, Hyunjae Ryan Kim, Pavel Sumazin, Federico M. Giorgi, Vez Repunte-Canonigo, Pietro Paolo Sanna
Summary: Substance use disorders are common in people with HIV, and excessive opioid intake can lead to neurotoxicity and cognitive impairment.
Article
Pharmacology & Pharmacy
Miao Sun, Yang Li, Min Liu, Qingxiao Li, Likai Shi, Xianghan Ruan, Yuting Huo, Zhikang Zhou, Xiaoying Zhang, Yulong Ma, Weidong Mi
Summary: We found that insulin treatment significantly improved LPS-induced cognitive decline, neuronal injuries, and blood-brain barrier disruption. Insulin treatment inhibited the activation of microglia and astrocytes, and the release of TNF-α and IL-13 in the hippocampus. Furthermore, insulin treatment inhibited LPS-induced ferroptosis in the hippocampus by decreasing iron accumulation levels, regulating ferroptosis-related proteins, and inhibiting oxidative stress injuries and lipid peroxidation.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2023)
Article
Neurosciences
Ismaheel Akinwale Adeniyi, Kabirat Temitope Babalola, Victor Adetayo Adekoya, Oyetola Oyebanjo, Abayomi Mayowa Ajayi, Samuel Adetunji Onasanwo
Summary: The study demonstrates that honey has potential in ameliorating lipopolysaccharides-induced neuroinflammation, improving memory impairment, anxiety, and motor coordination, reducing pro-inflammatory cytokine levels and oxidative stress. Additionally, honey restores damaged neuronal structure.
NUTRITIONAL NEUROSCIENCE
(2023)
Article
Medicine, Research & Experimental
S. V. Shirshev, E. G. Orlova, O. A. Loginova, I. V. Nekrasova, O. L. Gorbunova, I. L. Maslennikova
BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE
(2018)
Article
Medicine, Research & Experimental
N. S. Glebezdina, A. A. Olina, I. V. Nekrasova, E. M. Kuklina
BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE
(2018)
Article
Neurosciences
Aleksey Kulesh, Viktor Drobakha, Elena Kuklina, Irina Nekrasova, Vladimir Shestakov
JOURNAL OF STROKE & CEREBROVASCULAR DISEASES
(2018)
Article
Biotechnology & Applied Microbiology
I. L. Maslennikova, M. V. Kuznetsova, N. Toplak, I. V. Nekrasova, D. Zgur Bertok, M. Starcic Erjavec
LETTERS IN APPLIED MICROBIOLOGY
(2018)
Article
Biochemistry & Molecular Biology
S. Shirshev, I. Nekrasova, O. L. Gorbunova, E. G. Orlova
DOKLADY BIOCHEMISTRY AND BIOPHYSICS
(2019)
Article
Biochemistry & Molecular Biology
N. S. Glebezdina, A. A. Olina, I. Nekrasova, E. M. Kuklina
DOKLADY BIOCHEMISTRY AND BIOPHYSICS
(2019)
Article
Medicine, Research & Experimental
S. V. Shirshev, I. V. Nekrasova, O. L. Gorbunova, E. G. Orlova
BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE
(2019)
Article
Biochemistry & Molecular Biology
Elena Kuklina, Irina Nekrasova, Natalia Glebezdina
Summary: Semaphorin 4D (Sema4D) is widely present in the immune system and plays a crucial role in T lymphocyte activation. The activation of membrane Sema4D leads to phosphorylation of Lck/ZAP-70, suggesting its role as a receptor in immune regulation.
MOLECULAR IMMUNOLOGY
(2021)
Article
Immunology
Irina Nekrasova, Sergei Shirshev
JOURNAL OF NEUROIMMUNOLOGY
(2020)
Article
Medicine, General & Internal
A. Yu Bykova, A. A. Kulesh, N. A. Kayleva, E. M. Kuklina, V. V. Shestakov
BYULLETEN SIBIRSKOY MEDITSINY
(2019)
Article
Medicine, Research & Experimental
E. M. Kuklina, I. V. Nekrasova, Yu. V. Valieva
BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE
(2017)
Article
Cell Biology
S. V. Shirshev, I. V. Nekrasova, E. G. Orlova, O. L. Gorbunova
BIOLOGICHESKIE MEMBRANY
(2017)